• Journal of Preventive Medicine and Public Health
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• 제38권2호
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• pp.203-207
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• 2005

Objectives: Recently, the American Diabetes Association (ADA) redefined the criteria of prediabetes, which has lowered the diagnostic level of fasting plasma glucose (FPG) from 110 to 125 mg/dl, down to levels between 100 to 125mg/dl. The purpose of this study was to determine the predictive cutoff level of FPG as a risk for the development of diabetes mellitus in Korean men. Methods: A retrospective cohort study was conducted on 11,423 (64.5%) out of 17,696 males $\leq$30 years of age, and who met the FPG of $\leq$125 mg/dl and hemoglobin A1c of $\leq$ 6.4% criteria, without a history of diabetes, and who were enrolled at the screening center of a certain university hospital between January and December 1999. The subjects were followed from January 1999 to December 2002 (mean follow-up duration; 2.3(${\pm}0.7$) years). They were classified as normal (FPG <100mg/dl), high glucose (FPG $\geq$100mg/dl and <110mg/dl) and impaired fasting glucose (FPG $\geq$110mg/dl and $\leq$125mg/dl) on the basis of their fasting plasma glucose level measured in 1999. We compared the incidence of diabetes between the 3 groups by performing Cox proportional hazards model and used receiver operating characteristic analyses of the FPG level, in order to estimate the optimal cut-off values as predictors of incident diabetes. Results: At the baseline, most of the study subjects were in age in their 30s to 40s (mean age, 41.8(${\pm}7.1$) year). The incidence of diabetes mellitus in this study was 1.19 per 1,000 person-years (95% CI=0.68-1.79), which was much lower than the results of a community-based study that was 5.01 per 1,000 person-years. The relative risks of incident diabetes in the high glucose and impaired fasting glucose groups, compared with the normal glucose group, were 10.3 (95% CI=2.58-41.2) and 95.2 (95% CI= 29.3-309.1), respectively. After adjustment for age, body mass index, and log triglyceride, a FPG greater than 100mg/dl remained significant predictors of incident diabetes. Using the receiver operating characteristic (ROC) curve, the optimal cutoff level of FPG as a predictor of incident diabetes was 97.5 mg/dl, with a sensitivity and a specificity of 81.0% and 86.0%, respectively. Conclusion: These results suggest that lowering the criteria of impaired fasting glucose is needed in Korean male adults. Future studies on community-based populations, including women, will be required to determine the optimal cutoff level of FPG as a predictor of incident diabetes.

• 동의생리병리학회지
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• 제23권1호
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• pp.237-244
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• 2009

We investigated the effects of acupuncture stimulation on pulse wave variables and heart rate variability (HRV) in healthy adults. To evaluate twenty healthy volunteers (10 men, 10 women) had acupuncture into both Hapkok (Ll4) and Taechung (Liv3) for 15 minutes. Radial pulse, Heart Rate Variability, body temperature and blood pressure were checked before and after acupuncture to evaluate Pulse Wave Variability and Autonomous Function. The results were as follows; Heart rate was significantly increased while systolic blood pressure (mmHg) and diastolic blood pressure (mmHg) were significantly increased after acupuncture treatment. Sixteen subjects didn't change representative pulse wave variables after acupuncture treatment. Energy, height of main peak (H1), height of pre-dicrotic valley (H2) and height of descending valley (H4) were decreased while height of dicrotic peak (H5) was significantly decreased after acupuncture treatment. Time to main peak (T1), time to pre-dicrotic valley (T2), time to dicrotic peak (T5), total time (T) and T-T4 were decreased while time to descending valley (T4) was increased after acupuncture treatment. Total area (At), area of main peak (Aw) and ratio of diastolic period area (Ad) were decreased while ratio of systolic period area (As) and angle of main peak (MPA) were increased after acupuncture treatment. The standard deviation of all normal RR intervals (SDNN) was increased while the root mean square of successive differences between the normal heart beats (RMSSD) was significantly increased after acupuncture treatment by time domain analysis. Low frequency power (LF) and LF/HF ratio were decreased while high frequency power (HF) was significantly increased after acupuncture treatment by frequency domain analysis. This study suggests that acupuncture treatment changes pulse wave variability and heart rate variability. Further study on various acupuncture treatment for pulse wave variability and heart rate variability is required.

• Journal of Preventive Medicine and Public Health
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• 제38권4호
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• pp.415-419
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• 2005

Objectives : We wanted to evaluate the relationship between obesity and left colonic adenomatous polyps in Korean adult men. Methods : This study was conducted among 575 adults men (aged between 40 and 69), who had colonoscopy done from January to December 2002 during a routine health examination at Health Promotion Center, Ulsan University Hospital. The patients' colons were examined up to splenic flexure by using fiberoptic colonoscopy. A questionnaire survey on behavioral factors and physical measurements were also done. The body mass index (BMI) and waist-hip ratio (WHR) were used as the indices of obesity. The BMI was categorized into three levels: normal ($BMI{\leq}22.9$), overweight ($23{\leq}BMI{\leq}24.9$), and obese ($BMI{\geq}25.0$). The WHR was categorized into four levels with cutoff points at the 30th, 60th, and 90th percentile of the control group. Age, education, smoking, alcohol use and exercise were controlled for by performing multiple logistic regression analysis. Results : There were 99 cases of colonic adenomatous polyps. Four hundred seventy six subjects with normal colonoscopy findings served as the control. The BMI and WHR were associated with the adenomatous polyps (odds ratio, 1.81 [95% CI=1.02-3.19] for a $BMI{\geq}25.0$ as compared with a $BMI{\leq}22.9$, odds ratio, 3.94 [95% CI=1.77-8.77] for a $WHR{\geq}0.95$ as compared with a $WHR{\leq}0.86$). The BMI was not associated with the risk of adenomatous polyps after additional adjustment was made for the WHR, but the association between the WHR and adenomatous polyps was still positive and independent of the BMI (odds ratio, 4.15 [95% CI=1.63-10.59]). Conclusions : The results support that obesity, and particularly abdominal obesity, can be associated with an increased risk of incurring colonic adenomatous polyps.

• 대한지역사회영양학회지
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• 제21권4호
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• pp.378-385
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• 2016

Objectives: This study was conducted to investigate the association between sarcopenia and sarcopenic obesity and cardiovascular disease risk in Korean postmenopausal women. Methods: We analyzed data of 2,019 postmenopausal women aged 50-64 years who participated in the Korea National Health and Nutrition Examination Survey in 2008-2011 and were free of cardiovascular disease history. Blood pressure, height, and weight were measured. We analyzed the serum concentrations of glucose, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol and triglyceride levels. Waist circumference was used to measure obesity. Appendicular skeletal muscle mass was measured by dual-energy X-ray absorptiometry. Sarcopenia was defined as the appendicular skeletal muscle mass/body weight<1 standard deviation below the gender-specific means for healthy young adults. The estimated 10-year risk of cardiovascular disease risk was calculated by Pooled Cohort Equation. Subjects were classified as non-sarcopenia, sarcopenia, or sarcopenic obesity based on status of waist circumference and appendicular skeletal muscle mass. Results: The prevalence of sarcopenia and sarcopenic obesity was 16.3% (n=317) and 18.3% (n=369), respectively. The 10-year risk of cardiovascular disease risk in the sarcopenic obesity group was higher ($3.82{\pm}0.22%$) than the normal group ($2.73{\pm}0.09%$) and sarcopenia group ($3.17{\pm}0.22%$) (p < 0.000). The odd ratios (ORs) for the ${\geq}7.5%$ 10-year risk of cardiovascular disease risk were significantly higher in the sarcopenic obesity group (OR 3.609, 95% CI: 2.030-6.417) compared to the sarcopenia group (OR 2.799, 95% CI: 1.463-5.352) (p for trend < 0.000) after adjusting for independent variables (i.e., exercise, period of menopausal, alcohol use disorders identification test (AUDIT) score, income, education level, calorie intake, %fat intake and hormonal replacement therapy). Conclusions: Sarcopenia and sarcopenic obesity appear to be associated with higher risk factors predicting the 10-year risks of cardiovascular disease risk in postmenopausal women. These findings imply that maintaining normal weight and muscle mass may be important for cardiovascular disease risk prevention in postmenopausal women.

• 대한임상검사과학회지
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• 제51권1호
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• pp.50-56
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• 2019

본 연구는 성인 남성을 대상으로 체질량지수로 분류한 비만 유형에 따른 혈청 GGT와 요산농도의 차이와 관련성을 확인하고자 하였다. 2017년 1월부터 2018년 8월까지 경기지역 종합병원의 건강검진센터를 내원하여 건강검진을 실시한 20세 이상 성인 남성 14,283명을 대상으로 하였다. 비만 기준은 아시아-태평양지역 기준을 적용하였으며, 복부비만은 남성의 허리둘레 90 cm이상을 기준치로 정의하였다. 남성 대상자의 혈청 요산농도 상승은 7.0 mg/dL 이상, 혈청 GGT 상승은 56 IU/L 이상으로 정의하였다. 본 연구결과 혈청 GGT와 요산농도는 정상체중군보다 과체중과 비만군에서 높았으며, 비만군에서는 복부비만을 동반한 경우 혈청 GGT ($53.26{\pm}49.67IU/L$ vs $67.66{\pm}60.16IU/L$) 및 요산농도($6.22{\pm}1.26mg/dL$ vs $6.38{\pm}1.40mg/dL$)가 유의하게 높았다. 그러나 저체중군과는 차이가 없었다. 또한 과체중과 비만군은 정상체중군보다 혈청 GGT 상승과 고요산혈증의 위험이 높게 나타났으나, 저체중은 혈청 GGT 상승과 고요산혈증에 영향을 미치지 않는 것으로 나타났다. 따라서 성인 남성의 과체중 및 비만을 평가하는데 혈청 GGT와 요산이 유용하다고 판단된다.

• International Journal of Industrial Entomology and Biomaterials
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• 제1권2호
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• pp.115-122
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• 2000

A Bacillus thuringiensis designated NT0423, belonging to B. thuringiensis subsp. aizawai (H 7), was isolated from samples of dust and soil of sericultural farms. B. thuringiensis NT0423 having dualspecificity against Lepidoptera and Diptera produced bipyramidal inclusions consisting of two major polypeptides of approximately 130- and 70-kDa. Proteolytic processing by trypsin and gut juice of Bombyx mori yielded predominant proteins with molecular masses of about 66-kDa. The whole crystal protein of B. thuringiensis NT0423 immunologically was related to that of B. thuringiensis subsp. aizawai. PCR analysis showed that B. thuringiensis NT0423 has at least five crystal protein genes including cryIA(a), cryIA(b), cryIC, cryID and cryIIA, and southern blot was determined the location of each gene on intact and enzyme-digested plasmid DNA fragments. Except for cryIA(a) gene on the high molecular weight plasmid of 165-kb, all of four genes were located on the plasmid of 66-kb. The production of $\beta$-exotoxin from B. thuringiensis NT0423 was identified by the HPLC analysis. In addition, the $\beta$-exotoxin showed its ability to prevent pupation of treated larvae of house flies (Musca domestica) from developing into normal adults.

• 한국방사선학회논문지
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• 제5권4호
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• pp.161-169
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• 2011

본 연구는 입체적 분포를 형성한 시각신경계에 대하여 MRI 시스템의 경사자기장으로써 하나의 스캔 대상단면을 3차원 형태의 여러 방향으로 향하게 하는 다중사위 스캔각도의 변화에 관하여 실험하였고 기존의 단순각도 사방향 검사방법과 비교 고찰 하였다. 입체적 분포를 이루는 뇌의 시각신경계에 대하여 MR 시스템의 경사자기장으로써 국내 정상 성인을 대상으로 시각신경의 사위영상화를 위한 기존의 사위(시상-관상단면) 스캔방법과 다중사위(시상-관상-횡단면) 스캔각도의 변화를 실험하였다. 그 결과 다중각도를 이용한 사위스캔 방법이 기존의 스캔방법에 비해 더 넓은 영역의 해부학적 정보를 나타내는 것을 영상으로 확인하였다. 또한 시각신경을 명료하게 나타내기 위해서는 영상단면두께와 펄스시퀀스의 선택도 고려되어야할 것으로 확인 되었다.

• 한방재활의학과학회지
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• 제20권4호
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• pp.171-183
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• 2010

Objectives : The biomechanical relationship of leg length discrepancy(LLD), Lumbar lordosis, pelvic variance and degenerative scoliosis is one of the most important parameters when treat musculoskeletal disorders, however the reports are still controversial. The purpose of this study was to compare the relationships between the parameters and bothersomeness in subject with chronic ow back pain. Methods : Sixty female and eight male adults with non specific low back pain over 3 months were recruited. LLD was measured by tape measure method. Lumbar lordosis, lumbosacral angle and related pelvic parameters were measured using simple radiologic films of lumbosacral view. Results : Lumbar lordosis was significantly correlated to the lumbosacral angle, pelvic incidence and difference of the both iliac widths. Pelvic incidence had significant correlation with difference of the both iliac widths. And difference of both iliac widths was related with LLD by radiologic film. There was also significant correlation between the LLD by radiologic film and tape measurement. Visual analogue scale(chronic low back pain) of normal lordosis group was greater than hyperlordosis group. Conclusions : There were close biomechanical relationships between lumbar, pelvis, and lower extremity. But in order to determine the effect of structure on the chronic low back pain, global balance of musculoskeletal structure seems to be worth further researching.

• The Journal of Korean Physical Therapy
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• 제29권4호
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• pp.194-200
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• 2017

Purpose: This study examined the effect of Kettle bell swing exercise on the body composition and lower limb muscular activity. Methods: As subjects, 26 normal adults in their twenties were divided randomly into the experiment group (n=13), in which Kettle bell exercise was applied, and the control group (n=13), in which bar exercise was applied. Both groups participated in the interventions for eight weeks with three sessions per week. Each group was assessed before training and four and eight weeks into the training to determine the effects of training intervention within and between the groups. The body composition was measured with a body composition analyzer. The changes in muscle activity were measured with a surface electromyography. An independent t-test was conducted to test the significance between the groups according to the measurement points and Repeated measured ANOVA was performed to compare the groups according to the periods with the statistical significance level set to ${\alpha}=0.05$. Results: No significant changes to the main effects of time and the interactions of time according to the measurement points were observed in the Kettle bell and control groups in the body composition (p>0.05). The muscular activity of both muscles were significantly different between the Kettle bell and control groups according to the measurement points with the exception of the right lateral gastrocnemius muscle (p<0.05). Conclusion: These findings suggest that Kettle bell swing exercise can have positive effects on the development of lower limb muscles.

• 한국의류학회지
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• 제33권8호
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• pp.1190-1202
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• 2009

A 3D body scan measurement (SM) is used as an alternative to physical measurements (PM) as the information for designing industrial products. This study compared the mean difference (MD) between SM and PM by gender and analyzed the causes of the difference. The data used in this study were the scan measurements and physical measurements of adults aged twenty to seventy years old of the fifth Size Korea survey. The results of this study are as follows: 1. The comparison of MD between men and women for all subjects: The measurement of the significant differences between men and women were height, neck base girth, chest girth, under-bust girth, waist girth, armscye girth, back length, and foot length. The causes of difference are the difference of body shape. 2. The comparison of MD between men and women by BMI groups: Many measurements had significant differences between men and women at normal weight and overweight but underweight. Some measurements had significant differences only at a specific BMI group because the body shape difference between men and women is revealed clearly in the group. The comparison of MD between men and women by age groups: The measurements that show significant difference at more than four age groups were neck girth, chest girth, under-bust girth, waist girth, armscye girth, and foot length. The height and abdomen girth had a significant difference in the age range of 20's and 30's. There were measurements that increase MD with an increase in age; under-bust girth and lateral shoulder length for women and lateral shoulder length for men. This comparison of MD between men and women provide the correct guidelines for the use of SM.