• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.105-111
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• 2021

⁸⁹Zr is a positron-emitting radioisotope, which has known as well-suited radioisotope for use in a monoclonal antibody-based imaging agent for immuno-PET. The purpose of this study was to quantitatively evaluate the diagnostic ability of general trastuzumab and thio-trastuzumab as HER2 positive receptors based on Df hexadentate iron chelator. Desferrioxamine-p-SCN (Df-Bz-NCS) and desferroixamine-maleimide (Df-Mal) were purchased from Macrocyclics (Dallas, TX, USA). The trastuzumab was purchased from Roche (Schweiz), and thio-trastuzumab was obtained from professor Hyo-Jeong Hong group (Kangwon National University). The radioisotope ⁸⁹Zr was produced by domestic purification system and KIRAMS using medical cyclotron (50 MeV, Scantronix). The conjugates of Df-trastuzumab and Df-thio-trastuzumab were prepared with Df-Bz-NCS and Df-Mal under basic aqueous solution (pH 8-9) at room temperature, respectively. The conjugates purified by PD-10 column were mixed with dried ⁸⁹Zr chloride. ⁸⁹Zr-labeled conjugates were purified and concentrated by Amicon ultra centrifugal filter. The preparation step and time of ⁸⁹Zr-labeled conjugates was shorted as 4 steps within 2 hours. ⁸⁹Zr-labeled conjugates showed the highly radiochemical purity of over 98%, and were very stable until 7 days by the analysis of radio-ITLC method. Each radio-labeled conjugates were also exhibited the highly stability in both PBS buffer and mouse serum. Immuno-PET imaging of ⁸⁹Zr-labeled conjugates in mice bearing gastric cancer xenograft tumors with HER2 expression showed high tumor uptake in the NCI-N87 HER2-expressing. However, ⁸⁹Zr-Df-Mal-thio-trastuzumab showed a relatively lower tumor-to-background ratio than ⁸⁹Zr-Df-Bz-trastuzumab, as well as whole-body distribution. In the results, ⁸⁹Zr-Df-Bz-trastuzumab was evaluated to have a relatively higher HER2 diagnostic ability than ⁸⁹Zr-Df-Mal-thio-trastuzumab.

• Analytical Science and Technology
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• v.18 no.5
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• pp.386-390
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• 2005

The zinc(II) complex, $Zn(NCS)_2(C_3H_4N_2S)_2$, I, has been synthesized and characterized by single crystal X-ray diffraction, thermal analysis and infrared spectroscopy. The complex I crystallizes in the triclinic system, $P\bar{1}$ space group with a = 7.587(1), b = 8.815(1), $c=12.432(2){\AA}$, ${\alpha}=75.584(8)$, ${\beta}=83.533(9)$, ${\gamma}=68.686(8)^{\circ}$, $V=750.0(2){\AA}^3$, Z = 2, $R_1=0.036$ and ${\omega}R_2=0.101$. The central Zn(II) atom has a tetrahedral coordination geometry, with the heterocyclic nitrogen atoms of 2-aminothiazole ligands and the nitrogen atoms of isothiocyanate ligands. The crystal structure is stabilized by one-dimensional networks of the intermolecular $N-H{\cdots}S$ hydrogen bonds between the amino group of 2-aminothiazole ligands and the sulfur atom of isothiocyanate ligands. Based on the results of thermal analysis, the thermal decomposition reaction of complex I was analyzed to have three distinctive stages such as the loss of 2-aminothiazole, the decomposition of isothiocyanate and the formation of metal oxide.

• Convergence Security Journal
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• v.19 no.4
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• pp.151-163
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• 2019

As smart devices and communication technologies have developed rapidly, the healthcare industry in the globe is seeing remarkable issues on medical security. At the same time, personal medical records are being shared in the network, which would raise the risk of information security. This thesis aims to develop the curriculum to raise the awareness of information security among workers in medical institutions by referring to NCS(National Competency Standards) International standards, medical institutions' requirements and educational institutions' curriculums on information security based on proven results from medical devices and systems introduced in the public health centers, territorial branches, community health posts and primary, secondary, tertiary hospitals. Thus, this thesis offers the method to improve information security in healthcare institutions through validation testing conducted by medical practitioners and ICT experts.

• Journal of Engineering Education Research
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• v.20 no.5
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• pp.43-49
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• 2017

This paper deals with inter-relationship change of women's university students on the process of SW development project using social collaboration tool. Inter-relationship is one of the basic vocational competency in NCS(National Competency Standards) of Korea. We redesigned the curriculum of "Software Engineering" subject for this study and composed the project teams of students to develop software. The details of inter-relationship are satisfaction, communication, faith, friendliness, sensitivity, openness and consideration. From the result of this study, faith, openness and consideration have positive effect but satisfaction, communication, friendliness and sensitivity have no meaningful effect. The surveys were conducted in the beginning of semester and the same surveys were conducted again in the end of semester. The results were verified by paired t-test with SPSS 18.0. It is significant that the using of social collaboration tool for team project has positive effect on inter-relationship change, especially faith of women's university students. This study has some limitations for generalization but has meaning as new trial to enlarge the basic vocational competency of students in major subject, "Software Engineering". We expect new study for inter-relationship change of students to evaluate generality based on the proposed method in this paper.

• Journal of the Korean housing association
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• v.28 no.1
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• pp.55-62
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• 2017

As fast-speed of aging in modern society has led to increased concern for aging and health improvement of senior citizens, desire about having healthy living-environment has also increased. Living space for senior citizens has to play role of healing for their body feature as well as decrease in mental and psychological function. Color, as important factor that supplements degenerated sense and coping ability caused by aging, it has been revealed through modern medical science that color is effective for making nervous or calming down when it is delivered to one's nerve through sight. The purpose of this study is to suggest basic resource for color arrangement palette of living space and application method by color therapy to improve seniors' mental health by considering psychological and physical features caused by aging. First, consider psychological and physical feature of seniors and color therapy effect through previous research. Second, extract RGB value after selecting color that is helpful for their mental health by using palette from 'Korea Agency for Technology and Standards'. Third, extract other 3 colors that are similar with extracted color from 'NCS 1950 Color System'. Fourth, deduct palette of 3 color arrangement by using 'NCS Navigator' program. Lastly, extract arrangement palette for them by considering difference in visual features, and then suggest arrangement application for each palette through Computer Simulation.

• Convergence Security Journal
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• v.15 no.6_1
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• pp.49-57
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• 2015

Changes in the national intelligence security industry is becoming increasingly rapidly changing due to the development of the network and the use of the Internet. Information also can be called by critical information assets, as well as social infrastructure of the country's reality is that individuals at risk. These professionals make to prevent terrorists to destroy national defense system and network was absolutely necessary. But, Cyber Terror Response NCOs to be responsible for cyber terrorism requires a professional NCOs with advanced knowledge. National Competency Standards(NCS) using a national information security field tutors to conduct training courses teaching - learning model to develop and to apply.

• The Journal of Information Systems
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• v.33 no.1
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• pp.207-226
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• 2024

Purpose This study aims to develop a job model for data convergent talents to meet the rapidly changing demands of the data industry. To create a job model, we first define and categorize data convergent talents with balanced competencies in data technology and domain knowledge, and then develop a job model by investigating job areas, scope, activities, and competencies. Design/methodology/approach The research is conducted using the following procedures and methodology. First, we conduct a current status survey on data talent demand, data talent policies, data talent programs, and curricula at home and abroad; second, we collect opinions on the jobs and competencies required for data convergent talents and curricula for talent development through in-depth interview with experts; and third, we present the job areas and job activities of data convergent talents derived from the previous status survey and expert opinions based on the National Competency Standards(NCS). Findings The research findings indicate that there are total of six job roles for data convergent talents, including data scientist, data planner, data architect, data developer, data engineer, and data analyst. It was observed that each of these roles requires the development of common competencies within their respective fields, followed by a need for further specialization into specific competencies within each professional domain.

• Proceedings of the Korea Contents Association Conference
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• 2011.05a
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• pp.425-426
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• 2011

본 연구에서는 2000년대 중반 이후의 가요 CD 커버의 장르별 색채 특성에 대하여 분석하였다. 댄스, 락, 랩&힙합, 발라드의 4가지 장르로 구분하였고 KSCA (Korea Standard Color Analysis) 프로그램을 사용하여 각 이미지에서 5%이상 쓰인 주조색을 $L^*A^*B$, RGB, CMYK, 그리고 NCS 값으로 추출하여 색상 계열별로 사용 빈도를 정리하였다.

• Proceedings of KOSOMES biannual meeting
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• 2017.04a
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• pp.46-46
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• 2017

• Bulletin of the Korean Chemical Society
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• v.15 no.10
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• pp.842-845
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• 1994

Iodine-induced lactonization of ${\alpha}$-Phenylsulfonyl-${\gamma},{\delta}$-Unsaturated Amides provided 2,4-trans-substitued ${\gamma}$-butyrolactones in high selectivity. NBS-or NCS-induced lactonization of N,N-dimethyl-2-(phenylsulfonyl)-4-pentenamide in DME-$H-2O(2:1 vol)$ gave 2-halo-4-(halomethyl)-2-(phenylsulfonyl)-${\gamma}$-butyrolactone.