• 제목/요약/키워드: Kim Jae-kyung

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Hepatoprotective Activity of Chungpesagan-tang is Related to the Inhibition of ${\beta}-Glucuronidase$

  • Kim, Jae-Kwan;Bae, Hyung-Sup;Kim, Young-Suk;Cho, Ki-Ho;Lee, Kyung-Sup;Lee, Hae-Ung;Kim, Dong-Hyun
    • Natural Product Sciences
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    • v.7 no.3
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    • pp.63-67
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    • 2001
  • ${\beta}-Glucuronidase-inhibitory$ and hepatoprotective effects of Chungpesagan-tang, which has been used for liver diseases and stroke, on $CCl_4-induced$ hepatotoxicity of rats was investigated. Chungpesagan-tang potently inhibited ${\beta}-glucuronidases$. Serum AST, ALT and LDH levels of the $CCl_4$ group orally treated with Chungpesagan-tang (100 mg/kg) were lowered to 47, 28 and 58% of the $CCl_4-treated$ group, respectively. Among the ingredients of Chungpesagan-tang, Puerariae Radix, Scutellariae Radix and Rhei Rhizoma potently inhibited the ${\beta}-glucuronidase$ and protected $CCl_4-induced$ liver injury. The hepatoprotective activity of Puerariae Radix was affected by ingredients of Chungpesagan-tang: Scutellariae Radix had the synergistic activity, but Angelicae Tenussimae Radix exhibited the antagonistic activity. These results suggest that the ${\beta}-glucuronidase$ inhibitor of herbal medicines may protect $CCl_4-induced$ liver injury and puerarin should be a natural prodrug for the hepatoprotective effect.

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Design and Development of Integrated management module in In-Vehicle Infotainment System (차량 인포테인먼트 장치 통합관리 모듈 설계 및 개발)

  • Lee, Chae-Hyun;Oh, Hyun-Kyung;Park, So-Yeon;Kim, Seong-Woo;Jung, Jung-Hwa;Go, Seok-Ju;Kim, Jae-Soo;Kim, Ji-in
    • Proceedings of the Korea Information Processing Society Conference
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    • 2020.05a
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    • pp.87-90
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    • 2020
  • 우리 생활 속에 사물인터넷이 확산하면서 상호작용이 가능한 스마트 기기들이 증가하고 있다. 차량은 인간에게 친숙한 이동수단으로, 현재 차량 인포테인먼트(Infotainment) 시스템의 관심이 급증하고 있다. 하지만 해당 시스템은 기업마다 개발요소와 기준이 다르다. 본 논문에서는 차량 인포테인먼트 장치들을 통합적으로 관리하는 모듈을 설계 및 개발하고, 미래 인포테인먼트 서비스의 방향을 제시 하고자 한다. 본 논문의 모듈은 스마트폰과 마스터 디바이스(Device), 그리고 센서들을 사용해 제작되었으며, 모듈의 실제 차량의 적용 및 확장을 통해 더 나은 인포테인먼트 관리 모듈을 개발할 수 있을 것으로 기대한다.

Hepatoprotective Effect of Fermented Artemisia princeps PAMPANINI by Lactic Acid Bacteria (발효강화쑥의 간장해 보호효과)

  • Choi, Hyuck-Jae;Kim, Eun-Jin;Han, Myung-Joo;Baek, Nam-In;Kim, Dong-Hyun;Jung, Hae-Gon;Kim, Nam-Jae
    • Korean Journal of Pharmacognosy
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    • v.38 no.3 s.150
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    • pp.245-253
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    • 2007
  • Artemisia princeps PAMPANINI has been used in traditional medicine of the treatment of inflammatory, liver dysfunction and order disorder in the far east countries including Korea. The present study was carried out to investigate the hepatoprotective effects of ethanol extract of Artemisia princeps (AP) and its fermented agents (AP-F) by lactic acid bacteria derived from human intestinal bacteria on liver injured rat induced by $CCl_4$ and d-galactosamine. Hepatoprotective activity was monitored by estimating serum ALT, AST, ALP, LDH, superoxide dismutase (SOD), glutathione redeuctase (GR) and glutathione peroxidase (Gpx) activities in the liver injured by hepatotoxin. Pretreating rats with AP or AP-F at the same dosage regimen significantly suppressed the acute elevation of serum transaminase, ALP, LDH and GR activities, and significantly increased the lowering of blood SOD and GR activites induced by hepatoxin. Based on these findings, it is presumed that AP and APF may have the hepatoprotective effect on $CCl_4$ and d-galactosamine-induced hepatotoxicity rat.

Protective Mechanism of Hominis Placenta Extract Against ${H_2O_2}-Induced$ Apoptosis in $PGT-{\beta}$ Cells ($PGT-{\beta}$ 세포주에서 자하거 약침액의 $H_2O_2$로 인한 Apoptosis에 대한 방어 기전)

  • Jung-Chul, Seo;Jae-Dong, Lee;Dong-Suk, Park;Sung-Keel, Kang;Byung-Cheol, Ahn;Ee-Hwa, Kim;Soon-Ae, Kim;Hee-Jae, LeeK;Chang-Ju, Kim
    • The Journal of Korean Medicine
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    • v.22 no.3
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    • pp.92-97
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    • 2001
  • 목적 :본 연구는 최근 임상에서 많이 사용하는 자하거 약침액이 과산화수소($H_2O_2$)로 야기된 송과선 세포의 Apoptosis에 있어서 세포 보호에 미치는 영향과 그 기전을 분석하였다. 방법 :송과선 세포주에서 자하거 약침액의 $H_2O_2$로 인한 Apoptosis에 대한 방어 기전을 관찰하기 위하여 면역세포화학법. 세포화학법 및 reverse transcription-polymerase chain reaction (RT-PCR)을 시행하였다. 결과 : 자하거 약침액 투여군에서는 nuclear factor kappa B (NFkB), inducible nitric oxide synthase (iNOS), nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase의 발현이 $H_2O_2$ 투여군보다 감소하였다. RT-PCR에서는 caspase-3의 발현이 자하거 약침액 투여군에서 $H_2O_2$ 투여군보다 억제되었다. 결론: 이상의 결과를 통하여 자하거 약침액이 $H_2O_2$로 유발된 Apoptosis에서 세포보호 효과가 있으며 그 기전은 iNOS와 caspase-3의 억제에 기인할 가능성을 시사한다고 하겠다.

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Fast Array Architecture with Improved Reconfigurability (향상된 재구성능력을 가진 고속 어레이 구조)

  • Lee Jae-Ic;Kim Jinsang;Cho Won-Kyung;Kim Youngsoo
    • Proceedings of the IEEK Conference
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    • 2004.06b
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    • pp.451-454
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    • 2004
  • The reconfigurable architecture is increasingly important for design of multi-mode communication systems and computation-intensive DSP systems. The proposed coarse-grain architecture is based on a reconfigurable processing element consisting of a MAC unit, a register file, a context data register, and PE interconnect control blocks. The main feature of the Proposed architecture is the loop context which enables faster configuration. Also, we propose another area-efficient reconfigurable architecture with improved reconfigurability. The SystemC modeling results show that the proposed architecture can reduce 9 clock cycles of 2D DCT compared to existing architectures.

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Rapid Identification of Lactobacillus plantarium in Kimchi Using Polymerase Chain Reaction

  • Kim, Tae-Woon;Min, Sung-Gi;Choi, Dong-Hun;Jo, Jae-Sun;Kim, Hae-Yeong
    • Journal of Microbiology and Biotechnology
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    • v.10 no.6
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    • pp.881-884
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    • 2000
  • A polymerase chain reaction (PCR) was performed to rapidly identify Lactobacillus plantarum from type strains and kimchi samples. The PCR experiments were carried out using specific oligonucleotide primer sets based on the 16S rRNA gene sequences of L. plantarum. The expected DNA amplificate of 419 bp was obtained when either purified DNA or whole cells of L. plantarum strains reacted with LP primers, yet not with any of the other strains. The PCR product was confirmed by DNA sequencing. Accordingly, since the PCR method used is simple, specific, and rapid, it will be useful for monitoring and evaluation L. plantarum in the mixed microbial population found in kimchi.

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Studies on the General Pharmacological Activities of Eucommia ulmoides Oliver (두충나무의 일반약리활성(一般藥理活性) 연구(硏究))

  • Hong, Nam-Doo;Rho, Young-Soo;Kim, Jong-Woo;Won, Do-Hee;Kim, Nam-Jae;Cho, Bo-Sun
    • Korean Journal of Pharmacognosy
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    • v.19 no.2
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    • pp.102-110
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    • 1988
  • The pharmacological activities on water extracts of Cortex, Ramulus and Folium from the Eucommia ulmoides Oliver were studied, and the following results were observed. The vasodilative action on the rabbit ear blood vessel was recognized in the Cortex, Ramulus and Folium. The spontaneous motility and the contraction induced by Ach., $BaCl_2$ and histamine in the isolated ileum of mice were suppressed and inhibited in the Ramulus only. On the contrary, the analgesic and anti-inflammatory activities were noted in the Cortex and Folium. Furthermore, the hypotensive effect was recognized in the Folium. The diuretic, bile secretory and anti-fatigue effects were shown in the Cortex and Folium.

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Effect of bioconversioned ginseng and its butanol fraction on adenine-induced renal failure in rats

  • Shin, Yong-Wook;Choi, Hyuck-Jai;Park, Jong-Eun;Kim, Dong-Hyun;Kim, Nam-Jae
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.274.1-274.1
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    • 2003
  • To elucidate the effect of bioconversioned ginseng(Sun ginseng) and its butanol fraction on adenine-induced renal failure. rats were fed ad libitum on diet containing 0.75% adenine for 20 days to induce renal failure, and bioconversioned ginseng was orally administrated during the feeding period. On days 10 and 20, BUN, Creatinine, Ca and P contents were analyzed in serum and urine, and on days 20, BUN, Creatining, Ca and P contents were analyzed in serum and urine, and on days 20, blood pressure, hear pulse and relative kidney weight were measured. (omitted)

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GENERIC SUBMANIFOLDS OF AN ALMOST CONTACT MANIFOLDS

  • Cho, Eun Jae;Choi, Jin Hyuk;Kim, Byung Hak
    • Journal of the Chungcheong Mathematical Society
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    • v.19 no.4
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    • pp.427-435
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    • 2006
  • In this paper, we are to study the generic submanifold M of a Kenmotsu manifold and consider the integrability condition of the almost complex structure induced on the even-dimensional product manifold $M{\times}R^p{\times}R^1$ where p is the codimension.

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