• Journal of Microbiology and Biotechnology
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• 제23권8호
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• pp.1167-1175
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• 2013

Paratuberculosis (PTB) or Johne's disease is one of the most serious chronic debilitating diseases of ruminants worldwide that is caused by Mycobacterium avium subsp. paratuberculosis (MAP). MAP is a slow-growing bacterium that has very long latent periods, resulting in difficulties in diagnosing and controlling the disease, especially regarding the diagnosis of fecal shedders of MAP without any clinical signs. Based on this situation, attempts were made to identify biomarkers that show early responses to MAP infection in a macrophage cell line, RAW 264.7. In response to the infection with the bacterium, a lot of genes were turned on and/or off in the cells. Of the altered genes, three different categories were identified based on the time-dependent gene expression patterns. Those genes were considered as possible candidates for biomarkers of MAP infection after confirmation by quantitative RT-PCR analysis. To the best of our knowledge, this is the first attempt at discovering the host transcriptomic biomarkers of PTB, although further investigation will be required to determine whether these biomarker candidates are associated within the natural host.

• 대한수의학회지
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• 제41권1호
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• pp.73-78
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• 2001

Yersinia enterocolitica is an inhabitant in the lower intestinal tract of many domestic and wild animals as well as in the nature. Of the several forms of diseases caused by Y. enterocolitica, an acute enteritis, especially in young children, is the most common form. Infection of the bacteria usually occurs through fecal-oral route by contaminated foods or water, especially mountainspring water. Of the domestic animals, swine has been known as one of the most important carrier in the human infection. Based on the knowledge, prevalence of antibody against Y enterocolitica was investigated with swine sera collected from Korea for the survey of Y enterocolitica infection in swine. As the first step of this survey, we analyzed outer membrane protein (OMP) profiles of the representative strains of Y enterocolitica isolated from the feces of piglets and mountainspring water in Korea. Thirty-eight kDa OMP was identified as the common OMP regardless of origin, serotype, or biotype of Y enterocolitica isolates. Presence of antibody specific for 38 kDa OMP of Y enterocolitica in 1,076 swine sera collected from November 1999 to October 2000 was analysed with ELISA. Antibody titer in sows was significantly higher than that in piglets, growing pigs and finishing pigs (p<0.05). Also, there was seasonal difference in the prevalence of antibody against Y enterocolitica. These results would provide the basic knowledge for controlling the Y enterocolitica infection in human as well as swine.

• 한국직업건강간호학회지
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• 제15권1호
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• pp.40-49
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• 2006

Purpose: This study was designed to investigate nursing students' exposure experience to infectious diseases and their knowledge and performance for the nosocomial infection control. Method: The data was obtained from 292 nursing students having clinical experience at two university hospitals in Seoul from November 2005 to February 2006. Specific questionnaire was constructed and used for this study. The obtained data was analyzed by using the SPSS window program. Result: The results were as follow : 1. Among the evaluation scores of knowledge for the nosocomial infection control, the score of sterilization and the score of the intravenous therapy management were low(.14). 2. Among the evaluation scores of performance for the nosocomial infection control, the score of hand washing is low(1.63). 3. 86.3 percent of the nursing students had exposure experience to infectious disease. Many of them did not use the protective equipments in clinical experience nor took any treatment after the exposure to infectious diseases. Conclusion: Based on these results, we suggest that the programs for the nosocomial infection control should be developed for nursing students. It is also suggested that nursing students should be educated before their clinical experience to keep protected from the infection. In particular, the hand washing, sterilization and intravenous therapy management should be emphasized in the educational programs.

• Tuberculosis and Respiratory Diseases
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• 제55권4호
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• pp.361-369
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• 2003

연구배경 : 국내에서는 2003년의 사스 유행기에 사스 방역에서 만족할 만한 성과를 거두었으나, 유행이 다시 시작되거나, 다른 새로운 점염병의 가능성이 있다. 사스 전담 병원 중의 한 병원에서 직원들을 대상으로 시행한 사스에 대한 설문조사를 통해 병원 직원들의 사스에 대한 이해정도와 태도에 미치는 영향을 파악하여 향후의 유사한 상황에 대비한 기초자료를 얻고자 하였다. 방 법 : 강원대학교병원의 전 직원을 대상으로 인구 사회학적 사항, 사스에 대한 지식 측정, 진료 참여 의향, 사스의 사회적 파장에 대한 의견, 정보 취득에 대한 내용으로 설문조사를 시행하였다. 사스에 대한 지식 정도와 사스에 대한 태도와의 관련성, 인구 사회학적 특성과 사스에 대한 태도와의 관련성에 대해 분석하였다. 결 과 : 280명 중 251명의 직원이 응답하였고, 사스지식에 대한 평균점수는 $72.0{\pm}13.7$이었다. 사스전담 팀참여에 대해 50.6%에서 참여하겠다고 응답하였다. 본원이 격리전담을 담당하는데 반대하는 의견은 23.1%였다. 사스 지식에 대한 점수와 사스 관리에 대한 태도사이에는 관련성이 없었다. 교육에 참여한 사람과 참여하지 않은 사람들 사이에 지식 점수의 차이는 없었다. 교육 시 알고싶은 내용으로 사스환자 관리요령과 개인별 예방법에 대한 것이 가장 많았다. 결 론 : 대중 매체를 통한 사스환자 관리요령과 개인별 예방법에 대한 정확한 국가적 정보제공이 중요할 것으로 사료되며, 사스에 대한 지식수준과 태도와의 관련성이 없었다.

• 한국컴퓨터정보학회논문지
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• 제28권12호
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• pp.201-209
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• 2023

본 연구는 119구급대원 응급구조사에 대한 신종 감염병에 대한 지식 정도와 교육 현황, 스트레스, 교육의 필요도를 확인하여 신종 감염병에 대한 감염관리 교육에 기초가 되는 자료를 제공하고자 한다. 본 자료수집 기간은 2022년도 08월 10일부터 9월 18일까지 총 39일간이었고 총 105부이다. 본 연구의 분석은 SPSS 25.0 프로그램을 이용하였다. 연구 결과, 119구급대원 중 응급구조사의 성별은 남자가 54명(51.4%), 여자 51명(48.6%)으로 남자가 여자보다 많았으며 연령은 20대가 47명(44.8%), 30대 이상이 58명(55.2%)으로 30대 이상이 많았다. 총근무경력은 3년 이상 5년 이하가 37명(35.2%)으로 가장 높았다. 119구급대원 응급구조사의 COVID-19에 대한 교육 현황, 스트레스 및 신종 감염병에 대한 교육 필요도를 확인하고자 시도되었으며, COVID-19에 대한 교육 현황은 충분하지 못하였고, 신종 감염병에 대한 교육 요구도는 높은 것으로 나타났다. 신종 감염병에 자주 노출되는 119구급대원 중 응급구조사에게 이론 교육을 포함하여 개인보호장비 이론 및 실기 교육 훈련이 필요하다. 응급구조사가 되기 전인 대학생들의 교과목에 신종감염병과 개인보호장비 이론 및 실기 교육 프로그램이 개발되어야 한다.

• IMMUNE NETWORK
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• 제15권2호
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• pp.51-57
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• 2015

Vaccines are the most effective and cost-efficient method for preventing diseases caused by infectious pathogens. Despite the great success of vaccines, development of safe and strong vaccines is still required for emerging new pathogens, re-emerging old pathogens, and in order to improve the inadequate protection conferred by existing vaccines. One of the most important strategies for the development of effective new vaccines is the selection and usage of a suitable adjuvant. Immunologic adjuvants are essential for enhancing vaccine potency by improvement of the humoral and/or cell-mediated immune response to vaccine antigens. Thus, formulation of vaccines with appropriate adjuvants is an attractive approach towards eliciting protective and long-lasting immunity in humans. However, only a limited number of adjuvants is licensed for human vaccines due to concerns about safety and toxicity. We summarize current knowledge about the potential benefits of adjuvants, the characteristics of adjuvants and the mechanisms of adjuvants in human vaccines. Adjuvants have diverse modes of action and should be selected for use on the basis of the type of immune response that is desired for a particular vaccine. Better understanding of current adjuvants will help exploring new adjuvant formulations and facilitate rational design of vaccines against infectious diseases.

• Clinical and Experimental Pediatrics
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• 제50권2호
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• pp.127-131
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• 2007

Fever of unknown origin (FUO) has been a convenient term used to classify patients who warrant a particular systemic approach to diagnostic evaluation and management. The greatest clinical concern in evaluating FUO is identifying patients whose fever has a serious or life-threatening cause when a delay in diagnosis could jeopardize successful intervention. Thorough history and complete physical examination are critical to uncover the etiologic diagnosis. Most cases of FUO in children are caused by atypical presentations of common diseases rather than by typical manifestations of rare disorders. Selection of diagnostic tests and speed of investigation should be guided by a knowledge of the disease severity, patient age, epidemiologic and geographic information, and any positive findings from a detailed history and physical examination. The three most common causes of FUO in children are infectious diseases, connective tissue diseases, and malignancy. In general, the prognosis of FUO in children is better than that of adults. Although the outcome is dependent on the primary disease process, fever abates spontaneously in most cases in whom the cause of fever remains unclear.

• The Journal of Korean Physical Therapy
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• 제34권6호
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• pp.304-311
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• 2022

Purpose: The purpose of this study was to investigate the knowledge, awareness and performance of COVID-19 infection control among physical therapists and to identify the impact factors on performance Methods: Data were collected from March 16th to March 24th in 2022 from the physical therapist's in Busan. Data analysis was conducted on 170 surveys, after excluding 27 surveys that were found to be unsuitable for data analysis. Results: When correlating the study variables, knowledge and awareness were found to have a positive, meaningful correlation with performance. Performance of COVID-19 personal infection control regression analysis showed that the working department (clinic and long-term care hospital), clinical experience, the more knowledgeable, the awareness (personal), and the more clinical experience had significant positive impacts on the performance of COVID-19 infection control. Performance of COVID-19 treatment room infection control regression analysis showed that the working department (long-term care hospital), educational experience, the awareness (treatment room) had significant positive impacts on the performance of COVID-19 infection control Conclusion: The results of this study may be used as basic data for educating physical therapist's working at the COVID-19 response department. This study suggests that physical therapist's need educational programs to improve their knowledge and awareness and performance of infection control against infectious diseases such as COVID-19. Differentiated physical therapists practice education curricula must be developed and provided after understanding the varying characteristic of physical therapist's with different levels of work experience.

• 한국치위생학회지
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• 제22권3호
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• pp.189-197
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• 2022

Objectives: The purpose of this study was to investigate the level of systemic disease-related knowledge among dental hygienists and analyze the effect on their job performance, empowerment, and satisfaction to provide basic data for expanding education on systemic diseases among dental hygienists and improving their job performance, empowerment and satisfaction. Methods: A survey was conducted among dental hygienists working in Busan and Gyeongsangnam-do region, South Korea, from October 27 to November 10, 2020, with a total of 245 questionnaires included in the final analysis. Results: Results of analysis revealed an average score for systemic disease-related knowledge among dental hygienists of 16.53±3.33 points and the higher the systemic disease-related knowledge, the higher the job performance, empowerment, and satisfaction. The higher the coronary artery disease knowledge and respiratory and infectious disease knowledge, the higher the job performance, and the higher the respiratory and infectious disease knowledge, the higher the job empowerment and job satisfaction. Conclusions: This study revealed that the higher dental hygienists' level of systemic disease-related knowledge, the higher their job performance, empowerment, and satisfaction. Therefore, this study suggests that dental hygienists' education on systemic disease-related knowledge should be expanded, and diverse systemic disease education programs should be developed for application in clinical practice.

• Safety and Health at Work
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• 제8권3호
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• pp.246-249
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• 2017

Health-care workers are at risk of exposure to occupational infections with subsequent risk of contracting diseases, disability, and even death. A systematic collection of occupational disease data is useful for monitoring current trends in work situations and disease exposures; however, these data are usually limited due to under-reporting. The objective of this study was to review literature related to knowledge, risk perceptions, and practices regarding occupational exposures to infectious diseases in Malaysian health-care settings, in particular regarding blood-borne infections, universal precautions, use of personal protective equipment, and clinical waste management. The data are useful for determining improvements in knowledge and risk perceptions among health-care workers with developments of health policies and essential interventions for prevention and control of occupational diseases.