• Title/Summary/Keyword: Kyushu

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Isolation of Angiotensin I-Converting Enzyme Inhibitory Peptide from Chungkookjang (청국장으로부터 Angiotensin I 전환효소 저해 Peptide의 분리)

  • Matsui Toshiro;Yoo Hyung Jae;Hwang Jae Sung;Lee Dong Seok;Kim Han Bok
    • Korean Journal of Microbiology
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    • v.40 no.4
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    • pp.355-358
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    • 2004
  • Chunkookjang, Korean traditional fermented soybean food emerges as a functional food to improve intestinal function and blood circulation. During Chungkookjang fermentation, microorganisms, enzymes, and diverse bioactive compounds increase sharply. Chungkookjang contains diverse oligo-peptides. Formation of peptides was confirmed by SDS-PAGE. Solube fermented soybean in our sample contained Tyr, Gln-Lys, Trp, Gln, and Lys-Pro as major components. Lys-Pro (0.083 mg/100 g sample) was purified by HPLC analysis. Angiotensin I­converting enzyme (ACE) causes hypertension by converting angiotensin I to angiotension II. ACE inhibitory activity of Lys-Pro was determined to be $IC_{50}=32.1\;{\mu}M.$ Whether or not eating Chungkookjang can lower blood pressure was also determined. Sistolic blood pressure dropped by 15 mmHg, and diastolic blood pressure by 8 mmHg 2 hr after a single administration of 20 g of fermented soybean. Chungkookjang might be helpful in improving blood circulation since it has ACE inhibitor and antihypertenisve effect.

Li2O and Li2CO3 Thin Film Growth by LPMOCVD (LPMOCVD에 의한 Li2O 및 Li2CO3 박막의 증착)

  • Jung, Sang-Chul;Ahn, Ho-Geun;Imaishi, Nobuyuki
    • Applied Chemistry for Engineering
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    • v.10 no.2
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    • pp.225-230
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    • 1999
  • Low pressure metal organic chemical vapor deposition (LPMOCVD) of $Li_2O$ solid thin films from Li(DPM) in nitrogen-oxygen or argon-oxygen atmosphere was experimentally investigated by using a small hot wall tubular type reactor. XRD and ESCA analysis revealed that $Li_2CO_3$ film grew in nitrogen-oxygen atmosphere and $Li_2O$ grew in argon-oxygen atmosphere. The grown lithium oxide or carbonate reacted with silicon or silica base materials to produce silicates. The CVD model analysis by means of the well-known micro trench method and Monte Carlo simulation was not fully successful, but a set of data on gas phase reaction rate constant and surface reaction constant was obtained.

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Gas sensing properties of $In_{2}O_{3}$ thin film prepared by spin-coating method (스핀 코팅에 의한 $In_{2}O_{3}$ 박막의 가스감지특성)

  • Chung, Wan-Young;Lim, Jun-Woo;Lee, Duk-Dong;Yamazoe, Noboru
    • Journal of Sensor Science and Technology
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    • v.7 no.2
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    • pp.117-123
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    • 1998
  • The $In_{2}O_{3}$ thin films were fabricated on a alumina substrate by spin-coating method and the gas sensing properties were tested. The coating solution was synthesized by the mixing of aqueous solution of $In(OH)_{3}$ and acetic acid, and ammonium carboxymethyl cellulose as a binder. The $In_{2}O_{3}$ thin films between 71 and 210nm thick were obtained by spin-coating between 1 and 7 times followed by drying at $110^{\circ}C$ and calcining at $600^{\circ}C$. The films consisted of a dense stack of tiny $In_{2}O_{3}$ particles between 23 and 27nm in diameter and covered well large grains of the alumina substrate. Then film thickness was well controlled by the number of spin-coating. The fabricated $In_{2}O_{3}$ films showed high sensitivity and very fast response property to CO and $H_{2}$.

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Magnetospheric and ionospheric responses to the passage of solar wind discontinuity on 24 November 2008

  • Kim, Khan-Hyuk;Park, Jong-Sun;Lee, Dong-Hun;Park, Young-Deuk;Angelopoulos, V.;Nishitani, N.;Hori, T.;Shiokawa, K.;Yumoto, K.;Baishev, D.
    • The Bulletin of The Korean Astronomical Society
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    • v.36 no.2
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    • pp.91-91
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    • 2011
  • The passage of the interplanetary discontinuity (i.e., sudden increases in the solar wind speed, density, and IMF strength) was detected by ACE near GSE (x, y, z) ~ (222, -36, 3) Re upstream of Earth around 22:48 UT on November 24, 2008. About 55 min later, this solar wind discontinuity was observed by Geotail near GSE (x, y, z) ~ (23, 18, -7) Re in front of Earth's bow shock. From the propagation time of the solar wind discontinuity between ACE and Geotail, it is expected that the discontinuity front is aligned with the Parker spiral and strikes the postnoon dayside magnetopause first. Using coordinated multi-point measurements (THEMIS and GOES) at or in geosynchronous orbit, we observed a tailward propagating sudden impulse (SI), excited by the interplanetary discontinuity, around 23:50 UT with its front retaining alignment similar to that of solar wind discontinuity. The SI event appears a negative-then-positive variation in the H component at high latitude Chokurdakh (CHD: MLAT ~ 64.7 deg) in the prenoon sector, which is opposite sense of normal SI event. During the positive deflection at CHD, the SuperDARN Hokkaido radar detected the downward motion of the ionosphere, implying westward electric field enhancement, at subauroral latitudes near CHD meridian. In our study we will discuss magnetospheric and ionospheric responses to the passage of the solar wind discontinuity using multi-point observations in space and on the ground.

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A Study on Safety Assessment for Ship Sailing under Electric Power Cable (해월(海越)송전선 하부의 선박 통항 안전성 평가에 관한 연구)

  • Kim, Hyun-Jong;Hong, Tae-Ho
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.13 no.1 s.28
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    • pp.55-60
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    • 2007
  • Many electric power cables span the sea in Korean archipelago. Lots of shipping routes were established between the islands in the same area and ships frequently sail under the cable which cross the seas. Sometimes electric power cables were accidently broken by sailing ships and catastrophic damage of island industry followed thereby. If navigators have detailed knowledge about the height of electric power cable, the ship's sailing condition will be greatly improved. But at the present time, navigators have limited data about the electric power cable. Those are the horizontal distance between pylons, the height of pylons and minimum height of electric power cable. This study introduced the calculating methodology to find out the height of cable at any position between pylons. The ship's tracks were recorded and traffic safety was assessed by statistical method in relation to cable height.

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Plasmonic Nanosheet towards Biosensing Applications

  • Tamada, Kaoru
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.105-106
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    • 2013
  • Surface plasmon resonance (SPR) is classified into the propagating surface plasmon (PSP) excited on flat metal surfaces and the local surface plasmon (LSP) excited by metalnanoparticles. It is known that fluorescence signals are enhanced by these two SPR-fields.On the other hand, fluorescence is quenched by the energy transfer to metal (FRET). Bothphenomena are controlled by the distance between dyes and metals, and the degree offluorescence enhancement is determined by the correlation. In this study, we determined thecondition to achieve the maximum fluorescence enhancement by adjusting the distance of ametal nanoparticle 2D sheet and a quantum dots 2D sheet by the use of $SiO_2$ spacer layers. The 2D sheets consisting of myristate-capped Ag nanoparticles (AgMy nanosheets) wereprepared at the air-water interface and transferred onto hydrophobized gold thin films basedon the Langmuir-Schaefer (LS) method [1]. The $SiO_2$ sputtered films with different thickness (0~100 nm) were deposited on the AgMy nanosheet as an insulator. TOPO-cappedCdSe/CdZnS/ZnS quantum dots (QDs, ${\lambda}Ex=638nm$) [2] were also transferred onto the $SiO_2$ films by the LS method. The layered structure is schematically shown in Fig. 1. The result of fluorescence measurement is shown in Fig. 2. Without the $SiO_2$ layer, the fluorescence intensity of the layered QD film was lower than that of the original QDs layer, i.e., the quenching by FRET was predominant. When the $SiO_2$ thickness was increased, the fluorescence intensity of the layered QD film was higher than that of the original QDs layer, i.e., the SPR enhancement was predominant. The fluorescence intensity was maximal at the $SiO_2$ thickness of 20 nm, particularly when the LSPR absorption wavelength (${\lambda}=480nm$) was utilized for the excitation. This plasmonic nanosheet can be integrated intogreen or bio-devices as the creation point ofenhanced LSPR field.

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The Widespread Distribution of the Venomous and Poisonous Blue-lined Octopus Hapalochlaena spp., in the East/Japan Sea: Possible Effects of Sea Warming

  • Kim, Ji-Hoe;Suzuki, Toshiyuki;Shim, Kil-Bo;Oh, Eun-Gyoung
    • Fisheries and Aquatic Sciences
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    • v.15 no.1
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    • pp.1-8
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    • 2012
  • The geographical distribution of the toxic blue-lined octopus (commonly known as the blue-ringed octopus), Hapalochlaena spp., around the East/Japan Sea was investigated. Observation records of the octopus were gathered using commercial search engines on the Internet. A questionnaire to complement and enhance the base data was conducted that targeted fishermen from areas where the octopus was most likely to occur, i.e., the southeast coast and islands of Korea in the East/Japan Sea. Overall, 32 observational records of the blue-lined octopus were found from Korea and Japan. In Korea, only one record, from 2003, was found on a website; none of the 240 fishermen who participated in the questionnaire reported seeing blue-lined octopus. However, a total of 31 observations of the blue-lined octopus from 2004 to July 2010 were found from 17 different regions in the East/Japan Sea and neighboring waters in Japan. Twenty-two cases were from coastal Honshu Island, and nine were from the west coast of Kyushu Island, Japan. The northern distributional boundary of the blue-lined octopus on the Japanese coast was off Fukui Prefecture around latitude $36^{\circ}$10' N. Our results indicate that the blue-lined octopus is distributed extensively along the Japanese coast, at a low frequency, in the East/Japan Sea.

ANIMAL AND HUMAN STUDIES ON THE ROLE OF SOYBEAN, RICE AND NUTS CONSUMPTION IN HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS

  • Imaizumi Katsumi
    • Proceedings of the Korean Society of Food Science and Nutrition Conference
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    • 2001.12a
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    • pp.61-68
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    • 2001
  • Soybean, rice and nuts are the staple foods in South East Asia. In order to clarify the function of these foods in relation to coronary heart diseases, we have done a series of experiments using animals and humans. Soybean protein preparations (SPI) in comparison with an animal protein, casein (CAS), resulted in reducing atherosclerotic lesion development in apolipoprotein (apo) E deficient mice that develop an advanced lesion similar to that in humans. This action was attributed to the protein, since the ethanol-extracted SPI (EE-SPI), from which isoflavones and saponins removed, lowered the lesion development in apo E-deficient mice. However, The EE-SPI, compared to the SPI, resulted in a decrease of mRNA for key proteins of cholesterol metabolism (low density lipoprotein receptor and cholesterol 7$\alpha$-hydroxylase) in hypercholesterolemic rats, followed by an elevation of the serum cholesterol level, indicating a contribution of isoflavones to the serum cholesterol level. Rice protein (RPI) was also effective to lower the lesion development in apo E deficient mice. Both the SPI and RPI led to an increased level of the serum NOiN03, metabolites of NO. This effect appeared to be attributed to their high content of arginine. Besides, C57BL/6J mice fed a diet containing whole grain rice had an elevation of the serum high-density lipoprotein cholesterol. Furthermore, rice bran oil and the unsaponifiable fraction that is rich in plant sterols were effective to lower serum cholesterol levels in hypercholeserolemic rats. Finally, we tested if walnuts consumption would be hypocholesterolemic for Japanese. A diet containing walnuts effectively lowered the serum total and low density lipoprotein cholesterol in Japanese men and women. These animal and human experiments would be relevant to advocate publics to keep consuming diets including soybean, rice and nuts for their healthful life.

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Ab initio Study of the Complexes of Trimethyl Ether of Monodeoxycalix[4]arene with Potassium Ion: Cation-π Interactions

  • Lee, Hyung-Dae;Kim, Kwang-Ho;Lee, Ho-Jun;Lee, Sik;Nanbu, Shinkoh;Choe, Jong-In
    • Bulletin of the Korean Chemical Society
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    • v.27 no.4
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    • pp.508-514
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    • 2006
  • In this study, we have performed ab initio computer simulations to investigate the conformational and complexation characteristics of the trimethyl ether of p-tert-butylmonodeoxycalix[4]arene (6) with a potassium ion. The structures of different conformers of 6 and their potassium complexes were optimized by using ab initio RHF/6-31G and B3LYP/6-31G(d,p) methods. The relative stability of the various conformers of the uncomplexed 6 is in following order: cone (most stable) > 1-partial-cone ~ 2i-partial-cone > 2-partial-cone ~ 1,3-alternate > 3i-partial-cone. However, the relative stability of the conformational complexes of 6 with $K^+$ is in the following order: 2-partial cone ~ 1,3-alternate > cone > 3-partial cone > 1-partial cone (least stable). The highest binding strengths of 2-partial-cone and 1,3-alternate complexes originate from two strong cation-$\pi$ interactions and two strong cation-oxygen interactions in the complex of 6+$K^+$. Due to the cation-$\pi$ interactions, the calculated C-C bond distances in the arenes of the $K^+$-complexes are about 0.0048 $\AA$ longer than the values of their isolated hosts.

The Numerical Simulation of Volcanic Ash Dispersion at Aso Caldera Volcano using Ash3D Model (Ash3D 모델을 이용한 아소 칼데라 화산에서의 화산재 확산 수치모의 연구)

  • Chang, Cheolwoo;Yun, Sung-Hyo
    • Journal of the Korean earth science society
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    • v.38 no.2
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    • pp.115-128
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    • 2017
  • Aso caldera volcano is located in central Kyushu, Japan which is one of the largest caldera volcanoes in the world. Nakadake crater is the only active central cone in Aso caldera. There was an explosive eruption on October 8, 2016, the eruption column height was 11 km, and fallout ash was found 300 km away from the volcano. In this study, we performed a numerical simulation to analyze the ash dispersion and the fallout tephra deposits during this eruption using Ash3D that was developed by the United States Geological Survey. The result showed that the ash would spread to the east and northeast, that could not affect the Korean peninsula, and the volcanic ash was deposited at a place from a distance of 400 km or more in the direction of east and northeast. The result was in close agreement with the identified ashfall deposits. Ash3D can be useful for quick forecast for the effects of hazards caused by volcanic ash.