• Title/Summary/Keyword: Kim's model

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(I) Synthesis of model microspheres and adsorption study of bovine serum albumine. (모델 microspheres의 합성 및 bovine serum albumins의 흡착 연구)

  • Kim, Jung-Hyeon;Kim, U-Sik
    • Proceedings of the KOSOMBE Conference
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    • v.1992 no.11
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    • pp.157-160
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    • 1992
  • 표면에 여러 가지 기능성기를 가지는 microspheres는 immunoassay, drug delivery system, cell separation등 의용공학분야에 응용이 기대되고 있다. 이들 분야의 응용을 위하여 유화제를 사용하지 않으면서, 기존의 회분식, 반회분식, seed 중합법등의 문제점을 극복한 two stage shot growth technique올 개발하여 여러 가지 기능성기가 표면에 도입된 microspheres를 제조하였으며, 응용의 전단계로서 이들 microspheres에 대한 모델 단백질(BSA)의 흡착실험을 pH, 기능 성기의 종류와 양, BSA농도를 변수로 행하여 최대 흡착량을 보이는 조건을 결정하였다.

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A Study about Analysis of Weld Distortion using Genetic Algorithm (유전적 알고리듬을 이용한 용접변형 해석에 관한 연구)

  • Kim, Ill-Soo;Kim, Hak-Hyoung;Jang, Han-Kee;Kim, Hee-Jin;Kwak, Sung-Kyu;Ryoo, Hoi-Soo;Shim, Ji-Yeon
    • Journal of Welding and Joining
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    • v.27 no.4
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    • pp.54-59
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    • 2009
  • In the process to manufacture for metallic structures, control of welding deformation is one of an important problems connected with reliability of the manufactured structures so that welding deformation should be measured and controlled with quickly and actively. Also, welding parameters which have as lot of effects on welding deformation such as arc voltage, welding current and welding speed can also be controlled. The objectives for this study were to develop a simple 2-D FEM to calculate not only the transient thermal histories but also the sizes of fusion and heat-affected zone (HAZ) in multi pass arc welds including the butt and fillet weld type with dissimilar thickness, and to concentrate on a developed model for the finding the parameters of Godak's moving heat source model based on a GA. The developed model includes a GA program using MATLB and GA toolbox, and a batch mode thermal model using ANSYS software. Not only the thermal model was verified by comparison with Goldak's work but also the developed model was validated with molten zone section experimental data.

A Study on Relationships between Perceived Services and Satisfaction of SaaS(Software as a Service) (SaaS(Software as a Service)의 서비스 인지 및 만족도간의 상호관계성에 관한 연구)

  • Kim, Yong-Gu;Kim, Jun-Woo
    • Journal of Digital Convergence
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    • v.7 no.4
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    • pp.81-90
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    • 2009
  • SaaS (Software as a Service) provides software in the form of service via internet rather than software package. Thus a large number of users could use the service of new type of software service as long as they connect to internet. SaaS, as a delivery model attracted in the software industry, grows with impelling force. SaaS has been adopted as an information spreading strategy of small and medium corporate so that its effect has been recognized in both academic and practical areas. However, there are not much researches about it because SaaS is still in the introductory stage. This study focused on the success model of SaaS to find out the factors that affect usability and the satisfaction of users. The sample is based on the on-line survey for the 549 government officials who are using SaaS. At last, the number of the employed answers are 157 after unqualified ones are removed. The result shows that Security, Service quality, Price and System Integration significantly affect the usefulness and the satisfactions of users.

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LSD1-S112A exacerbates the pathogenesis of CSE/LPS-induced chronic obstructive pulmonary disease in mice

  • Jeong, Jiyeong;Oh, Chaeyoon;Kim, Jiwon;Yoo, Chul-Gyu;Kim, Keun Il
    • BMB Reports
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    • v.54 no.10
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    • pp.522-527
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    • 2021
  • Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. The post-translational modification of LSD1 is critical for the regulation of many of its biological processes. Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112A. Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCα inhibitor, Go6976. Thus, the lack of LSD1 phosphorylation exacerbates CSE/LPS-induced COPD by elevating inflammation and oxidative stress.

Forecasting Probability of Precipitation Using Morkov Logistic Regression Model

  • Park, Jeong-Soo;Kim, Yun-Seon
    • Communications for Statistical Applications and Methods
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    • v.14 no.1
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    • pp.1-9
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    • 2007
  • A three-state Markov logistic regression model is suggested to forecast the probability of tomorrow's precipitation based on the current meteorological situation. The suggested model turns out to be better than Markov regression model in the sense of the mean squared error of forecasting for the rainfall data of Seoul area.

Modeling Static Stability of Agricultural Tractor

  • Kim, Kyeong-Uk-;Park, Hong-Je-
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 1993.10a
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    • pp.1127-1136
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    • 1993
  • A mathematical model has been developed for the simulation of static stability of agricultural tractors. The model was based on Reichmann's model but modified to improve its shortcomings for practical applications. Two examples of model simulation were presented and showed its usefulness in evaluating the control and stability loss boundaries.

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Bayes Estimation in a Hierarchical Linear Model

  • Park, Kuey-Chung;Chang, In-Hong;Kim, Byung-Hwee
    • Journal of the Korean Statistical Society
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    • v.27 no.1
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    • pp.1-10
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    • 1998
  • In the problem of estimating a vector of unknown regression coefficients under the sum of squared error losses in a hierarchical linear model, we propose the hierarchical Bayes estimator of a vector of unknown regression coefficients in a hierarchical linear model, and then prove the admissibility of this estimator using Blyth's (196\51) method.

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A Study on the Korean National Police's Protesting Policing Policy through the Analysis of Negotiated Management Model (협의관리모델 분석을 통한 한국 경찰의 집회시위 관리정책 연구)

  • Hwang, Kyu-Jin;Kim, Hak-Kyong
    • Convergence Security Journal
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    • v.11 no.2
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    • pp.65-77
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    • 2011
  • In Western Europo and the US, there has been a general trend over 30 years of reducing the amount of force by the police, through a paradigm shift from 'Escalated Force Model' towards 'Negotiated Management Model'. In tune with this trend, for example, the Swedish Police have implemented the uniformed 'Dialogue Police' system, in order to establish communication contact with demonstrators, before, during, and after their events, The Negotiated Management Model involves a greater respect for the rights of protesters, a more tolerant approach to community, and improved intelligence, communication, and flexibility, in order to facilitate lawful protests and to reduce the possibility of an escalation of major public disorder. The Korean National Police (KNP) appears to be operated within this negotiated management framework, since in preparation for the G20 Seoul Summit, they have also emphasized good communication between the police and protest groups, by newly creating the concept of 'Protest Policing Through Facilitation of Lawful Protests'. In this context, this study first attempts to analyze not only the negotiated management model, but also the Swedish dialogue police. Secondly, the study conducts a comparative study between the KNP's Protest Policing Through Facilitation of Lawful Protest and the Swedish dialogue police system, particularly, in conjunction with the negotiated management. Although Korean and western police have different system and history, protest policing model is now approaching with each other through a link between conflict resolution techniques, such as dialogue, negotiation, mediation and facilitation. Finally, the study is to prove if the KNP's protest policing model corresponds with the negotiated management model, and further to suggest new 'Facilitation of Conflict Resolution Model' as a desirable future of the KNP's protest policing.

Accuracy Analysis of Ionospheric Delay of Low Earth Orbit Satellites by using NeQuick G Model

  • Bak, Serim;Kim, Mingyu;Kim, Jeongrae
    • Journal of Positioning, Navigation, and Timing
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    • v.10 no.4
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    • pp.363-369
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    • 2021
  • Since the Global Navigation Satellite System (GNSS) signal received from the low Earth orbit (LEO) satellite is only affected by the upper ionosphere, the magnitude of the ionospheric delay of Global Positioning System (GPS) signal received from ground user is different. Therefore, the ground-based two-dimensional ionospheric model cannot be applied to LEO satellites. The NeQuick model used in Galileo provides the ionospheric delay according to the user's altitude, so it can be used in the ionospheric model of the LEO satellites. However, the NeQuick model is not suitable for space receivers because of the high computational cost. A simplified NeQuick model with reduced computing time was recently presented. In this study, the computing time of the NeQuick model and the simplified NeQuick model was analyzed based on the GPS Klobuchar model. The NeQuick and simplified NeQuick model were applied to the GNSS data from GRACE-B, Swarm-C, and GOCE satellites to analyze the performance of the ionospheric correction and positioning. The difference in computing time between the NeQuick and simplified NeQuick model was up to 90%, but the difference in ionospheric accuracy was not as large as within 4.5%.