• Parasites, Hosts and Diseases
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• v.58 no.4
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• pp.413-419
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• 2020

Eosinophilia occurs commonly in many diseases including allergic diseases and helminthic infections. Toxocariasis has been suggested as one cause of eosinophilia. The present study was undertaken to examine the prevalence of toxocariasis in patients with eosinophilia and to identify the risk factors for toxocariasis. This prospective cohort study recruited a total of 81 patients with eosinophilia (34 males and 47 females) who visited the outpatient clinic at Seoul National University Hospital from January 2017 to February 2018 and agreed to participate in this study. The prevalence of toxocariasis was examined by T. canis-specific ELISA, and the various risk factors for toxocariasis were evaluated by a questionnaire survey. Among 81 patients with eosinophilia, 18 were positive for anti-T. canis antibodies (22.2%); 88.9% were male (16/18) and 11.1% were female (2/18). Multivariate statistical analysis revealed that males (OR 21.876, 95% CI: 1.667-287.144) with a history of consuming the raw meat or livers of animals (OR 5.899, 95% CI: 1.004-34.669) and a heavy alcohol-drinking habit (OR 8.767, 95% CI: 1.018-75.497) were at higher risk of toxocariasis in patients with eosinophilia. Toxocariasis should be considered a potential cause of eosinophilia when the patient has a history of eating the raw meat or livers of animals in Korea. A single course of albendazole is recommended to reduce the migration of Toxocara larvae in serologically positive cases with eosinophilia.

• Journal of Life Science
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• v.18 no.4
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• pp.537-541
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• 2008

White adipose tissue is now recognized as an important endocrine organ which secretes various signal factors and proteins termed 'adipokine'. Haptoglobin (Hp), which has been known as an acute phase protein, belongs to the adipokine. However, the function of Hp in adipose tissue remains unclear. To verify the role of Hp in preadipocytes, in this study, 3T3-L1 preadipocyte cells were stably transfected with human Hp gene and Hp-overexpressing cells were made. The Hp had no effect on cell growth of preadipocytes. By RT-PCR and Western blot analysis, the Hp inhibited gene expression of IL-6 and COX-2 and enhanced HO-1 synthesis in preadipocytes. Moreover, invasion assay showed the Hp suppressed migration of monocytes to preadipocytes. These findings suggest that the Hp may inhibit an inflammatory reaction in adipose tissue by regulating the expressions of pro-inflammatory and anti-inflammatory mediators, and by repressing monocytes/macrophages infiltration.

• Molecules and Cells
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• v.39 no.7
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• pp.557-565
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• 2016

The paired immunoglobulin-like type 2 receptor (PILR) family consists of two functionally opposite members, inhibitory $PILR{\alpha}$ and activating $PILR{\beta}$ receptors. PILRs are widely expressed in various immune cells and interact with their ligands, especially CD99 expressed on activated T cells, to participate in immune responses. Here we investigated whether PILR-derived agonists inhibit ${\beta}1$ integrin activity as ligands for CD99. PILR-derived peptides as well as PILR-Fc fusion proteins prevented cell adhesion to fibronectin through the regulation of ${\beta}1$ integrin activity. Especially, PILRpep3, a representative 3-mer peptide covering the conserved motifs of the PILR extracellular domain, prevented the clustering and activation of ${\beta}1$ integrin by dephosphorylating FAK and vinculin, which are major components of focal adhesion. In addition, PILRpep3 inhibited transendothelial migration of monocytes as well as endothelial cell tube formation. Furthermore, upon intraperitoneal injection of PILRpep3 into mice with collagen-induced arthritis, the inflammatory response of rheumatoid arthritis was strongly suppressed. Taken together, these results suggest that PILR-derived agonist ligands may prevent the inflammatory reactions of rheumatoid arthritis by activating CD99.

• 한국해양학회지
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• v.24 no.4
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• pp.165-171
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• 1989

To examine the sample variability of zooplankton, samples were collected at two stations in the nearshore off Anhung (Chungnam, Korea), using a NORPAC net (76 Cm diameter, 0.333 mm mesh size) for two days, April 5 and 6, 1989. The net was towed vertically to eliminate the source of variation due to vertical migration. During the period of 6 hours, triplicate sampling was done every one or two hour at each station. Species composition and abundances at two stations were not so different, but the abundances at each station varied greatly with respect to sampling time. Greater abundance at one sampling time ranged 2.3-8.7 times of smaller abundance at another sampling time. At the level of ${\alpha}=0.05$, however, mean abundances of different sampling time did not differ significantly from each other due to the large variance. It was believed that the large variance was caused by the time dependent effect of patchiness of which parameters were varied with time because of sea water movement. From the variation within the triplicate samples, it was considered that the abundance data obtained from single tow were not significantly different from the data in the range of 50-200% of those from single tow. From these results, the necessity for the replicate and time dependent sampling was indicated. In the nearshore like the sampling site of this study, it seemed to be better to reduce the number of stations for the replicate and time dependent sampling though the proper sampling scheme was to be decided based on the goal of the study.

• Journal of Welding and Joining
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• v.28 no.3
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• pp.92-98
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• 2010

Ferritic stainless steels, which have relatively small thermal expansion coefficient and excellent corrosion resistance, are increasingly being used in vehicle manufacturing, in order to increase the lifetime of exhaust manifold parts. But, there are limits on use because of the problem related to cosmetic resistance, corrosions of condensation and high temperature salt etc. So, Aluminum-coated stainless steel instead of ferritic stainless steel are utilized in these parts due to the improved properties. In this investigation, Al-8wt% Si alloy coated 409L ferritic stainless steel was used as the base metal during Gas Tungsten Arc(GTA) welding. The effects of coated layer on the microstructure and hardness were investigated. Full penetration was obtained, when the welding current was higher than 90A and the welding speed was lower than 0.52m/min. Grain size was the largest in fusion zone and decreased from near HAZ to base metal. As welding speed increased, grain size of fusion zone decreased, and there was no big change in HAZ. Hardness had a peak value in the fusion zone and decreased from the bond line to the base metal. The highest hardness in the fusion zone resulted from the fine re-precipitation of the coarse TiN and Ti(C, N) existed in the base metal during melting and solidification process and the presence of fine $Al_2O_3$ and $SiO_2$ formed by the migration of the elements, Al and Si, from the melted coating layer into the fusion zone.

• Geophysics and Geophysical Exploration
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• v.6 no.4
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• pp.171-179
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• 2003

In land and marine seismic survey, we generally set receivers with equal interval suppose that sampling interval Is too narrow. But the cost of seismic data acquisition and that of data processing are much higher, therefore we should design proper receiver interval. Spatial aliasing can be occurred on seismic data when sampling interval is too coarse. If we Process spatial aliasing data, we can not obtain a good imaging result. Trace interpolation is used to improve the quality of multichannel seismic data processing. In this study, we applied the Spitz algorithm which is widely used in seismic data processing. This algorithm works well regardless of dip information of the complex underground structure. Using prediction filter and original traces with linear event we interpolated in f-x domain. We confirm our algorithm by examining for some synthetic data and marine data. After interpolation, we could find that receiver intervals get more narrow and the number of receiver is increased. We also could see that continuity of traces is more linear than before Applying this interpolation algorithm on seismic data with spatial aliasing, we may obtain a better migration imaging.

• Geophysics and Geophysical Exploration
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• v.23 no.1
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• pp.13-21
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• 2020

The acquisition and processing of long-offset data are essential for imaging deep geological structures in marine seismic surveys. It is challenging to derive an accurate subsurface image by employing conventional data processing to long-offset data owing to the normal moveout (NMO) stretch and non-hyperbolic moveout phenomena induced by seismic anisotropy. In 2017, the Korea Institute of Geoscience and Mineral Resources conducted a simultaneous two-dimensional multichannel streamer and ocean-bottom seismic survey using a 5.7-km streamer and an ocean-bottom seismometer to identify the deep geological structure of the Ulleung Basin. Herein, the actual geological subsurface structure was obtained via the sequential iterative updating of the velocity and anisotropic parameters of the long-offset data obtained using a multichannel streamer, and anisotropic prestack Kirchhoff migration was performed using the updated velocity and anisotropic parameters as input parameters. As a result, the reflection energy in the long-offset traces, which showed non-hyperbolic moveout owing to seismic anisotropy, was well aligned horizontally and NMO stretches were also reduced. Thus, a more precise and accurate migrated image was obtained, minimizing the distortion of reflectors and mispositioned reflection energy.

• Molecules and Cells
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• v.44 no.9
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• pp.658-669
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• 2021

Enhancers have been conventionally perceived as cis-acting elements that provide binding sites for trans-acting factors. However, recent studies have shown that enhancers are transcribed and that these transcripts, called enhancer RNAs (eRNAs), have a regulatory function. Here, we identified putative eRNAs by profiling and determining the overlap between noncoding RNA expression loci and eRNA-associated histone marks such as H3K27ac and H3K4me1 in hepatocellular carcinoma (HCC) cell lines. Of the 132 HCC-derived noncoding RNAs, 74 overlapped with the eRNA loci defined by the FANTOM consortium, and 65 were located in the proximal regions of genes differentially expressed between normal and tumor tissues in TCGA dataset. Interestingly, knockdown of two selected putative eRNAs, THUMPD3-AS1 and LINC01572, led to downregulation of their target mRNAs and to a reduction in the proliferation and migration of HCC cells. Additionally, the expression of these two noncoding RNAs and target mRNAs was elevated in tumor samples in the TCGA dataset, and high expression was associated with poor survival of patients. Collectively, our study suggests that noncoding RNAs such as THUMPD3-AS1 and LINC01572 (i.e., putative eRNAs) can promote the transcription of genes involved in cell proliferation and differentiation and that the dysregulation of these noncoding RNAs can cause cancers such as HCC.

• The Korean Journal of Archival Studies
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• no.13
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• pp.41-90
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• 2006

It's needed for the archivists to design a flexible and stable ERMS(Electronic Records Management System) which can ingest and store records through a consistent way and let users search and use records easily what they want. The basis of the design for ERMS are the conceptual composition and the logical and physical structure of the records when they are stored and managed in the ERMS. This paper explains the process of defining components and designing structure of electronic records using 3-layered approaches which consist of conceptual, logical and physical layer and shows advantages of this approaches. After benchmarking the information models of OAIS which is a reference model for the long-term preservation of digital information objects, this paper applies the model of AIP to a record as a 'Record AIP' and discusses the composition and structure of it. It's a critical task to identify mandatory or optional metadata groups which consists of the 'Record AIP's in the conceptual layer. This paper emphases that the metadata group related to services for the record information to users is required as a result of benchmarking OAIS information models. Various issues about the structure of 'Record AIP's are discussed according to the kind of preservation strategy such as migration or emulation and whether the encapsulation of records is required or not in the logical layer.

• Journal of Wetlands Research
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• v.21 no.1
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• pp.84-94
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• 2019

The Seocheon and Yubu Island mudflats in Geum Estuary are important stopover sites for migratory birds as energy supplementation area in the East Asia-Australasian Flyway. Benthic invertebrates in the tidal flats are important food resources for the migratory birds. In other words, benthic invertebrates in the tidal flats play an important ecological role in energy flow. This study was conducted to investigate the relationship between benthic invertebrate assemblages and environmental factors in Seocheon and Yubudo tidal flats in the Geum Estuary. As a result of the benthic invertebrate assemblage during the fall migration season, the total species number was 147, density and biomass were $1,772{\pm}1,342individuals/m^2$ and $445.1{\pm}807.6g/m^2$, respectively. Based on the appearance species and the density data, the result of analysis of mutual similarity among sampling sites was divided into two groups. Group A was the Macrophthalmus-Heteromastus community and Group B was the Spio-Urothoe-Mandibulophoxus community. Group B showed higher mean species number, density and biomass than Group A. The BIO-ENV analysis showed that the benthic invertebrate assemblages were most affected by the combination of sand content % and sediment sorting (${\rho}=0.500$). The variables of significant relationship with species number and biomass were sediment sorting (p=0.015) and the pore water DO(Dissolved Oxygen, p=0.003) in sediment, respectively.