• Natural Product Sciences
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• 제17권2호
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• pp.65-79
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• 2011

Reactive oxygen species potentially cause damage to cellular components including lipids, protein and DNA; this oxidative damage plays a key role in the pathogenesis of neurodegenerative disease, cardiovascular disease, metabolic disease and cancer. On the basis of the oxidative stress hypothesis, a number of studies have been performed to search for an efficient and safe antioxidant. Although in vitro studies have provided promising results, only a limited number of natural and synthetic antioxidants have been developed for clinical application due to their low efficacy and side-effects. Thus, the discovery of new antioxidants with marked efficacy and safety has attracted worldwide attention in recent decades. Since plants are recognized as important sources of natural antioxidants, our research has focused on the discovery of new naturally occurring antioxidants from medicinal plants. The purpose of this review is to open a new prospect in the field of search for natural antioxidants from medicinal plants by summarizing our recent findings. Using in vitro bioassay systems such as 2,2-diphenyl-1-picrylhydrazyl, superoxide radical scavenging tests and lipid peroxidation models, we have tested over than 350 species of medicinal plants for their antioxidant activity and selected several of them for further investigation. During the research on the discovery of effective natural antioxidants from the medicinal plants selected, we have isolated several new and known antioxidant compounds that include stilbene glycosides, phenolic glycosides, flavonoids, oligostilbenes, and coumarins. Our results suggest that the presence of antioxidant compounds in the medicinal plants might be associated with the traditional use to treat inflammation, cardiovascular disease and various chronic diseases.

• 한국식물학회:학술대회논문집
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• 한국식물학회 2002년도 춘계학술발표대회:발표눈문요지록
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• pp.111-111
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• 2002

• Natural Product Sciences
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• 제11권4호
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• pp.199-206
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• 2005

Investigation of M. peregrina aerial parts revealed the isolation and identification of 4-flavonoidal compounds, quercetin, quercetin-3-0-rutinoside (rutin), chrysoeriol-7-0-rhamnoside 6,8,3',5'-tetramethoxy apigenin. The compounds were identified by TLC, PC, MS, and $H^1-NMR$. The fatty acids and unsaponifiable matter were studied. The $LD_{50}$ for M. peregrina was 113.4 mg/100g b.wt. Repeated intraperitoneal injection of 1/20 and 1/10 $LD_{50}$ (5.67 mg and 11.34 mg/100g b.wt.) of defatted alcoholic of M. peregrina for 30 days induced significant decrease in serum glucose, liver enzymes and lipid components. M. peregrina administered i.p., 30min prior to carrageenan at the above doses significantly inhibited the rat paw oedema response, In acute pain models, namely, the acetic acid-induced writing and hot-plate assay, M. peregrina exhibited marked analgesic properties. In addition, M. peregrina administered at time of indomethacin injection inhibited the development of gastric lesions in rats.

• Journal of Nutrition and Health
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• 제37권5호
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• pp.364-372
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• 2004

The purpose of this study was to investigate the possibility of medicinal plants application as an edible functional food resource. We carried out to develop a traditional functional beverage by using hot-water extraction of 4 medicinal plants (Polygonatun sibiricum, Ophiopogonis radix, Lycii fructus, Schizandriae frutcus) and we examined the effects of drink on physiological response during exercise and recovery phase. The subjects were male baseball players, and exercise protocol was performed with 45 minutes treadmill running and 85％ VO$_2$ max intensity. Brix, pH and titratable acidity of developed drink were 9.5％, 3.3 and 0.22％. The approximate nutritional composition of beverage was carbohydrate, 5.98％, total dietary fiber, 0.42％, crude protein, 0.70％, crude fat, 0.20％ and crude ash, 0.20％. Developed. traditional functional beverage contained K (4.00 mg％), Na (3.68mg％), Ca (2.54mg％), Mg (1.60mg％) and Fe (0.29mg％). Developed beverage drinking group showed a lowest heart rate during exercise and recovery phase than the other two group (water group and ion beverage group). In the change of blood lactate concentration, developed beverage intake group showed a significant lowest values during exercise and recovery phase. And blood hematocrit values and osmolarity were lowest in the developed beverage intake group. In these results, exercise performance capacity was expected to improve most highly with the developed drink from composition with medicinal plants. Also developed beverage was effective in recovery of exercise-induced fatigue. Thus developed drink with medicinal plants can be used as a functional material improving decrease fatigue effects in beverage industry.

• KSBB Journal
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• 제19권2호
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• pp.125-131
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• 2004

당뇨병에 효능을 보이는 생리활성소재의 탐색원을 발굴하기 위한 방법의 하나로 동양의학 데이터베이스의 처방정보를 활용 하였다. 신동의약보감에 포함되어 있는 131건의 당뇨병 처방천연 약재의 처방 빈도와 처방분량을 분석하였다. 처방 순위와 처방 분량에 따라 마련된 점수표 (score table)를 기준으로 총 처방점수 (total prescription score)를 작성하였다. 선행 연구 결과들을 조사 한 결과 총 처방점수가 높은 약재들을 소재로 한 관련 보고들이 많은 것으로 나타났다. 결과적으로 당귀, 황련, 맥문동, 인삼, 칡, 생지황, 오미자, 복령, 지모, 천화분 등이 당뇨병에 효과가 있으며 이들 약재를 이용한 항당뇨 소재의 탐색 방법 이 제안되었다.

• 한국약용작물학회지
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• 제11권2호
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• pp.127-134
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• 2003

천연 보존제, 기능성 식품 및 화장품 그리고 의약품 신소재의 발굴을 위한 전단계로서 국내산 약용식물 160종 209점에 대한 DPPH 라디칼 소거 및 linoleic acid 과산화 저해 등의 항산화능을 평가하였다. DPPH 라디칼 소거능에서는 $13.5{\mu}g/ml$의 $RC_{50}$을 보인 ${\alpha}-tocopherol$을 대조구로 하였을 때 쥐손이풀 지상부, 뱀무 지상부, 이질풀 지상부, 오동나무 잎이 각각 $19.3{\mu}g/ml,\;22.5{\mu}g/ml,\;23.9{\mu}g/ml,$ 및 $27.2{\mu}g/ml$로서 우수하였고, linoleic acid과산화 반응에 대해서는 고로쇠나무 잎 등 38점의 식물추출물이 90%이상의 강한 항산화력을 나타내었다.

• 한국약용작물학회지
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• 제20권6호
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• pp.421-433
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• 2012

This study was carried out to survey the vascular plants in 6 regions including around Hopo-Bridge of Yangsan region at waterfronts of Nakdong river, Korea. Distributed plants were surveyed from April to November, 2011. The vascular plants in 6 regions (around Mulgeum-chuisujang, Mulgeum-station, Jeungsan-ri, Hopo-bridge, Kumoh-bridge and lower part of Yangsan-stream) were total 135 taxa of 3 divisions, 4 classes, 37 orders, 66 families, 116 genera, 114 species, 2 subspecies and 19 varieties. The most number of species is Campanulales of 14.1% in Dicotyledoneae of 81.5% among total species. Regional distribution of species is mainly around Mulgeum-chuisujang and Jeungsan-ri as 61% among total species, and other regions is in 24 ~ 44%. Ecologically, there were herbaceous plants 75% and woody plants 25%, and 9 species of aquatic plants in herbaceous plants. Medicinal (herbal) plants included in KP (The Korean Pharmacopoeia) and KHP (The Korean Herbal Pharmacopoeia) were 56 species including Platycodon grandiflorum (Jacq.) A. De Candolle, Peucedanum japonicum Thunberg and etc., and folk herb plants were 14 species including Metaplexis japonica Makino, Commelina communis Linn$\acute{e}$ and etc. among total 135 species.

• 대한약침학회지
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• 제22권3호
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• pp.131-139
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• 2019

Introduction: Mastalgia is the most common benign breast disorder during the fertility period of women. So far a wide range of natural or complementary medicines is used to cure mastalgia. Sanitary organizations need complete and suitable details to help women, for making the proper decision for alternative treatment based on the evidence. The aim of the present study is to introduce medicinal plant-based treatments about mastalgia and summarizes clinical trials about this disorder. Method: The articles were provided using mixture of keywords including cyclic pain, breast, treatment, therapeutics, therapy, clinical trial, herbal, drug, mastalgia and all the probable terms, in national and international databases SID, Iran Medex, Magiran, PubMed, Scopus, Medline, Science direct and Cochrane library, in both Persian and English languages. All cross-sectional and review articles about herbal treatment of mastalgia until 2018 November were studied. Results: Nineteen articles from all of the available articles (45 cases) and a sample size about of (1987 cases) were included in our study. The articles were clinical trials. The results revealed that mastalgia could be healed by Nigella sativa, Vitex agnus-castus, curcumin, Hypericum perforatum, Citrus sinensis, wheat germ, and Ginkgo biloba. Conclusion: Most of the evaluated medicinal plants possessing antioxidant compounds with anti-inflammatory and analgesic properties, exhibited healing effects in the treatment of mastalgia. Thus, medicinal plants can be considered in the treatment of mastalgia; however, further investigations are needed to obtain more details about their probable side effects.

• Natural Product Sciences
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• 제27권4호
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• pp.217-227
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• 2021

This study is a record of ethnomedicinal knowledge in Begumganj province focussed on medicinal plants and their local uses for primary health care. The aim was to document and preserve the ethnomedicinal knowledge used by traditional healers of Begumganj upazila, Bangladesh, to treat human diseases and evaluate the relative efficacy of the medicinal plants. The uses of medicinal plants were documented as an ethnomedicinal data sheet using direct observation, field interview, plant interview and group interview techniques from December 2012 to January 2014 in the study area. Data were collected from 98 traditional healers through a questionnaire survey and analyzed through informant consensus factor and fidelity level. This study revealed comprehensive relationship among various diseases and families, forms and parts of plants and modes of preparation. Overall, 75 plant species under 71 genera of 47 families were documented, which are used to treat 41 diseases. Data analysis revealed that 41.33%, 14.67%, 36% and 8% of the medicinal plant species were herbs, shrubs, trees, and climbers, respectively. Leaves were the most used parts, followed by stem, root, fruit, bark, latex and rhizome. The most frequently treated diseases were dysentery, rheumatism and skin diseases. This is the first ethnobotanical survey, which recorded the importance of medicinal plants in Begumganj upazila, Bangladesh. This study can contribute to preserving the indigenous knowledge on the traditional use of medicinal plants in this region and new drug development with attracting future generations towards traditional healing practice.

• 한국약용작물학회지
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• 제22권1호
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• pp.1-7
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• 2014

Codonopsis lanceolata (Campanulaceae) has been used in traditional medicines, as its roots contain several kinds of 3,28-bidesmosidic triterpenoid saponin with high medicinal values. In this study, we induced hairy root-derived transgenic plants of C. lanceolata and analyzed triterpenoid saponins from the leaf, stem and root. Transgenic plants were regenerated from the hairy roots via somatic embryogenesis. The saponins are lancemaside A, B and E, foetidissimoside A, and aster saponin Hb. Transgenic plants contained richer triterpenoids saponin than wild-type plants. Major saponin lancemaside A was the most abundant saponin in the stem from transgenic-plant, $4.76mg{\cdot}1^{-1}dry$ stem. These results suggest that transgenic plants of C. lanceolata could be used as medicinal materials for the production of triterpene saponins.