• 정신신체의학
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• 제31권2호
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• pp.108-117
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• 2023

연구목적 신체 증상 장애(Somatic Symptom Disorder, SSD)는 다양한 신체 증상의 발현을 특징으로 하며, 현재까지 환자군 내에서 증상 심각도에 따른 자율신경계 활성의 차이에 대해서는 연구된 바가 거의 없다. 이에 본 연구에서는 신체 증상 장애 환자군에서 심박변이도(Heart Rate Variability, HRV) 차이를 검정하여 증상 심각도에 따른 자율신경계 변화를 반영하는 대표적 지표를 분석하였다. 방 법 2020년 9월 18일부터 2021년 10월 29일까지 강남세브란스병원 정신건강의학과에 내원했던 환자 중, DSM-5 진단 기준에 따라 SSD로 진단받은 환자 총 51명의 의무기록을 후향적으로 수집하였다. 이후, 집단 간 인구사회학 및 임상적 선택편의 보정을 위해 역확률 가중치(Inverse Probability Treatment Weighting, IPTW)를 적용하여 HRV 지표 차이 검정을 실시하였다. 결 과 신체 증상 심각도와 LF (nu), HF (nu), LF/HF, 그리고 SD1/SD2, Alpha1/Alpha2는 통계적으로 유의한 상관관계를 보였으며, IPTW 적용 후 비중증군은 27명(53.0%), 중증군은 24명(47.0%)로 보정되었고, 인구사회학적 요인 및 임상적 특성 차이가 유의미하지 않아 동질성이 확보되었다. 본 모형 분석 결과 고위험군일수록 시간 영역의 RMSSD (β=-0.70, p=0.003), pNN20 (β=-1.04, p=0.019), 주파수 영역은 LF (nu) (β=0.29, p<0.001), HF (nu) (β=-0.29, p<0.001), LF/HF (β=1.41, p=0.001), 그리고 비선형 영역에서는 SampEn15 (β=-0.35, p=0.014), SD1/SD2 (β=-0.68, p<0.001), Alpha1/Alpha2 (β=0.43, p=0.001)에서 유의미한 차이가 검정되었다. 결 론 신체 증상 심각도에 따른 HRV 지표의 차이는 시간과 주파수 영역, 그리고 비선형 영역 전반에서 검정되었으며, 신체 증상이 심할수록 교감신경의 과활성화 및 부교감신경의 저하를 시사하는 HRV 지표들이 유의미하게 높은 경향성을 보였다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.176-178
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• 1997

We are exposed to the various types of external stimuli, and many researches have been conducted to analyze the emotional changes to the stimuli quantitatively. In this paper, changes of human emotion was studied by analyzing HRV from ECG signals which were varied by the auditory stimulus. Power contents for each frequency bands were calculated from HRV waveforms. Two peak values representing autonomic nervous system status, HF and LF, were used to extract the parameters. An analysis on the normalized HF/LF to the subjective rating of the subject were performed. It was assumed that the positive emotional changes evoked by the auditory stimuli, the HF values representing activation of the parasympathetic nervous system, are increased much higher than the LF values, activation of the sympathetic nervous system. Results showed that the parasympathetic nervous system works more actively than the sympathetic nervous system to the stimuli which cause the positive emotional changes.

• 한국가금학회지
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• 제48권1호
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• pp.41-50
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• 2021

최근 병아리의 성 감별은 닭의 반성유전자를 이용한 깃털 감별법이 산업적으로 널리 이용되고 있으나, 한국토종닭에서는 아직 깃털 감별법이 활용되지 않고 있다. 따라서 본 연구에서는 한국토종닭의 깃털 감별의 산업적 적용을 위하여 닭의 조우성과 만우성 유전자를 이용한 자가성감별 계통을 조성하고자 한 것이다. 기초 계군으로 한국재래닭 적갈색종 557수를 대상으로 하여 조우성과 만우성의 유전자 빈도를 분석한 결과, 각각 0.814와 0.186으로 추정되어 본 집단으로 깃털자가성감별 계통의 구축이 가능한 것으로 판단되었고, 이를 바탕으로 조우성 부계통과 만우성 모계통의 종계 계군을 조성하였다. 모계통 조성에 이용할 만우성 동형접합체(KK) 수컷 선발을 위하여 검정교배를 실시한 결과 40수 중3수가 동형접합개체로 확인되었다. 조우성 종계와 만우성 종계 간의 생산능력을 비교하기 위하여 생존율, 체중, 초산일령, 산란율 및 난중을 분석한 결과, 조우성 닭은 생존율이 우수하였고, 만우성 닭은 산란율이 우수한 것으로 나타났으나, 다른 생산능력에서는 조우성과 만우성 닭 간에 차이가 없는 것으로 나타났다. 더불어 조성된 깃털 자가성감별 계통으로부터 생산된 병아리의 암수 감별의 유효성을 검정한 결과, 98.6%의 감별 일치율을 보였다. 따라서 한국토종닭을 이용한 깃털 자가성감별계통 조성 가능성과 더불어 이의 산업적 활용 가능성을 제시한다.

• 대한의용생체공학회:의공학회지
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• 제33권3호
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• pp.141-147
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• 2012

In this paper, we have investigated effects of two specific meditations (Chinese qigong meditation and Kundalini yoga meditation) on the heart rate variability (HRV), which is a well-known quantitative measure of autonomic balance, of skilled students. To analyze the effects, the MIT/BIH physionet database was utilized. The database includes RR intervals of eight skilled Chinese qigong meditators (5 women and 3 men; age range 26-35) and four skilled Kundalini yoga meditators (2 women and 2 men; age range 20-52). RR intervals of each subject were measured before and during the meditations. For HRV analysis, we have used typical four HRV parameters - the low frequency to high frequency power ratio (LF/HF ratio), SD2/SD1 ratio, sample entropy, and fractal dimension. The LF/HF ratio was calculated by the autoregressive spectrum and the SD2/SD1 ratio was derived from the Poincar$\grave{e}$ plot. The sample entropy was computed from the phase space plot and the fractal dimension was estimated by the Higuchi's algorithm. In the experiments, the Wilcoxon signed rank test was employed because we used small datasets and compared HRV parameters before and during the meditations. As a result, we have found increment of the LF/HF and SD2/SD1 ratios in both meditations; whereas the sample entropy is decreased during the meditations. In addition, the fractal dimension is increased during the Chinese qigong meditation; whereas it is decreased during the Kundalini yoga meditation. The results show that the sympathetic nervous system is generally more activated in skilled Chinese qigong and Kundalini yoga meditators, but the activation of the parasympathetic nervous tone is suppressed.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1997년도 한국감성과학회 연차학술대회논문집
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• pp.85-89
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• 1997

We present several biosignal measurement results and analysis algorithms for the visual stimulus from International Affective Picture Sytem. Sine human body is nonlinear dynamic system, we investigated both linear and nonlinear methods. We found that the alpha wave of EEG, the chaos of peripheral blood pressure, the LF/HF of HRV and thd retutn map of RR interval were good parameters for the measuremet of human sensibility. These can be used as the parameters for the measurement of human sensibility.

• 감성과학
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• 제7권4호
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• pp.51-56
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• 2004

본 연구의 목적은 각각의 색채 자극 하에서의 생리신호를 측정하고자 하였다. 실험에 사용된 색채는 빨강, 노랑, 녹색, 파랑, 보라, 그리고 백색을 사용하였다. 실험은 방음 암실에서 이루어졌으며, 건강한 성인 남, 여 30명을 대상으로 하였다. 생리신호의 측정은 뇌파와 심전도를 측정하였다. 뇌파의 실험결과는 차가운 색 계통의 색채에서 $\alpha$파의 상대 전력비가 증가한 것을 볼 수 있었다. 또한 심전도의 HRV 분석 결과도 차가운 색 계통에서 HF/LF의 비가 증가한 것을 볼 수 있었으며, 이 결과로서 색채 조명이 인체의 감성변화에 영향을 미치는 것을 알 수 있었으며, 이 결과를 활용하여 색채 환경 설계에 도움을 줄 수 있으리라 사료된다.

• Journal of Korean Neurosurgical Society
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• 제52권3호
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• pp.215-220
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• 2012

Objective : There were previous reports of redundant nerve roots (RNRs) focused on their clinical significance and pathogenesis. In this study, we investigated the significant radiologic findings that correlate with RNRs occurrence. These relations would provide an advanced clue for clinical significance and pathogenesis of RNRs. Methods : Retrospective research was performed with data from 126 patients who underwent surgery for central lumbar spinal stenosis (LSS). Finally, 106 patients with common denominators (inter-observer accuracy : 84%) were included on this study. We divided the patients into two groups by MRI, patients with RNRs and those with no RNRs (NRNRs). Comparative analyses were performed with clinical and radiologic parameters. Results : RNRs were found in 45 patients (42%) with central LSS. There were no statistically significant differences between the two groups in severity of symptoms. On the other hand, we found statistically significant differences in duration of symptom and number of level included (p<0.05). In the maximal stenotic level, ligamentum flavum (LF) thickness, LF cross-sectional area (CSA), dural sac CSA, and segmental angulation are significantly different in RNRs group compared to NRNRs group (p<0.05). Conclusion : RNRs patients showed clinically longer duration of symptoms and multiple levels included. We also confirmed that wide segmental angulation and LF hypertrophy play a major role of the development of RNRs in central LSS. Together, our results suggest that wide motion in long period contribute to LF hypertrophy, and it might be the key factor of RNRs formation in central LSS.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1987년도 한국자동제어학술회의논문집; 한국과학기술대학, 충남; 16-17 Oct. 1987
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• pp.364-369
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• 1987

It has recently shown that a solenoid valve can be utilized in a hydraulic position-control system by discontinuous control methods. The objective of this study is to investigate the effects of solenoid valves on the response characteristics of a hydraulic position-control system by applying two kinds of discontinued control methods i.e., Simple On-Off (SOF) and Pusating On-Off(POF) controls. Three types of solenoid valves i.e. low-frequency, closed-center type (LF/C), high-frequency, closed-center type (HF/C), low-frequency, tandem-center type(LF/T) were used in this study. Effects of loading conditions and control parameters on the response characteristics were experimentally examined and compared each other. Pressure transients within the actuator were also studied.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1997년도 한국감성과학회 연차학술대회논문집
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• pp.91-94
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• 1997

Objective of this stuey was to find the corrdlation between emotiona changes and the parameters of HRV spectrum evoked by tactile stimualtion. Twenty-one subjects were useds and five different types of materials, dry cottn, wet cotton, paper, sandpaper, and vinyl were applied to the left hand of each subject as a tactile stimulation. The results showed that HF/LF(ratio of high to low frequency amplitude calculated from power spectrum of HRV) decreased as the subject experienced the unpleasant emotion caused by wet cotton and sandpaper. On the othr hand, when the subject experienced the comfort, HF/LF increased. It was concluded that the proprsed methods can be applied to evaluate the characteristic changes in the autonomic nervous system which regulates the human emotion in the psychological aspects.

• 감성과학
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• 제1권1호
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• pp.93-103
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• 1998

In this paper, we present change of human sensiblity when the 26 healthy female subjects were exposed with visual picture stimulus. We used Intermational Affective Picture System as the visual stimulus. The methods are AutoRegressive(AR) spectrum which is a linear method and Return Map which is a nonlinear mithod. SR spectrum may variability(HRV). The LF/HF of HRV and the variation of Return Map were analyzed from ECG signal of the female subjects. Return Map of RR intervals were analyzed by computiong the variation. When the subjets were stimulated by the pleasant pictures, LF/HF and variation were decreased compared with unpleasant stimulus, We may obtain good parameters for the measurement of the change of human sensibility for the visual picture stimulus.