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http://dx.doi.org/10.20307/nps.2015.21.4.268

Anti-inflammatory Effect of Dactyloquinone B and Cyclospongiaquinone-1 Mixture in RAW264.7 Macrophage and ICR Mice  

Lee, Dong-Sung (Department of Biomedical Chemistry, Konkuk University)
Hwang, In Hyun (Department of Chemistry, University of Iowa)
Im, Nam-Kyung (College of Pharmacy, Keimyung University)
Jeong, Gil-Saeng (College of Pharmacy, Keimyung University)
Na, MinKyun (College of Pharmacy, Chungnam National University)
Publication Information
Natural Product Sciences / v.21, no.4, 2015 , pp. 268-272 More about this Journal
Abstract
Sesquiterpene-quinone is a class of secondary metabolites frequently encountered from marine sponge. The present study was designed to examine the anti-inflammatory action of sponge-derived dactyloquinone B (DQB) and cyclospongiaquinone-1 (CSQ1) mixture using lipopolysaccharide (LPS)-induced inflammatory responses. We measured the production of nitric oxide (NO), tumor necrosis factor-alpha ($TNF-{\alpha}$), $interleukin-1{\beta}$ ($IL-1{\beta}$), and interleukin-6 (IL-6) and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein. $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6 production, which increased by treatment with LPS, were significantly inhibited by DQB and CSQ1 mixture. It also decreased the production of NO production, and iNOS and COX-2 expression. Furthermore, it reduced 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema of ICR mice. These results demonstrate that sesquiterpene-quinone, DQB and CSQ1 mixture, might serve as a chemical pipeline for the development of anti-inflammatory agent.
Keywords
Dactyloquinone B; Cyclospongiaquinone-1; Anti-inflammatory effect; Ear edema model;
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