• Title/Summary/Keyword: KoreaMed

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Proposal of the Pharmacoepidemiologic Methodology Application to Research for Sasang Constitutional Pharmacology (약물역학연구 방법론의 체질약리연구 적용에 대한 제안)

  • Kim, Sang-Hyuk;Yoo, Jong-Hyang;Lee, Si-Woo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.24 no.5
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    • pp.753-757
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    • 2010
  • The objectives of this paper is to propose the pharmacoepidemiologic methodology to Research for Sasang Constitutional Pharmacology. We mainly searched "Journal of Pharmacoepidemiology and Risk Management". And we also searched "J Korean Oriental Med.", "J of Sasang Constitutional Med.", "J. Oriental Physiology & Pathology", "Korean J Orient Int Med." using these kew words - "adverse event" or "side effect" and "Sasang Contitution" or "Constitution" or "Constitutional medicine". Through the examination of the Pharmacoepidemiologic methodology and current research for sasang constitiutional pharmacology, we could establish the proposal to collect objective constitutional medical reaction. For the actualization of this proposal, the more advanced studies will have to be carried out continuously.

Purification and Characterization of an Intracellular Inulinase from Bacillus sphaericus 188-1

  • Kim, Jae-Ho;Kwak, Yoon-Jin;Lee, Jong-Tae;Park, Shin-Yang;Lee, Jong-Soo
    • Preventive Nutrition and Food Science
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    • v.7 no.4
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    • pp.421-426
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    • 2002
  • In order to obtain basal data for industrial application of inulinase from Bacillus sphaeicus 188-1, its intracellular inulinase was purified by ammonium sulfate fractionation and column chromatography on DEAE-Sephadex A-50 and Sephadex G-100. The enzyme was homogeneous as judged by SDS-polyacrylamide gel electrophoresis, with an apparent molecular weight of 29 kDa. Inulinase activity was optimal at pH 6.5 and 4$0^{\circ}C$. The enzyme activity was significantly inhibited by Cu$^{2+}$, Cd$^{2+}$ and Hg$^{2+}$. The inulinase exhibited an apparent Km value of 0.014% for inulin.

Upper and Lower Bounds of the Expected Busy Period for the Triadic Med(N, T, D) Policy (삼변수 Med(N, T, D) 운용방침에 따른 Busy Period 기대값의 상한과 하한 유도)

  • Rhee, Hahn-Kyou
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.36 no.1
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    • pp.58-63
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    • 2013
  • Using the known result of the expected busy period for the triadic Med (N, T, D) operating policies applied to a controllable M/G/1 queueing model, its upper and lower bounds are derived to approximate its corresponding actual values. Both bounds are represented in terms of the expected busy periods for the dyadic Min (N, T), Min (N, D) and Min (T, D) or Max (N, T), Max (N, D) and Max (T, D) with the simple N, T and D operating policies without using any other types of triadic operating policies such as Min (N, T, D) and Max (N, T, D) policies. All three input variables N, T and D are equally contributed to construct such bounds for estimation of the expected busy period.

Med-StyleGAN2: A GAN-Based Synthetic Data Generation for Medical Image Generation (Med-StyleGAN2: 의료 영상 생성을 위한 GAN 기반의 합성 데이터 생성)

  • Jae-Ha Choi;Sung-Yeon Kim;Hae-Rin Byeon;Se-Yeon Lee;Jung-Soo Lee
    • Proceedings of the Korea Information Processing Society Conference
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    • 2023.11a
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    • pp.904-905
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    • 2023
  • 본 논문에서는 의료 영상 생성을 위한 Med-StyleGAN2를 제안한다. 생성적 적대 신경망은 이미지 생성에는 효과적이지만, 의료 영상 생성에는 한계점을 가지고 있다. 따라서 본 연구에서는 의료 영상 생성에 특화된 StyleGAN 기반 학습 모델을 제안한다. 이는 다양한 의료 영상 어플리케이션에 활용할 수 있으며, 생성된 의료 영상에 대한 정량적, 정성적 평가를 수행함으로써 의료 영상 생성 분야의 발전 가능성에 대해 연구한다.

The Applicability of Minimum Entropy Deconvolution Considering Spatial Distribution of Sampling Points (지하수 함양량 추정시 공간상에서의 자료 Sampling 방법에 따른 Minimum Entropy Deconvolution의 적용성에 관한 검토)

  • Kim Tae-Hee;Kim Yong-Je;Lee Kang-Keun
    • Journal of Soil and Groundwater Environment
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    • v.11 no.3
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    • pp.52-58
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    • 2006
  • Kim and Lee (2005) suggested Minimum Entropy Deconvolution (MED) to estimate the temporal sequence of the relative recharge. However this study by Kim and Lee (2005) was just related to the verification of the conceptual approach with MED. In this study, we try to characterize the applicability of MED in the case of spatially heterogeneous recharge (distance from recharge area). Simulated results were recorded with some specific sampling points. Estimated results from this study show higher than 0.8 in cross-correlation with the original recharge sequence. In addition, the physical and mathematical meanings of the applied filter length was also investigated. It was revealed that the length of filter is highly related to the spatial distance between recharge area and the monitoring site, and the apparent shape of hydraulic head change.

Nationwide Incidence Estimation of Uterine Cervix Cancer among Korean Women (한국 여성에서의 자궁경부암 발생률)

  • Park, Byung-Joo;Lee, Moo-Song;Ahn, Yoon-Ok;Choi, Young-Min;Ju, Yeong-Su;Yoo, Keun-Young;Kim, Hun;Yew, Ha-Seung;Park, Tae-Soo
    • Journal of Preventive Medicine and Public Health
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    • v.29 no.4 s.55
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    • pp.843-851
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    • 1996
  • To estimate the incidence of uterine cervix cancer among Korean women, we have conducted a study using the claim data on the beneficiaries of Korea Medical Insurance Corporation (KMIC). All medical records of the potential cases with diagnosis of ICD-9 180, 181, 182, 199, 219, 233 in the claims sent by medical care institutions in the whole country to the KMIC from January 1988 to December 1989, were abstracted and Gynecology specialist reviewed the records to identify the new cases of uterine cervix cancer among the potential cases during the corresponding period. Using these data, the incidence of uterine cervix cancer among Korean women was estimated as of July 1, 1988 to June 30, 1989. The crude rate was estimated to be 17.34(95% CI: $16.76\sim17.92$) per 100,000 and the cumulative rates for the ages $0\sim64\;and\;0\sim74$ were 1.7% and 2.2%, respectively. The age-adjusted rate for the world population was 19.93 per 100,000 which was higher than those of other Asian countries including China and Japan in $1983\sim1987$. The truncated rate for ages $35\sim64$ was 52.05 per 100,000 which was one of the highest in the world. With increasing age, the incidence rate increased to 78.11 per 100,000 in women aged $55\sim59$ years, then it decreased in the older groups. This finding suggests that detecting rate of uterine cervix cancer may decrease in women aged 60 years or older due to inadequate medical care seeking behavior. In the geographical area, the SIR of Jeju province was significantly low but it might be due to statistical unstability by small case numbers.

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