• Title/Summary/Keyword: Korean sponge

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Tissue Engineering with rhBMP-2;Bone Reconstruction in Implant Dentistry (rhBMP-2를 이용한 조직공학;치과 임프란트에서의 골 재건)

  • Wikesj, Ulf ME.;Hanisch, Oliver;Danesh-Meyer, Michael J.;Cho, Kyoo-Sung;Kim, Chong-Kwan
    • Journal of Periodontal and Implant Science
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    • v.29 no.3
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    • pp.447-472
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    • 1999
  • The preclinical and clinical studies reviewed herein show that rhBMP-2 induces normal physiologic bone in relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone, and allows placement and osseointegration of dental implants. Clearly, the bone inducing capacity of rhBMP-2 is carrier and site dependent. rhBMP-2 in an absorbable collagen sponge carrier induces relevant bone formation in space providing defects. Space providing carries extends this possibility to non-space providing sites. Notably, some ceramic and polymeric biomaterials may substantially interfere with rhBMP-2 induced osteogenesis.

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Effect of Marine Toxins on the Rabbit Platelets (해양생물독의 혈소판 응집작용에 관한 연구)

  • 박영현
    • Journal of Food Hygiene and Safety
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    • v.10 no.2
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    • pp.73-79
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    • 1995
  • Incidents of seafood and massive fish kills have been rapidly increasing in both frequency and geographical distribution and the socioeconomic impacts brought by those incidents. However, the biological origins of those marine toxins have not been well clarified. Most of the marine organisms investigated are filter-feeder, which accumulate toxins from their food and/or their symbiotic microalgae. We have examined the action on rabbit platelets of marine toxins isolated from cultured dinoflagellates and sponge collected at Okinawa. Maitotoxin (MTX) is a water-soluble toxin isolated from the cultured dinoflagellate Gambierdiscus toxicus which causes a seafood poisoning in tropical regions. Zooxanthellatoxin A (ZT-A) was isolated from exteracts of cultured symbiotic dinoflagellate Symbiodinium sp. (socalled zooxanthella) from flatworms of the genus Amphiscolops collected at Okinawan marine sponge Theonella sp. MTX caused a disaggregation and a dissolution of large aggregates. ZT-A caused a dissolution of small aggregates followed by a increment of light tranmission. TZ-A caused an initial and transient shape change followed by a sustained aggregation and a increment of large aggregates. In conclusion, marine toxins exert unique patterns on the light trasmission and the size of aggregates in rabbit platelets by their concentrations and kinds

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Effects of βig-h3/Chitosan Dressing on Dermal Fibroblast and Wound Healing (βig-h3포함 키토산 상처 도포제의 섬유아세포 증식 및 상처치유 개선 능 평가)

  • Cho, Ae-Ri;Choi, Hee-Sun
    • Journal of Pharmaceutical Investigation
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    • v.39 no.1
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    • pp.51-54
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    • 2009
  • ${\beta}ig$-h3, is a TGF-${\beta}$-induced gene product, extracellular matrix protein with 68 kDa MW(683 amino acids) and has been known for its possible roles in cell adhesion, spreading, migration and proliferation. To minimize a proteolytic degradation of ${\beta}ig$-h3, ${\beta}ig$-h3 incorporated chitosan sponge was prepared and its effects on fibroblast adhesion and migration were investigated. And its wound healing efficacy was evaluated in deep 2nd degree burn rabbit ear wound model. ${\beta}ig$-h3 enhanced fibroblast adhesion and proliferation. In histological observation, a significant over-proliferation of epidermal regeneration was observed in ${\beta}ig$-h3/chitosan dressing applied wound while epidermal regeneration was not proceeded yet in chitosan only treated wound. ${\beta}ig$-h3/sponge dressing could enhance epidermal regeneration.

A study on Chemical Constituents from Marine Sponge Luffariella sp. (해양 해면 Luffariella sp.의 화학적 성분에 대한 연구)

  • Park, Sun Ku;Kim, Taek Jae;Cho, Hyun-Woo
    • Analytical Science and Technology
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    • v.9 no.4
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    • pp.355-363
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    • 1996
  • The two metabolites, Aaptamine(1) and Demethyl(oxy)aaptamine(2) were isolated from marine Sponge Luffariella sp., collected in October 1992, Manado Bay, Sulawesi in Indonesia showed in vitro activity against KB cancer cell line. Their structures were elucidated by $^1H-$, $^{13}C-NMR$, $^1H-^{13}C$(1 bond) heteronuclear multiple quantum coherence spectroscopy(HMQC), electron ionization mass spectroscopy(EIMS), ultra-violet spectroscopy(UV) and infrared spectroscopy(IR).

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Anti-inflammatory Effect of Dactyloquinone B and Cyclospongiaquinone-1 Mixture in RAW264.7 Macrophage and ICR Mice

  • Lee, Dong-Sung;Hwang, In Hyun;Im, Nam-Kyung;Jeong, Gil-Saeng;Na, MinKyun
    • Natural Product Sciences
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    • v.21 no.4
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    • pp.268-272
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    • 2015
  • Sesquiterpene-quinone is a class of secondary metabolites frequently encountered from marine sponge. The present study was designed to examine the anti-inflammatory action of sponge-derived dactyloquinone B (DQB) and cyclospongiaquinone-1 (CSQ1) mixture using lipopolysaccharide (LPS)-induced inflammatory responses. We measured the production of nitric oxide (NO), tumor necrosis factor-alpha ($TNF-{\alpha}$), $interleukin-1{\beta}$ ($IL-1{\beta}$), and interleukin-6 (IL-6) and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein. $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6 production, which increased by treatment with LPS, were significantly inhibited by DQB and CSQ1 mixture. It also decreased the production of NO production, and iNOS and COX-2 expression. Furthermore, it reduced 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema of ICR mice. These results demonstrate that sesquiterpene-quinone, DQB and CSQ1 mixture, might serve as a chemical pipeline for the development of anti-inflammatory agent.

Offsprings Produced by Transcervically Inseminating Frozen-thawed Semen into Uterus of a Estrus-induced Saanen Goat during Non-breeding Season

  • Yong, Hwan-Yul;Kim, Min-Ah;Bae, Bok-Soo;Kim, Seung-Dong;Jo, Shin-Il;Lim, Yang-Mook;Yoo, Mi-Hyun;Ha, Yong-Hee;Oh, Chang-Shik;Kim, Doo-Hee
    • Journal of Embryo Transfer
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    • v.25 no.2
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    • pp.89-92
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    • 2010
  • We report herein the successful results of estrus induction, sperm cryopreservation and kids born by transcervical insemination of frozen-thawed semen in a Saanen goat. Flugestone acetate (FGA: 60 mg) was inserted into vagina for 15 days. The goat was intramuscularly injected with 400 IU PMSG and 200 IU hCG ($PG600^{(R)}$: Intervet, Korea) a day before withdrawal of the FGA sponge. Follicles and corpora lutea were identified on both ovaries by laparoscopy. Artificial insemination was performed 46 hours after removal of FGA sponge. The concentration of frozen-thawed semen was $3.975{\times}10^8/ml$ and 0.5 ml of frozen-thawed semen was transcervically inseminated into uterine body under anesthesia. Three kids, all females, were born 144 days after artificial insemination. This is the first report producing kids by transcervical insemination of frozen-thawed semen in a Saanen goat of which the estrus was induced by FGA sponges, PMSG and hCG during non-breeding season in Korea.

A Study on the Synthesis of Titanium Hydride by SHS(Self-propagating High-temperature Synthesis) Method and the Preparation of Titanium Powder (SHS법에 의한 티타늄 수소화물 합성 및 티타늄 분말 제조에 관한 연구)

  • Ha, Ho;Park, Seung-Soo;Lee, Hee-Cheol
    • Applied Chemistry for Engineering
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    • v.5 no.2
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    • pp.263-273
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    • 1994
  • Titanium powder prepared by dehydrogenating the titanium hydride which is synthesized by reacting Ti-sponge (99.67%) with hydrogen using the self-propagating high-temperature synthesis method. In the synthesis of titanium hydride, the particle size of the product was found dependent on the amount of hydrogen incorporated into the titanium such that the particle size of titanium hydride decreased with increasing hydrogen pressure and after-burn time. In the dehydrogenation process, as the dehydrogenation time increase, the particle size of titanium powder increased due to partial melting and sintering of titanium particles.

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A study on cytocompatibility of ion beam-irradiated chitosan sponges (이온 빔 조사 처리된 키토산 스펀지의 세포적합도에 관한 연구)

  • Ku, Young
    • Journal of Periodontal and Implant Science
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    • v.28 no.2
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    • pp.281-291
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    • 1998
  • Chitosan is a biodegradable and non-toxic material with a molecular weight of 800-1,500Kd which can be obtained in various forms with extraordinary chemical structures and biological characteristics of which enables it to be used in many fields as a biomaterial. Ion irradiation is a useful tool to modify chemical structures and physical properties of high molecular weight polymers. The basic hypothesis of this study is that when surface properties of chitosan in a sponge form are modified with ion beam-irradiation and cell adhesion properties of chitosan would improve and thereby increase the regenerative ability of the damaged bone. The purpose of this study was to illuminate the changes in the cytocompatibility of chitosan sponges after ion beam-irradiation as a preliminary research. Argon($Ar^+$) ions were irradiated at doses of $5{\times}10^{13}$, $5{\times}10^{15}$ at 35 keV on surfaces of each sponges. Cell adhesion and activity of alkaline phosphatases were studied using rat fetal osteoblasts. The results of this study show hat ion beam-irradiation at optimal doses($5{\times}10^^{13}\;Ar^+\;ion/cm^2$) is a useful method to improve cytocompatibility without sacrificing cell viability and any changing cell phenotypes. These results show that ion beam-irradiated chitosan sponges can be further applied as carriers in tissue engineering and as bone filling materials.

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Fever and Fever Management in Children: A Literature Review (아동의 발열과 발열관리: 문헌고찰)

  • Jeong, Yong-Sun;Kim, Jin-Sun
    • Child Health Nursing Research
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    • v.16 no.1
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    • pp.30-40
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    • 2010
  • Purpose: The purposes of this review were to identify whether available evidence supports the nursing interventions that are commonly used to reduce fever in children and to introduce research findings into practice. Methods: Journal databases and clinical guidelines from 1990 to 2009 were searched. The search terms were fever, febrile convulsion, fever management, fever phobia, child, antipyretics, temperature, external cooling, tepid sponge bath, and physical treatment. Results: Evidence suggests that uncomplicated fever is relatively harmless, but it is an important immunological defense. Antipyretics should not routinely be used with the sole aim of reducing body temperature in children with fever who are otherwise well. Currently a lack of evidence supports the practice of alternating acetaminophen and ibuprofen, and the routine use of tepid sponge bath. Conclusion: Currently, fever management in children does not reflect research evidence. Pediatric nurses can play an important role by encouraging clinical research in this area and also by enhancing research utilization in their practice. Moreover, pediatric nurses can educate parents about evidence-based fever management. Evidence-based educational interventions for pediatric nurses need to be developed and evaluated to improve the quality of nursing care in the management of childhood fever.

Yves Klein and Menswear Fashion design research (이브 클랭(Yves Klein)의 작품을 응용한 남성복 패션디자인 연구)

  • Kim, Jae-Hwan;Kan, Ho-Sup
    • Journal of Fashion Business
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    • v.16 no.2
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    • pp.74-87
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    • 2012
  • Many fashion designers were inspired by arts. Not only arts itself but also the sprit of the artist links with fashion. This study based on French artist Yves Klein who died in 1962, at the age of 34. Klein created over a thounsand works in only seven years. Among the his various art collections, it is focused on Yves Peintures, I.K.B(International Klein Blue) and Sponge sculpture. The extracted some of core concepts including aesthetic of Klein about color and line, space perception in monochrome and expansion of monochrome toward three dimensional sponge sculptures were transformed into fashion design. As a result, Yves Sweats project, which is T-shirts project based on Yves Peintures, designed as a three-dimentional expansion of Monochrome and it was shown at Fall/Winter 2011-12 Tranoi homme trade show in Paris. Also Yves Klein collection was designed as a ready-to-wear menswear collection that was presented at Fall/Winter 2011-12 Seoul Fashion Week.