• 대한수의학회지
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• 제38권4호
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• pp.823-828
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• 1998

This study was carried out to determine the causative agent and the clinical features of dermatophytosis occurred in 3 dogs from Tae-gu, Korea between 1996 and 1997. Specimens of hair and scale, collected from skin lesions were inoculated on potato dextrose agar and mycobiotic agar supplemented with thiamine and inositol. The agar plates were incubated at $25^{\circ}C$ for 2 weeks. Growing fungi isolated were identified by the morphological and growth characterization on bromocresol purple-milk solids-glucose medium, Christensen urea broth and trichophyton media, and by hair perforation tests. Skin lesions were observed in legs, abdomen, ears, face and head with alopecia of various sizes accompanied by itching and/or inflammation. The causative agent of dermatophytosis in the 3 dogs was identified as Microsprum gypseum and Trichophyton rubrum (mixed infection, dog 1), T rubrum (dog 2) and T raubitschekii (dog 3). The dermatophytosis by T rubrum and T raubitschekii was first found on animals in Korea.

• 대한수의학회지
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• 제47권3호
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• pp.281-283
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• 2007

This study was conducted to survey of Ehrlichia (E.) canis and Borrelia (B.) burgdorferi antibodies among clinically healthy German shepherd dogs (116 females and 120 males) using a ELISA kit (SNAP 3Dx; IDEXX Laboratories, USA) in Korea. Whole blood samples are collected from the 236 dogs and are tested to detect E. canis and B. burgdorferi antibodies by using ELISA kit (SNAP 3Dx; IDEXX Laboratories, USA). Confidence interval comparisions revealed that dogs of 4-6 years have higher prevalence with a seropositive result (CI=0.17-0.45) in E. canis than the other age groups but there are no differences among age groups in B. burgdorferi. Also, no differences with a seropositive result were found among different regions in E. canis and B. burgdorferi antibodies. In conclusion, this study was the first large scale survey of canine E. canis and B. burgdorferi antibodies in Korea and provide an useful reference for clinicians.

• 대한수의학회지
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• 제42권4호
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• pp.545-550
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• 2002

The raccoon dog (Nyctereutes procyonoides) may be infected by Dirofilaria immitis. However, there has been no report on dirofilarial infection in the raccoon dog in Korea. In this study, we report on D. immitis infection in two wild raccoon dogs captured in the Daejeon area. The two raccoon dogs were referred to the Veterinary Teaching Hospital, Chungnam National University for diagnosis of D. immitis infection. The modified Knott's test for the detection of blood D. immitis microfilariae was positive, and serological test (FASTest$^{(R)}$ HW Antigen ELISA kit, Diagnostik Mega Cor, Austria) for D. immitis was positive as well. Additionally, D. immitis microfilariae were differentiated from other microfilariae by using acid phrnphatase histochemical staining (Leucognost-SP$^{(R)}$kit, Diagncstica MERCK, Germany). The two raccoon dogs were necropsed and D. immitis infection was confirmed.

• 대한수의학회지
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• 제58권2호
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• pp.103-106
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• 2018

Three aged dogs, all over 15 years old, with multiple seizure events and various neurologic signs such as head turn and ataxia were brought to the referring hospital. Two cases were tentatively diagnosed with intracranial meningioma based on magnetic resonance imaging, and one case was histopathologically confirmed as meningioma at necropsy. All dogs improved after initiation of pulsed high-dose hydroxyurea (HU) treatment. Clinical sign relapses were managed by repeating high-dose HU without obvious side effects. Pulsed high-dose HU can be applied when clinical signs are refractory to the traditionally recommended dosage for intracranial meningioma in dogs.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 춘계학술대회 논문집
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• pp.43-44
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• 2003

The subacute toxicity and toxicokinetics of a type IV phosphodiesterase inhibitor, CJ-10882, were evaluated after single (on the 1st day) and 4-week (on the 27th day) oral administration of the drug, in doses of 0 (to serve as a control), 2, 10 and 50 mg/kg/d, to male and female dogs (n = 3 for male and female dogs for each dose). During the test period, clinical signs, mortality, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, organ weight and histopathology were examined.(omitted)

• 대한수의학회지
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• 제40권4호
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• pp.747-753
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• 2000

Helicobacter species have commonly been isolated from the gastric mucosa of humans and animals, however have not been known its association with clinical signs. This study was aimed to detect and identify Helicobacter species in the canine stomach by urease test and polymerase chain reaction(PCR). A total of 87 dogs in Kangwon and Kyunggi areas from August, 1998 to June, 1999 were examined. The detection rate of Helicobacter species by urease test for fundal biopsy samples was 83.9%, and positive rate was increased as incubation time was increased. Helicobacter species was detected in the seventy seven dogs(88.5%) of total 87 dogs by PCR. The fifty five strains of the 77 strains of Helicobacter species were identified as H heilmannii and the three strains were identified as H felis by PCR, but the nineteen strains were not identified.

• 대한수의학회지
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• 제45권3호
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• pp.411-416
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• 2005

Hermaphroditism was discovered in four dogs at surgery. For the classification of the type of hermaphroditism in each case, gross morphological and histopathological studies were performed. Based on the histopathological studies, two dogs were diagnosed as unilateral true hermaphroditism because they had mixed gonad containing testis and ovary in unilateral gonad. Whereas two dogs were diagnosed as male pseudohermaphroditism because they had only testis and uterus that had endometrial atrophy. After resection, further follow-up of several months revealed no evidence of clinical abnormalities.

• 대한수의학회지
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• 제37권2호
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• pp.425-438
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• 1997

To assess the testicular toxicity induced by DA-125, a new anthracycline anticancer agent, the test substance was intraveneously administered to male beagle dogs at dose levels of 0, 0.0023, 0.0375, 0.15, and 0.6 mg/kg/day, 6 days a week for 26 weeks. At 0.6 mg/kg/day, 1 out of 3 dogs had died on day 42 of treatment and the other dogs were sacrificed on days 46 and 122 of treatment due to the increasingly severe clinical condition. Clinical signs considered to be related to treatment were included anorexia, vomiting, salivation, decreased activity, mucous and/or dark faeces, diarrhea, and swelling, abscess and/or ulceration of injection sites. Suppression in body weight gain, reduction in food intake, decreases in testicular weight and size, and hemorrhage of epididymis were also observed in male dogs. Microscopically, severe degenerative changes such as atrophy of seminiferous tubules, loss of germ cells, degeneration of germ cells, vacuolization of Sertoli cells, and hyperplasia of Leydig cells were observed in all dogs. Azoospermia in epididymal tubules, atrophy of epithelia in the cauda epididymis, and prostate atrophy were also found. At 0.15 mg/kg/day, anorexia, vomiting, salivation, diarrhea, and swelling of injection sites were observed. In addition, suppression in body weight gain and decreases in testicular weight and size were found in male dogs. Atrophy of seminiferous tubules, decrease of germ cells, degeneration, exfoliation and retention of germ cells, vacuolization of Sertoli cells, and hyperplasia of Leydig cells were observed by histopathological examination. Azoospermia in epididymal tubules and prostate atrophy were also found. At 0.0375 mg/kg/day, there were no clinical signs considered to be indicative of a reaction to treatment, but testicular size was significantly reduced. Microscopically, decreases in the number of spermatogonia and epidydimal speramtozoa were found. There were no evidences of general or testicular toxicity at 0.0023 mg/kg/day. These results indicate that DA-125 produces significant and persistent damage to the spermatogenic compartments of the testes in male beagle dogs.

• 한국동물위생학회지
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• 제41권1호
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• pp.1-8
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• 2018

Hematological and serum biochemical analyses are routinely used to screen dogs for disease and monitor their clinical progression. These values in dogs may be affected by internal factors, such as breed and age, and external factors like environment, diet, and lifestyle. Apparently, subclinical breed-related variations in hematologic and serum biochemical results have been characterized for Bernese Mountain dogs, Alaskan Malamutes, English Setters, and Golden Retrievers. It is possible that some breed-related differences in clinical pathology analyses may reflect evidence of underlying disease and impact clinical decision plan. In this study, we estimated hematologic and serum biochemical parameters in small breed dogs and compared among four different breed dogs. Blood samples were collected from 38 domestic dogs that were 10 Beagles, 9 Malteses, 10 Poodles, and 9 Miniature Schnauzers. In terms of RBC count, Beagle ($7.2{\pm}0.24{\times}10^3cells/{\mu}L$) showed significantly (P<0.05) higher count than other breeds (Maltese, $6.51{\pm}0.25{\times}10^3cells/{\mu}L$; Poodle, $6.35{\pm}0.24{\times}10^3cells/{\mu}L$; and Miniature Schnauzer, $6.35{\pm}0.25{\times}10^3cells/{\mu}L$). For MCV, Miniature Schnauzer ($67.05{\pm}0.84fl$) results were significantly (P<0.05) higher than Beagle with $64.33{\pm}0.8fl$. For cholesterol value, Beagle ($163.3{\pm}9.15mg/dl$) had significantly (P<0.05) higher values than Miniature Schnauzer with $119.12{\pm}9.64mg/dl$. There was no statistically difference among breeds in terms of enzyme markers of liver diseases. In conclusion, data obtained from this study may be valuable as breed-related variability for interpretation of the results in hematologic and serum biochemical analysis among four small breed dogs.

• 한국임상수의학회지
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• 제14권2호
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• pp.357-360
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• 1997

Occipital dysplasias in five dogs showing various neurologic signs of unknown origin were diagnosed with clinical examination and skull radiographic assessment at this university teaching hospital. The severities of occipital dysplasia were Grade III in four dogs and Grade II in one dog. Major clinical signs were ataxia and convulsion. In skull radiographs, there were dorsal extents of the foramen magnum reached nuchal crest in all cases. Also, hydrocephalus or vertebral malformation was complicated in three cases.