• The KIPS Transactions:PartD
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• v.8D no.6
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• pp.665-672
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• 2001

ITA (Information Technology Architecture) satisfies the requirements of information system, supports the information used in the institution's business to guarantee the interoperability and security, and analyzes the components of information system. ITA consists of EA (Enterprise Architecture), TRM (Technical Reference Manual) and SP (Standard Profile). The SP, one of the major components of ITA, is a set of information technology standards. In this paper, to construct and utilize the ITA, we mention the applications of information technology about the SP system implementation based on the TRM. The SP management system implemented in this paper is the first trial in Korea, and designs the software with object oriented programming languages such as JSP and Java. Moreover the basic and detailed specification based on the UML notation, system design using the component and system design pattern consisting of software architectures enhance the software reusability. And the constructed system in this paper shows less maintenance cost by using the public softwares such as Linux system, Korean DBMS, Apache and Tomcat, etc. Finally, the system includes the SP reference system which is used in the other institutions and cannot be found in other institutions. Also it includes the additional diverse service modules which support the subsequent processing for the establishment and revision of standards via internet.

• Restorative Dentistry and Endodontics
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• v.28 no.5
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• pp.402-408
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• 2003

This study was done to present a criterion in selection of the most proper light sources and materials by measuring metamerism index(MI) of the light curing composite resins with spectrocolorimeter. Metamerism is defined when two objects appear to be the same color in one illuminant but different in another. This is due to the fact that they have different spectral curves that fail to match under the second illuminant. In this study, A1 & A3 shade of five light curing composite resins (Esthet-X, Filteck Z250, Filteck A110. Charisma. Vitalescence) were chosen based on Vita shade. Five samples were made for shade of each product with Teflon mold (diameter: 15mm, thickness: 2mm). Metamerism index of each samples on a Barium sulfate plate($L^{*}=96.54,{\;}a^{*}=0.19,{\;}b^{*}=0.01$) prepared for sample fixation were measured with spectrocolorimeter(Miniscan XE plus. Model 4000s. Hunter Lab. USA) by applying standard light source D^{65}, C. Fcw, TL84 and A. Standardization was done with reference standard(X=80.8, Y=85.7, Z=90.8) and light trap. The results were as follows. 1. Different resins with same Vita shade showed recognizable color difference (${\delta}E^{*}>2$). 2. All composites had MI below accepted value 0.5 between standard illuminant(D$_{65}$, C, & A) and below 1.5 under fluorescent condition (Fcw & TL84). 3. MI value between $D^{65}$ and A showed higher value than MI value between other source of light(p<0.01). 4. All resins except Z250 showed MI value that A3 is higher than A1 between $D^{65}$ and A(p<0.05).except Z250 showed MI value that A3 is higher than A1 between $D^{65}$ and A(p<0.05).

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.29 no.2
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• pp.92-108
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• 2017

Present work shows a numerical method to analysis of interaction analysis between solitary wave and onshore bridge. Numerical simulation is carried out by TWOPM-3D (three-dimensional one-field model for immiscible two-phase flows), which is based on Navier-Stokes solver. To do this, the solitary wave is generated numerically in numerical wave channel, and numerical results and experimental results were compared and analyzed in order to verify the applicability of force acting on an onshore bridge. From this, we discussed precisely the characteristics of horizontal and vertical forces (uplift and downward forces) changes including water level and velocity changes due to the variation of solitary wave height, water depth, onshore bridge's location and type, and number of girder. Furthermore, It is revealed that the maximum horizontal and vertical forces acting on the girder bridge show different varying properties according to the number of girder, although each maximum force acting on the girder bridge is proportional to the increasement of incident solitary wave height, and the entrained air in the fluid flow affects the vertical force highly.

• Microbiology and Biotechnology Letters
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• v.42 no.2
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• pp.106-113
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• 2014

For the development of high value consumables utilizing jujube and grape, we investigated the biological activities of a variety of existing fermentation products of jujube and grape. The results revealed that ethanol fermentation products of jujube and grape had a higher antioxidative activity than acetic acid fermentation products. In addition, the ethanol fermentation products of jujube (JEF) had the highest antioxidative activity, with it being greater than that of the ethanol fermentation products of grape (GEF), the acetic acid fermentation products of jujube (JAF) and the acetic acid fermentation products of grape (GAF). As regards tests on whitening effects, JEF exhibited the highest tyrosinase inhibition effects amongst the test groups. However, when immunofluorecence was employed, JAF was seen to inhibit the expression of proteins related to the whitening effect. In the lipopolysaccharide-stimulated mode peritoneal macrophage model, all tested groups of fermentation products (JEF, GEF, JAF and GAF) suppressed nitric oxide production dose-dependently, with ethanol fermentation products demonstrating a higher nitric oxide expression inhibition effect than acetic acid fermentation products. When subjected to antibacterial activity tests, GAF exhibited antibacterial activity against all tested strains except Propionibacterium acnes. Both GAF and JEF revealed high antibacterial activity against Escherichia coli.

• Journal of Korea Technology Innovation Society
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• v.15 no.1
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• pp.203-223
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• 2012

This study aimed to identify the factors of failure in cases where there was feasibility but was not successful in commercializing technology. For the study, 92 feasibility reports for new technologies were collected, and among these 4 studies that showed definite failure in commercialization of technology were analyzed in depth. Further analysis was based the factors pointed out by previous frameworks such as 1) discussion on success or failure in commercialization of technology, 2) that of venture company, and 3) valuation of technology studies. Previous studies pointed out success and failure factors as lack of funding, uncontrollable accidents, managing ability, inability for mass production and so forth, which had little difference to the pre-feasible evaluation of four cases. However, real reason was the lack of understanding technologies such as composition of technologies, production technologies required by stages, and lack of understanding of floor technologies. The misunderstandings were occurred regardless of CEO's experience and expertise. We did not touch the evaluation model of pre-feasibility studies, although we dealt with the failure of the pre-studies. The reason we do not generalize the results of this study is the fact that we dealt with only small cases.

• Journal of Korea Technology Innovation Society
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• v.14 no.2
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• pp.223-245
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• 2011

We have analysed the impact of innovation on the employment in the Korean Service sector using KIS 2006 data. Our study is based on Bogliacino and Pianta (2010)'s model, which involves two main innovation strategies, technological competitiveness and cost competitiveness, as the main explanatory innovation variables for the employment dynamics. Empirical results show that an increase in demand was the strongest driver for an increase in employment in all four service sectors, including Science-based, specialized supplier, size and information intensive, and supplier dominated. Innovation strategy appeared to have a significant effect on employment at the firm level; Technological competitiveness showed a positive effect on employment in science based sector while cost competitiveness appeared to give a negative effect in specialized supplier sector. The firms in size and information intensive sector showed that increase in wages gives negative impact on their employment. However, cost competitiveness did not give any significant effect on employment dynamics of firms in size and information intensive sector and supplier dominated sector. This finding is different from the research of Bogliacino and Pianta (2010) on the European countries. One possible explanation would be that innovation strategy does not affect employment of firms in size and information intensive sector and supplier dominated sector since the level of innovativeness of these sectors in Korea fall behind that of European countries.

• Nutrition Research and Practice
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• v.12 no.3
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• pp.199-207
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• 2018

BACKGROUND/OBJECTIVES: Fermented Laminaria japonica (FL), a type sea tangle used as a functional food ingredient, has been reported to possess cognitive improving properties that may aid in the treatment of common neurodegenerative disorders, such as dementia. MATERIALS/METHODS: We examined the effects of FL on scopolamine (Sco)- and ethanol (EtOH)-induced hippocampus-dependent memory impairment, using the Passive avoidance (PA) and Morris water maze (MWM) tests. To examine the underlying mechanisms associated with neuroprotective effects, we analyzed acetylcholine (ACh) and acetylcholinesterase (AChE) activity, brain tissue expression of muscarinic acetylcholine receptor (mAChR), cAMP response element binding protein (CREB) and extracellular signal-regulated kinases 1/2 (ERK1/2), and immunohistochemical analysis, in the hippocampus of mice, compared to current drug therapy intervention. Biochemical blood analysis was carried out to determine the effects of FL on alanine transaminase (ALT), aspartate transaminase (AST), and triglyceride (TG) and total cholesterol (TC) levels. 7 groups (n = 10) consisted of a control (CON), 3 Sco-induced dementia and 3 EtOH-induced dementia groups, with both dementia group types containing an untreated group (Sco and EtOH); a positive control, orally administered donepezil (Dpz) (4mg/kg) (Sco + Dpz and EtOH + Dpz); and an FL (50 mg/kg) treatment group (Sco + FL50 and EtOH + FL50), orally administered over the 4-week experimental period. RESULTS: FL50 significantly reduced EtOH-induced increase in AST and ALT levels. FL50 treatment reduced EtOH-impaired step-through latency time in the PA test, and Sco- and EtOH-induced dementia escape latency times in the MWM test. Moreover, anticholinergic effects of Sco and EtOH on the brain were reversed by FL50, through the attenuation of AChE activity and elevation of ACh concentration. FL50 elevated ERK1/2 protein expression and increased p-CREB (ser133) in hippocampus brain tissue, according to Western blot and immunohistochemistry analysis, respectively. CONCLUSION: Overall, these results suggest that FL may be considered an efficacious intervention for Sco- and EtOH-induced dementia, in terms of reversing cognitive impairment and neuroplastic dysfunction.

• Nutrition Research and Practice
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• v.12 no.3
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• pp.191-198
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• 2018

BACKGROUD/OBJECTIVES: Neuroinflammation plays critical role in neurodegenerative disorders, such as Alzheimer's disease (AD). We investigated the effect of three licorice varieties, Glycyrhiza uralensis, G. glabra, and Shinwongam (SW) on a mouse model of inflammation-induced memory and cognitive deficit. MATERIALS/METHODS: C57BL/6 mice were injected with lipopolysaccharide (LPS; 2.5 mg/kg, intraperitoneally) and orally administrated G. uralensis, G. glabra, and SW extract (150 mg/kg/day). SW, a new species of licorice in Korea, was combined with G. uralensis and G. glabra. Behavioral tests, including the T-maze, novel object recognition and Morris water maze, were carried out to assess learning and memory. In addition, the expressions of inflammation-related proteins in brain tissue were measured by western blotting. RESULTS: There was a significant decrease in spatial and objective recognition memory in LPS-induced cognitive impairment group, as measured by the T-maze and novel object recognition test; however, the administration of licorice ameliorated these deficits. In addition, licorice-treated groups exhibited improved learning and memory ability in the Morris water maze. Furthermore, LPS-injected mice had up-regulated pro-inflammatory proteins, such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2, interleukin-6, via activation of toll like receptor 4 (TLR4) and nuclear factor-kappa B ($NF{\kappa}B$) pathways in the brain. However, these were attenuated by following administration of the three licorice varieties. Interestingly, the SW-administered group showed greater inhibition of iNOS and TLR4 when compared with the other licorice varieties. Furthermore, there was a significant increase in the expression of brain-derived neurotrophic factor (BDNF) in the brain of LPS-induced cognitively impaired mice that were administered licorice, with the greatest effect following SW treatment. CONCLUSIONS: The three licorice varieties ameliorated the inflammation-induced cognitive dysfunction by down-regulating inflammatory proteins and up-regulating BDNF. These results suggest that licorice, in particular SW, could be potential therapeutic agents against cognitive impairment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.5
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• pp.346-353
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• 2016

In the design conditions of some research reactors, the siphon phenomenon can cause continuous efflux of water during pipe rupture. A siphon breaker is a safety device that can prevent water efflux effectively. However, the analysis of the siphon breaking is complicated because many variables must be included in the calculation process. For this reason, a simulation program was developed with a user-friendly GUI to analyze the siphon breaking easily. The program was developed by MFC programming using Visual Studio 2012 in Windows 8. After saving the input parameters from a user, the program proceeds with three steps of calculation using fluid mechanics formulas. Bernoulli's equation is used to calculate the velocity, quantity, water level, undershooting, pressure, loss coefficient, and factors related to the two-phase flow. The Chisholm model is used to predict the results from a real-scale experiment. The simulation results are shown in a graph, through which a user can examine the total breaking situation. It is also possible to save all of the resulting data. The program allows a user to easily confirm the status of the siphon breaking and would be helpful in the design of siphon breakers.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.10 no.6
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• pp.1124-1131
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• 2006

The recent medical treatment guidelines and the development of information technology make hospitals reduce the expense in surrounding environment and it requires improving the quality of medical treatment of the hospital. Moreover, MIS, PACS(Picture Archiving and Communication System), OCS, EMR are also developing. Medical Information System is evolved toward integration of medical IT and situation is changing with increasing high speed in the ICT convergence. Mobile component refers to construct wireless system of hospital which has constructed in existing environment. Through RFID development in existing system, anyone can log on easily to internet whenever and wherever. It is the core technology to implement automatic medical processing system. This paper provides a basic review of RFID model, PACS application component services. In addition, designed and implemented database server's component program and client program of mobile application that recognized RFID tag and patient data in the ubiquitous environments. This system implemented mobile PACS that performed patient data based db environments, and so reduced delay time of requisition, medical treatment, lab.