• YAKHAK HOEJI
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• v.46 no.1
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• pp.63-68
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• 2002

The purpose of this study was to estimate the population pharmacokinetics of clarithromycin in healthy adult Korean and to investigate the factors influencing the pharmacokinetics of clarithromycin. The population pharmacokinetic parameters of clarithromycin were calculated with the data from healthy adult Koreans. A total of 798 plasma concentrations obtained from 78 subjects after administration of a single oral dose of 250 mg or 500 mg were used for the modeling. The concentration-time data were fitted to a one-compartment open model assuming a first-order absorption and elimination with no lag time. The correlations between various factors [such as sex, age, height, weight, sect creatinine (Scr) and dose and pharmacokinetic parameters were estimated with stepwise linear recession analyses. The selected covariates were incorporated in the population model of NONMEM, and the importance of each covariate was investigated by means of backwards elimination. The apparent clearance (CL/F) was significantly correlated to Scr and sex, and the apparent volume of distribution (Vd/F) was significantly correlated to Scr and height in a nonlinear relationship. The population values of Ka was 1.8 h $r_{-1}$, CL/F was 37.71 L/hr, Vd/F was 200 L and t/ sub 1/2 / was 3.68 hrs for a male Korean with 170 m height and 1.0 mg/dL Scr.

• Environmental and Resource Economics Review
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• v.21 no.2
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• pp.341-369
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• 2012

Population aging has been one of the serious problems in Korea. Aging can affect social and economic features including energy consumption. This paper analyzed how population aging makes an effect on residential electricity demand. Yearly data from 1965 to 2010 were collected. The long and short-run demands for residential electricity were estimated with respect to Korean aging index. The results show that population aging reduces residential electricity demands in the short run significantly, but the effect decreases in the long run. However, population aging still negatively affects residential electricity consumption in long run. If population keep aging as Korean government expected, then the residential electricity demand per capita will grow less than 3%.

• Animal cells and systems
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• v.14 no.4
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• pp.291-296
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• 2010

Population ecological characteristics of growth and mortality play an important role in understanding the population dynamics of marine mammals. The instantaneous coefficients of natural and bycatch mortality were estimated for minke whales (Balaenoptera acutorostrata) in Korean waters using a population assessment model composed of bycatch and abundance data. The survivorship curve of this population was fitted to the data, and then the curve was revised using age-specific relative bycatchability coefficients ($q_t$). Instantaneous coefficients of natural and bycatch mortality of minke whales were estimated as 0.024/year and 0.076/year, respectively, and from this the survival rate was estimated as 0.905. This estimated survival rate was comparable to other cetaceans in other regions. The $q_t$ for this population ranged from 0.020 to 0.193. The revised survival rates were higher when the $q_t$ was taken into account. The mortality coefficient, survival rate, $q_t$ and survivorship curves had not previously been determined for minke whale in this area. This estimate could serve as fundamental information to assess the status of this population and for conservation and rational management.

• Korea journal of population studies
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• v.2 no.1
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• pp.5-16
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• 1978

The main purpose of this study is to examine the recent level of fertility and potentiality of the Korean population in Japan and to investigate some forces which influence the fertility of them using survey data. Some estimates of the level of fertility for the Korean population in Japan in 1974 are presented in Table 1. Comparing the some estimates for 1974 with those for 1969, the level of fertility in 1974 was realistically declined. It also indicated that potentiality of Koreans in Japan showed decreasing population. For investigating some factors affecting fertility, total births is selected which regressed on some variables believed in general to be influential in determiaing fertility. It was used a step-wise multiple regression to determine the independent as well as the combined effects of each of the variables. The SPSS computer program was used to perform the anlysis. Result from this data reveals that wife's family size preference as relevant predictor does influence the fertility of Koreans in Japan at this point considering that the age group of 20-29 is very much related. By employing multiple classification analysis, the analysis is concluded by nothing that the wi 3 family size preference has an even stronger relationship with economic factors than any other facto 3.

• Animal Systematics, Evolution and Diversity
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• v.39 no.4
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• pp.264-271
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• 2023

The edible jellyfish Rhopilema esculentum occurs in waters throughout northeastern Asia, including in Korea, China, and Japan. In Korean waters, R. esculentum has appeared in two regions (Gangwha and Muan). Based on the appearance of young medusae and coastal distribution records, these two regions may be key R. esculentum breeding sites. In the present study, we investigate and compare the genetic structure of R. esculentum in the two regions using mitochondrial sequences (16S ribosomal RNA and cytochrome c oxidase subunit I). The genetic diversity of the R. esculentum population at Ganghwa exceeded that of the population at Muan. Despite considerable geographic separation (400 km) between the two regions(Gangwha and Muan), our haplotype network suggests that the Gangwha and Muan populations of R. esculentum are related. The simple and monotonous genetic structure of the Muan population shows that R. esculentum emergence is relatively recent. In contrast, the Gangwha population shows evolution. Moreover, jellyfish of the Gangwha population are genetically diverse and remain constant despite environmental fluctuations in the Han River. The Gangwha area is considered to be the old origin of R. esculentum in Korea.

• Korean Journal of Environment and Ecology
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• v.26 no.3
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• pp.374-381
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• 2012

In this study, ecological characteristics of Zacco platypus population in Lake Hoengseong region, including the up-and downstream in Lake, were investigated from April to November, 2010. The results compared with regional dynamics of Z. platypus population showed a dominant population among the other fish population, and also upstream has relatively high as 1,707 (78.70%) individuals than those of other sites. The regression coefficient (b) in relation to length-weight on Z. platypus population were 3.28 which appeared relatively a stabilized habitat condition in Lake Hoengseong region and 3.28 at the upstream and 3.10 in Lake Hoengseong and 3.09 at the downstream. Condition factor on Z. platypus population in Lake Hoengseong region showed stabilized population as 0.003 value, and especially the condition factors at the upstream were relatively higher than those at the downstream and Lake Hoengseong, indicate that Z. platypus population at the upstream displayed to be maintained as the most good condition in relation to trophic states. As a results of compared with body size on Z. platypus population, was investgated as highly distribute between 30~50mm and 70~90mm at upstream; 60~80mm in Lake Heongseong; 70~100mm at downstream, respectively. As a results, Z. platypus population at the upstream among Lake Hoengseong region displayed the most stabilized growth condition, and Z. platypus population were inhabitable in lotic and lentic environments based on good habitat condition.

• Journal of the Korean Association of Geographic Information Studies
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• v.26 no.4
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• pp.173-187
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• 2023

In an era of population decline, depopulated regions facing challenges in attracting inbound population migration must enhance urban vitality through the attraction of living populations. This study focuses on Busan, a city experiencing population decline, comparing the spatiotemporal distribution characteristics of registered residents and living populations in various administrative districts (Eup-Myeon-Dong) using mobile communication big data. Administrative districts are typified based on population change patterns, and regional characteristics are analyzed using indicators related to urban decline and vitality. Spatiotemporal distribution analysis reveals generally similar density patterns between registered residents and living populations; however, a distinctive feature is observed in the city center areas where the density of registered residents is low, while the density of living populations is high. Divergent trends in spatial patterns of change between registered residents and living populations show clusters of registered population decline in low-density areas and clusters of living population decline in high-density areas. Areas adjacent to declining living populations exhibit large clusters of population changes, indicating a spillover effect from high-density to neighboring areas. Typification results reveal that, even in areas with a decline in registered residents, there is active population influx due to commuting or visiting. These areas sustain an increase in the number of businesses, confirming the presence of industrial and economic growth. However, approximately 47% of administrative districts in Busan are experiencing a decline in both registered residents and living populations, indicating ongoing regional decline. Urgent measures are needed for enhancing urban vitality. The study emphasizes the necessity of utilizing living population data as an urban planning indicator, considering the increasing limit distance of urban activities and growing interregional interaction due to advancements in transportation and communication.

• Physical Therapy Korea
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• v.23 no.2
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• pp.93-99
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• 2016

Background: Parametric statistical procedures are typically conducted under the condition in which a sample distribution is statistically identical with its population. In reality, investigators use inferential statistics to estimate parameters based on the sample drawn because population distributions are unknown. The uncertainty of limited data from the sample such as lack of sample size may be a challenge in most rehabilitation studies. Objects: The purpose of this study is to review the bootstrapping method to overcome shortcomings of limited sample size in rehabilitation studies. Methods: Articles were reviewed. Results: Bootstrapping method is a statistical procedure that permits the iterative re-sampling with replacement from a sample when the population distribution is unknown. This statistical procedure is to enhance the representativeness of the population being studied and to determine estimates of the parameters when sample size are too limited to generalize the study outcome to target population. The bootstrapping method would overcome limitations such as type II error resulting from small sample sizes. An application on a typical data of a study represented how to deal with challenges of estimating a parameter from small sample size and enhance the uncertainty with optimal confidence intervals and levels. Conclusion: Bootstrapping method may be an effective statistical procedure reducing the standard error of population parameters under the condition requiring both acceptable confidence intervals and confidence level (i.e., p=.05).

• Development and Reproduction
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• v.22 no.3
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• pp.283-288
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• 2018

The author carried out PCR-based genetic platform to investigate the hierarchical polar dendrogram of Euclidean genetic distances of one bastard halibut population, particularly for Paralichthys olivaceus, which was further connected with those of the other fish population, by involving with the precisely designed oligonucleotide primer sets. Eight oligonucleotides primers were used generating excessively alterating fragments, ranging in size of DNA bands from larger than approximately 100 bp to less than 2,000 bp. As regards average bandsharing value (BS) results, individuals from Hampyeong population (0.810) displayed lower bandsharing values than did individuals from Wando population (0.877). The genetic distance between individuals approved the existence of close relationship in the cluster II. Relatively, individuals of one bastard halibut population were fairly related to that of the other fish population, as shown in the polar hierarchical dendrogram of Euclidean genetic distances. The points of a noteworthy genetic distance between two P. olivaceus populations demonstrated this PCR procedure is one of the quite a few means for individuals and/or populations biological DNA investigates, for species security and proliferation of bastard halibut individuals in coastal region of the Korea.

• 대한생식의학회:학술대회논문집
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• 2004.11a
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• pp.71-71
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• 2004