• 제목/요약/키워드: Kinship analysis

검색결과 30건 처리시간 0.021초

선형혼합모형을 이용한 유전체 자료분석방안에 대한 연구 (Efficient strategy for the genetic analysis of related samples with a linear mixed model)

  • 임정민;성주헌;원성호
    • Journal of the Korean Data and Information Science Society
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    • 제25권5호
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    • pp.1025-1038
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    • 2014
  • 가족 자료를 활용한 연속형 표현형의 전장유전체분석 (genome-wide association analysis)은 주로 선형혼합모형을 이용하며, 분산공분산행렬은 가족 구성원간의 유전적 거리를 고려하여 결정된다. 그러나 가족 구성원들의 표현형의 유사성은 유전적 요인과 환경적 요인에 의하여 발생함에도 불구하고, 표현형의 유사성은 단지 유전적 요인에 의해서 발생한다고 가정한다. 예를 들어 키의 경우 부부 사이에 양의 상관관계가 존재하나 유전적 요인만 고려하여 독립으로 가정한다. 선형혼합 모형에서 분산공분산 구조를 잘못 가정하는 경우, 검정통계량의 1종 혹은 2종의 오류를 적절히 관리할 수 없다. 본 논문에서는 다양한 유형의 분산공분산구조를 가정할 수 있는 선형혼합모형과 이를 기반으로 한 검정통계량을 제안하였다. 모의실험을 통하여 제안한 방법이 기존의 모형보다 통계적 검정력이 우수함을 확인하였다. 또한 체질량지수 (body mass index; BMI)의 전장유전체 분석에 적용하여 기존에 알려지지 않은 새로운 원인 유전자를 규명하였다.

Genetic diversity analysis in Chinese miniature pigs using swine leukocyte antigen complex microsatellites

  • Wu, Jinhua;Liu, Ronghui;Li, Hua;Yu, Hui;Yang, Yalan
    • Animal Bioscience
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    • 제34권11호
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    • pp.1757-1765
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    • 2021
  • Objective: The swine leukocyte antigen (SLA) gene group, which is closely linked and highly polymorphic, has important biomedical significance in the protection and utilization of germplasm resources. However, genetic polymorphism analyses of SLA microsatellite markers in Chinese miniature pigs are limited. Methods: Eighteen pairs of microsatellite primers were used to amplify the SLA regions of seven miniature pig breeds and three wild boar breeds (n = 346) from different regions of China. The indexes of genetic polymorphism, including expected heterozygosity (He), polymorphic information content (PIC), and haplotype, were analyzed. The genetic differentiation coefficient (Fst) and neighbor-joining methods were used for cluster analysis of the breeds. Results: In miniature pigs, the SLA I region had the highest numbers of polymorphisms, followed by the SLA II and SLA III regions; the region near the centromere had the lowest number of polymorphisms. Among the seven miniature pig breeds, Diannan small-ear pigs had the highest genetic diversity (PIC value = 0.6396), whereas the genetic diversity of the Hebao pig was the lowest (PIC value = 0.4330). The Fst values in the Mingguang small-ear, Diannan small-ear, and Yunnan wild boars were less than 0.05. According to phylogenetic cluster analysis, the South-China-type miniature pigs clustered into one group, among which Mingguang small-ear pigs clustered with Diannan small-ear pigs. Haplotype analysis revealed that the SLA I, II, and III regions could be constructed into 13, 7, and 11 common haplotypes, respectively. Conclusion: This study validates the high genetic diversity of the Chinese miniature pig. Mingguang small-ear pigs have close kinship with Diannan small-ear pigs, implying that they may have similar genetic backgrounds and originate from the same population. This study also provides a foundation for genetic breeding, genetic resource protection, and classification of Chinese miniature pigs.

1993-2016년 신문기사를 통해 본 명절스트레스 양상에 대한 내용분석 (A study on the content analysis of holiday stress shown in the news articles from 1993 to 2016)

  • 김미동;김해란
    • 한국가족관계학회지
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    • 제22권4호
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    • pp.107-134
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    • 2018
  • Objectives: The purpose of this study is to have diachronic understanding of holiday stress that has become the social issues through the analysis on the news articles about holiday stress from 1993 to 2016. Method: For this purpose, 416 articles and 457 cases about holiday stress from 5 daily newspapers such as Chosun Ilbo, Joongang Ilbo, Dong-A, Hankyoreh and Kyunghyang Shinmun etc. have been analyzed, conducting the qualitative and quantitative analysis together. Results: Firstly, the articles on holiday stress have been increased, showing the rapid increase per year for the last 20 years. It is presumed to be closely related to the socio-economic situation. Second, although there have been 'married women' overwhelmingly as the subject of holiday stress, the frequency of the young generation has been increasing recently including the 'married women'. Third, the 96.7% of the contents from psychological appeal appeared in the case of holiday stress is related to family values. Especially, the holiday stress related to 'value of patriarchy' was the biggest stress. However, there has been increasing holiday stress caused by 'value of kinship' and 'value of marriage' recently. Forth, as a countermeasure against the holiday stress, the 'perception on the change of family values' has been quantitatively suggested and it has become actively appeared in terms of contents after mid-2000s. However, it has been appeared low in terms of quantity and content recently. Conclusions: This study has significance since it has been verified that the holiday stress started from 'married women' but it has been expanded to the young generation and it is related to the change and co-existence of family values of our society.

Expansion of an invasive species, Ailanthus altissima, at a regional scale in Japan

  • Chuman, Misaki;Kurokochi, Hiroyuki;Saito, Yoko;Ide, Yuji
    • Journal of Ecology and Environment
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    • 제38권1호
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    • pp.47-56
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    • 2015
  • Ailanthus altissima, which is recognized as an invasive tree in the Western world, has been widely observed in Japan. To investigate how A. altissima expanded within-population and to new populations within a region, 446 A. altissima trees were sampled from three separate sites (A, B, and C) including 35 distantly positioned patches, with three chloroplast DNA markers and nine nuclear microsatellite markers. We detected 2, 2, and 3 chloroplast haplotypes in sites A, B, and C, respectively. In addition, 271, 40, and 41 nuclear genotypes were detected in sites A, B, and C, respectively. The clonal richness value was 0.85, 0.78, and 0.53 in sites A, B, and C, respectively. Most trees with the same genotypes were distributed in the same patch, indicating that range expansion by asexual reproduction was limited to a maximum of 45 meters. According to autocorrelation analysis, the extent of nonrandom spatial genetic structure was approximately 0-2 km in sites A and C. KINGROUP analyses showed that 812, 74, and 111 nuclear genotype pairs were detected to have kinship in sites A, B, and C, respectively. Most nuclear genotype pairs were detected within the same patches or sites. These results indicate that the number of A. altissima trees gradually increased from seeds, some of which were produced by trees within sites, meaning that this species could regenerate naturally. This shows the need for the future management of A. altissima as an invasive species in Japan.

농촌노인의 자기효능감에 영향을 미치는 요인: 사회적 자본의 매개효과를 중심으로 (Study on Variables Affecting Rural Elderly's Self Efficacy: Focused on Mediating Effect of Social Capital)

  • 오영은;이정화
    • 한국지역사회생활과학회지
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    • 제28권4호
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    • pp.561-579
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    • 2017
  • The rural elderly population has social capital based on regionalism and kinship, which acts as a positive function in terms of their self-efficacy. Self-efficacy refers to the belief in one's own abilities. In general, elderly people with high self-efficacy maintain a healthy life and age successfully. This study examines how the rural elderly population perceive their self-efficacy and social capital and analyzes the role of social capital as a mediating variable. Social capital consists of 4 aspects; trust, norms, network and participation. For this study, data were gathered from 344 rural elderly people aged 60 years and over. The results of this study were as follows. According to the analysis of the structure equation modeling effect, the direct effect of subjective health status on self-efficacy, the indirect effect of the parameters of norms and the total effect were all statistically significant. Second, the direct effect of adult children's support on self-efficacy was significant, and the indirect effects of the parameters of trust, norms and total effect were all statistically significant. This study confirmed that social capital has a mediating effect on the relationship among the subjective health status of the rural elderly, adult children's support and self-efficacy. Furthermore, social capital had a positive impact on the self-efficacy of the rural elderly. Based on these results, a policy for making use of the social capital of the rural elderly should be developed.

농촌부부의 배우자역할평가와 결혼만족도 (- Role Evaluation of the Spouse and its Efect on Marital Satisfaction Among the Korean Rural Couples -)

  • 서광희
    • 대한가정학회지
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    • 제31권1호
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    • pp.97-120
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    • 1993
  • This study is designed to understand marital relationships of the rural couples in Korea. The primary purposes of this study are to examine the relationship between marital satisfaction and role evaluation of the spouse and to construct a path model in which shows the relationships among background variables, role evaluation of the spouse and marital satisfaction. Structured guestionnaires from 435 couples with school-age children and teenagers living in rural area are analyzed in this study. The major findings are as follows : 1. Factor analysis of the role evaluation of the spouse results I 4 factors for both husbands and wives; emotional support-sexual role child socialization-economic role, kinship role and housekeeping role. 2. The most important factor influencing the marital satisfaction is the role evaluation of the spouse o emotional support-sexual relation. While the number of children, and role evaluations of the spouse influence directly on the marital satisfaction of the wives, age, level of education, level of income and husband's occupation influence indirectly through role evaluations of the spouse on that of wives. 3. For husbands, family life cycle and their occupation influence indirectly on the marital satisfaction of the husbands and the marital satisfaction of them is also mediated by role evaluations of the wieves. Level of income of the family not only influences directly on marital satisfaction but influences on it indirectly. 4. Marital satisfaction is mediated by role evaluations of the spouse. The role evaluation of the spouse on emotional support-sexual relation has the most powerful effect on the marital satisfaction for both wives and husbands. About 60 percent of the variance in the marital satisfaction of rural couples can be explained by the role evaluation of the spouse. therefore, the result of the result of the study indicates that the role evaluation of the spouse on emotional support-sexual relation plays a significant part in determining the marital satisfaction of rural couples.

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청년층 세대 비교로 살펴본 가족 건강성과 기능 요구도: 1차 및 2차 에코부머를 중심으로 (A generational comparison of young adults' needs for family strengths and functions : A study on 1st and 2nd echoboomers)

  • 강민지;유계숙
    • 한국가족관계학회지
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    • 제23권3호
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    • pp.131-152
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    • 2018
  • Objectives: The purpose of this study was to compare the first echo boomer to second in the needs for family strengths and family functions, after controlling the sociodemographic characteristics. Method: For this study, a survey was conducted with 406 never-married young adults, which has 182 first echo boomers and 224 seconds echo boomers as using the same self-report questionnaire. Results: First, the two echo boomer groups exhibited similar patterns in their perception of the three family strengths, positive family values, pursuit of coexistence, and spiritual value, in that order. On the other hand, in regard to family functions, groups' perceived emotion entertainment leisure function as core functions of the family, but the second echo boomers, unlike the first echo boomers, expressed a higher need for economic functions rather than functions for children generation. Second, the analysis of this study indicated that, even in cases where first and second echo boomers had the same social-demographic characteristics, the latter in contrast with the former tended not to regard spiritual values such love for shared ethical values, compassion, and religious beliefs as a family strength, and did not require functions for children generation of the family. Conclusions: From these findings, the differences in the needs for family strengths and functions expressed by the two generations belonging to two different birth cohorts were influenced by various changes in Korean society occurring between the two generations, such as the social divergence in the functions of care and nurture, the increase in one-person and childless households, and the weakening of kinship-centered or communitarian forms of familism.

인물뉴스의 특성과 결정요인 연구: 사회자본(Social Capital) 이론을 중심으로 (Study on gatekeeping in selecting process of people in the news: Based on Social Capital theory)

  • 이완수
    • 한국언론정보학보
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    • 제32권
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    • pp.295-332
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    • 2006
  • 이 연구는 인물 뉴스를 현장에서 직접 제작하고 있는 국내 일간지 게이트키퍼들이 어떤 요인과 경로 그리고 관행을 갖고 인물 뉴스를 생산하는지 알아 보고자 했다. 특히 게이트키퍼와 사회적 엘리트간의 연결 고리인 지연, 학연, 혈연 등 이른바 '연줄망'이 인물 뉴스 결정과정에 실제로 영향을 미치는지에 주목했다. 이를 위해 일간 신문 사람면 담당 게이트 키퍼와 심층 인터뷰를 실시했으며, 동시에 내용분석을 했다. 분석결과 인물 뉴스 게이트키퍼들은 사회적 상류층이나 엘리트들을 지지하고 있었으며, 엘리트와 함께 경제적 교환행위에 참여하거나 정치사회적 영향력 확대를 통해서 사회자본을 공유했다. 이 과정에서 관계를 중시하는 사적 연줄망이 인물 뉴스 결정의 한 요인이 되고 있음을 확인했다. 실제 보도 내용을 분석한 결과에서도 인물 뉴스는 주로 고위 관리, 기업체 대표, 의사, 법조인, 교수, 문화 예술인, 언론인 등 남성 상류층이 편향적으로 많이 보도됐다. 또 이들 엘리트계층을 소개하는 뉴스 내용도 사회적으로 의미 있거나 공익 성격이 짙은 '공적 뉴스'보다는 개인 알리기나 PR 뉴스와 같은 '사적 뉴스'가 월등히 많다는 사실도 보여줬다.

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양자제도를 통해 본 조선후기 가족구조와 가계계승: 의성김씨 호구단자 분석을 중심으로 (Family Structure and Succession of the Late Chosun Seen through Male Adoption)

  • 박수미
    • 한국인구학
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    • 제30권2호
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    • pp.71-95
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    • 2007
  • 이 글은 조선후기 호적자료외 양자계승기록을 단서로 조선후기 양반가족의 가계계승 원리와 가족유형을 규명해 보고자 한다. 이 글의 분석자료는 1669년에서 1913년까지 의성김씨 호구단자이다. 분석 결과 조선후기의 가족형태와 조선전기나 조선중기의 가족형태 사이에 많은 차이가 발견되었는데, 그 변화의 방향은 부계계승원리의 강화이며 그 한가운데 양자제도가 자리하고 있었다. 분석자료의 전체 호구 평균가구원수는 5.66명으로 17세기 초에 비해 가족규모가 매우 커졌으며 가족구성원의 친족 범위도 매우 넓어져, 17세기 초 양반가의 가족원이 되는 근친자 종류가 6종의 자였던 데 비해 의성김씨 호구단자에 나타난 그것은 무려 70종이었다. 조선전기 양반가 분석결과와 달리 의성김씨 집안의 가족형태는 직계가족, 방계가족의 비율이 45%를 넘을 뿐 아니라 18세기, 19세기 모두 가장 큰 비중을 차지하는 가족형태는 확대가족이고 부부가족의 비중은 1/3 수준으로 약화되는 등, 가구구성의 친족범위가 더욱 확장되었다. 의성김씨 호구단자에서 입양을 통해 가계를 계승한 사례는 전체 호구 가운데 무려 33.8%에 이른다. 적장자가 호주자리를 승계할 때까지 살아 있을 확률이 낮았던 당시의 인구학적 환경 속에서 적장자가계계승 원리를 확고하게 지키는 방법으로 활용된 것이 양자제도였음을 다시 한 번 확인할 수 있었다. 조선후기 종족집단은 자신의 직계혈통에게 가계를 계승하는 것보다도 입양을 통해서라도 '적장자 자리'라는 명분을 유지하는 것이 더욱 중요했던 사회이고 이런 양반가의 소임을 다하기 위해 적임자를 찾을 때까지 호주대리인을 내세우는 등 양자제도를 보편화시켰던 것이다. 또한 제작된 믹서는 외부의 IF 발룬을 필요하지 않아 소형화가 가능하다. 본 논문에서 설계 및 제작된 94 GHz MIMIC single balanced cascode믹서는 기존의 balanced 믹서와 비교하여 높은 격리 특성을 나타내었다.L 및 FPGA를 이용하여 실시간으로 구현 검증되었다. 0.25um CMOS 표준 셀 라이브러리를 이용하여 합성하였을 때, 총 게이트 수는 37K개였으며 7.5개의 라인 메모리가 사용되었다. 추적관찰이 필요하겠다.다.참굴 D상 유생을 대상으로 먹이효과를 조사한 결과 실험구와 대조구간 유생의 성장 및 생존율에 유의한 차이를 보이지 않았다.C$에서 73.3%, $10^{\circ}C$에서 63.3% 및 $5^{\circ}C$에서 56.7%로 수온이 $30^{\circ}C$ 이내에서는 높을수록 높은 경향을 보였다. 염분에 따른 잠입 실험 결과는 실험 개시 300분 경과 후 염분 30 psu에서 93.3%로 가장 높았고, 35 psu에서 90.0%, 25 psu에서 83.3%, 20 psu에서 60.0%, 15 psu 이하에서는 거의 잠입이 이루어 지지 않았다. 따라서, 적정 살포를 위한 잠입률은 치패의 크기와 상관없이 저질종류는 모래 (75%) + 뻘 (25%), 입자크기는 1 mm 모래에서 높게 나타났다. 공기 중 노출시간은 짧을수록, 수온은 $30^{\circ}C$ 이내에서 높을수록, 염분은 20-35 psu 이내에서 높을수록 잠입률이 높은 경향을 나타내었다. 교수학습모형에 관련된 지식을 묻는 내용으로 주로 출제되었다.

만성통증 환자의 통증 조절 (Chronic pain control in patients with rheumatoid arthritis)

  • 은영
    • 근관절건강학회지
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    • 제2권1호
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    • pp.17-40
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    • 1995
  • Rheumatoid arthritis is the one of the chronic diseases, one of its major symptoms is a chronic pain. Despite developing medical treatment and surgical techniques, it is suggested that to control the pain is the goal of the treatment. But pain is an inner experience and even those closest to the patient cannot truly observe its progress or share in its suffering. The National Academy of Sciences Institute of Medicine's report on Pain and Disability concluded that there is no objective measure of pain-(exactly) no pain thermometer-nor can there ever be one, because the experience of pain is inseparable from personal perception and social influence such as culture. To explore chronic pain experience is to understand the process and property of the patient's perception of pain through the response to pain, the coping with pain, and the adaptation to pain. Therefore a qualitative study was conducted in order to gain an understanding of pain experience of patients with RA in korea. I used naturalistic inquiry as a research methodology, which had 5 axioms, the first is that realities are multiple, constructed, and holistic, the second is that knower and known are interactive, inseparable, the third is only time and context bound working hypotheses(idiographic statements) are possible, the forth is all entities are in a state of mutual simultaneous shaping, so that it is impossible to distinguish causes from effects and the last is that inquiry is value-bound. Purposive sampling was conducted as a sampling. 20 subjects who experienced pain over 10 years, lived in middle-sized city and big city in Korea, and 17 women and 3 men. The subject's age was from 32 to 62 (average 48.8), all were married, living with their spouse and children, except two-one divorced and the other widow before they became ill. I collected data using In depth structured interview. I had interviews two or three times with each subject, and the interviews were conducted at each subject's home. Each interview lasted about two hours an average. A recording was taken with the consent of the subject. I used inductive data analysis-such as unitizing and categorizing. unitizing is a process of coding, whereby raw data are systematically transformed and aggregated into units. Categorizing is a process wherby previously unitized data are organized into categories that provide descriptive or inferential information about the context or setting from which the units were derived. This process is used constant comparative method. The pain controlling process is composed of behavior of pain control. The behaviors of pain control are rearranging of ADL, hiddening role conflict, balancing treatment, and changing social relation. Rearranging of ADL includes diet management, sleep management, and the adjustment of daily life activities. The subjects try to rearrange their daily activities by modified style of motions, rearranging time span & range of activities, using auxillary facilities, and getting help in order to keep on the pace of daily life. Hiddening role conflict means to reduce conflicts between sick role and their role as a family member. In this process, the subjects use two modes, one is to control the pain complaints, and the other is to internalize the value which is to stay home is good for caring her children and being a good mother. To control pain complaints is done by 'enduring', 'understanding' the other family members, or making them undersood in order to reduce pain. Balancing treatment is composed of two aspects. One is to keep the pain within the endurable level, the other is to keep in touch with medical personnel in order to get the information of treatment and emotional support. Changing social relation is made by information seeking and sharing, formation of mutual support relation, and finally simplification of social relationships. The subjects simplify their social relationships by refraining from relations with someone who makes them physically and psychologically strained. In particular the subjects are apt to avoid contact with in-laws, and the change of relation to in-laws results in lessening the family boundary. In the course of this process, they confront the crisis of family confict result in family dissolution. This crisis is related to the threat of self-existence. Findings from this study contribute to understanding the chronic pain experience. To advance this study, we should compare this result with other cases in different cultural contexts. I think to interpret these results, korean cultural background should be considered. Especially the different family concept, more broader family members and kinship network, and the traditional medical knowledge influences patients' behavior.

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