• 치과방사선
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• 제23권1호
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• pp.49-66
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• 1993

The purpose of this study was to investigate the early effects of irradiation on the temporomandibular joint in rats. Male rats were singly irradiated with the dose of 5 Gy or 10 Gy to their head and neck region by /sup 60/Co X ray. Experimental animals were sacrificed at each of the following time intervals -1, 2, 3, 5, 7 and 14 days. The specimens were examined with a light microscope, and treated with H & E staining and immuno-histochemical staining. The results were as follows, 1. By light microscopic findings, proliferative and hypertrophic zone were narrowed and hematopoietic cells were few in number at 5 days after irradiation. Repair signs were seen at 7 days after irradiation when decrease in osteoclast, increase in hematopoietic cells and increase of proliferative zone were noted. The 10 Gy irradiated group showed more severe histopathologic change than the 5 Gy group, and their repair was more slow. 2. In the S -100 antibody, positive cells were examined in the glenoid fossa. Positive cells of irradiated group showed more slight decrease in number than the control group. Low radiosensitivity and slow repair was noted in the glenoid foosa. 3. The interarticular disc was high radioresistant, and any histopathologic changes were not seen in disc. 4. Repair was examined clearly with the response to the antibodies. Especially by 5 days after irradiation 5 Gy group showed S-l00 positive cells in hypertrophic zone next to proliferative zone, chondroitin-4-sulfate positive cell in erosive zone next to hypertrophic zone, type-1 collagen positive cell in subchondral bone.

• 한국균학회지
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• 제40권4호
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• pp.296-298
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• 2012

본 연구는 야생버섯으로부터 혈관계질환 관련 생리활성을 확인하여 혈관계질환을 위한 기능성식품 개발에 재료로 사용하기 위해 야생버섯 33종의 야생버섯 메탄올 추출물을 제조하여 심혈관계 질환 생리활성을 확인하였다. 긴대밤그물버섯(Boletellus elatus)과 벽돌빛뿌리버섯(Heterobasidion insulasis)이 높은 혈전용해 활성과 트롬빈저해효과, 항산화활성을 나타내 혈관계질환 치료나 예방을 위한 기능성식품 개발에 이용 가능할 것으로 기대된다.

• Food Science and Biotechnology
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• 제16권4호
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• pp.600-604
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• 2007

In this study, we first prepared 3 kinds of powders with different molecular masses from the crude protein-bound polysaccharide extract of Agraricus blazei Murill through ultrafiltration, followed by spray-drying. Then, the antitumor activities of the powders were analyzed. Size exclusion chromatography coupled with a multi-angle laser-light-scattering system showed the 3 powders had the following molecular ranges: below 10 kDa (SD-1), 10 to 150 kDa (SD-2), and above 150 kDa (SD-3), representing peak molecular weights of $8.26{\times}10^3,\;9.65{\times}10^4$, and $5.94{\times}10^6\;g/mol$, respectively. All the powders stimulated macrophage RAW264.7 cells to produce nitric oxide, of which SD-2 and SD-3 were superior to the crude extract powder (CP-SD), while SD-1 showed the lowest activity. Similar results were found for their cytotoxicities against human cancer cell lines (A549, MCF-7, and AGS), where the highest activity was obtained with the SD-2 treatment for 72 hr at $1,000\;{\mu}g/mL$. The MCF-7 cell line was less sensitive to the powders than the other cells. From this research we found that ultrafiltration, in combination with spray-drying, is applicable for preparing protein-bound polysaccharide powders with higher antitumor activities.

• 약학회지
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• 제35권6호
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• pp.497-503
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• 1991

Six novel 5-substituted-1-[2-(3-methoxy-2-hydroxyphenyl)-1-methoxyethyl]uracils 2a-f were prepared by condensation of 2,4-bis(trimethylsilyloxy)-5-substituted uracils with 2,7-dimethoxy-2,3-dihydrobenzofuran (9) in the presence of Lewis acid. The 2,3-dihydrobenzofuran derivative 9 was obtained by intramolecular acetalization of 2-acetoxy-3-methoxyphenyl acetaldehyde (8) which was synthesized by oxidative cleavage of 1-allyl-2-acetoxy-3-methoxybenzene (7) using osmium tetroxide followed by $NaIO_4$. Compounds 2a-f were evaluated for in vitro antiviral activity against HSV-1, HSV-2 and HRV. None of these compounds showed activity with $ID_{50}$ values up to $100\;{\mu}g/ml$ except for 5-chlorouracil derivative 2d which exhibited antiviral activity against HSV-1 with $ED_{50}$ $30\;{\mu}g/ml$. In the antitumor activity against L1210 and P388 leukemia cell lines, 2d showed activity with $ID_{50}$ values of $14\;{\mu}g/ml$ and $11.6\;{\mu}g/ml$, and 2c with $ID_{50}$ values of $22.9\;{\mu}g/ml$ and $8.8\;{\mu}g/ml$, respectively.

• Plant Resources
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• 제3권3호
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• pp.200-205
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• 2000

This study selects Sunwol local group, Gusang local group and Yongjun local group to examine the appropriate amount of applied fertilizer in cultivating the double crop seed of Alisma plantago by transplantation in the southern area, improve and complements the double cropping techniques and contribute to stable production. While the plant height is 45,47 and 49cm and the number of leaves is 11.7, 12.5 and 14.4 at non-fertilizing plot, the plant height is 67, 72 and 75cm and the number of leaves is 15.8, 17.2 and 19.3 at all fertilizing plot and their growth is active and in the character of plant height and the number of leaves, especially in the groove of N-P$_{2}$O$_{5}$-K$_{2}$O= 30-15-45kg/10a, the mean plant height of Sunwol is 75cm and mean number of its leaves is 19.3, the mean plant height and number of leaves in Gusang are 72cm and 17.2 respectively and those of Yongjun are 67cm and 15.8 respectively. While the number of floral axis is 1,2 in non-fertilizing plot, that of the whole varieties in all fertilizing plot is 3, 4, 5 and the mean floral axis of Sunwol is N-P$_{2}$O$_{5}$-K$_{2}$O = 10-5-15, 20-10-30, 30-15-45 kg/10a and 18-0-18 of complex fertilizer and 21-17-17kg/10a and it is small in all fertilizing plot. The yield of dry root per 10a is high in all fertilizing grooves and especially in the groove of N-P$_{2}$O$_{5}$-K$_{2}$O = 30-15-45 kg/10a, it is 372.6kg, in the groove of 18-0-18kg/10a using complex fertilizer, it is 389.1kg and in that of 21-17-17kg/10a, it is 376.7kg.6.7kg.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 1999년도 추계종합학술대회
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• pp.390-394
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• 1999

본 논문에서는 twisted-pair 채널특성을 이용하여 가우스 및 원단누화 잡음환경에서의 디지털가입 자라인의 BER 성능평가를 Semi-analytic 시뮬레이션 방법에 의해 수행하였다. 그 결과로서 감쇄가 없는 경우의 시뮬레이션 결과는 이론치보다 E$^{b}$ /N$^{0}$ 면에서 0.5dB 이내의 열화를 보석 시뮬레이션의 타당성을 보인다. 전송거리가 5000m로 길어지면 BER=l0$^{-7}$ 에서 E$^{b}$ /N$^{0}$ 는 약 4dB, 일정거리에서 나이퀴스트 주파수가 512kb/s로 높아지면 약 2dB 정도 열화한다. 또한 원단누화 잡음에 의한 영향은 전송거리면에 있어서는 원단누화 잡음 감쇄정수 k=$10^{-10}$ 이상일 때, 나이귀스트 주파수면에서는 k=$10^{-14}$ 이상일 때 크게 나타난다. 본 해석의 결과는 향후 국내외 디지털가입자라인의 표준화 제정에 기본적인 데이터로 활용될 수 있을 것이다.

• Macromolecular Research
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• 제15권5호
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• pp.437-442
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• 2007

Poly(ethylene glycol) methyl ether (PEG)-poly(${\beta}$-amino ester) (PAE) block copolymers were synthesized using a Michael-type step polymerization, and the construction of pH-sensitive polymeric micelles (PM) investigated. The ${\beta}$-amino ester block of the block copolymers functioned as a pH-sensitive moiety as well as a hydrophobic block in relation to the ionization of PAE, while PEG acted as a hydrophilic block, regardless of ionization. The synthesized polymers were characterized using $^1H-NMR$, with their molecular weights measured using gel permeation chromatography. The $pK_b$ values of the pH-sensitive polymers were measured using a titration method. The pH-sensitivity and critical micelle concentration (CMC) of the block copolymers in PBS solution were estimated using fluorescence spectroscopy. The pH dependent micellization behaviors with various bisacrylate esters varied within a narrow pH range. The critical micelle concentration at pH 7.4 decreased from 0.032 to 0.004 mg/mL on increasing the number of methyl group in the bisacrylate from 4 to 10. Also, the particle size of the block copolymer micelles was determined using dynamic light scattering (DLS). The DLS results revealed the micelles had an average size below 100 nm. These pH-sensitive polymeric micelles may be good carriers for the delivery of an anticancer drug.

• 멤브레인
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• 제22권1호
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• pp.35-45
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• 2012

양극산화 알루미나(AAO)막의 나노 사이즈 미세공(세공 크기 20 nm, 10 nm 및 200 nm)을 주형으로 사용하여 전도성 고분자인 폴리피롤, 폴리아닐린 중합체 및 폴리피롤/폴리아닐린 공중합체 나노와이어를 제조하였다. 미세공 주형 내에서 전도성 고분자의 성장은 세공의 벽면을 따라 튜브 형태로서 성장하였으며, 3시간 이후에는 내부가 완전히 채워진 나노와이어가 형성되었다. AAO 막을 수산화나트륨 용액으로 퍼리하여 세공 내에 형성된 전도성 고분자 나노와이어를 회수 하였으며. 회수된 나노와이어�l 직경과 길이는 주형 막의 세공 형상과 일치하였다. 통상의 용액 중합법으로 제조된 전도성 고분자 분말과 비교하여 주형 합성법으로 제조된 전도성 고분자 나노와이어는 결정성과 열적 안정성이 향상되었으며, 전기 저항은 4~60% 감소하였다.

• 한국식품과학회지
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• 제34권6호
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• pp.1018-1022
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• 2002

일산화질소(NO) 처리가 저장 중 황도 복숭아의 생리적 및 품질특성에 미치는 영향을 조사하기 위하여, 과실을 수확하여 밀폐용기에 넣고 $10^{\circ}C$에서 $N_2$ 치환 후 4시간 동안 NO(0, 10, 100 ppm) 처리한 다음 MA(0.05 mm LDPE) 포장하여 15일간 저장실험을 실시하였다. NO 100 ppm 처리는 복숭아의 에틸렌 생성과 과육경도 손실을 억제시키는 효과가 확인되었으나 가용성 고형물, 적정산도 및 표면색도의 변화에는 영향을 미치지 않는 것으로 나타났다. NO처리와 병행한 $N_2$치환 처리는 과실의 호흡과 에틸렌 생성을 억제시키는데 기여하였으며, MA포장은 NO 전처리와 무관하게 과육경도와 표면녹색의 손실을 억제하는 효과가 있었으나 가용성 고형물과 적정산도의 감소를 초래하였다.

• 방사선산업학회지
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• 제4권4호
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• pp.297-306
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• 2010

Due to the increasing incidence of diabetes, obesity and hypertensive, stevia has been placed great attentions as the sweetener to substitute sucrose in the world. Stevia was introduced to Korea in 1970's, but it has not been an attractive crop in that time. However, recently it has more attention for the natural food sweet additives. Because stevia have many problems for cultivation especially cultivar, seed germination, fertility, uniformity and glycoside quality, the sport mutation was attempted to in vitro plants for the improvement of some characteristics. The young in vitro plants was nursed on MS medium supplemented with $1mg\;l^{-1}\;GA_3$. Shoots of 10 cm height were irradiated with 0~200 Gy of gamma ray and the every node was separated and inoculated on MS basic medium. The lethality, number and length of shoot, numbers of node and branch were investigated for the evaluation of radiosensitivity. The optimum dose of gamma ray seemed to be around 80 Gy for the sport mutation induction in stevia. The lower node was more sensitive than higher node to radiation.