Browse > Article
http://dx.doi.org/10.14405/kjvr.2018.58.2.103

Clinical management of suspected intracranial meningioma in three dogs with pulsed high-dose hydroxyurea  

Cho, Jae-Geum (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
Song, Kun-Ho (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
Seo, Kyoung-Won (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
Publication Information
Korean Journal of Veterinary Research / v.58, no.2, 2018 , pp. 103-106 More about this Journal
Abstract
Three aged dogs, all over 15 years old, with multiple seizure events and various neurologic signs such as head turn and ataxia were brought to the referring hospital. Two cases were tentatively diagnosed with intracranial meningioma based on magnetic resonance imaging, and one case was histopathologically confirmed as meningioma at necropsy. All dogs improved after initiation of pulsed high-dose hydroxyurea (HU) treatment. Clinical sign relapses were managed by repeating high-dose HU without obvious side effects. Pulsed high-dose HU can be applied when clinical signs are refractory to the traditionally recommended dosage for intracranial meningioma in dogs.
Keywords
brain neoplasms; chemotherapy; hydroxyurea; meningioma; seizures;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Adamo PF, Forrest L, Dubielzig R. Canine and feline meningiomas: diagnosis, treatment, and prognosis. Compend Contin Educ Vet 2004, 26, 951-966.
2 Dickinson PJ. Advances in diagnostic and treatment modalities for intracranial tumors. J Vet Intern Med 2014, 28, 1165-1185.   DOI
3 Ettinger SJ, Feldman EC. Neurologic disease. In: Textbook of Veterinary Internal Medicine. 8th ed. pp. 1363-1464, Saunders, St. Louis, 2017.
4 Horta RS, Martins BC, Martins GC, Marcinowska A. Advances in diagnosis and management of intracranial and spinal meningiomas in dogs and cats. Rev Port Cienc Vet 2015, 110, 172-180.
5 LeCouteur RA, Withrow SJ. Tumors of the nervous system. In: Withrow and MacEwen's Small Animal Clinical Oncology. 4th ed. pp. 583-589, Elsevier Saunders, St. Louis, 2007.
6 Motta L, Mandara MT, Skerritt GC. Canine and feline intracranial meningiomas: an updated review. Vet J 2012, 192, 153-165.   DOI
7 Sturges BK, Dickinson PJ, Bollen AW, Koblik PD, Kass PH, Kortz GD, Vernau KM, Knipe MF, LeCouteur RA, Higgins RJ. Magnetic resonance imaging and histological classification of intracranial meningiomas in 112 dogs. J Vet Intern Med 2008, 22, 586-595.   DOI
8 Newton HB. Hydroxyurea chemotherapy in the treatment of meningiomas. Neurosurg Focus 2007, 23, E11.
9 Schrell UMH, Rittig MG, Anders M, Koch UH, Marschalek R, Kiesewetter F, Fahlbusch R. Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea. J Neurosurg 1997, 86, 840-844.   DOI
10 Sessums K, Mariani C. Intracranial meningioma in dogs and cats: a comparative review. Compend Contin Educ Vet 2009, 31, 330-339.
11 Tamura S, Tamura Y, Ohoka A, Hasegawa T, Uchida K. A canine case of skull base meningioma treated with hydroxyurea. J Vet Med Sci 2007, 69, 1313-1315.   DOI