• Journal of Science and Technology Studies
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• v.10 no.2
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• pp.107-141
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• 2010

Visualization techniques are transformed into reliable representations through socio-technological processes which include the agreement on the instrument and the embodiment of practices in relevant scientific communities. Visual representations thus produced are justified by realistic and epistemic virtues in science. This paper analyzes different visual images presented in the scientific papers of two research groups who argue different theories about the mechanism of face perception. These two scientific groups use the same fMRI technology; yet, different experimental paradigms and visual stimuli change their hypotheses into distinct testable theories, which in turn lead to different evidences to support their own theories. Visual evidences are intermediate representations which lie between fMRI brain images and scientific theories, and theoretical models obtain the scientific value based on the consistency in the chain of visual representations. This study shows that representations in science tend to be good representations within the context of scientific communities. It will provide a chance to think of the value and limit of the scientific knowledge

• Korean Journal of Social Welfare
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• v.64 no.2
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• pp.85-109
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• 2012

This qualitative study explored a middle-aged lesbian's life and her identities by the oral life history approach in feminist epistemology, where the participant is not the object but the subject of knowledge. The participant kept her own perspective that her homosexuality was not intrinsic but constructed. In her life's history, she was a "docile body" accepting socially constructed historical meaning of homosexuality, as well as a "resistant body" protesting against social discrimination and oppression for homosexual population. She overcame an embedded negative recognition of her scaled injured body and her sexuality as "deficient". Finally, she showed an amazing resilience and an indomitable spirit for reconstructing the meaning of her body as "blessed." Beyond the deficient body, as an active agent not the pathologic sexual minority, she could cultivate compassion and empathy for others. From the results, it is important how to place gender and sexuality in the context of social work theory and practice. Sexuality, not sexual orientation, is 'our' collective agenda to address the social problems which were associated with social hierarchy, inequality, and injustice.

• Tuberculosis and Respiratory Diseases
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• v.43 no.4
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• pp.630-636
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• 1996

Bronchiolitis obliterans organizing pneumonia(BOOP) is a pathologic entity characterized by the formation of plugs of fibrous tissue in bronchioles and alveolar ducts. It clad been described in association with several connective tissue diseases, i.e. systemic lupus erythematosus, Behcet's disease, polymyositis-dermatomyositis, polymyalgia rheumatica and Sjogren's syndrome. Recently, there were few additional reports on BOOP, anteceded by rheumatoid arthritis. We clad experienced a case of 60 years old female patient who clad been admitted for acute respiratory difficulty and abnormal chest roentgenographic findings. She was diagnosed as having rhematoid arthritis 20 years ago. On the course of our treatment, she did not respond to antibiotics. Moreover, no microorganism grew in the sputum and blood. Thus, the bronchoscopic biopsy was done. The patient showed a dramatic response to steroid therapy, and the pathologic bindings of the bronchoscopic biopsy confirmed as BOOP. To our knowledge, this is the first reported case of BOOP anteceded by rheumatoid arthritis in Korea.

• Tuberculosis and Respiratory Diseases
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• v.79 no.4
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• pp.257-266
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• 2016

Background: Idiopathic pulmonary fibrosis is a common interstitial lung disease; it is a chronic, progressive, and fatal lung disease of unknown etiology. Over the last two decades, knowledge about the underlying mechanisms of pulmonary fibrosis has improved markedly and facilitated the identification of potential targets for novel therapies. However, despite the large number of antifibrotic drugs being described in experimental pre-clinical studies, the translation of these findings into clinical practices has not been accomplished yet. NADH:quinone oxidoreductase 1 (NQO1) is a homodimeric enzyme that catalyzes the oxidation of NADH to $NAD^+$ by various quinones and thereby elevates the intracellular $NAD^+$ levels. In this study, we examined the effect of increase in cellular $NAD^+$ levels on bleomycin-induced lung fibrosis in mice. Methods: C57BL/6 mice were treated with intratracheal instillation of bleomycin. The mice were orally administered with ${\beta}$-lapachone from 3 days before exposure to bleomycin to 1-3 weeks after exposure to bleomycin. Bronchoalveolar lavage fluid (BALF) was collected for analyzing the infiltration of immune cells. In vitro, A549 cells were treated with transforming growth factor ${\beta}1$ (TGF-${\beta}1$) and ${\beta}$-lapachone to analyze the extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT). Results: ${\beta}$-Lapachone strongly attenuated bleomycin-induced lung inflammation and fibrosis, characterized by histological staining, infiltrated immune cells in BALF, inflammatory cytokines, fibrotic score, and TGF-${\beta}1$, ${\alpha}$-smooth muscle actin accumulation. In addition, ${\beta}$-lapachone showed a protective role in TGF-${\beta}1$-induced ECM expression and EMT in A549 cells. Conclusion: Our results suggest that ${\beta}$-lapachone can protect against bleomycin-induced lung inflammation and fibrosis in mice and TGF-${\beta}1$-induced EMT in vitro, by elevating the $NAD^+$/NADH ratio through NQO1 activation.

• Journal of Technologic Dentistry
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• v.31 no.2
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• pp.15-22
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• 2009

This study examined and analyzed the demographical characteristics of the study target and their expectancy level on the factors in selecting dental medical institutes (basic elements of dental clinics, traffic convenience, physical environment of dental clinic and explicit qualification of dentist) with the questionnaire survey method with 222 questionnaires answered and returned (return rate 88.8%) out of 250 copies distributed to the 1st, 2nd and 3rdyear college students attending technical colleges located in Cheongwon-Gun, Chungbuk, Korea from March 26 to April 7, 2009. The results of this study are as follows: 1. The demographical characteristics of the study target group consisting of 225 college students include 92.3% of age 20s (205 students); 123 males (55.4%) and 99 females (44.6%); the number of those who had at least one experience to visit dental clinic was 199 (89.6%) and 23 (10.4%) of those with no-visiting experience. 2. The descriptive statistics for the selection factor showed that basic elements, traffic convenience, physical environment and explicit qualification of dentist were regarded important as in order. In particular, the factors considered in selecting dental clinic was ordered from most to least in their importance beginning with cleanness of dental clinic as the most important factor, dentist's trustworthiness, kindness of medical staffs, low medical fee, dentist's knowledge level, modernized medical equipments and convenience in using medical facilities as the least. On the contrary, brand name of dental clinic, age, college, sex and appearance of dentist were rated low in order in terms of their importance in selecting dental clinic. 3. As for the difference in the selection factors across demographical characteristics, while male students placed importance on traffic convenience and physical environment of dental clinic, female students placed more importance on dentist's qualification and basic elements of dental clinic. With respect to the difference in the selection factors across the visiting experiences, while those with visiting experience regard traffic convenience more importantly, those without visiting experience regarded physical environment of dental clinic, dentist's qualification and basic elements of dental clinic. 4. In terms of pearson correlation coefficient, the result showed that all aspects in selecting dental clinic were positively correlated. Particularly, the correlation between physical environment of dental clinic and dentist's explicit qualification were correlated highest. Significant positive correlations were found high in traffic convenience, physical environment of dental clinic, dentist's explicit qualification and basic elements of dental clinic in order.

• Journal of the Economic Geographical Society of Korea
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• v.14 no.3
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• pp.241-262
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• 2011

The aim of this study is to examine the changes of institution, quantity and approach methods of research results in the history of Korean economic geography during the last fifty-five years (1956-2010) and to offer the preparations for the future research. The history Korean economic geography can be divided into four periods: 'period of cradle' (1956-1962), 'period of establishment' (1963-later 1970s)', 'period of leap (the former half of 1980s-the former half of 1990s)', and 'period of transition (since later 1990s)'. Many departments of geography education and geography have been founded in the 'period of establishment' and 'period of leap'. Among the total research matters (1,621), 44.4 percent of research results have been made in 2000s and the most researched field was that of manufacturing geography, which occupied 27.7 percent. In the approach methods, about two-thirds of the results are the empirical inductive approach and the research frameworks method which clarified the regional structures and theory of spatial system occupied each about 40 percent. In the future, each research field of Korean economic geography is expected to take more serious view of nature environment, thorough regional survey, and preference of economy-society-culture-knowledge in the research framework of spatial network theory.

• Journal of the Economic Geographical Society of Korea
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• v.17 no.2
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• pp.249-263
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• 2014

Established as the first science park in the world in the late 1950's, the Research Triangle Park(RTP) has not jut grown significantly but also has been successful in the transition from the exogenous development model to the endogenous development model. In this context, this paper attempts to explore the evolutionary path of the RTP by drawing upon the concept of triple-helix spaces of regional innovation. Firstly, the three research universities in the triangle area, as a knowledge space, played a fundamental role for forming the RTP. However, it is difficult to say that the regional universities, as opposed to the Silicon Valley and the Boston area, have had a significant impact on inducing the dynamics of the cluster evolution and the triple helix spaces. Secondly, it can be argued that the North Carolina's Board of Science and Technology, which was formed in 1961 but traced back to the 1950's in its origin, has been a centerpiece of a consensus space that makes a contribution to creating, sustaining and transforming the RTP as a triple-helix-based innovation cluster. Thirdly, there have been a plenty of agents to be an innovation space in the RTP. Particularly, the North Carolina Biotechnology Center(NCBC) and the Microelectronic Center of North Carolina(MCNC) have been the boundary permeable agents to make triple-helix agents interact. Today, the RTP has the triple-helix spaces with the structure that a consensus spaces is centered on out of the three, but all of those are inter-connected and influenced by each other. It can be claimed that the RTP today shows the dynamic structure of cluster evolution in a way in which the existing industry sectors have adapted to the changes in external environment and the new industry sectors have emerged at the same time.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.24 no.12
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• pp.1181-1189
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• 2013

In this paper, a retrodirective anatenna array system is proposed and the possibility of actively cancelling electromagnetic waves based on this system is investigated. When a rectrodirective array system receives an electromagnetic wave, it can send waves in the direction of the incoming signal without prior knowledge of the direction. In applications to cancellation of radar signals, the system can generate and send signals to the radar so that it cancels the radar signals that are reflected back to the radar. In such a system, isolation between the input and output ports is a key factor that determines the effectiveness of cancellation. In this work, a dual-conversion mixer system is proposed to maximize the isolation. Since this minimizes the difference between the direction of reflection of radar signals and the transmission of cancellation signals, the effectiveness of cancellation is maximized. Experimental results for a metallic plate and metallic cylinder shows as much as 29-dB reduction in reflection for a $2{\times}2$ retrodirective array based on proposed dual-conversion mixer system, which verifies the proposed method of active cancellation.

• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.4
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• pp.693-705
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• 2012

It is increasing the necessity of technology cooperation between nations, in the world, more and more. The international cooperation for the technology development have the dissipating effect of costs and risks and encourage efficient use of the knowledge and eventually help the firms better access overseas market easily. The S&T diplomacy of Korea is, at present, on international S&T cooperation to secure technologies to strengthen base of science, technology and innovation. This tendency is closely related with the governance issue in international S&T cooperation. And This international S&T cooperation is connected with the internationalization of firms. But it is getting more difficult for a firm, especially smaller firm like Korean SME to sustain the technological advantage over any significant period. The small and medium sized enterprises as Korean SME, internationalization of R&D is difficult just to think in terms of one framework with the limited accumulation of informations and experiences. So against that situation, this paper shows a new concept 'SME co-ordinator' as the role client(or player) reinforcing international S&T cooperation, sustaining the technological advantage for Korean SME. And 'SME co-ordinator' leads Korean SME to progress 'open innovation' not 'close innovation' as well as serving adequate information about appropriate partners and capable employer to help manage the international S&T cooperation for Internationalization of Industrial R&D for Korean SME.

• CELLMED
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• v.4 no.1
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• pp.5.1-5.8
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• 2014

Healthcare-associated infection represents a frequent cause of mortality that increases hospital costs. Due to increasing microbial resistance to antibiotics, it is necessary to search for alternative therapies. Consequently, novel alternatives for the control of resistant microorganisms have been studied. Among them, plant antimicrobial protein presents enormous potential, with flowers being a new source of antimicrobial molecules. In this work, the antimicrobial activity of protein-rich fractions from flower tissues from 18 different species was evaluated against several human pathogenic bacteria. The results showed that protein-rich fractions of 12 species were able to control bacterial development. Due its broad inhibition spectrum and high antibacterial activity, the protein-rich fraction of Hibiscus rosa-sinensis was subjected to DEAE-Sepharose chromatography, yielding a retained fraction and a non-retained fraction. The retained fraction inhibits 29.5% of Klebsiella pneumoniae growth, and the non-retained fraction showed 31.5% of growth inhibition against the same bacteria. The protein profile of the chromatography fractions was analyzed by using SDS-PAGE, revealing the presence of two major protein bands in the retained fraction, of 20 and 15 kDa. The results indicate that medicinal plants have the biotechnological potential to increase knowledge about antimicrobial protein structure and action mechanisms, assisting in the rational design of antimicrobial compounds for the development of new antibiotic drugs.