• 한국환경보건학회지
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• 제41권5호
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• pp.358-367
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• 2015

Objectives: This study was performed to evaluate the analytical method for PAH metabolites in human urine using enzyme hydrolysis and solid-phase extraction coupled with LC-(ESI)-MS/MS technique. Methods: We employed HPLC tandem mass spectrometry techniques with appropriate pre-treatment for analysis of 16 OH-PAHs in human urine. Samples were hydrolysis by ${\beta}$-flucuronidase/Aryl sulfatase, and target compounds were extracted by solid-phase extraction with a strata-x cartridge. Cross-validation was performed between Eulji University and Green Cross laboratories with 200 human urine samples. Results: The accuracies were between 90.3% and 118.8%, and precisions (relative standard deviations) were lower than 10%. The linearity obtained was satisfying for the 16 OH-PAH compounds, with a coefficient of determination ($r^2$) higher than 0.99. The results of cross-validation at the two organizations were compared by ICC (interclass correlation coefficient) values. The cross-validation results were excellent or good for all compounds. Conclusion: An analytical method was validated for low nanogram levels of 16 OH-PAHs in human urine. Also, satisfying results were obtained for method validation such as accuracy, precision and ICC of cross-validation.

• 한국중재학회지:중재연구
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• 제21권1호
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• pp.57-72
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• 2011

According to Japanese Patent Act, the Japanese Patent Office, administrative organization, was authorized to decide validation of patent. However, Supreme Court of Japan held that a court is able to decide the invalidation of patent in 11th April, 2000, which caused the reform of Japanese Patent Act in June 2004. Reformed Patent Act established the article 104-3 and makes it for a court to decide the patentability where there are grounds for a patent invalidation. Through this amendment to the Patent Act, the legislative system to decide the patent validation has been reorganized and furthermore alleged infringer is allowed to argue against the patent validation by making use of infringement litigation procedure through defenses against patent invalidation as well as invalidation trial procedure for to file a request for a trial for patent invalidation to the Japanese Patent Office. That is to say, the article 104-3 was established in the Japanese Patent Act in the wake of Kilby, and thus a court, which is judicial authority, not administrative disposition agency is also able to decide the patent validation. Thus this article discuss how a court, the authority of which only patent infringement cases fell under, has been authorized to arbitrate cases about the patent validation and the decision of the patent validation in a court.

• 한국정보과학회논문지:데이타베이스
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• 제36권6호
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• pp.422-433
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• 2009

시맨틱 웹을 위한 하나의 보안연구로, 본 논문에서는, 온톨로지 계층 구조와 RDF 트리플 패턴에 기반한 RDF 접근 권한 명세 모델을 소개한다. 또한 권한 명세 모델을 승인된 접근 권한들에 대한 RDF 질의 유효성 검증 과정에 적용한다. RDF 트리플 패턴을 가지는 대표적 RDF 질의 언어인 SPARQL 또는 RQL 질의는 RDF 트리플 패턴 형식으로 명세된 접근 권한에 따라 실행 거부되거나 인가될 수 있다. 이러한 질의 유효성 검증 과정을 효율적으로 수행하기 위하여 RDF 포함 관계 추론에서의 주요한 권한 충돌 조건들을 분석한다. 다음으로 분석된 충돌조건과 Dewey 그래프 레이블링 기술을 활용하는 효율적 질의 유효성 검증 알고리즘을 제시한다. 실험을 통하여 제시된 검증 알고리즘이 합리적인 유효성 검증 시간과, 데이터와 접근권한들이 증가할 때 확장성을 가짐을 보인다.

• 산업경영시스템학회지
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• 제46권3호
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• pp.285-292
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• 2023

As various accidents have occurred in underground spaces, we aim to improve the quality validation standards and methods as specified in the Regulations on Producing Integrated Map of Underground Spaces devised by the Ministry of Land, Infrastructure and Transport of the Republic of Korea for a high-quality integrated map of underground spaces. Specifically, we propose measures to improve the quality assurance of pipeline-type underground facilities, the so-called life lines given their importance for citizens' daily activities and their highest risk of accident among the 16 types of underground facilities. After implementing quality validation software based on the developed quality validation standards, the adequacy of the validation standards was demonstrated by testing using data from two-dimensional water supply facilities in some areas of Busan, Korea. This paper has great significance in that it has laid the foundation for reducing the time and manpower required for data quality inspection and improving data quality reliability by improving current quality validation standards and developing technologies that can automatically extract errors through software.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2000년도 추계학술발표대회 및 bio-venture fair
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• pp.147-150
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• 2000

크로마토그래피 칼럼 검증전용으로 미니 칼럼을 이용한 자동화된 크로마토그래피 시스템(MiniValChrom)을 개발하였다. 이 시스템은 생산용 칼럼을 scale-down한 미니칼럼을 자동적으로 반복사용 하면서 실험실 내에서 ex-situ로 크로마토그래피 공정의 검증을 수행할 수 있게 설계되었다.

• Communications for Statistical Applications and Methods
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• 제12권2호
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• pp.413-423
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• 2005

Consider the problem of estimating the underlying regression function from a set of noisy data which is contaminated by a long tailed error distribution. There exist several robust smoothing techniques and these are turned out to be very useful to reduce the influence of outlying observations. However, no matter what kind of robust smoother we use, we should choose the smoothing parameter and relatively less attention has been made for the robust bandwidth selection method. In this paper, we adopt the idea of robust location parameter estimation technique and propose the robust cross validation score functions.

• Near Infrared Analysis
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• 제1권1호
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• pp.1-7
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• 2000

A convenient algorithm for optimizing wavelength selection in multiple linear regression (MLR) has been developed. MOP (MLP Optimization Program) has been developed to test all possible MLR calibration models in a given spectral range and finally find an optimal MLR model with external validation capability. MOP generates all calibration models from all possible combinations of wavelength, and simultaneously calculates SEC (Standard Error of Calibration) and SEV (Standard Error of Validation) by predicting samples in a validation data set. Finally, with determined SEC and SEV, it calculates another parameter called SAD (Sum of SEC, SEV, and Absolute Difference between SEC and SEV: sum(SEC+SEV+Abs(SEC-SEV)). SAD is an useful parameter to find an optimal calibration model without over-fitting by simultaneously evaluating SEC, SEV, and difference of error between calibration and validation. The calibration model corresponding to the smallest SAD value is chosen as an optimum because the errors in both calibration and validation are minimal as well as similar in scale. To evaluate the capability of MOP, the determination of benzene content in unleaded gasoline has been examined. MOP successfully found the optimal calibration model and showed the better calibration and independent prediction performance compared to conventional MLR calibration.

• Journal of Community Nutrition
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• 제5권2호
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• pp.83-92
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• 2003

Several self-administered dietary assessment questionnaires have recently been developed, validated, and used in nutritional epidemiological and clinical studies in Japan. This article describes recent evidence on development and validation of them. After extensive search of published articles both in English and Japanese languages, we identified 25 articles on 13 questionnaires of which validation studies have existed. Number of foods/menus assessed varied from 31 to 169 according to questionnaires. Eleven questionnaires were food frequency type, either with fixed portion size or semiquantitative, and two diet history types. All the 13 questionnaires were validated against intakes assessed with dietary record or 24-hour recall, and only two with biomarkers. Number of subjects used in the studies was between 23 and 350. All the studies used adult subjects. In the studies with dietary record or recall, the correlation coefficient for or orgy intake was between 0.22 and 0.65 (median = 0.44). Median correlation coefficient for nutrients was between 0.21 and 0.61. In the studies with biomarkers, serum marine-origin n-3 polyunsaturated fatty acids and carotenes, and urinary potassium seemed useful biomarkers. In conclusion, recent progress of this field in Japan is remarkable. But more research is needed for validation studies with biomarkers, and the development and validation of questionnaires for children and elderly subjects. (J Community Nutrition 5(2) : 83∼92,2003)

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2004년도 Proceedings of ISRS 2004
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• pp.35-38
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• 2004

We developed a Near Real-Time Validation System (NRVS) for the Level-2 Products of AQUA Satellite. AQUA satellite is the second largest project of Earth Observing System (EOS) mission of NASA. This satellite provides the information of water cycle of the entire earth with many different forms. Among its products, we have used five kinds of level-2 geophysical parameters containing rain rate, sea surface wind speed, skin surface temperature, atmospheric temperature profile, and atmospheric humidity profile. To use these products in a scientific purpose, reasonable quantification is indispensable. In this paper we explain the near real-time validation system process and its detail algorithm. Its simulation results are also analyzed in a quantitative way. As reference data set in-situ measured meteorological data which are periodically gathered and provided by the Korea Meteorological Administration (KMA) is processed. Not only site-specific analysis but also time-series analysis of the validation results are explained and detail algorithms are described.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2004년도 Proceedings of ISRS 2004
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• pp.298-301
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• 2004

The aim of this study is to cross-validate of spatial probability model, artificial neural network at Boun, Korea, using a Geographic Information System (GIS). Landslide locations were identified in the Boun, Janghung and Youngin areas from interpretation of aerial photographs, field surveys, and maps of the topography, soil type, forest cover and land use were constructed to spatial data-sets. The factors that influence landslide occurrence, such as slope, aspect and curvature of topography, were calculated from the topographic database. Topographic type, texture, material, drainage and effective soil thickness were extracted from the soil database, and type, diameter, age and density of forest were extracted from the forest database. Lithology was extracted from the geological database, and land use was classified from the Landsat TM image satellite image. Landslide susceptibility was analyzed using the landslide­occurrence factors by artificial neural network model. For the validation and cross-validation, the result of the analysis was applied to each study areas. The validation and cross-validate results showed satisfactory agreement between the susceptibility map and the existing data on landslide locations.