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Effect of Gamigyuibi-tang on the Penile Erection Induced by Apomorphine Hel and Erectic Dysfunction Induced by p,p-DDE  

Hwang Joo Min (Joeun oriental clinic)
Kang Dong Yun (Gamchodang oriental clinic)
Byun Sung Hui (College of Oriental Medicine, Daegu Hanny University)
Kim Eun Ha (College of Oriental Medicine, Daegu Hanny University)
Kim Sang Chan (College of Oriental Medicine, Daegu Hanny University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.17, no.4, 2003 , pp. 980-990 More about this Journal
Abstract
The effect of Gamigyuibi-tang on the penile erection induced by apomorphine HCI and on the erectile dysfunction induced by p,p-DDE, an environmental hormone derivate of DOT, were monitored using male cats. The changes of penile length, diameter, erectic periods and histological profiles of corpus cavernosum and corpus spongiosum were observed with blood testosterone levels. In conclusion, dose-dependent and significant increase of penile length, diameter, erectic periods and blood testosterone levels were detected in the Gamigyuibitang-dosing groups compared to other groups. In addition, it is also demonstrated that the increasement of congestion of blood vessels and dilation of connective tissues, and decreasement of adipocytes in the corpus cavernosum and/or corpus spongiosum of the Gamigyuibitang-dosing groups. According to these results, it is considered that Gamigyuibitang has some augmentation effect against to apomorphine HCI inducing penile erection and it also suggested that Gamigyuibitang has favorable effect to treatment of erectic dysfunctions induced by p,p-DDE.
Keywords
Gamigyuibi-tang(加味歸脾湯); Penile erection; Apomorphine; Environmental hormone;
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