• Bulletin of the Korean Chemical Society
• /
• v.29 no.2
• /
• pp.323-327
• /
• 2008

A focused library of pyrazole-based compounds was constructed towards novel transcription factor inhibitors. Complementary hydrogen bonding interaction with b-sheet peptide structures was the basis for the design of 5-amino-3-pyrazole carboxamide scaffold. From the preliminary inhibition assay against several transcription factors, compounds 7e and 8g were identified as novel lead compounds against HIF-1a and NF-AT transcription factors, respectively.

• The Transactions of the Korean Institute of Electrical Engineers
• /
• v.39 no.7
• /
• pp.680-691
• /
• 1990

In this paper the conventional resonant inverters are compared and a novel parallel resonant dc pulse inverter for high performance motor drive system is proposed. The design method and related equations for the novel resonant inverter are derived. Also, a current controller for the resonant inverter is proposed and compared with PI current controller of the conventional PWM inverter by analog simulation. The novel resonant inverter and the current controller are implemented to verify the suggested design principles. The analog simulation and the experimental results shown the satisfactory operation of the proposed inverter and the controller.

• American Studies
• /
• v.43 no.2
• /
• pp.1-25
• /
• 2020

This paper examines the benefits of teaching The Adventures of Wu Han of Korea in secondary education in Korea. The novel is a rare sample of twentieth-century American fiction that features a Korean protagonist. What is notable in this novel is that its major Korean characters seem to share the mindset of their American author and creator and represent the Western perspective in their discourse of Korean/Eastern idea and culture. The novel is packed with Orientalist attitudes and could be taught as a case study of Orientalism. Teachers can also use the novel to teach students the art of close reading by analyzing selected scenes from the text.

• Proceedings of the Korean Geotechical Society Conference
• /
• 1999.10a
• /
• pp.131-136
• /
• 1999

In this study, novel activated silicate grout solution for injection grouting was prepared by the reaction of ordinary waterglass with alkaline earth metal salts mixture by means of the high-speed stirring method with strong shearing force, and its chemical and physical properties were investigated. The variation of its gelation time plotted with the amount of dilution water showed that this novel silicate had better gelation characteristics in comparison with ordinary waterglass. And some other engineering characteristics of this grout such as durability and mechanical properties were investigated experimentally. The whole experimental results established that this novel silicate grout was a good alternative with an existing ordinary waterglass grouting method.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.56 no.3
• /
• pp.498-505
• /
• 2007

This paper proposes the novel flux barrier that built in q-axis in rotor of IPM type BLDC motor. The novel flux barrier aims to reduce the motor vibration with reduced cogging torque and lessened torque ripple by the sinusoidal waveform distribution of the flux generated in the permanent magnet. For optimization of the novel flux barrier, the Taguchi method is effectively employed which considered multiple objective quality characteristics, such as cogging torque, average torque and efficiency. The result of proposed model compare with the initial model and it is verified by 2D finite element method (FEM) results.

• The Transactions of the Korean Institute of Electrical Engineers P
• /
• v.61 no.2
• /
• pp.93-96
• /
• 2012

We have designed high performance prism light-guide plate (LGP) in 17 inch TFT-LCD. In test result to embody high brightness BLU in case of LGP of base and upper surface with 17 inch, thickness 8mm adding prism construct. Using optical simulation, we forecast the brightness and uniformity in LGP with prism structure. And we adopted novel injection mold method and Nickel stamper to make actual evolution sample. Novel injection mold process has steady heating time zone in heat cycle time of injection mold process. For this novel heat cycle control, we achieved above 90[%] height prism structure as our design. It is superior brightness improvement than previous that of printing form about some 20[%] and in this course to embody actual material it succeeded prism LGP production by 17 inch injection form process.

• Proceedings of the Korean Society for Applied Microbiology Conference
• /
• 2000.04a
• /
• pp.128-134
• /
• 2000

In the course of flora analysis of soil Archaea, we found very strange 16S rDNA clones, which could possibly constitute a sister clade from known two archael, Crenarchaeota and Euryarchaeota, lineages. Overall signature sequences showed that the clones were closely related to domains Archaea and Eucarya. However, at least nine nucleotides distinguished the novel clones from domains Archaea and Eucarya. Phylogenetic trees drawn by maximum parsimony, neighbor joining and maximum likelihood methods also showed unique phylogenetic position of the clones. A very specific primer set was synthesized to detect the presence of the novel group of organisms in terrestrial environments. A specific DNA fragment was amplified from all of paddy soil DNAs, and this fact suggests that the novel organisms inhabit paddy soils.

• Proceedings of the Korean Magnestics Society Conference
• /
• 2015.05a
• /
• pp.32-33
• /
• 2015

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2004.11a
• /
• pp.575-578
• /
• 2004

In this study, we designed HAN(hybrid-aligned nematic) cell using novel tilt angle control method. It was possible to make novel HAN cell using a single polyimide by hot plate baking method. This new HAN cells showed slower response time as compared with conventional HAN cell. However, the alignment state and V-T curve of HAN cell using novel method were acceptable. Also, it showed better C-V characteristic than that of conventional HAN cell.

• Korean Journal of Veterinary Pathology
• /
• v.1 no.2
• /
• pp.91-96
• /
• 1997

General steps in the discovery and development of novel drugs in the United States are presented. The first step is the discovery of novel drugs. Brief histories and mechanisms of a few novel drugs in the American market are outlined. In this presentation preclinical animal toxicologic studies (drug safety evaluateion) are emphasized in regard to drug development. When preclinical animal studies have defined the toxicity and the doses at which it occurs an Investigational new Drug Application (IND) is submitted to the Food and Drug Administration (FDA) An IND notifies the FDA the intention to begin testing a novel drug in human subjects.