• Journal of Environmental Science International
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• v.18 no.8
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• pp.857-865
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• 2009

The physical properties of an atmospheric boundary layer in Wolryong, a west coastal region of Jeju, South Korea, in terms of the atmospheric stability and roughness length, is important and relevant to both engineers and scientists. The study is aiming to understand the atmospheric stability around this region and its effect on the roughness length. We calculate the Monin-Obukhov length(L) against 3 typical regions of the atmospheric condition - unstable regime (-5$-0.2{\leq}H/L{\leq}0.2$) and stable regime (0.2

• Journal of Microbiology and Biotechnology
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• v.17 no.1
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• pp.116-122
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• 2007

An efficient enzyme system for the synthesis of L-tyrosine was developed using a fed-batch reactor with continuous feeding of phenol, pyruvate, and ammonia. A thermo- and chemostable tyrosine phenol-lyase from Symbiobacterium toebii was employed as the biocatalyst in this work. The enzyme was produced using a constitutive expression system in Escherichia coli BL21, and prepared as a soluble extract by rapid clarification, involving treatment with 40% methanol in the presence of excess ammonium chloride. The stability of the enzyme was maintained for at least 18 h under the synthesis conditions, including 75 mM phenol at pH 8.5 and $40^{\circ}C$. The fed-batch system (working volume, 0.51) containing 1.0 kU of the enzyme preparation was continuously fed with two substrate preparations: one containing 2.2 M phenol and 2.4 M sodium pyruvate, and the other containing 0.4 mM pyridoxal-5-phosphate and 4M ammonium chloride (pH 8.5). The system produced 130g/I of L-tyrosine within 30h, mostly as precipitated particles, upon continuous feeding of the substrates for 22 h. The maximum conversion yield of L-tyrosine was 94% on the basis of the supplied phenol.

• Journal of Environmental Health Sciences
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• v.33 no.5
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• pp.392-396
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• 2007

Aquatic ecotoxicity of bisphenol A, a well-known endocrine disrupter in mammals, was studied using laboratory-reared Daphnia magna as a test organism. The static acute 48 h $EC_{50}$ of bisphenol A for daphnid neonates(<24 hold) was 12.9 mg/l and 110 h $LC_{50}$ values of bisphenol A for daphnid embryos of different ages after deposition into the brood chamber increase with ages in the range of 1.55 mg/l-8.91 mg/l. Also, 48 h $EC_{50}s$ generally increase with daphnid's ages in the range of 12.9 mg/l-19.8 mg/l. In the acute toxicity tests using mature daphnids, the lethal response and immobility all showed good concentration-response relationship with exposure concentration and exposure time, showing little difference between lethality and immobility. These results clarify that acute toxicity tests, using daphnid and its embryo, could also be useful tools easily available for the assessment of ecotoxicity of various harmful chemicals.

• Speech Sciences
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• v.10 no.2
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• pp.303-318
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• 2003

This paper attempts to investigate the tonal implementations of English stress clash, arguing that a preceding stress shifts leftward when two lexical stresses conflict across word boundaries or that H* and L* pitch accents are alternatively manifested on the stressed syllables, establishing intonational peak and valley contours. We claim that the H*/L* alternation might be a tonal strategy to avoid stress clash, and that pitch could be solely manipulated to display a rhythmic effect with maintaining lexical stress. In the experiment, we examined two-word combinations whose boundaries involve stress clash, and divided them into two categories. One has the preceding words involving a heavy syllable ahead of stress to guarantee the place for a shifting stress and the other, a light syllable, in which case stress shift is completely prevented. We analyzed the distribution of pitch accents in the word combinations, focusing on the pitch configurations in the cases where stress should not be shifted. Results show that approximately 50% of the stimuli show stress shift in the heavy syllable combinations of the preceding words; the preceding stress is moved leftward within the word. The other 50% and the light syllable combinations show various pitch accents patterns; H* and L* alternation, deaccentuation of either stressed syllable, or L-insertion between two H* pitch accents, etc. We interpret this as a rhythmic effect of tone to avoid stress clash and suggest that a true stress clash would be confined into cases without H*/L* contours.

• Journal of Environmental Health Sciences
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• v.29 no.3
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• pp.65-71
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• 2003

The injection concentration of corrosion inhibitor increases under the pH 7, temperature of 2$0^{\circ}C$, and alkalinity of 35 mg/l (as CaCO$_3$), the corrosion rate gradually decreased. When the corrosion inhibitor of 10 mg/l is injected, the corrosion rate for carbon steel pipe, galvanized steel pipe, and copper pipe reduces for 37, 66 and 61 % respectively that it is more efficient on galvanized steel pipe and copper pipe. As a result of examination of corrosion rate at pH 6, 7, and 8 when injecting 10 mg/l of corrosion inhibitor under the conditions of 2$0^{\circ}C$ in water temperature and 35 mg/l (as CaCO$_3$) in alkalinity, the efficiency of the corrosion inhibitor increases as the pH increases. For carbon steel pipe, it does not show much a difference with the change of the pH condition, but galvanized steel pipe and copper pipe clearly show the corrosion rate depending on the change of the pH condition. The efficiency of corrosion inhibitor is low as the concentration of residual chlorine is high, but it does not show a great influence at 0.4 mg/l or less. For each pipe type, in the case of carbon steel pipe, the range of increase of corrosion speed following the residual chloride is higher than the other pipe types. In the meantime, the effect following the residual chlorine in copper pipe is low.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.45.2-45.2
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• 2018

CS molecule is known to be adsorbed onto dust in cold dense cores, causing its significant depletion in the center region of cores. This study is aimed to investigate the depletion of CS molecule with optically thin $C^{34}S$ molecular line observations, including significance of its differentiation depending on the evolutionary status of the dense cores. We mapped five evolved starless cores, L1544, L1552, L1689B, L694-2 and L1197 using two molecular lines, $C^{34}S$ (J=2-1) and $N_2H^+$ (J=1-0) with NRO 45 m telescope. The $H^2$ column density and temperature structures of each targets were obtained by SED fitting for Herschel continuum images and the internal number density profiles by model fitting. All of the integrated intensity maps of $C^{34}S$ show depletion holes and 'semi-ring-like' distribution, indicating that the depletion of CS is clear and general. The radial profiles of CS abundance also show significant decrease towards the core center, while $N_2H^+$ abundance is almost constant or enhanced. We find that the more evolved cores with higher $H^2$ density tend to have a stronger depletion of CS. Our data strongly support claims that CS molecule generally depletes out in the central regions of starless dense cores and such chemical differentiation is closely related to their evolution.

• The Korea Journal of Herbology
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• v.26 no.1
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• pp.53-58
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• 2011

Objectives : The purpose of this study is to investigate effects of Scutellariae Radix Water Extract on hydrogen peroxide production in RAW 264.7 mouse macrophages. Methods : Scutellariae Radix produced from South Korea (SK) and Scutellariae Radix produced from China (SC) were extracted by hot water. Effects of SK and SC on hydrogen peroxide production in RAW 264.7 were measured by dihydrorhodamine 123 assay after 2, 4, 20, 24, 28, 44, and 48 h incubation at the concentrations of 10, 25, 50, and 100 ug/mL. Results : SK significantly increase hydrogen peroxide production in RAW 264.7 cells for 2, 4, 20, 24, 28, 44, and 48 h incubation at the concentrations of 10, 25, 50, and 100 ug/mL (P < 0.05). SC also significantly increase hydrogen peroxide production in RAW 264.7 cells for 4, 20, 24, 28, and 48 h incubation at the concentrations of 10, 25, 50, and 100 ug/mL (P < 0.05). For 2 h incubation, SC significantly increase hydrogen peroxide production in RAW 264.7 cells at the concentrations of 10, 25, and 100 ug/mL (P < 0.05). For 44 h incubation, SC significantly increase hydrogen peroxide production in RAW 264.7 cells at the concentrations of 10, 25, and 50 ug/mL (P < 0.05). Conclusions : These results suggest that Scutellariae Radix has the immune - enhancing property related with its increasement of hydrogen peroxide production in macrophages.

• Journal of Nutrition and Health
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• v.30 no.8
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• pp.930-935
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• 1997

Fatty acid binging proteins(FABP) are distinct but related gene productes which are found in many mamalian cell types. FABP bind long chain fatty acids in vitro. However, their functions and mechanisms of action, in vivo, remain unknown . Also not known is whether all FABP function similaryly in their respective cell types. or whether different FABP have unique functions. The puropose of the present study was to assess whether different members of the FABP family exhibit different structural and function properties. A comparison was made between heart(H-FABP) and liver (L-FABP). The results show that the binding sites of both FABP are hydrophobic in nature, although the L-FABP site is more nonpolar than the H-FABP site. Additionally, the bound ligand experiences less motional constraint within the H-FABP binding site than within the L-FABP binding site. In accordance with these differences in structural properties, it was found that anthroyloxy-fatty acid transfer from H-FABP to membranes is markedly faster than from L-FABP. moreover, the mechanism of fatty acid transfer to phospholipid membranes appears to occur via transient collisional interactions between H-FABP and membranes. In contrast , transfer of fatty acid from L-FABP occurs via an aqueous diffusion mechanism.

• Journal of Veterinary Clinics
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• v.14 no.2
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• pp.195-200
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• 1997

In order to compare the pharmacokinetic profiles of enrofloxacin-HCL)ENFLX-HCL) and enrofloxacin-KOH (ENFLX-KOH) after oral administration in broiler chickens, the study was performed. The chickens used in this study weighed $1.82 {\pm}0.2 kg$ and clinically healthy. The dose of intravenous and lral administration was 5 mg per kg of body weight as enrofloxacin. After intravenous injection of enrofloxacin, it showed two-compartment model with the rapid distribution phase and the slow elimination phase. The mean apparent volume of distribution (Vd) was 2.70 l/kg. The mean half-life of elimination and distribution showed 8.26 h and 0.44 h, respectively. The mean area under curve (AUC) was calculated as $19.7 {\mu} g{\cdot} h/ml$. After oral administration of ENFLX-HCL and ENFLX-KOH with a rate of dose 5 mg of enrofloxacin/kg of body weight, Both of the products were showed one-compartment model unlike that of i.v. enrofloxacin standard solution showed the mean bioavailability of 79.64% for the ENFLX-KOG and 86.24% for the ENFLX-HCL. The mean total body clearance of the former was 0.24 l/kg/h and the latter 0.42 l/kg/h. Both enorfloxacin formulations seemed to have good tissue distribution and penetration as indicated by large volume of distribution : 2.72 l/kg for the -KOH and 4.44 l/kg for the -HCL. With the results obtained in this study, ENFLX-HCL could be used in place of its salt form in chickens.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.1
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• pp.62.1-62.1
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• 2014

We present preliminary results on the chemical differentiation of two dense gas tracers CS and $N_2H^+$ in five 'evolved' starless cores, L1544, L1552, L1689B, L694-2 and L1197, using our mapping observations in $C^{34}S$(J=2-1) and $N_2H^+$(J=1-0) with Nobeyama 45-m telescope. We compared the intensity maps of two molecular lines with 850 ${\mu}m$ continuum data which precisely trace the density distribution of the dense cores, finding that all of our targets show the central depletion holes in CS distribution, but the similar distribution in $N_2H^+$ to the one in dust continuum. Our data confirm the claim that CS molecule generally deplete out in the central region in starless cores, while $N_2H^+$ keep abundant as they get evolved. The detailed quantitative analysis on CS depletion in the dense cores, for example, the size of CS depletion area and radial (or gas density) dependence of CS depletion, is underway and will be presented in the meeting.