• Archives of Pharmacal Research
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• v.25 no.4
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• pp.505-510
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• 2002

An improved kinetic assay for prekallikrein activator (PKA), a potential vasodilator, has been developed to be used as an indicator for quality control during production of human albumin preparations. It consists of two reaction stages. In the first stage, PKA and prekallikrein are incubated at $37^{\circ}C$ for 45 min to allow the transformation into kallikrein. Kallikrein, a serine protease, catalyzes the splitting of p-nitroaniline (pNA) from its substrate H-D-Pro-Phe-Arg-pNA(S-2302). The rate at which pNA is released was measured spectrophotometrically at 405 nm. Prekallikrein, a substrate of PKA was purified by DEAE ion-exchange chromatography and the major potential variations in the assay were optimized; pH 8.0 and 150 mM sodium chloride were chosen to give a proper ionic strength. Reaction times in the range of 10 to 360 min provided linear dose-response curves. The concentration of prekallikrein was adjusted to fall between 1:1 and 1:3 dilutions to generate a linear standard calibration curve. Under the optimized conditions, reproducibility was checked. In a precision test, the coefficient of variation (CV) stayed within ${\pm}4%$ and the dose-response curve showed a good correlation (${r^2}=0.999$). An accuracy test with an international standard of PKA afforded a mean recovery of 97.5%.

• Smart Structures and Systems
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• v.21 no.3
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• pp.373-387
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• 2018

Semi-active isolation systems based on leverage-type stiffness control strategies have been widely studied. The main concept behind this type of system is to adjust the stiffness in the isolator to match the fundamental period of the isolated system by using a simple leverage mechanism. Although this system achieves high performance under far-field earthquakes, it is unsuitable for near-fault strong ground motion. To overcome this problem, this study considers the potential energy effect in the control law of the semi-active isolation system. The minimal energy weighting (MEW) between the potential energy and kinetic energy was first optimized through a series of numerical simulations. Two MEW algorithms, namely generic and near-fault MEW control, were then developed to efficiently reduce the structural displacement responses. To demonstrate the performance of the proposed method, a two-degree-of-freedom structure was employed as a benchmark. Numerical results indicate that the dynamic response of the structure can be effectively dampened by the proposed MEW control under both far-field and near-fault earthquakes, whereas the structural responses resulting from conventional control methods may be greater than those for the purely passive control method. Moreover, according to experimental verifications, both the generic and near-fault MEW control modes yielded promising results under impulse-like earthquakes. The practicability of the proposed control algorithm was verified.

• The Journal of Korea Robotics Society
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• v.12 no.3
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• pp.339-349
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• 2017

In this paper, we present a finite-time sliding mode control (FSMC) with an integral finite-time sliding surface for applying the concept of graph theory to a distributed wheeled mobile robot (WMR) system. The kinematic and dynamic property of the WMR system are considered simultaneously to design a finite-time sliding mode controller. Next, consensus and formation control laws for distributed WMR systems are derived by using the graph theory. The kinematic and dynamic controllers are applied simultaneously to compensate the dynamic effect of the WMR system. Compared to the conventional sliding mode control (SMC), fast convergence is assured and the finite-time performance index is derived using extended Lyapunov function with adaptive law to describe the uncertainty. Numerical simulation results of formation control for WMR systems shows the efficacy of the proposed controller.

• Structural Engineering and Mechanics
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• v.81 no.5
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• pp.633-645
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• 2022

The active tuned mass damper (ATMD) is an efficient and reliable structural control system for mitigating the dynamic response of structures. The inertial force that an ATMD exerts on a structure to attenuate its otherwise large kinetic energy and undesirable vibrations and displacements is proportional to its excursion. Achieving a balance between the inertial force and excursion requires a control law or feedback mechanism. This study presents a technique for the optimum design of a sliding mode controller (SMC) as the control law for ATMD-equipped structures subjected to earthquakes. The technique includes optimizing an SMC under an artificial earthquake followed by testing its performance under real earthquakes. The SMC of a real 11-story shear building is optimized to demonstrate the technique, and its performance in mitigating the displacements of the building under benchmark near- and far-fault earthquakes is compared against that of a few other techniques (proportional-integral-derivative [PID], linear-quadratic regulator [LQR], and fuzzy logic control [FLC]). Results indicate that the optimum SMC outperforms PID and LQR and exhibits performance comparable to that of FLC in reducing displacements.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.582-588
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• 1993

A scheme of dynamic optimization for batch reactor his been developed and applied to a semi-batch esterification reactor. To obtain optimal operating conditions for the given semi-batch reactor system with complex reaction kinetic and process constraints, a general nonlinear programming solver and finite element techniques have been introduced. The optimization results for the complex reactor system have been compared with those of Kumar et al. [1984] to show better optimization performance. The proposed optimizing scheme has been applied to the free end time problem to obtain the realistic operating condition. The results can supply valuable information for economic operation of the given batch esterification reactor.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.233-236
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• 1996

This paper describes a liner state-space model for a flexible stick balencer. The method employed to generate the model utilizes a separable formulation of assumed modes to represents the transverse displacement due to bending Lagrangian dynamics are applied to determine the kinetic and potential energies for the system. The resultant dynamic equations are then organized into a state space model and linearized using Taylor series expansion method. A minimum order observer is designed to estimate unmeasurable states.

• Proceedings of the KSR Conference
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• 2005.11a
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• pp.101-106
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• 2005

During braking at a train, thermal energy is generated due to the frictions between disk and lining and wheel and shoe. In general, the braking transfers the kinetic energy into thermal energy. Therefore. the frictional characteristics are varied according to the braking force, the thermal resistance, and the thermostable, etc. Using a Dynamo testing we have studied the frictional characteristics and the thermal distribution to investigate a stable speed and to improve the testing method through comparing and analysing in the measurement or the thermocouple temperature and infrared camera.

• Bulletin of the Korean Chemical Society
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• v.20 no.9
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• pp.1031-1034
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• 1999

Tin oxide films have been grown employing the chemical vapor deposition technique under reduced pressure conditions using tetramethyltin as the precursor and oxygen as the oxidant. An activation energy derived for the deposition reaction under representative deposition conditions has a value of 89±3 kJ mol-1, suggesting a typical kinetic control. Deposition rates of tin oxide films exhibit a near first order dependence on tetramethyltin partial pressure and a zeroth order dependence on oxygen partial pressure. This study provides the first quantitative information about the growth kinetics of tin oxide films from tetramethyltin by the cold-wall low-pressure chemical vapor deposition.

• Architectural research
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• v.8 no.2
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• pp.37-42
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• 2006

Starting from the quadratic optimal control algorithm, this study obtains the relation of the performance index for constrained systems and Gauss's principle. And minimizing a function of the variation in kinetic energy at constrained and unconstrained states with respect to the velocity variation, the dynamic equation is derived and it is shown that the result compares with the generalized inverse method proposed by Udwadia and Kalaba. It is investigated that the responses of a 10-story building are constrained by the installation of a two-bar structure as an application to utilize the derived equations. The structural responses are affected by various factors like the length of each bar, damping, stiffness of the bar structure, and the junction positions of two structures. Under an assumption that the bars have the same mass density, this study determines the junction positions to minimize the total dynamic responses of the structure.

• Proceedings of the KIPE Conference
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• 2018.07a
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• pp.354-355
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• 2018

Flywheel energy storage system (FESS) operates motor or generator by utilizing the stored kinetic energy in the rotating mass. Thus, the FESS can support the frequency control of the power system. However, the FESS is disabled when the rotor speed reaches to its minium value. Thus, the second frequency dip occurs in the power system. This paper proposes the frequency control scheme of FESS based on a variable gain depending on the rotor speed and frequency deviation. The proposed scheme prevents the second frequency dip because the variable gain decreases depending on the stored in the FESS. The performance of the proposed scheme is investigated for the IEEE 14-bus system.