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http://dx.doi.org/10.15230/SCSK.2014.40.1.95

Screening for Anti-inflammatory Activities in Extracts from Korean Herb Medicines  

An, Sang Mi (Dermapro Skin Research Center, DERMAPRO LTD.)
Kim, Hyoung Gun (Dermapro Skin Research Center, DERMAPRO LTD.)
Choi, Eun Jung (Dermapro Skin Research Center, DERMAPRO LTD.)
Hwang, Hyoung Hoon (Dermapro Skin Research Center, DERMAPRO LTD.)
Lee, Eunseok (Dermapro Skin Research Center, DERMAPRO LTD.)
Baek, Ji Hwoon (Dermapro Skin Research Center, DERMAPRO LTD.)
Boo, Yong Chool (Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Medical Education Program for Human Resources, Kyungpook National University School of Medicine)
Koh, Jae Sook (Dermapro Skin Research Center, DERMAPRO LTD.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.40, no.1, 2014 , pp. 95-108 More about this Journal
Abstract
Cosmetics are products used over long periods by the public, and their safety is very important. Contact dermatitis induced by cosmetics is the result of an inflammatory response of the skin to direct irritancy. The initial event that this inflammatory response is observed is the release of pro-inflammatory cytokines. In this study, the anti-inflammatory activities of extracts from Korean herb medicines were investigated using RAW264.7 macrophage. Among the fifty one extracts tested, the ethanol extracts from Biotae Orientalis Folium, Biotae Orientalis Folium (roasted), Cyperi Rhizoma, Nepetae Spica, Benincasae Semen, Dioscoreae Rhizoma, Dioscoreae Rhizoma (roasted), Mori Ramulus, Pini Ramulus and Alismatis Rhizoma reduced the cytotoxicity and inhibited the productions of Nitric oxide (NO) and cytokines such as interleukin (IL)-1${\beta}$, IL-6 and tumor necrosis factor (TNF)-${\alpha}$n lipopolysaccharide (LPS)-induced RAW264.7 macrophage. Additionally, they didn't induce the skin irritation when tested the human patch test. Overall, the result of this study suggests that the extracts of the ten Korean herb medicines are useful cosmetic agents for preventing the skin irritation.
Keywords
Korean herb medicines; anti-inflammatory activities; Skin irritation; Cosmetics;
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Times Cited By KSCI : 7  (Citation Analysis)
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