• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1775-1781
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• 2014

Background: To assess the long term clinical outcome of preoperative radiotherapy with or without chemotherapy followed by limb sparing surgery in patients with non-metastatic soft tissue sarcomas (STS) of the extremities. Materials and Methods: Sixty patients with locally advanced STS were retrospectively analyzed. The median tumor diameter was 12 cm. All patients were treated with preoperative radiotherapy delivered with two different fractionation schedules (35Gy/10fr or 46-50Gy/23-25fr). Neoadjuvant chemotherapy was added to 44 patients with large and/or high grade tumors. Surgery was performed 2-6 weeks after radiotherapy. Chemotherapy was completed up to 6 courses after surgery in patients who had good responses. Results: Median follow-up time was 67 months (8-268 months). All of the patients had limb sparing surgery. The 5-year local control (LC), disease free (DFS) and overall survival (OSS) rates for all of the patients were 81%, 48.1% and 68.3% respectively. 5-year LC, DFS and cause specific survival (CSS) were 81.7%, 47%, 69.8%, and 80%, 60%, 60% in the chemoradiotherapy and radiotherapy groups, respectively. On univariate analysis, patients who were treated with hypofractionation experienced significantly superior LC, DFS and CSS rates with similar rates of late toxicity when compared with patients who were treated with conventional fractionation and statistical significance was retained on multivariate analysis. Conclusions: Treatment results are consistent with the literature. As neoadjuvant chemoradiotherapy provides effective LC and CSS with acceptable morbidity, it should be preferred for patients with large and borderline resectable STS.

• 한국임상약학회지
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• 제16권1호
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• pp.63-68
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• 2006

Gabapentin, 1-(aminomethyl-1-cyclohexyl)acetic acid, is anew antiepileptic drug related to ${\gamma}-aminobutyric$ acid(GABA) currently being introduced in therapy worldwide. The bioavailability and pharmacokinetics of gabapentin capsules were examined in 22 volunteers who received a single oral dose in the fasting state by randomized balanced $2{\times}2$ crossover design. After dosing, blood samples were collected for a period of 24 hours and analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). Time course of plasma gabapentin concentration was analyzed with non-compartmental and compartmental approaches. $WinNonlin^{(R)}$, the kinetic computer program, was used for compartmental analysis. One compartment model with first-order input, first-order output with no lag time and weighting by $1/(predieted\;y)^2$ was chosen as the most appropriate pharmacokinetic model for the volunteers. The major pharmacokinetic parameters $(AUC_{0-24hr},\;AUC_{inf},\;C_{max}\;and\;T_{max})$ and other parameters $(K_a,\;K_{el},\;V_d/F\;and\;Cl/F)$ of $Gapentin^{TM}$ (test drug) and $Neurontin^{TM}$ (reference drug) were estimated by non-compartmental analysis and compartmental analysis. The 90% confidence intervals of mean difference of logarithmic transformed $AUC_{0-24hr}\;and\;C_{max}$ were $log(0.9106){\sim}log(1.l254)\;and\;log(0.8521){\sim}log(1.0505)$, respectively. It shows that the bioavailability of the test drug is equivalent with that of the reference drug. There was no statistically significant difference between the two drugs in all pharmacokinetic parameters.

• Journal of Power Electronics
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• 제16권6호
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• pp.1991-2004
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• 2016

An LC filter is required to reduce the output current ripple in the auxiliary resonant snubber inverter (ARSI) for high-performance applications. However, if the traditional control method is used in the ARSI with LC filter, then unnecessary current flows in the auxiliary circuit. In addressing this problem, a novel load-adaptive control that fully uses the filter inductor current ripple to realize the soft-switching of the main switches is proposed. Compared with the traditional control implemented in the ARSI with LC filter, the proposed control can reduce the required auxiliary current, contributing to higher efficiency and DC-link voltage utilization. In this study, the detailed circuit operation in the light load mode (LLM) and the heavy load mode (HLM) considering the inductor current ripple is described. The characteristics of the improved ARSI are expressed mathematically. A prototype with 200 kHz switching frequency, 80 V DC voltage, and 8 A maximum output current was developed to verify the effectiveness of the improved ARSI. The proposed ARSI was found to successfully operate in the LLM and HLM, achieving zero-voltage switching (ZVS) of the main switches and zero-current switching (ZCS) of the auxiliary switches from zero load to full load. The DC-link voltage utilization of the proposed control is 0.758, which is 0.022 higher than that of the traditional control. The peak efficiency is 91.75% at 8 A output current for the proposed control, higher than 89.73% for the traditional control. Meanwhile, the carrier harmonics is reduced from -44 dB to -66 dB through the addition of the LC filter.

• 조명전기설비학회논문지
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• 제18권5호
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• pp.61-68
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• 2004

최근, 연료전지는 새로운 발전시스템으로 주목받고 있다. 연료전지는 저전압/대전류의 전기적 특성을 가진다. 그러므로 일반 상용부하에 적용하기 위해서는 승압용 컨버터와 인버터가 필요하다. 제안된 시스템은 연료전지의 전압을 380[Vdc]로 승압하기 위한 절연형 DC-DC 컨버터와 단상 220[Vac]로 변환하기 위한 LC 필터를 가진 PWM 인버터로 구성된다. 또한, 연료전지 발전시스템용 양방향 DC-DC 컨버터는 부하 응답 특성을 개선시키기 위하여 구성하였다. 본 논문에서는 풀 브리지 컨버터와 단상 인버터를 설계하고 제작하였으며, 시뮬레이션과 실험을 통해 연료전지 발전 시스템이 분산전원에 적용이 가능함을 보여준다.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2001년도 학술대회논문집
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• pp.123-127
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• 2001

In this paper, prototype high-power-factor single-stage electronic ballast for fluorescent lamps is designed and implemented. A new low cost single stage high power factor electronic ballast for fluorescent lamps is based on integration of two-boost converter and LC type high frequency resonant converter. A ballast is obtained by simple construction, because full bridge rectifier diode is eliminated and simple control circuit is applied. Using two boost converter operating positive and negative half cycle respectively at line frequency (60Hz), operation in discontinuous conduction mode performs high power factor. The experimental results Show the good performance as PF 0.99, $A_{THD}$ 15.4%, and CF 1.65 at Output 63.5W.W.

• Journal of Power Electronics
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• 제18권4호
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• pp.997-1006
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• 2018

This paper proposes a transformerless photovoltaic (PV) power converter system based on the DC/AC boost inverter, which can solve the leakage current and second-order ripple power issues in single-phase grid-connected PV inverters. In the proposed topology, the leakage current can be decreased remarkably since most of the common-mode currents flow through the output capacitor, by-passing parasitic capacitors, and grounding resistors. In addition, the inherent ripple power component in the single-phase grid inverter can be suppressed without adding any extra components. Therefore, bulky electrolytic capacitors can be replaced by small film capacitors. The effectiveness of the proposed topology has been verified by simulation and experimental results for a 1-kW PV PCS.

• Journal of Power Electronics
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• 제12권3호
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• pp.458-467
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• 2012

Single phase converters suffer from ripple power pulsating at twice the line frequency. The ripple power is usually absorbed by a bulky capacitor bank and/or a dedicative LC resonant link, resulting in a low power density and a high cost. An alternative solution is using a dc link active power filter (APF) to direct the pulsating power into another energy-storage component. The main dc link filter capacitor can then be reduced substantially. Based on a mainstream dc APF topology, this paper proposed a new control strategy incorporating both dual-loop control and repetitive control. The circuit parameter design is also re-examined from a control point of view. The proposed APF scheme has better control performance, and is more suited for high power applications since it works in CCM and with a low switching frequency.

• 전기학회논문지
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• 제67권8호
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• pp.1047-1054
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• 2018

This paper proposed the strategies for controlling both the heater temperature and the output voltage of a single-phase inverter for the heat treatment. The single-phase inverter system for the heat treatment controls the heater temperature to its reference one, and also it limits the inverter output voltage to 60 V for safety. The stability may be deteriorated due to the large time constant difference between the heater temperature and inverter output voltage. In order to ensure the stability, a hysteresis on/off control approach for the heater temperature control is adapted, and both the open-loop and the closed-loop control strategies of the output voltage are suggested. The performances for the proposed strategies are demonstrated with the experiments.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2009년도 9th International Meeting on Information Display
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• pp.1371-1374
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• 2009

According to depth cues of an image, the optical engine of the solid volumetric true 3D display can project a sequence of slices of a 2D image to corresponding display at a set of liquid shutters (LC) locating at different depth. A single DLP optical engine developed for a solid volumetric true 3D display consists of a lamp, reflector, color wheel, hollow integrator, relays, DMD, and projection lens. The simulation results show that the optical engine designed for single DLP volumetric true 3D display satisfies the requirements.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2012년도 전력전자학술대회 논문집
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• pp.564-565
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• 2012

본 논문에서는 이미 설치되어 있는 TRIAC 위상제어 조광기에 LED조명장치를 적용할 경우 발생되는 낮은 위상 각에서의 LED플리커 현상, 입력 필터단 캐패시터의 피크 전압 상승으로 인한 부품 손상 및 소음 발생, TRIAC 유지전류 부족으로 인한 오동작 그리고 LC공진에 의한 비정상 오실레이션 등의 원인을 해결하기 위한 방안을 제시하였다. 그리고 이를 개선할 수 있는 Single Stage PSR PWM 컨버터를 설계하였으며 구현에 의하여 타당성을 입증하였다.