• Title/Summary/Keyword: Kinetic resolution

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Principle of Rehabilitation after the Arthroscopic Anterior Cruciate Ligament Reconstruction (관절경적 전방 십자인대 재건술 후의 재활 치료 원칙)

  • Kyung Hee-Soo;Kim Hee-Soo
    • Journal of Korean Orthopaedic Sports Medicine
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    • v.2 no.1
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    • pp.6-14
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    • 2003
  • The goal of rehabilitation after ACL reconstruction are return the patient to a reinjury level of activity with stable joint, removing pivot shift phenomenon, preservation of meniscus, restoration of range of motion, and minimize patello-femoral complication. The ACL reconstruction should avoid immediate surgery. The preoperative phase emphasizes two important factors. (1) The patient should have a resolution of knee swelling, a return of full ROM, and a normal gait. (2) The patient should be mentally prepared for the operation and subsequent rehabilitation. The postoperative rehabilitation program emphasizes extension, closed kinetic chain function exercises. The regular follow-up is important.

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Huge Direct Numerical Simulation of Turbulent Combustion-Toward Perfect Simulation of IC Engine-

  • Tanahashi, Mamoru
    • 한국전산유체공학회:학술대회논문집
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    • 2008.03a
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    • pp.359-366
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    • 2008
  • Current state and perspective of DNS of turbulence and turbulent combustion are discussed with feature trend of the fastest supercomputer in the world. Based on the perspective of DNS of turbulent combustion, possibility of perfect simulations of IC engine is shown. In 2020, the perfect simulation will be realized with 30 billion grid points by 1EXAFlops supercomputer, which requires 4 months CPU time. The CPU time will be reduced to about 4 days if several developments were achieved in the current fundamental researches. To shorten CPU time required for DNS of turbulent combustion, two numerical methods are introduced to full-explicit full-compressible DNS code. One is compact finite difference filter to reduce spatial resolution requirements and numerical oscillations in small scales, and another is well-known point-implicit scheme to avoid quite small time integration of the order of nanosecond for fully explicit DNS. Availability and accuracy of these numerical methods have been confirmed carefully for auto-ignition, planar laminar flame and turbulent premixed flames. To realize DNS of IC engine with realistic kinetic mechanism, several DNS of elemental combustion process in IC engines has been conducted.

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Huge Direct Numerical Simulation of Turbulent Combustion - Toward Perfect Simulation of IC Engine -

  • Tanahashi, Mamoru
    • 한국전산유체공학회:학술대회논문집
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    • 2008.10a
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    • pp.359-366
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    • 2008
  • Current state and perspective of DNS of turbulence and turbulent combustion are discussed with feature trend of the fastest supercomputer in the world. Based on the perspective of DNS of turbulent combustion, possibility of perfect simulations of IC engine is shown. In 2020, the perfect simulation will be realized with 30 billion grid points by 1EXAFlops supercomputer, which requires 4 months CPU time. The CPU time will be reduced to about 4 days if several developments were achieved in the current fundamental researches. To shorten CPU time required for DNS of turbulent combustion, two numerical methods are introduced to full-explicit full-compressible DNS code. One is compact finite difference filter to reduce spatial resolution requirements and numerical oscillations in small scales, and another is well-known point-implicit scheme to avoid quite small time integration of the order of nanosecond for fully explicit DNS. Availability and accuracy of these numerical methods have been confirmed carefully for auto-ignition, planar laminar flame and turbulent premixed flames. To realize DNS of IC engine with realistic kinetic mechanism, several DNS of elemental combustion process in IC engines has been conducted.

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Optimal Sensor Allocation of Cable-Stayed Bridge for Health Monitoring (사장교의 상시감시를 위한 최적 센서 구성)

  • Heo, Gwang-Hee;Choi, Mhan-Young
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.6 no.2
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    • pp.145-155
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    • 2002
  • It is essential for health monitoring of a cable-stayed bridge to provide more accurate and enough information from the sensors. In experimental modal testing, the chosen measurement locations and the number of measurements have a major influence on the quality of the results. The choice is often difficult for complex structures like a cable-stayed bridge. It is extremely important a cable-stayed bridge to minimize the number of sensing operations required to monitor the structural system. In order to obtain the desired accuracy for the structural test, several issues must take into consideration. Two important issues are the number and location of response sensors. There are usually several alternative locations where different sensors can be located. On the other hand, the number of sensors might be limited due to economic constraints. Therefore, techniques such as methodologies, algorithms etc., which address the issue of limited instrumentation and its effects on resolution and accuracy in health monitoring systems are paramount to a damage diagnosis approach. This paper discusses an optimum sensor placement criterion suitable to the identification of structural damage for continuous health monitoring. A Kinetic Energy optimization technique and an Effective Independence Method are analyzed and numerical and theoretical issues are addressed for a cable-stayed bridge. Its application to a cable-stayed bridge is discussed to optimize the sensor placement for identification and control purposes.

Comparison of the Kinetic Behaviors of Fe2O3 Spherical Submicron Clusters and Fe2O3 Fine Powder Catalysts for CO Oxidation

  • Yoo, Seung-Gyun;Kim, Jin-Hoon;Kim, Un-Ho;Jung, Jin-Seung;Lee, Sung-Han
    • Bulletin of the Korean Chemical Society
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    • v.35 no.5
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    • pp.1379-1384
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    • 2014
  • ${\alpha}-Fe_2O_3$ spherical particles having an average diameter of ca. 420 nm and ${\alpha}-Fe_2O_3$ fine particles (< 10 ${\mu}m$ particle size) were prepared to examine as catalysts for CO oxidation. Kinetic studies on the catalytic reactions were performed in a flow reactor using an on-line gas chromatography system operated at 1 atm. The apparent activation energies and the partial orders with respect to CO and $O_2$ were determined from the rates of CO disappearance in the reaction stage showing a constant catalytic activity. In the temperature range of $150-275^{\circ}C$, the apparent activation energies were calculated to be 13.7 kcal/mol on the ${\alpha}-Fe_2O_3$ spherical submicron clusters and 15.0 kcal/mol on the ${\alpha}-Fe_2O_3$ fine powder. The Pco and $Po_2$ dependencies of rate were investigated at various partial pressures of CO and $O_2$ at $250^{\circ}C$. Zero-order kinetics were observed for $O_2$ on both the catalysts, but the reaction order for CO was observed as first-order on the ${\alpha}-Fe_2O_3$ fine powder and 0.75-order on the ${\alpha}-Fe_2O_3$ spherical submicron clusters. The catalytic processes including the inhibition process by $CO_2$ on the ${\alpha}-Fe_2O_3$ spherical submicron powder are discussed according to the kinetic results. The catalysts were characterized using XRD (X-ray powder diffraction), FE-SEM (field emission-scanning electron microscopy), HR-TEM (high resolution-transmission electron microscopy), and $N_2$ sorption measurements.

ORFEUS OBSERVATIONS OF ULTRAVIOLET EXCITED HIGH-J MOLECULAR HYDROGEN

  • Lee, Dae-Hee;Dixon, W. Van Dyke;Min, Kyoung-Wook;Pak, Soo-Jong
    • Journal of The Korean Astronomical Society
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    • v.42 no.6
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    • pp.145-153
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    • 2009
  • We present measurements of diffuse interstellar $H_2$ absorption lines in the continuum spectra of 10 early-type stars. The data were observed with the Berkeley Extreme and Far-Ultraviolet Spectrometer (BEFS) of the ORFEUS telescope on board the ORFEUS-SPAS I and II space-shuttle missions in 1993 and 1996, respectively. The spectra extend from the interstellar cutoff at 912 $\AA$ to about 1200 $\AA$ with a resolution of ~ 3000 and statistical signal-to-noise ratios between 10 and 65. Adopting Doppler broadening velocities from high-resolution optical observations, we obtain the $H_2$ column densities of rotational levels J" = 0 through 5 for each line of sight. The kinetic temperatures derived from J" = 0 and 1 states show a small variation around the mean value of 80 K, except for the component toward HD 219188, which has a temperature of 211 K. Based on a synthetic interstellar cloud model described in our previous work, we derive the incident UV intensity IUV and the hydrogen density $n_H$ of the observed components to be -0.4 $\leq$ log $I_{UV}\leq2.2$ and $6.3{\leq}n_H2500cm^{-3}$, respectively.

Optimization of the Reaction Conditions and the Effect of Surfactants on the Kinetic Resolution of [R,S]-Naoroxen 2,2,2-Trifluoroethyl Thioester by Using Lipse (리파아제를 이용한 라세믹 나프록센 2,2,2-트리플로로에틸 씨오에스터의 Kinetic Resolution에서 반응조건 죄적화와 계면활성제 영향)

  • Song, Yoon-Seok;Lee, Jung-Ho;Cho, Sang-Won;Kang, Seong-Woo;Kim, Seung-Wook
    • KSBB Journal
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    • v.23 no.3
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    • pp.257-262
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    • 2008
  • In this study, the reaction conditions for lipase-catalyzed resolution of racemic naproxen 2,2,2-trilfluoroethyl thioester were optimized, and the effect of surfactants was investigated. Among the organic solvents tested, the isooctane showed the highest conversion (92.19%) in a hydrolytic reaction of (S)-naproxen 2,2,2-trifluoroethyl thioester. In addition, the isooctane induced the highest initial reaction rate of (S)-naproxen 2,2,2-trifluoroethyl thioester ($V_s=2.34{\times}10^{-2}mM/h$), the highest enantioselectivity (E = 36.12) and the highest specific activity ($V_s/(E_t)=7.80{\times}10^{-4}mmol/h{\cdot}g$) of lipase. Furthermore, reaction conditions such as temperature, concentration of the substrate and enzyme, and agitation speed were optimized using response surface methodology (RSM), and the statistical analysis indicated that the optimal conditions were $48.2^{\circ}C$, 3.51 mM, 30.11 mg/mL and 180 rpm, respectively. When the optimal reaction conditions were used, the conversion of (S)-naproxen 2,2,2-trifluoroethyl thioester was 96.5%, which is similar to the conversion (94.6%) that was predicted by the model. After optimization of reaction conditions, the initial reaction rate, lipase specific activity and conversion of (S)-naproxen 2,2,2-trifluoroethyl thioester increased by approximately 19.54%, 19.12% and 4.05%, respectively. The effect of surfactants such as Triton X-100 and NP-10 was also studied and NP-10 showed the highest conversion (89.43%), final reaction rate of (S)-naproxen 2,2,2-trifluoroethyl thioester ($V_s=1.175{\times}10^{-2}mM/h$) and enantioselectivity (E = 59.24) of lipase.

High Resolution Transmission Electron Microscopy Observations on Sintering Processes in KNbO3 Ceramics

  • Lee, Hwack Joo;Kim, Young Heon;Ryu, Hyun;Cho, Yang-Koo;Nahm, Sahn
    • Applied Microscopy
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    • v.47 no.3
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    • pp.203-207
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    • 2017
  • A homogeneous $KNbO_3$ (KN) phase was formed by sintering at $1,040^{\circ}C$ for 1 hour, without formation of the $K_2O$-deficient secondary phase even though suffering the minor loss of $K_2O$. KN liquid phase was formed during sintering and abnormal grain growth occurred in this specimen. The detailed microstructural observations on KN during sintering were carried out using high resolution transmission electron microscopy. The ledged structures were found at the KN grain boundary and the abnormal grain growth was performed by the lateral migration of these ledges in the presence of the liquid phase. The liquid pockets were found in the KN grains. They have various external shapes mainly due to the kinetic factors. They have atomically flat interfaces with some ledges with one atomic height. The slight deficient $K_2O$ by evaporation might somewhat reduce the melting point of KN from the reported at $1,058^{\circ}C$. The liquid pockets play an important role in supplying the liquid phase during the abnormal grain growth in the sintering process of KN ceramics.

Solvent Effect on Preservation and Inversion of the Chirality in the Processes of Nucleophilic Substitution Reaction of Organic Compound bearing Optical Activity Resolution (광학활성 분리능을 갖는 유기화합물의 친핵성치환반응에서 키랄성의 유지 및 반전에 미치는 용매효과)

  • Lee, Yong-Hee;Lee, Young-Sei
    • Journal of the Korean Society of Industry Convergence
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    • v.7 no.3
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    • pp.299-303
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    • 2004
  • A systematic investigation for the reactivity and solvent effect was studied on the reaction of optical resolving agents with the optically active assistant compounds. The reaction rate constants of the nucleophillic substitution reactions were determined by means of conductometric method The linear solvent energy relationship based on the solvent parameters and the thermodynamic parameters was discussed on the reactions of various physiological active compounds and optical resolving agents The reaction mechanism was discussed from the kinetic results compared with the optical purity.

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광학활성 Styrene Oxide 제조를 위한 고기능성 유전자 재조합 Epoxide Hydrolase 생촉매 개발

  • Lee, Su-Jeong;Lee, Ji-Won;Lee, Eun-Jeong;Kim, Hui-Suk;Lee, Eun-Yeol
    • 한국생물공학회:학술대회논문집
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    • 2003.04a
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    • pp.435-438
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    • 2003
  • Epoxide hydrolase(EH) catalyze the enantioselective hydrolysis of racemic epoxides to corresponding diols. A recombinant Pichia pastoris with EH from Rhodotorula glutinis has been constructed by reverse transcriptase-polymerase chain reaction(RT-PCR). The recombinant biocatalyst enantioselectively hydrolyze (R)-styrene oxide faster than (S)-enantiomer. The catalytic activity of recombinant biocatalyst was 7-fold higher than that of wild-type strain. The recombinant EH biocatalyst can be used for kinetic resolution for the production of enantiopure styrene oxide.

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