• Title/Summary/Keyword: Korean herb medicines

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A tendency of herbal medicines on anti-viral effect (항바이러스 효과에 응용되는 한약의 연구 동향)

  • Lim, Sung-Woo
    • THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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    • v.4 no.1
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    • pp.199-209
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    • 1998
  • In order to find antiviral effect against Human immunodeficiency virus(HIV), Herpes simplex virus type I(HSV-1) and II(HSV-2) from herb medicines, publicated 29 paters on anti-viral effect of herbal medicines and a convenient virus-induced cytopathic effect (CEP) inhibition assay was introduced. The major virus on experiment are HIV, Hepatitis B virus and HSV-1,2. Those of other studies showed inhibition of infected virus DNA replication and screening test of herbal medicines. More than 15 extractions were prepared by pure water boiling from herbal medicines, and their toxicity of infected cell and anti-viral activities were evaluated. Among them, the major part of herbal medicines showed cell stability compared with the contrast. Cytotoxic concentration (CC) of the $H_2O$ extracts of Padoo against HIV was <4.0, Hyungbangpaedoksan against HIV was 9.3, Whangyonhaedoktang against HIV-1 and HSV-2 was 15.3. These are high level cytotoxic concentration compared with the contrast. But antiviral effect was unable to figure out for selective $index(SI)=CC_{50}/EC_{50}$. The other herbal medicines were unable to showed potent anti-HIV and anti-HSV activity. The antiviral activation using herbs in this thesis have unlimited objects, to select research object will help to show the direction of antiviral drug development that have less side effect and more excellent efficiency.

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A Literature Review of Herbal Medicines on Osteoporosis Studies - Reviewing Articles Published after Year 2000 (골다공증 연구에 사용되는 처방(處方) 및 본초(本草)에 관한 문헌 연구 - 2000년 이후 발표된 논문을 중심으로)

  • Kim, Min-Beom;Kim, Sung-Soo;Chung, Seok-Hee
    • Journal of Korean Medicine Rehabilitation
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    • v.20 no.1
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    • pp.91-107
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    • 2010
  • Objectives : The purpose of this study was to investigate which herbs and herbal formulae are frequently used for the treatment of osteoporosis since 2000. Methods : We searched the CENTRAL, MEDLINE, AMED, CINAHL, Scopus, KISS, Korea MED, KERIS, Kmbase, Dbpia, J-STAGE, CNKI, J Oriental Rehab Med., J Korean Oriental Med., J Oriental Gynecol. using search key words osteoporosis, osteopenia, bone density and bone loss combined with herbal, botanical plant and phytomedicine. Results : 73 studies were reconfirmed and 83 herbs have been found. For single herb, most of them were categorized into Boyik-yak(補益藥, Buyi-yao). For herbal formulae, various herbal formulae are used. Calculating each herb in consisted in each herbal formula, Angelica Gigas Radix(當歸) and Rehmanniae Radix Preparat(熟地黃) turned out to be the most frequently used herb. Conclusions : Further studies regarding herbal medicines on osteoporosis are needed.

A Survey of the Presence of Aflatoxins in Herb Medicines (한약재중의 아플라톡신 오염도 조사)

  • Park, Sung-Kyu;Jang, Jung-Im;Ha, Kwang-Tae;Kim, Sung-Dan;Kim, Ouk-Hee;Choi, Younh-Hee;Seung, Hyun-Jeung;Kim, Si-Jung;Lee, Kyeong-Ah;Jo, Han-Bin;Choi, Byung-Hyum;Kim, Min-Young
    • Journal of Food Hygiene and Safety
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    • v.24 no.2
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    • pp.169-173
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    • 2009
  • A survey of total aflatoxin levels was conducted on 145 samples(carthamiflos, thujae semen, giycyrrhizae radix et rhizoma) collected in Yakyeang markets in Seoul. Aflatoxin levels were quantified by the immunoaffinity column clean-up method followed by performance liguid chromatography(HPLC)-fluorescence detector(FLD). Aflatoxins were found in 10(6.9%)samples including 5 Arecae semen, 4 Thujae semen, 1 Zizyphi semen with a range of $0.45{\sim}79.15\;{\mu}g/kg$. Generally These results show that the contamination level of aflatoxins in Herb Medicines consumed in Korea is high compared with the standard in Korea Herb Medicine Code($10\;{\mu}g/kg$ as aflatoxin B1). It is considered that aflatoxin concentration was increased in herb medicines during a storage and drying in herb medicines examined

Identifying Theoretical Characteristics of Traditional Medicines in Korea, China, and Japan through the Herb Usage Data (한약재 사용량 데이터 분석을 통한 한국, 중국, 일본 전통의학의 이론적 특성 비교연구)

  • Park, Mu Sun;Lee, Choong Yeol;Lee, Tae Hee;Kim, Youn Sub;Kim, Chang Eop
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.32 no.3
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    • pp.149-156
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    • 2018
  • Traditional medicines (TM) in Korea, China, and Japan share most of the theories and therapeutic tools, but there are also differences due to their unique histories and cultures. Here, we aim to identify the differences in the utilization of TM theory between three countries by analyzing herb usage data in terms of the related traditional theories. Herb usage data of each country was collected from "Investigation of Korean medicine use and herbal medicine consumption survey" (Korea), "Analytical report on circulation of key Chinese medicinal materials" (China), and "Survey report on raw material crude drug usage" (Japan). Fifty five herbs with sixty features belonging to five theoretical categories (four properties, five tastes, targeting meridians, treatment strategies, and herbal parts) were selected and analyzed. Weight Sum Model (WSM) and Network-Based Group Features (NBGF) were used to compare the theoretical characteristics of TM between three countries. For the statistical evaluation, we developed and applied Herb Set Enrichment Analysis (HSEA) for WSM and NBGF results. HSEA for WSM results revealed the kidney meridian were targeted more in Korea than Japan, while the spleen meridian were targeted more in Japan than Korea. Herbs with sour taste were used more in Japan than China. HSEA for NBGF results found that NBGF including warm, neutral, sweet, and tonifying features were more dominant in Korea and than Japan, while NBGF including cold, bitter, heat-clearing features were more dominant in Japan than the others. These results suggest that TM in Korea, China, and Japan have unique aspects of practice patterns and theoretical utilization.

An Experimental Study on the Comparison between Sasang Herbal Medicine for So-Eum and So-Yang Type Using Issatchenkia orientalis (KCTC 7277) (Issatchenkia orientalis (KCTC 7277)를 이용한 소음인과 소양인 약재의 비교 실험연구)

  • Park, Young Joo;Choi, Ji Eun;Kang, Young Min;Kim, Jong Yeol
    • KSBB Journal
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    • v.32 no.1
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    • pp.46-53
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    • 2017
  • There are four types (So-Eum, So-Yang, Tae-Eum, Tae-Yang type) in Sasang constitutional medicine (SCM). In SCM, not only people but also herbal medicine are classified into four types. To date, there has been very little evidence of experimental classifications in SCM. So, we adapted Issatchenkia orientalis in two different culture media made from the herbal medicines for So-Eum and for So-Yang type. And the adapted Issatchenkia orientalis was inoculated into another eight culture media made from the herbal medicines for So-Eum and for So-Yang type. The mass reduction was measured every 12 hours for 2 days. Then, we analyzed the statistical differences of herbal medicines for So-Eum and for So-Yang type. There were significant differences of variables (R: rate of change in mass reduction, S: convex degree of mass reduction graph) in herbal medicine media for So-Eum (p=0.001, 0.001, respectively.). Suggesting a microbiological method of Sasang medicine research, current study may contribute to the establishment of experimental Sasang constitutional herbal medicine.

Investigation of Pathogenic Microbial Contamination in Medicinal Herb Products on the Market (유통 한약재에 대한 병원성미생물 분포)

  • Ham, Hee Jin;Yu, In Sil;Lee, Jib Ho;Kim, Su Jin;Yu, Young Ah;Lee, En Sun;Kim, Hee Sun
    • Korean Journal of Medicinal Crop Science
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    • v.25 no.2
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    • pp.108-114
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    • 2017
  • Background: The study was conducted to investigate the distributions of faecal bacteria in commercial oriental medicine herb products. Methods and Results: A survey was conducted on the microbial contamination levels and antimicrobial specificity of Bacillus cereus and other microbes using 106 oriental medicine herb products on sale in Seoul. Pouring and isolation methods such as standard plate counts were used to identify the bacteria. The isolated bacterias included coliforms, Bacillus spp., Enterococcus spp., Staphylococcus spp., Listeria spp.were identified by using gram staining and an API (analytical profile index) kit. Antimicrobial drugs discs were determined by CLSI (clinical and laboratory standards institute). Conclusions: The bacterial isolates present in the herbal medicines included 98 coliforms, 45 Bacillus spp., 29 Enterococcus spp., and 2 Listeria spp. Among these, there were nine Bacillus cereus strains, one Enterococcus faecium strain, and one Enterococcus faecalis strain present. The 9 Bacillus cereus strains were tested for susceptibility to 36 types of antibiotics products by the disc diffusion method. The strains showed resistance to 13 of these antibiotic products and semi-resistance to 5 antibiotic products. On the basis of these results, any oriental medicine herb product can be assumed to be contain resistant or semi-resistant bacterial strains. Therefore, we suggest prescribing guidelines and special management for the use of antibiotics in farms producing oriental medicine herb products.

The Immuno-Regulatory Effects of Onbi-tang and Dangguijakyak-san in Minimal Change Nephrotic Syndrome (미세변화 현증후군에서 온비탕과 당귀작약산이 면역조절기능에 미치는 영향)

  • 안영민;안세영;두호경
    • The Journal of Korean Medicine
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    • v.21 no.1
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    • pp.20-28
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    • 2000
  • The purpose of this research is to investigate the synergistic effect of herb medicines with hydrocortisone and the regulation effect on the immune system of Onbitang and Dangguijakyaksan at the supernatant of PHA-P stimulated PBMC in the patients with minimal change nephrotic syndrome(MCNS). From the measurement of the concentration rate of IL-4, sCD23 and IL-13, the experiment yielded the following results : The Onbitang group showed a greater tendency to suppress IL-4 and IL-13 levels in MCNS group with no statistical significance. It showed very strong suppression in soluble CD23 compared with control group in MCNS group. The Dangguijakyaksan group, though not statistically significant, was inclined to suppress IL-4 level in MCNS group. It shows stronger suppression in sCD23 and IL-13 levels than these of control group in MCNS group. As for the synergistic effect, the group of hydrocortisone with herb medicines(Onbitang or Danguijakyaksan) produced more suppressive effect to IL-13 level in MCNS group than that of hydrocortisone-only group. They also tended to suppress sCD23 and IL-4 levels, though no statistical significance can be given. As to the suppressive effect of 1L-13 level, the group of Onbitang with hydrocortisone showed an increase of 22.6%, while the group of Dangguijakyaksan with hydrocortisone showed 14.7%. So Onbitang is more effective than Dangguijakyaksan. From the above results, a combinative treatment(herb medicines with hydrocortisone) can be an alternative method to substitute for steroid therapy. It can be a more effective therapy than steroid-only therapy because it is expected to reduce side effects and it shows more special effect to suppress IL-13 level. Based on the present results, further investigation concerning the serum IgE elevation is needed.

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A Study on Changes in the Gut Microbiome of Herbal Medicines for Treating Obesity Using Literature Review (문헌 고찰을 통한 비만 치료 한약의 장내미생물 변화 연구)

  • Kim, Seung Won;Cheon, Jin Hong;Kim, Ki Bong
    • The Journal of Pediatrics of Korean Medicine
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    • v.36 no.2
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    • pp.40-51
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    • 2022
  • Objective This study identified useful herbal medicines and prescriptions for obesity treatment by analyzing herbal medicines and prescriptions that showed meaningful results in weight loss by changing the gut microbiota. Methods Using PubMed, we selected and studied 23 papers showing meaningful results on weight loss through changes in the gut microbiota using herbal medicines. Result Of the 23 selected papers, 17 were of studies using herbal medicines, and 6 of studies using prescriptions. Pomegranate peel, Flos Lonicera, Rehmannia glutinosa, Rhein, Coix seed, Platycodon grandiflorus, mulberry leaves, Poria cocos, asperuloside, Bupleuri radix, Astragalus polysaccharides, Ephedra sinica, Ganoderma lucidum, Hirsutella sinensis, Caulis spatholobi, aconite, and Bletilla striata were used as herbal medicine. Linggui zhugan-tang, Bofutsushosan, Shenling baizhu powder, Chowiseungcheng-tang, Daesiho-tang, and Yijin-tang were used as prescription. Conclusion Seventeen herbal medicines and six prescriptions associated with meaningful results in weight loss through changes in the gut microbiota, suggest the possibility of treatment and prevention of obesity through herbal medicine.

A review of atopic dermatitis in traditional Chinese medicine

  • Lee, Sang-Chang;Lee, Young-Seob;Seong, Man-Jun;Choi, Mi-Sun;Kang, Suk-Hoon;Lee, Sheng-Ho;Kim, Jong-Hak;Kim, Min-San;Kwon, Dong-Yeul
    • Journal of Evidence-Based Herbal Medicine
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    • v.1 no.2
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    • pp.35-43
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    • 2008
  • Herbal medicines have an accurate effect on atopic dermatitis, and at the same time, they hardly have adverse reactions. However, herbal medicines are difficult to be quantitatively analyzed due to low-quality preparation and types. In addition, herbal medicines have raised many problems as they have not been standardized and their active components have not been analyzed. Patients with atopic dermatitis began to recognize the effectivity and safety of herbal medicines. Accordingly, standardization, biological analyses, animal experiments and clinical trials should be generally performed in order that herbal medicines may be recognized all over the world. A standard, which is to objectively judge the curative effect of atopic dermatitis, should be established as soon as possible. Case studies and RCTs (Randomized Controlled Trials) should be actively performed on the basis of rigid clinical trial design to the end that the curative effect of herbal medicines is recognized all the world over.

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Screening for Anti-inflammatory Activities in Extracts from Korean Herb Medicines (국산 생약 추출물의 항염증 활성 스크리닝)

  • An, Sang Mi;Kim, Hyoung Gun;Choi, Eun Jung;Hwang, Hyoung Hoon;Lee, Eunseok;Baek, Ji Hwoon;Boo, Yong Chool;Koh, Jae Sook
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.40 no.1
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    • pp.95-108
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    • 2014
  • Cosmetics are products used over long periods by the public, and their safety is very important. Contact dermatitis induced by cosmetics is the result of an inflammatory response of the skin to direct irritancy. The initial event that this inflammatory response is observed is the release of pro-inflammatory cytokines. In this study, the anti-inflammatory activities of extracts from Korean herb medicines were investigated using RAW264.7 macrophage. Among the fifty one extracts tested, the ethanol extracts from Biotae Orientalis Folium, Biotae Orientalis Folium (roasted), Cyperi Rhizoma, Nepetae Spica, Benincasae Semen, Dioscoreae Rhizoma, Dioscoreae Rhizoma (roasted), Mori Ramulus, Pini Ramulus and Alismatis Rhizoma reduced the cytotoxicity and inhibited the productions of Nitric oxide (NO) and cytokines such as interleukin (IL)-1${\beta}$, IL-6 and tumor necrosis factor (TNF)-${\alpha}$n lipopolysaccharide (LPS)-induced RAW264.7 macrophage. Additionally, they didn't induce the skin irritation when tested the human patch test. Overall, the result of this study suggests that the extracts of the ten Korean herb medicines are useful cosmetic agents for preventing the skin irritation.