• Journal of Life Science
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• v.14 no.4
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• pp.553-559
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• 2004

To improve quality as a food source and functional properties of traditional fermented soybean paste (Doenjang), the Korean herb medicines (group I ∼ IV) extracted at 121$^{\circ}C$ for 2.5 hours were used as brine sources. Capsule Meju were fermented in cool brines with three different concentration (group A, B and C) of the extracts at room temperature for 3 months in large earthenware jars. The effect of traditional soybean Doenjang (refer as DHM below) supplemented with the extract of herb medicines on the food quality and chemical characteristics were examined. General composition of DHM (moisture 58.2%∼61.9%, pH 5.32∼5.56, total acidity 3.07∼3.70 ml, salt 11.7∼13.9%) did not differ from those of control (moisture 61.9%, pH 5.50, total acidity 3.25 ml, salt 12.6%). Concentration of reducing sugar, crude protein, crude lipid and amino type nitrogen were higher in DHM than those of control without addition of the extracts. Water insoluble-brown index showed no difference by the extracts. However, the former had higher water soluble-brown index than the latter, and within the DHM, groups I and II were higher than groups III and IV. Lightness values (L) of Hunter color index in groups I and II were 24.32 and 31.04, respectively. Redness values (a) of all DHMs were lower than that of control. Yellowness value (b) of groups III and IV were similar to that of control group, and Hunter b values of group I and II were lower than that of control.

• The Journal of Korean Medicine
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• v.29 no.1
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• pp.207-222
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• 2008

Objectives : I report 12 cases of strabismus presented at [Oriental Medical Clinic of Kim Joong-Ho and Strabismus - Amblyopia Clinic, East-West Neo Medical Center, Kyung Hee University] from 2nd March 2006 to 29th February 2008. All have experienced good improvement of strabismus by treatment with Oriental medicine. Methods : Patients were treated with acupuncture, infra-red and herb medicine. The acupuncture points of (B2) 絲竹空(TE23) 承泣(S1) 陽白(G14) 太陽(E36) were mainly used. Herb medicines prescribed were Gagamseunggal-tang and Gamiboik-tang. Results : 9 cases of strabismus were caused by paralysis of the sixth cranial nerve and the third cranial nerve, while 3 cases happened with concomitant strabismus of esotropia and exotropia. They were treated to recover paralytic muscles and unelastic muscles around the eyes and face. Treatment took between 1 and 8 months. Conclusions : In the results of this study, treatment was effective to correct position at the eyeball. I report it is possible to treat strabismus successfully with Oriental medicine in a shorter time compared to western medicine.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.313-353
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• 2023

Objectives: Heart failure is a chronic disease with increasing prevalence rates despite advancements in medical technology. Korean medicine utilizes herbal prescriptions to treat heart failure, but little is known about the specific herbal medicines comprising the network of herbal prescriptions for heart failure. This study proposes a novel methodology that can efficiently develop prescriptions and facilitate experimental research on heart failure by utilizing existing databases. Methods: Herbal medicine prescriptions for heart failure were identified through a PubMed search and compiled into a Google Sheet database. NetMiner 4 was used for network analysis, and the individual networks were classified according to the herbal medicine classification system to identify trends. K-HERB NETWORK was utilized to derive related prescriptions. Results: Network analysis of heart failure prescriptions and herbal medicines using NetMiner 4 produced 16 individual networks. Uhwangcheongsim-won (牛黃淸心元), Gamiondam-tang (加味溫膽湯), Bangpungtongseong-san (防風通聖散), and Bunsimgi-eum (分心氣飮) were identified as prescriptions with high similarity in the entire network. A total of 16 individual networks utilized K-HERB NETWORK to present prescriptions that were most similar to existing prescriptions. The results provide 1) an indication of existing prescriptions with potential for use to treat heart failure and 2) a basis for developing new prescriptions for heart failure treatment. Conclusion: The proposed methodology presents an efficient approach to developing new heart failure prescriptions and facilitating experimental research. This study highlights the potential of network pharmacology methodology and its possible applications in other diseases. Further studies on network pharmacology methodology are recommended.

• Journal of Haehwa Medicine
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• v.20 no.1
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• pp.161-174
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• 2011

Objectives : This paper researched methods of washing Herb medicine through research papers of washing Crops Materials and Methods : We collected research papers on Washing crops. Then we analysed them according to washing methods. Results : The following results were obtained in this study. 1. Herbal fruit, wash using a conveyor belt. 2. Leafy herbs, soak in a chlorine solution or ozone solution and rinse it. sometimes using micro bubble system. 3. Radix, wash with high pressure sprinkling water. 4. Cortex, wash under running water by hand washing. Conclusion : Herb medicines need a washing methods for each region. so Herbs should be washed in a suitable methods for each region.

• Journal of Haehwa Medicine
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• v.14 no.2
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• pp.143-151
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• 2005

Gobjectives and Methods to investigate into the course of incurable and relapse renal stones' differentiation of symptoms and signs and to effectively improve treatment of incurable and relapse renal stones through Oriental Medicine. To search for the papers about treatment of incurable and relapse renal stones from 1994 till 2004, and re-search papers about treatment for indicated differentiation of disease. Result and conclusions : 1. It is the kidney vacuity additionally the deficiency of qi(氣) in middle-burner that the incurable and relapse renal stones' differentiation of disease. 2. The cause is taking an overdose of attacking renal stones to eliminate dampness and heat medicine, aging, chrome disease. a sex act excess, insufficiency of congenital qi(氣), insufficient exercise, wrong treatment and stress. 3. Herb medicines are constituted supplementing kidney drugs for inhibition of renal stone's creation, drugs to diuresis and dissolve calculi, and drugs 10 exclude stasis blood(瘀血) on account of renal stones. 4. Anti-renal stone measures me sufficiently drinking water, not eating greasy food. taking medicine for supplementing kidney, diuresis and dissolve calculi by periods, and drinking substitute water to boll down medical herb as Lysimachiae Herba (金錢草) Polygoni Avicularis Herba(篇蓄).

• Korean Journal of Pharmacognosy
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• v.31 no.4
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• pp.455-458
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• 2000

Research on pesticide residues as endocrine disruptors in natural medicines was initiated by Korea Food & Drug Administration this year. We determined the presence and levels of certain pesticides in selected natural medicines. The natural medicines collected this year are Glycyrrhiza Root, Cinnamon Bark, Pueraria Root, Polygonatum Rhizome, Jujube, Schizandra Fruit, Lycium Fruit, Liriope Tuber, Eucommia Bark, Peony Root, Korean Angelica, Dioscorea Rhizome, Cnidium Rhizome, Cassia Seed, Platycodon Root, Comus Fruit, Mentha Herb, Epimedium Herb, Bupleurum Root, and Ginger, which have no data for pesticide residues and 192 samples of them were circulated in Korea, 28 samples were circulated in China. In order to analyze many pesticides in large number of samples we used simultaneous multi-residue analysis of pesticides by GC-ECD, which was followed by GC-MSD analysis to confirm the identity of the detected pesticide in each sample.

• The Journal of Internal Korean Medicine
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• v.20 no.1
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• pp.122-132
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• 1999

Purpose : Hepatitis B virus DNA transfected cell line(HepG2.2.15) was cultured to evaluate the effect of herbs on the expression of HBeAg and the replication of HBV. HepG2.2.15 produces HBV particles as well as viral proteins into cell culture media. Methods : Extracts of herbs were adminitered to the cells on the proper concentration. Culture media was collected 48 hours after the herbal administration and HBeAg level in the media was examined by ELISA method. To confirm that the anti-viral effect was not due to direct cytotocixity of the extracts, normal cell proliferation was shown by cell counting. And as of the interference in protein synthesis of HepG2.2.15 by herb-extracts, we used the result of study that we performed before by ${\alpha}FP$ assay using EIA method. Results& Conclusion : Herb medicines like 地楡(Sanguisorbae Radix) and 覆盆子(Rubi Frusctus) showed significant inhibitory effect on HBeAg expression at p<0.01 and 五味子(Acanthopanacis Cortex) at p<0.05. Whereas, though some herbs such as ?草根(Rubiae Radix), 山査(Crataegii Fructus), 白芍藥(Paeoniae Radix Alba), and 大黃(Rhei Radix et Rhizoma) showed the tendecy to suppress HBeAg. most of them were not significant statistically. From the above, we could conclude that those herb medicines can be applied to patients effectively and further studies on effective fraction of some herbs are thought to be needed.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.82-91
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• 2009

Objectives : The purpose of this study is to investigate whitening effects and anti-wrinkle effects of a few 80% ethanol extracted herbal medicines. Methods : In the first study, a few 80% ethanol extracted herbal medicines were screened for their inhibitory activities against the tyrosinase. In the second study, a few 80% ethanol extracted herbal medicines were screened for their inhibitory activities against elastase. Results : 1. We showed 28%, 27% and 19% inhibitions of mushroom tyrosinase at 500 $\mu$g/ml concentration of ASR, AIF and ABR extracts and they were showed higher anti-tyrosinase activity than arbutin's. We also could observe that the decreased mushroom tyrosinase activities in RR, CML, LR, AGR and TH extracts. 2. RR, AF and ABR (final concentrstion 1 mg/ml) were appeared 60%, 98%, 83% of inhibitions of elastase activity, and they were showed higher anti-elastase activity than that of ursolic acid. We also could observe that the decreased elastase activities in AIF, AR, LR and CML extracts. Conclusions : These results suggest that ASR, AIF and ABR extracts contribute to the anti-melanin activities and represent potential sources of whitening agent, and RR, AF and ABR extracts contribute to the anti-elastase activities and represent potential sources of anti-wrinkle agent. These results suggest that some herbal medicines could be strong potential sources of inhibition about anti-aging and whitening effects for the skin.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.3
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• pp.208-219
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• 2009

Object : Understanding the importance of the external treatment of nasal polyps and let know the necessity of development of the effect of herb medicine to use in these days. Method : I investigated about 12 oriental medical texts which recorded the external treatment of nasal polyps. I separated them to three part (prescription, herb medicine, the way of making the external application) and check the frequency. Also compared the external treatment of oriental medicine and western medicine. Result : 1. Prescription: There are 48 prescriptions -Nyosasan is used 4 cases, Gwajungsan is used 2 cases and others only 1 case each. 2. Herb-med: There are 67 herb medicines - Herba Asari(細辛) is used 15 cases, Pedicellus Melo (瓜蔕) is used 11 cases, Alunite(白礬) is used 10 cases, Realgar(雄黃)is used 9 cases. 3. The way of making the external application: obstructive method is used 19 cases, attaching method is used 9 cases, blowing method is used 8 cases, plaster method is used 7 cases, pouring method is used 3 cases. 4. The treatment takes about 1day to 15days and the soften nasal polyps like a water can be expect the positive prognosis. Conclusion: The external treatment is very important to treat nasal polyps. So we need to research more on eliminating the toxicity of the herb medicine and develop the convenient way of using the external treatment.

• Journal of Evidence-Based Herbal Medicine
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• v.1 no.2
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• pp.27-33
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• 2008

Allergic rhinitis comes within snuffle in Chinese medicine. For generations, physicians have believed that the internal factors that cause this disease are pulmonary tuberculosis, splenic hypofunction and loss of virility, and its external factors are a cold, an uncommon atmosphere and an uncommon flavor. From the viewpoint of Chinese medicine, this symptom was fundamentally cured by "abidance by individuality, locality and seasons", on the basis of demonstration. In result, visceral function was recovered. In Chinese medicine, a disease is etiologically cured by the principles of Wholism and by discriminating among symptoms. In particular, "method for replenishing Qi and securing Exterior" has been widely used among the foregoing therapeutics. According to modern pharmacology, Astragli Radix, Atractylodis Macrocephalae Rhizoma and Ledebouriellae Radix all have antihistaminic effects and strengthen of the masticating and swallowing function of the recticuloendothelial system. This disease can be cured by controlling immunity and allergic reactions. Besides, it is necessary to take moderate exercise, to strengthen constitution, to avoid causative substances, to control ingesting flesh, meat and shrimps, to eat little, and to avoid what is cold and raw.