• Clinical and Experimental Reproductive Medicine
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• 제49권4호
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• pp.225-238
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• 2022

The ultimate goal of human assisted reproductive technology is to achieve a healthy pregnancy and birth, ideally from the selection and transfer of a single competent embryo. Recently, techniques for efficiently evaluating the state and quality of preimplantation embryos using time-lapse imaging systems have been applied. Artificial intelligence programs based on deep learning technology and big data analysis of time-lapse monitoring system during in vitro culture of preimplantation embryos have also been rapidly developed. In addition, several molecular markers of the secretome have been successfully analyzed in spent embryo culture media, which could easily be obtained during in vitro embryo culture. It is also possible to analyze small amounts of cell-free nucleic acids, mitochondrial nucleic acids, miRNA, and long non-coding RNA derived from embryos using real-time polymerase chain reaction (PCR) or digital PCR, as well as next-generation sequencing. Various efforts are being made to use non-invasive evaluation of embryo quality (NiEEQ) to select the embryo with the best developmental competence. However, each NiEEQ method has some limitations that should be evaluated case by case. Therefore, an integrated analysis strategy fusing several NiEEQ methods should be urgently developed and confirmed by proper clinical trials.

• Clinical and Experimental Reproductive Medicine
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• 제45권1호
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• pp.52-55
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• 2018

This study retrospectively assessed whether time-lapse data relating to developmental timing and morphology were associated with clinical outcomes, with the eventual goal of using morphokinetic variables to select embryos prospectively for cryopreservation. In this study, we examined the clinical outcomes of single vitrified-warmed blastocyst transfer cycles that were cultured in a time-lapse incubation system. The morphokinetic variables included uneven pronuclei, an uneven blastomere, multinucleation, and direct, rapid, and irregular division. A total of 164 single vitrified-warmed blastocyst transfer cycles were analyzed (102 cycles of regularly developed blastocysts and 62 cycles of blastocysts with morphokinetic variables). No significant differences in the age of females or the standard blastocyst morphology were found between these two groups. The regularly developed blastocysts showed significantly higher implantation and clinical pregnancy rates than the blastocysts exhibiting morphokinetic variables (30.4% vs. 9.7% and 37.3% vs. 14.5%, respectively; p< 0.01). The blastocysts that exhibited morphokinetic variables showed different mean development times compared with the regularly developed blastocysts. Although morphokinetic variables are known to have fatal impacts on embryonic development, a considerable number of embryos developed to the blastocyst stage. Morphokinetic variables had negative effects on the implantation and clinical pregnancy rates in vitrified-warmed blastocyst transfer cycles. These findings suggest that blastocysts cultured in a time-lapse incubation system should be considered for selective cryopreservation according to morphokinetic variables.

• Journal of Periodontal and Implant Science
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• 제35권4호
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• pp.991-1002
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• 2005

The purpose of this study was to compare the effect of desensitizing agents applied on hypersensitive root surface following periodontal treatment. This study included 21 subjects(168 vital teeth). To evaluate dentin sensitivity, three clinical tests(tactile, air stream, cold water) were tried and three different densensitizing agents(MS coat, Elmex gel. Superseal) were individually applied. After application, reassessment was done at 1 minute, 1 week, 1 month and 3 months. The results were as follows : 1. The degree of dentin sensitivity was measured highly in the sequence of cold water, air stream and tactile and significantly decreased in all four groups with lapse of time(p<0.05). 2. There was no significant difference between all four groups in the tactile test with lapse of time. 3. There was no significant difference between three experimental groups in the air stream test with lapse of time. however, one minute later, it was measured highly in the sequence of Superseal, MS coat and Elmex 4. There was no significant difference between three experimental groups in the cold water test with lapse of time. As a result of this study, all of three agents were significantly effective in reducing dentin hypersensitivity and these agents could be positively employed to patients complaining of dentin hypersensitivity following periodontal treatment.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 D
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• pp.1639-1641
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• 1999

This paper deals with the seasonal variation of soil resistivity and the special characteristic for ground rods by lapse of time. The ground resistance was changed by humidity, temperature of earth and earth resistance. In this experiment, we studied the resistivity during the period from June 1995 to May 1996 by the soil and the corrosion of the ground rods. As a result, the soil resistivity during the period are appeared minimum in summer and maximum in winter. The loss in weight of Fe rod appeared higher than Cu, Al, Cu-Zn, and St. In the lapse of time, Fe rod was reduced 1.2 % later two years and 1.95 % later three years in weight. Cu rod was defected oxygens of 14.7 % later two years and 30.3 % later three years by EDX.

• 지구물리와물리탐사
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• 제16권4호
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• pp.293-299
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• 2013

최근 한반도의 Direct Simulation Monte Carlo (DSMC)법에 의한 다중지연시간창(Multiple Lapse Time Window; MLTW)법 해석에서 속도구조보다 진원 깊이의 영향이 훨씬 더 크다는 것이 보고되어, 깊이가 약 10 km에 해당되는 지진 41개와 79 지점의 관측점을 잇는 경로가 330개에 이르는 자료에 대하여 DSMC법을 이용, 이전에 연구된 5가지 속도구조를 재검증하였다. 그 결과, 표층 진원을 가정한 해석적 모델보다 10 km 진원의 DSMC법 적용 균일모델의 잔차가 크게 개선된 반면, 속도구조 모델 간의 잔차값 차이는 비교적 작음을 확인하였다.

• 한국환경보건학회지
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• 제26권4호
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• pp.122-128
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• 2000

This study was carried out to survey trihalomethane formation potential(THMFP) levels in drinking underground water and to examine its characteristics in Kunsan area. In drinking underground water, THMFP increased with the lapse of reaction time and 96hr-THMFP was the highest of THMFPs examined. In many cases, 24hr-THMFP, 48hr-THMFP and 96hr-THMFP reflected 2hr-THMFP level due to the largest composition ratio of CHCl$_3$ decreased with the lapse of reaction of CHCl$_3$ among THM individuals. CHCl$_3$ was mostly formed within early 2hour of reaction time, but CHClBr$_2$ and CHBr$_3$ continued their formation until 48 hour. Accordingly, the composition ratio of CHCl$_3$ decreased with the lapse of reaction time while that of total Br derivatives increased. 96hr-THMFPs of drinking underground water in Kunsan area ranged from N.D.(not detected)~98.80 $\mu\textrm{g}$/$\ell$ and, in general, those of western section of Kunsan area, closer to the coast, showed the higher tendency. But, from their large range of variance, it could be considered that THMFPs differ individually even in the same section depending on such factors as the difference of water stream, circumstances of management and so on. All the parameters for water quality examined(pH, KMnO$_4$ consumption;UV$_{254}$ , TOC. Cl$^{[-10]}$ ) showed very week corelation with 96h-THMFP.

• 지구물리와물리탐사
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• 제16권4호
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• pp.217-224
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• 2013

모델변수의 증감 및 분해능을 고려하는 새로운 교차모델 제한자를 사용한 시간경과 역산 알고리듬을 개발하였다. 증감을 고려한 교차모델 제한자는 같은 변화비를 갖는 모델변수에 같은 제한을 가한다. 이 교차모델 제한자는 모델변수의 증감에 관계없이 의미 있는 변화를 보이는 모델변수들을 강조할 수 있다. 분해능 교차모델 제한자는 분해능이 낮은 모델변수에 작은 제한을 가하는 반면, 분해능이 높은 모델변수에는 큰 제한을 가한다. 따라서 분해능이 낮은 모델변수도 시간 경과에 따라 의미 있는 변화를 보일 경우 효과적으로 식별할 수 있다. 3차원 전기비저항 모니터링 자료의 수치실험을 통하여 이들 두 교차모델 제한자의 타당성을 검증하였다. 최종적으로, 방조제의 안정성 평가를 위하여 서해안에 위치한 방조제에서 얻은 3 차원 전기비저항 모니터링 자료의 처리에 개발된 시간경과 역산법을 적용하였다. 시간경과 역산의 결과 모니터링이 수행된 기간 동안 방조제에 주목할 만한 변화가 없는 것으로 해석되었다.

• 대한원격탐사학회지
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• 제25권6호
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• pp.507-515
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• 2009

Land surface temperature (LST) is a key environmental variable in a wide range of applications, such as weather, climate, hydrology, and ecology. However, LST is one of the most difficult surface variables to observe regularly due to the strong spatio-temporal variations. So, we have developed the LST retrieval algorithm from COMS (Communication, Ocean and Meteorological Satellite) data through the radiative transfer simulations under various atmospheric profiles (TIGR data), satellite zenith angle (SZA), spectral emissivity, and surface lapse rate conditions using MODTRAN 4. However, the LST retrieval algorithm has a tendency to overestimate and underestimate the LST for surface inversion and superadiabatic conditions, respectively. To minimize the overestimation and underestimation of LST, we also developed day/night LST algorithms separately based on the surface lapse rate (local time) and recalculated the final LST by using the weighted sum of day/night LST. The analysis results showed that the quality of weighted LST of day/night algorithms is greatly improved compared to that of LST estimated by original algorithm regardless of the surface lapse rate, spectral emissivity difference (${\Delta}{\varepsilon}$) SZA, and atmospheric conditions. In general, the improvements are greatest when the surface lapse rate and ${\Delta}{\varepsilon}$ are negatively large (strong inversion conditions and less vegetated surface).

• Journal of Oral Medicine and Pain
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• 제20권2호
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• pp.307-315
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• 1995

The purpose of this study was to assess the efficacy of several thermal therapies using ice pack, moist-hot pack and ultrasound, separately and concomitantly and to obtain the background information on the vascular changes after thermophysical therapies. The author had used 15 healthy subjects were examined and the subjects were divide into 5 groups : ice pack, moist-hot pack, ultrasound, ice pack and moist-hot pack, ice pack and ultrasound. Observation were made immediate before and 0,5,10,20,30,45,60,90 minutes after treatment. Thermography was performed in an Agema 870 thermovisio with 0.1$^{\circ}C$ difference of gradual temperature shift. The results were as follows : 1. Using ice pack only, the surface temperature of the masseter region was increased lapse of time, and most remarkably 90 minutes after the treatment. 2. Using moist-hot pack only, the surface temperature of the region was remarkably increased immediately after the treatment, but decreased lapse of time. 3. Using moist-hot pack with ice pack, the surface temperature of the face was remarkably increased immediately after the treatment, and decreased lapse of time, Hyperthermia was maintained for a longer time as compared with the group of moist-hot pack only. 4. Using ultrasound only, the surface temperature of the region was increased gradually, and most remarkably 30 minutes after the treatment, but decreased in the course of time. 5. Using ultrasound combined with ice pack, the surface temperature of the region was gradually decreased until 30 minutes after the treatment, and decrease to some extend at 45 minute. And then a gradual increase observed over the remaining period of the experiment. 6. Hyperthermia were maintained for a long time in the groups using ice pack combined with moist-hot pack and ultrasound as compared with the other groups. Our data suggest that ice pack can promote the efficacy of other thermal therapies.

• 대한물리치료과학회지
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• 제27권3호
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• pp.56-66
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• 2020

Background: The purpose of this study was to investigate the effects of pulsed-ultrasound intervention and continued-ultrasound on the PPT (pressure pain threshold), CK (creatine kinase) and LDH (lactate dehydrogenase) recovery of before EIMD (exercise-induced muscle damage). Design: Randomized Controlled Trial. Methods: Thirty subjects who are student in their 20s at a university participated in this study, these subjects were assigned into three groups, a control group (n=10), experiment group I (n=10), and experiment group II (n=10). The subjects in experimental group were intervened by pulsed-ultrasound and continued-ultrasound, while ones on control group weren't by any intervention after induced EIMD. Results: First, In the comparison of the PPT, there were significant variations with the lapse the time in three groups (p<.001) and there was a significant interaction of time and group (p<.001). In the among group comparison, the PPT of experimental group II was significantly larger than those of other groups (p<.01). Second, In the comparison of the CK, there were significant variations with the lapse the time in three groups (p<.001) and there was a significant interaction of time and group (p<.001). In the among group comparison, the CK of experimental group II was significantly smaller than those of other groups (p<.001). Third, In the comparison of the LDH, there were significant variations with the lapse the time in three groups (p<.001) and there was a significant interaction of time and group (p<.001). In the among group comparison, the LDH of experimental group II was significantly smaller than those of other groups (p<.001). Conclusion: The above results revealed that the continued-ultrasound intervention before an exercise had a positive effect of muscle function after EIMD. Therefore we can consider the continued ultrasound as a considerable intervention method to prevent or reduce an exercise injury.