• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.980-990
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• 2003

The effect of Gamigyuibi-tang on the penile erection induced by apomorphine HCI and on the erectile dysfunction induced by p,p-DDE, an environmental hormone derivate of DOT, were monitored using male cats. The changes of penile length, diameter, erectic periods and histological profiles of corpus cavernosum and corpus spongiosum were observed with blood testosterone levels. In conclusion, dose-dependent and significant increase of penile length, diameter, erectic periods and blood testosterone levels were detected in the Gamigyuibitang-dosing groups compared to other groups. In addition, it is also demonstrated that the increasement of congestion of blood vessels and dilation of connective tissues, and decreasement of adipocytes in the corpus cavernosum and/or corpus spongiosum of the Gamigyuibitang-dosing groups. According to these results, it is considered that Gamigyuibitang has some augmentation effect against to apomorphine HCI inducing penile erection and it also suggested that Gamigyuibitang has favorable effect to treatment of erectic dysfunctions induced by p,p-DDE.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.5
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• pp.602-610
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• 2013

This study was aimed to evaluate the cavernosal relaxation effect of Crataegii fructus(CF) in the contracted rabbit penile corpus cavernosum by agonists.In order to study the effect of CF on the vasoconstriction of rabbit penile corpus cavernosum, isolated rabbit penile corpus cavernosum tissues were used for the experiment using organ baths containing Krebs solution.To investigate the cavernosal relaxation of CF, CF extract at $0.01{\sim}3.0mg/m{\ell}$ was added after penile corpus cavernosum were contracted by norepinephrine(NE) $1{\mu}M$. To analyze the mechanism of CF's vasorelaxation, CF extract infused into contracted penile tissues by NE after each treatment of indomethacin(IM), $N{\omega}$-nitro-L-arginine(L-NNA), methylene blue(MB), tetraethylammonium chloride(TEA).To study the effect of CF on influx of extracellular calcium chloride($Ca^{2+}$) in penile tissues, in $Ca^{2+}$-free krebs solution, $Ca^{2+}$ 1 mM infused into contracted penile tissues by NE after pretreatment of CF. Cytotoxic activity of CF on human umbilical vein endothelial cell(HUVEC) was measured by MTT assay, and nitric oxide(NO) prodution was measured by Griess reagent. CF relaxed cavernosal strip with endothelium contracted by NE, but in the strips without endothelium, CF-induced relaxation was significantly inhibited. The pretreatment of L-NNA, MB, TEA decreased significantly on the cavernosal relaxation than not-treatment of them. But the pretreatment of IM had no significant effect on the cavernosal relaxation. In $Ca^{2+}$-free krebs solution, when $Ca^{2+}$ infused into contracted penile tissues by NE, pretreatment of CF inhibit contraction induced by adding $Ca^{2+}$.NO production wasn't increased by treatment of CF on HUVEC. This findings showed that CF is effective for the relaxation of rabbit penile corpus cavernosum, and we suggest that CF relax rabbit corpus cavernosal smooth muscle through multiple action mechanisms that include increasing the release of nitric oxide from corporal sinusoidal endothelium, inhibition of $Ca^{2+}$ mobilization into cytosol from the extracellular fluid, and maybe a hyperpolarizing action.

• Korean Journal of Veterinary Research
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• v.36 no.1
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• pp.39-49
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• 1996

The present study was performed to investigate the distribution of neuropeptide Y immunoreactivities in the corpus striatum of the Korean squirrels. The animals were perfused with 4%-paraformaldehyde and the brain was cut serially into $40{\mu}m$ thick coronal sections. Sections either were stained with cresyl violet or were stained immunohistochemically. The corpus striatum was divided into the caudate nucleus, putamen and globus pallidus. Anterior part. however, of the striatum was observed as the combined caudate-putamen. NPY immunoreactive (NPY-IR) neurons were medium-sized. The corpus striatum contained a low level of NPY-IR fibers, whose distribution appeared to be related to the immunoreactive perikarya. Large numbers of NPY-IR neurons in the caudate-putamen and caudate nucleus were expressed in medial and ventral parts. In the anterior part of the putamen NPY-IR neurons were scattered throughout the nucleus; in posterior part were found generally in the lateral and ventral parts. The density of NPY-IR fibers of the putamen were low, whose distribution appeared to be related to the perikarya. The globus pallidus contained NPY-IR fibers only in the lowest density. In brief, NPY-immunoreactivities in the corpus striatum are heterogenous in distribution. These findings may reflect innate characteristics of the specific neural circuit in the corpus striatum itself.

• Journal of the Korean Society for information Management
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• v.33 no.3
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• pp.321-343
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• 2016

This study aimed to design a semi-automatic web-based pilot system 1) to build a Korean novel geo-name, 2) to update the database using automatic geo-name extraction for a scalable database, and 3) to retrieve/visualize the usage of an old geo-name on the map. In particular, the problem of extracting novel geo-names, which are currently obsolete, is difficult to solve because obtaining a corpus used for training dataset is burden. To build a corpus for training data, an admin tool, HTML crawler and parser in Python, crawled geo-names and usages from a vocabulary dictionary for Korean New Novel enough to train a named entity tagger for extracting even novel geo-names not shown up in a training corpus. By means of a training corpus and an automatic extraction tool, the geo-name database was made scalable. In addition, the system can visualize the geo-name on the map. The work of study also designed, implemented the prototype and empirically verified the validity of the pilot system. Lastly, items to be improved have also been addressed.

• The Journal of Korean Association of Computer Education
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• v.12 no.2
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• pp.87-96
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• 2009

We propose a Korean spacing-error correction system that requires small memory usage although the proposed method is a mixture of rule-based and statistical methods. In addition, to train the proposed model to be robust in mobile colloquial sentences in which spelling errors and omissions of functional words are frequently occurred, we propose a method to automatically transform typical colloquial corpus to mobile colloquial corpus. The proposed system uses statistical information of syllable uni-grams in order to increase coverages on new syllable patterns. Then, the proposed system uses error correction rules of two or more grams of syllables in order to increase accuracies. In the experiments on fake mobile colloquial sentences, the proposed system showed relatively high accuracy of 92.10% (93.80% in typical colloquial corpus, 94.07% in typical balanced corpus) spite of small memory usage of about 1MB.

• Phonetics and Speech Sciences
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• v.13 no.3
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• pp.31-37
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• 2021

The fundamental frequency, or f0, is an important acoustic measure in the prosody of human speech. The current study examined the f0 distribution of a corpus of spontaneous speech in order to provide normative data for Korean speakers. The corpus consists of 40 speakers talking freely about their daily activities and their personal views. Praat scripts were created to collect f0 values, and a majority of obvious errors were corrected manually by watching and listening to the f0 contour on a narrow-band spectrogram. Statistical analyses of the f0 distribution were conducted using R. The results showed that the f0 values of all the Korean speakers were right-skewed, with a pointy distribution. The speakers produced spontaneous speech within a frequency range of 274 Hz (from 65 Hz to 339 Hz), excluding statistical outliers. The mode of the total f0 data was 102 Hz. The female f0 range, with a bimodal distribution, appeared wider than that of the male group. Regression analyses based on age and f0 values yielded negligible R-squared values. As the mode of an individual speaker could be predicted from the median, either the median or mode could serve as a good reference for the individual f0 range. Finally, an analysis of the continuous f0 points of intonational phrases revealed that the initial and final segments of the phrases yielded several f0 measurement errors. From these results, we conclude that an examination of a spontaneous speech corpus can provide linguists with useful measures to generalize acoustic properties of f0 variability in a language by an individual or groups. Further studies would be desirable of the use of statistical measures to secure reliable f0 values of individual speakers.

• Phonetics and Speech Sciences
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• v.12 no.4
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• pp.37-45
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• 2020

This paper quantitatively calculated the speech frequency of the discourse markers 'a', 'eo', and 'eum' and the speech duration of these discourse markers using the Seoul Corpus, a spontaneous speech corpus. The sound durations were confirmed with Praat, the Seoul Corpus was analyzed with Emeditor, and the results were presented by statistical analysis with R. Based on the corpus analysis, the study investigated whether a particular factor is preferred by speakers of particular categories. The most prominent feature of the corpus is that the sound durations of female speakers were longer than those of men when using the 'eum' discourse marker in a final position. In age-related variables, teenagers uttered 'a' more than 'eo' in an initial position when compared to people in their 40s. This study is significant because it has quantitatively analyzed the discourse markers 'a', 'eo', and 'eum' by gender and age. In order to continue the discussion, more precise research should be conducted considering the context. In addition, similarities can be found in "e" and "ma" in Japanese(Watanabe & Ishi, 2000) and 'uh', 'um' in English(Gries, 2013). afterwards, a study to identify commonalities and differences can be predicted by using the cross-linguistic analysis of the discourse.

• The Journal of the Korea Contents Association
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• v.4 no.4
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• pp.133-139
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• 2004

This paper proposes a Korean sentence boundary detection system which employs k-nearest neighbor algorithm. We proposed three scoring functions to classify sentence boundary and performed comparative analysis. We uses domain independent linguistic features in order to make a general and robust system. The proposed system was trained and evaluated on the two kinds of corpus; ETRI corpus and KAIST corpus. As experimental results, the proposed system shows about $98.82\%$ precision and $99.09\%$ recall rate even though it was trained on relatively small corpus.

• Korean Journal of Animal Reproduction
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• v.20 no.3
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• pp.225-232
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• 1996

The purpose of this study was to evaluate effects of hormonal treatments on corpus lutea, follicles and development stage of embryos for enhancing the production efficiency of in vivo porcine embryos suitable to introduce fo foreign genes. Hundred and twenty gilts were allocated to 6 experimental group in different combinations of hormones PG 600, PMSG, hCG and altrenogest. When gilts were treated with chorionic gonadotrophin 200 IU and serum gonadotrophin 200 IU(PG 600), altrenogest, serum gonadotrophin (PMSG) 1,000 IU, and chorionic gonadotrophin(hCG) 750 IU (PAPh), the numbers of corpus luteum (30.4) were significantly higher than those of other treatment groups (P<0.05). The number of corpus luteum from ovary in either right (9.1) or left (10.1) side was not significantly changed with hormone treatments. Number of follicles in control was 20.7, which was higher than those of hormonal treatment groups. The average numbers of 1, 2, 4 and 8 cell staged embryos were 8.1, 1.4, 1.6 and 1.0 in control, but the numbers of 1-cell stage in PAPh treatment group was 24.2, which was significantly higher than those of treatment groups (P<0.05). Therefore, these data indicated that hormonal treatment, especially PAPh, enhanced the developments of follicles, corpus lutea and embryos and increased the collection rate of the 1-cell stage embryos to introduce of foreign genes.

• Korean Journal of Cognitive Science
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• v.19 no.2
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• pp.143-161
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• 2008

The goal of this paper is to extract the hyponymy relation between words in the corpus. Adopting the basic algorithm of Hearst (1992), I propose a method of pattern-based extraction of semantic relations from the corpus. To this end, I set up a list of hypernym-hyponym pairs from Sejong Electronic Dictionary. This list is supplemented with the superordinate-subordinate terms of CoroNet. Then, I extracted all the sentences from the corpus that include hypemym-hyponym pairs of the list. From these extracted sentences, I collected all the sentences that contain meaningful constructions that occur systematically in the corpus. As a result, we could obtain 21 generalized patterns. Using the PERL program, we collected sentences of each of the 21 patterns. 57% of the sentences are turned out to have hyponymy relation. The proposed method in this paper is simpler and more advanced than that in Cederberg and Widdows (2003), in that using a word net or an electronic dictionary is generally considered to be efficient for information retrieval. The patterns extracted by this method are helpful when we look fer appropriate documents during information retrieval, and they are used to expand the concept networks like ontologies or thesauruses. However, the word order of Korean is relatively free and it is difficult to capture various expressions of a fired pattern. In the future, we should investigate more semantic relations than hyponymy, so that we can extract various patterns from the corpus.