• Proceedings of the Plant Resources Society of Korea Conference
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• 2010.05a
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• pp.18-18
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• 2010

Glucosinolates(GSLs) are major secondary products($\beta$-thioglucoside N-hydroxysulfates) containing sulfates that are found mainly in Cruciferae family such as cabbage, broccoli, radish, turnip, kale, mustard and rapeseed as the important crops in agronomic and economic aspects. Especially, isothiocyanates(ITCs) have been shown to inhibit carcinogenesis with regulation cancer cell development followed by regulating target enzymes, inducing cell cycle arrest and apoptosis against various human cancer cell lines. Total desulfo(DS)-GSLs of nine type in 210 Korean leaf mustard accessions were isolated and confirmed using electrospray ionization mass spectrometric(ESI-MS/MS) method and DS-GSLs powerful library maked from several reference data. The isolated individual DS-GSLs were identified by removed $\beta$-D-glucopyranose residue ($C_6H_{11}O_5$, MW 163) from MS/MS data. Among them sinigrin(41.7%), glucoiberverin(21.7%) and gluconasturtiin(12.6%) were major components, Especially, despite gluconapin was minor component, accession K046197-1 and K046197-2 showed higher content of 4.11 and 3.31 mg/g(DW), respectively. The total GSLs contents in 210 accessions were ranged from 5.3 to 23.2 mg/g(DW) with a mean value of 13.0 mg/g(DW). As a result of principal component analysis(PCA), the individual GSLs loading plots were composed of three groups and components belonged to each group showed correlationship in quantitative pattern.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.29 no.3
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• pp.14-26
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• 2016

Objectives : This study was performed to investigate the protective effects and mechanisms of Salvia miltiorrhizae Radix extract (SME) on endotoxin shock.Methods : We used two models; LPS-induced sepsis model for in vivo model, and murine peritoneal macrophages responses for in vitro. SME was administrated orally to mice. After 1 hr, LPS was injected intraperitoneally. Survival rate was checked each time per 12 hr for 5 days. Mice were sacrificed 3 hr after LPS injection, then blood samples and organs were harvested. Cytokines secretion was measured by ELISA. Organs tissues were observed with microscope. Murine peritoneal macrophages were cultured for 1 hr either in a medium alone or in a medium that contained SME, as indicated. Then, the cells were treated with LPS for 24 hr. mRNA levels of cytokines were measured by real-time RT-PCR. Cytokine levels in the supernatants were measured by ELISA. The amount of nitrite was measured by using the Griess method to evaluate NO production. The cell lysates were analysed by Western blotting using antibodies for iNOS and β-actin was used as an internal control to monitor equal protein loading.Results : SME improverd the survival rate of mice model. SME inhibited the secretion of inflammatory cytokines and organs damages on Endotoxin Shock model. SME suppressed cytokine expression, cytokine secretion,NO production, iNOS expression in LPS-induced murine peritoneal macrophages.Conclusions : The results suggest that SME has protective effects on endotoxin shock through suppression of inflammatory cytokines, organ damages, NO production and so on.

• KCI Concrete Journal
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• v.12 no.2
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• pp.23-30
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• 2000

This paper presents behavior of concrete pavement at transverse joint subject to static test load. The test was conducted on 1/10 scale model in the laboratory. Load transfer across the crack is developed either by the interlocking action of the aggregate particles at the faces of the joint or by a combination of aggregate interlock and mechanical devices such as dowel bars. In this study, significant three variables considered to the performance of joints were selected. : (a)diameter of dowel bars(2.5mm, 3.0mm, 4.0mm), (b)presence or absence of dowel bars, (c)aggregate types(crushed stone, round stone). Experimental results were analyzed to find relationships among displacement of discontinuous plane at jointed slab, load transfer efficiency and joint opening, etc. Displacement of discontinuous plane at joint was decreased according to the increase of dowel bar diameter. In addition, it is found that model slabs made using crushed stone had better load transfer characteristics by aggregate interlock than model slabs made using similarly graded round stone. Displacement of discontinuous plane was increased according to the increase of loading. In addition, it was decreased as dowel diameter(2.5mm, 3.0mm, 4.0mm) was increased. In the case of slab without dowel bars, displacement of discontinuous plane was greatly increased and load transfer effciency of slab applied crushed stone was shown 30 percent greater than round stone. In addition, load transfer efficiency of slabs, which were made using crushed and round stone without dowel bars, was decreased to 20 percent and 30 percent, respectively as it was compared with slabs made us-ing dowel bars.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.5
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• pp.56-62
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• 2010

This paper presents the development process of roof carrier assembly using a one side release system for a vehicle. An RV(Recreational Vehicle) or SUV(Sports Utility Vehicle) has a roof carrier system on an upper surface of a roof panel for loading large or long size baggage. Such a roof carrier system is comprised of a roof rack longitudinally mounted on a roof panel and cross bar perpendicularly installed in the horizontal direction. Several locking mechanisms used in most vehicle roof carrier systems are composed with both side releasable locking ones. The obvious drawback to this arrangement is that when the user desires to reposition the cross bar, first one of the locking members must be unlocked and then the user must walk around to the opposite side of the vehicle to unlock the other member. In this paper, we proposed a newly locking mechanism, which allows a user simultaneously place both locking members of the roof carrier in locked and unlocked positions. In order to estimate design compatibility, structural and modal analysis is performed. Furthermore, a prototype based on the proposed design has been made, and then durability test carried out. From the simulation and experimental results, the proposed roof carrier system is proved effective and safe.

• Tunnel and Underground Space
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• v.29 no.6
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• pp.523-531
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• 2019

In the applications of rock mechanics or rock engineering including drill and blast, drilling and mechanical excavation, the fracture toughness is an important factor. Several methods have been proposed to measure the fracture toughness of rocks. In this study, wedge splitting test specimen which is prepared with ease and tested under compression loading was used to obtain mode I fracture toughness of rocks. The equation of stress intensity factor through numerical analysis is proposed from the stress state of crack tip considering both vertical and horizontal loads due to the vertical load acting on the wedge. The validity of the wedge splitting test method was confirmed by comparing the mode I fracture toughness values obtained by the GD and SENB test specimens.

• Journal of Korean Society of Steel Construction
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• v.9 no.4 s.33
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• pp.557-578
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• 1997

The objective of the study in this paper was to develop a beam-column element to model members with purely flexural yielding, as well as members with yielding under combined flexure and axial force during severe earthquake ground motins. The developed element can be considered as an one-component series hinge type model. It has the capability to model plastic axial deformation and changes in axial stiffness, and employs hardening rules to handle monotonic, cyclic or arbitrary loading. In general, when compared to experimental results and fiber model predictions, the element showed significantly better performance than the bilinear hinger model and could properly model the beam-column behavior of bare steel members in moment resisting frames. The developed element can more accurately predict local deformation demands and overall responses of structural systems under earthquake loadings than the bilinear hinge element.

• Journal of Periodontal and Implant Science
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• v.39 no.2
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• pp.185-192
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• 2009

Purpose: The aim of this study was to examine the correlation of the subjective and the objective evaluation of edentulous ridge bone quality, and to evaluate the change of the dental implant stability in each bone density group for early healing period after implant installation. Methods: Sixty-seven implants(Osstem implant$^{(R)}$, Seoul, Korea) were included in this study. We evaluated the bone density by 2 methods. The one was the subjective method which was determined by practitioner s tactile sense, the other was the objective bone type was based on Hounsfield units. The implant stability in each bone type group was assessed by resonance frequency analyzer(Osstell mentor$^{(R)}$). Data were analyzed for the change of the implant stability, and they were compared to verify the difference of groups at the time of installation, 2, 6, 10, 14 weeks postoperatively. Spearman's correlation was used to demonstrate the correlation between the subjective and the objective evaluation of the bone density, and analysis of variance(ANOVA) was used to analyze the differences of implant stability at each time point. Results: There was no close relation between the subjective and the objective evaluation of the bone density(r=0.57). In the subjective groups, there was statistically significant difference between the type 1 and 3 at 10 weeks and between the type 2 and 3 at 14 weeks. In the objective groups, there was no statistically significant difference between the D 1, 2, 3, 4, and 5 group with regard to RFA from baseline to 14 weeks(P>0.1). Conclusions: The implant stability increased over time during the study, and it was improved with bone density proportionally after 2weeks postoperatively. It is recommended that the decision of bone density is base on Hounsfield unit for implant loading time.

• Journal of Korean Society on Water Environment
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• v.22 no.1
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• pp.104-109
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• 2006

TPLMS programs in four large rivers have been developed to improve the water quality from possible pollutants originated from watershed areas. The success of TPLMS program is depended on nonpoint source control. Currently, the pollutant loading from nonpoint pollution sources is gradually increasing as developing the nearby watershed. However, there are not enough data concerning on nonpoint pollution in Korea because of lacking of monitoring activities. It is the main reason of uncertainty. Therefore, this manuscript will summarize the EMCs in various landuses based on monitoring program. Also the EMC in each paved area will be compared and discussed to find the differences. When the EMC is compared by average monitored sample concentrations, the EMC values are 2-4 times higher than sample concentrations. It means the monitoring program is very important in the field of nonpoint pollution. The pollutant loadings from bridge landuse is higher than loadings from parking lot and highway because of more traffic activities.

• Journal of the Society of Naval Architects of Korea
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• v.30 no.4
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• pp.136-152
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• 1993

This study is intended to develop an accurate and efficient, analytical thin-walled beam model, and to analyze overall behavior of SWATH ship under repeated overloads. SWATH ship is idealized to a simple thin-walled beam of channel type. An analytical beam model is formulated by the stress component with geometrically(fully) nonlinear thin-walled beam and treated numerically by the Finite Element Method. An efficient cyclic plasticity model is also included, suitable for material nonlinear behavior under complex loading conditions. The local stress distribution can be very exactly represented and the material yielding propagation, easily traced. In addition, the local treatment of the effect of shear deformation improves the representation of deformation and shear stress distribution along the section contour. It is desirable to use the analytical thin-walled beam at initial design stage, and is needed to improve the practical thin-walled beam model advancing the current approach.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.32 no.3A
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• pp.139-148
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• 2012

Circular concrete-filled tubes (CFTs) are composite members, which consists of a steel tube and concrete infill. CFTs have been used as building columns and bridge piers due to several advantages such as their strength-to-size efficiency and facilitation of rapid construction. Extensive experimental studies about CFT have been conducted for past decades. However experimental results alone are not sufficient to support the engineering of these components. Complementary advanced numerical models are needed to simulate the behavior of CFT to extend the experimental research and develop predictive tools required for design and evaluation of structural systems. In this study, a finite element modeling technique for CFT was developed. The confinement effects, and behavior of CFT subjected various types of loading predicted by the proposed finite element model for CFT were verified by comparing with test results.