• Title/Summary/Keyword: Kim Chi-in

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BRCA1 Promoter Hypermethylation Signature for Early Detection of Breast Cancer in the Vietnamese Population

  • Truong, Phuong Kim;Lao, Thuan Duc;Doan, Thao Phuong Thi;Huyen, Thuy Ai
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.22
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    • pp.9607-9610
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    • 2014
  • Breast cancer, a leading cause of death among women in most countries worldwide, is rapidly increasing in incidence in Vietnam. One of biomarkers is the disruption of the genetic material including epigenetic changes like DNA methylation. With the aim of finding hypermethylation at CpG islands of promoter of BRCA1 gene, belonged to the tumor suppressor gene family, as the biomarker for breast cancer in Vietnamese population, sensitive methyl specific PCR (MSP) was carried out on 115 samples including 95 breast cancer specimens and 20 normal breast tissues with other diseases which were obtained from Ho Chi Minh City Medical Hospital, Vietnam. The result indicated that the frequency of BRCA1 hypermethylation reached 82.1% in the cases (p<0.001). In addition, the DNA hypermethylation of this candidate gene increased the possibility to be breast cancer with high incidence via calculated odd ratios (p<0.05). In conclusion, hypermethylation of this candidate gene could be used as the promising biomarker application with Vietnamese breast cancer patients.

Effects of Tai Chi Exercise on Muscle Strength, Balance, Flexibility and Bone Mineral Density of Community Dwelling Elderly Women (타이치 운동이 지역사회 여성노인의 근력, 균형감, 유연성과 골밀도에 미치는 효과)

  • So, Heeyoung;Ju, Kyungok;Park, Insook;Song, Rhayun;Kim, Hyunli;Ahn, Sukhee
    • Korean Journal of Adult Nursing
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    • v.25 no.1
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    • pp.105-112
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    • 2013
  • Purpose: The purpose of this study was to examine the effects of Tai Chi exercise on muscle strength, balance, flexibility and bone mineral density among community dwelling elderly women. Methods: A quasi-experimental pretest-posttest design with a nonequivalent comparison group was utilized, Elderly women were recruited from the community settings and assigned to either the treatment group (n=30) or the comparison group (n=34). Both groups completed the pretest and the posttest measures at six months with an 29.7% of dropouts. Tai Chi exercise was performed for 60 minutes, three times a week for 24 weeks. The study participants were referred to the sports clinic of the university hospital where an exercise therapist and a technician measured muscle strength, balance, flexibility, and bone mineral density without the knowledge of the group assignment. Data were collected from June 14, 2010 to May 27, 2011. Results: At the completion of 6 month Tai Chi exercise, the experimental group showed a significant difference in knee flexor strength (t=3.26 p=.002), flexibility (t=-2.93, p=.005), and bone mineral density in femur (t=2.20, p=.032), compared to the control group. Conclusion: Tai Chi exercise could be performed safely to community dwelling elderly women and effective for preventing declining in physical function in this population. Whether or not this health benefits would lead fall prevention will require further study.

The Effect of the Taeguk Gi-Gong Exercise on Insulin Resistance and Blood Glucose in Patients with Type II Diabetes Mellitus (태극건강기공이 제 2형 당뇨인의 인슐린저항성 및 혈당에 미치는 효과)

  • Jeong, Ihn-Sook;Lee, Hwa-Ja;Kim, Myung-Hee
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.14 no.1
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    • pp.44-52
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    • 2007
  • Purpose: This study was done to investigate the effect of Tai Chi Qigong exercise program on insulin resistance and blood glucose in patients with type 2 diabetes. Method: This was a quasi-experimental study used a non-equivalent control group pretest-posttest design. Participants included 39 patients with type 2 diabetes mellitus patients (ages between 40-70)(experimental group, 19, control group, 20). The Tai Chi Qigong exercise program consisted of 5 minute warming up, 30-minute main exercise, and 5 minute cooling down, and was conducted twice a week for 10 weeks. The outcome variables were insulin resistance (proinsulin, C-peptide, insulin, insulin sensitivity index) and blood glucose (fasting, post prandial 2hr, HbA1c). Data was analyzed using ANCOVA, with pre-test values as covariates, to examine difference between pre and post measures between the two groups. Results: The Tai Chi Qigong was effective in lowering postprandial 2hr blood glucose. Conclusion: Twice a week 10 week-Tai Chi Qigong exercise seems to be too short to improve insulin excretion or resistance, and fasting blood sugar and HbA1C in patients with type 2 DM. A Tai Chi Qigong program at least 3 times per week or longer is recommended.

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Influence of the Cooling Rate on the Phase Precipitation of Super Duplex Stainless Steel (슈퍼 듀플렉스 스테인리스강의 응고·냉각 시 상석출에 미치는 냉각속도의 영향)

  • Jang, Eun Seok;Kim, Ki Young;Kim, Suk Jun
    • Journal of Korea Foundry Society
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    • v.35 no.2
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    • pp.23-28
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    • 2015
  • This work presents the effect of the cooling rate on the precipitation of super duplex stainless steel. Specimens of super duplex stainless steel with a specific composition were cooled at various cooling rates after being melted at $1550^{\circ}C$ in a directional solidification furnace. Ferrite (${\delta}$), Austenite (${\gamma}$), Sigma (${\sigma}$), and Chi (${\chi}$) phases were precipitated when the cooling rate was lower than 0.22 K/s. When the cooling rate was 0.22 K/s or faster, ${\sigma}$ and ${\chi}$ phases were not precipitated.

Loss of Expression of Cyclin D2 by Aberrant DNA Methylation: a Potential Biomarker in Vietnamese Breast Cancer Patients

  • Truong, Phuong Kim;Lao, Thuan Duc;Doan, Thao Phuong Thi;Huyen Le, Thuy Ai
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.6
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    • pp.2209-2213
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    • 2015
  • DNA methylation of tumor suppressor gene promoters is the most frequent phenomenon leading to inactivation of function, consequently driving malignant cell transformation. Cyclin D2 is implicated in tumor suppression. In our study, we carried out the MSP assay to evaluation the methylation status at CpG islands in the cyclin D2 promoter in breast cancer cases from the Vietnamese population. The results showed that the frequency of methylation reached 62.1% (59 of 95 breast cancer tumors), but was low in non-cancer specimens at 10% (2 of 20 non-cancer specimens). Additionally, with an RR (relative risk) and OR (odd ratios) of 6.21 and 14.8, DNA hypermethylation of cyclin D2 increased the possibility of malignant transformation. Our results confirmed the cyclin D2 hypermethylation could be used as the potential biomarker which could be applied in prognosis and early diagnosis of Vietnamese breast cancer patients.

Fintech and Banking: Evidence from Vietnam

  • LIEN, Nguyen Thi Kim;DOAN, Thu-Trang Thi;BUI, Toan Ngoc
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.9
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    • pp.419-426
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    • 2020
  • The paper focuses on understanding fintech and the application of fintech in the banking sector in Vietnam. To solve this research objective, the authors analyze fintech development trends, especially the fintech application in the banking sector in Vietnam. To improve the quality of fintech services at banks, the authors conducted consideration of factors affecting customers' intention to use fintech services. To accomplish this, the authors collected data through a survey of 620 customers of the banks located in Ho Chi Minh City - the largest economic center in Vietnam. For the analytical method, the authors used multivariate regression to estimate the research model. Research results show that fintech service is very important for the banking sector in Vietnam. Moreover, this paper has achieved great success by identifying the factors that influence customers' intention to use fintech services. Accordingly, the intention to use fintech (INT) services is positively affected by the perception of usefulness (PU), social impact (SI), customer trust (TRU), and perceived ease of use (PEU). Based on the results of this study, bank managers will have a basis to improve the quality of fintech services. Not only that, the results of this study are also valuable for policymakers and researchers.

Project Cost Management in Construction Industry in Ho Chi Minh City

  • Kim, Soo-Yong;Tuan, Kiet Nguyen;Luu, Van Truong;Le, Tam Thuong
    • International conference on construction engineering and project management
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    • 2015.10a
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    • pp.70-71
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    • 2015
  • Cost management always being the matters for project manager as well as other entities involved the construction projects. Vietnam is emerging country, many construction works were carried out and lot of construction projects will be developed in the near future with a huge investment capital come from outside and inside Vietnam. In recent years, international project management firms enter the Vietnam construction market, some issues emerged need to be solved. In which cost and schedule of the construction project was put in a thoroughly consider of not only project management team but also stakeholders. The research attempts to identify and assess the relationship of factors affecting the construction cost in construction phase in Ho Chi Minh City, Vietnam. Five main factor groups Owners/clients; Consultants; Contractors; Resource and Other were identified to propose the solution for cost management.

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Antecedents Affecting Purchase Intention of Green Skincare Products: A Case Study in Vietnam

  • BUI, Thong Quang;NGUYEN, Nhu-Ty;NGUYEN, Khanh Kim;TRAN, Thanh-Tuyen
    • The Journal of Asian Finance, Economics and Business
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    • v.8 no.3
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    • pp.1295-1302
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    • 2021
  • The study aims to investigate the antecedents affecting purchase intention in the category of green skincare products. Many studies have used the theory of planned behavior to investigate factors affecting intention to purchase products in general. This paper not only retests the influences of attitude, subjective norm, perceived behavioral control on the intention to buy eco-friendly skincare products but also suggests a new antecedent - environment knowledge of purchase intention. More importantly, this study is the first to propose the moderating effect of country of origin and product knowledge on the relationship between attitude and purchase intention. This study employs a sample of 350 female customers from 18 to 39 years old in Ho Chi Minh City. The research applies the Multiple Linear Regression to analyze the proposed hypotheses in the conceptual framework and results in significant outcomes. The result shows that attitude is the most influential factor then, subjective norm, perceived behavioral control and environmental knowledge. Most importantly, the findings of this study suggest that product knowledge is found to moderate the effect of attitude on purchase intention. The finding of moderating effect is a new contribution to the literature and future research can be carried out to validate this result.