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Hepatoprotective Effect of Fermented Artemisia princeps PAMPANINI by Lactic Acid Bacteria  

Choi, Hyuck-Jae (East-West Medical Research Institute, Kyung Hee University)
Kim, Eun-Jin (East-West Medical Research Institute, Kyung Hee University)
Han, Myung-Joo (Department of Food and Nutrition, Kyung Hee University)
Baek, Nam-In (Graduate School of Biotechnology and Plant Metabolism Research Center, Kyung Hee University)
Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University)
Jung, Hae-Gon (Ganghwa Argicultural R&D Center)
Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University)
Publication Information
Korean Journal of Pharmacognosy / v.38, no.3, 2007 , pp. 245-253 More about this Journal
Abstract
Artemisia princeps PAMPANINI has been used in traditional medicine of the treatment of inflammatory, liver dysfunction and order disorder in the far east countries including Korea. The present study was carried out to investigate the hepatoprotective effects of ethanol extract of Artemisia princeps (AP) and its fermented agents (AP-F) by lactic acid bacteria derived from human intestinal bacteria on liver injured rat induced by $CCl_4$ and d-galactosamine. Hepatoprotective activity was monitored by estimating serum ALT, AST, ALP, LDH, superoxide dismutase (SOD), glutathione redeuctase (GR) and glutathione peroxidase (Gpx) activities in the liver injured by hepatotoxin. Pretreating rats with AP or AP-F at the same dosage regimen significantly suppressed the acute elevation of serum transaminase, ALP, LDH and GR activities, and significantly increased the lowering of blood SOD and GR activites induced by hepatoxin. Based on these findings, it is presumed that AP and APF may have the hepatoprotective effect on $CCl_4$ and d-galactosamine-induced hepatotoxicity rat.
Keywords
Artemisia princeps PAMPANINI; Fermented Artemisia; lactic acid bacteria; hepatoprotective; transaminase; antioxidative;
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Times Cited By KSCI : 5  (Citation Analysis)
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