• Childhood Kidney Diseases
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• 제16권2호
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• pp.109-114
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• 2012

Medullary sponge kidney disease (MSK)는 신장 수질 피라미드부위에서 야기되는 희귀질환으로 collecting precalyceal duct의 낭종성 확장(dilatation)과 ectasia을 특징으로 한다. MSK 환자의 발생 빈도에 대해서는 명확히 알려진 바가 없으며, 특히 소아 청소년 연령에서는 매우 드물게 발견된다. 연구자들은 국내 소아신장학회 회원들을 대상으로 MSK 환자의 전수 조사를 실시하였고 현재까지 문헌상으로 보고된 관련 유전자들인 GDNF, ATP6V1B1, ATP6V0A4 유전자에 대한 분석을 실시하였기에 이를 보고하는 바이다.

• 한국임상수의학회지
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• 제15권2호
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• pp.325-330
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• 1998

The purpose of this study is to investigate the effect of acupuncture after the induction of acute kidney disease in dogs by ethylene glycol. Twenty four mixed breed, adult cats were used in the experiment. Ethylene glycol was administered orally at 1 ml/kg in 24 cats, and then 6 cats were treated by acupunchuture 6 cats were treated by electroacupuncture, 6 cats were treated by acupuncture and 6 cats were not treated as a control group. Treatment was done once daily far 4 dsys. The acupoint used were Gan-shu and Tai-xi. The effect of acnpuncture was evaluated by clinical symptom, blood chemical values, electrocardiogram (ECG) and histopathologkal findings. After treatement, acupuncture group revealed relatively fast recovery compared with other groups, in clinical symptoms, blood chemical values, ECG waves and histopathological findings. Laserpuncture group revealed secondly fast recovery compared with control group.

• Biomolecules & Therapeutics
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• 제29권4호
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• pp.365-372
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• 2021

Type 2 diabetes mellitus (T2DM) leads to many health problems like diabetic nephropathy (DN). One of the key factors for chronic kidney disease and end-stage renal disease (ESRD) is T2DM. Extensive work is being done to delineate the pathogenesis of DN and to extend possible remedies. This review is intended to understand the nature of DN risk factors, progression, effects of glycemic levels, and stages of DN. We also explored the novel diagnostic and therapeutic approaches for DN such as gene therapy and stem cell treatments.

• 대한간학회지
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• 제24권4호
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• pp.351-357
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• 2018

The advent of novel, direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) infection has revolutionized its treatment by producing a sustained virologic response of more than 95% with few side effects and no comorbidities in the general population. Until recently, ideal DAA regimens have not been available to patients with severe renal impairment and end-stage renal disease because there are limited data on the pharmacokinetics, safety, and efficacy of treatment in this unique population. In a hemodialysis context, identifying patients in need of treatment and preventing HCV transmission may also be a matter of concern. Recently published studies suggest that a combination of paritaprevir/ritonavir/ombitasvir and dasabuvir, elbasvir/grazoprevir, or glecaprevir/pibrentasvir successfully treats HCV infection in chronic kidney disease stage 4 or 5 patients with or without hemodialysis.

• Hip & pelvis
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• 제34권2호
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• pp.122-126
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• 2022

Tumoral calcinosis is a rare disease characterized by massive subcutaneous soft tissue deposits of calcium phosphate around large joints in patients with chronic kidney disease. Invasion of bone by tumoral calcinosis is rare. We experienced a case involving a femoral neck pathologic fracture due to bony invasion of tumoral calcinosis in a 46-year-old female with chronic kidney disease who had been on dialysis for 15 years. Successful outcomes were obtained by performance of total hip arthroplasty for treatment of the pathologic fracture of the femoral neck. Careful precaution is necessary to prevent pathologic fractures in patients with tumoral calcinosis around the hip joint.

• Childhood Kidney Diseases
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• 제1권1호
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• pp.31-37
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• 1997

목적 : DMSA스캔은 신장의 형태학적 질환의 진단에 유용한 방사선과적 검사이다. 본원에서 DMSA스캔을 시행한 환아중 일측성으로 동위원소 섭취가 안되는 환아를 대상으로 이들의 성별, 연령별 분포와 임상적 소견, 원인질환 및 동반질환을 분석하고 이에 대한 치료 및 예후를 알아보고자 하였다. 방법 : 1980년부터 1995년까지 16년간 본원에 내원하여 DMSA 스캔을 시행한 생후 1일부터 15세 환아중 일측성으로 신기능을 상실한 경우와 5% 이내로 매우 저하되어 있는 61명을 대상으로 이들의 성별, 연령별 분포와 내원하게 된 주소, 내원당시의 임상적 소견, 정맥내 신우조영술, 복부초음파, 배뇨성 방광요관조영술, 최종 진단명, 동반되어있는 반대편 신장 및 전신 질환, 내원당시의 혈액검사, 치료, 그리고 추적 관찰후의 결과 등에 대한 항목을 조사하고 상호 연관관계를 분석하였다. 결과 : 1) 대상 환아의 연령 분포는 평균 3.3세였으며, 특히 1세이하가 전체의 46%였고 성별 분포는 남녀 1.4:1의 비율로 남아가 많았다. 2) 내원하게된 주소는 산전초음파에서 신장 이상이 발견된 경우가 31.2%로 가장 많았으며, 다음으로 반복적 요로감염, 복부종괴 촉지, 육안적 혈뇨, 복통 순이였으며, 다른 질환의 평가중 우연히 신장 이상이 발견된 경우도 26.2%를 차지하였다. 3) 내원당시 임상적 소견은 발열, 농뇨 등의 요로감염 증상이 가장 많았고, 고혈압, 복부종괴 촉지, 육안적 혈뇨, 변비, 무증상, 현미경적 혈뇨 순이였다. 4) 비기능성 신장의 최종진단명은 다낭성 신이형성(multicystic dysplastic kidney)이 36.1%로 가장 많았고, 수신증, 신발육부전, 신형성부전 순이였다. 5) 비기능성 신장의 치료는 47.5%에서 수술적 치료를 시행받았고, 수술적 치료중 신적출술이 75.9%(전체의 36.1%)로 가장 많았으며 그외에는 근피적 방광루조성술, 요관방광문합술, 신적출 및 신이식 순이였고, 32.8%는 치료없이 추적관찰만 했던 환아들이였다. 6) 반대측 신장에 침범된 질환은 수신증이 90.5%로 가장 많았고 신형성부전, 신원거대감소증이 각각 1례였다. 7) 총 61명의 환아중 4명이 만성 신부전으로 이행하였는데 이들은 모두 반대편 신장에도 심한 병변이 동반되었던 경우였으며 그 외의 환아들은 비교적 예후가 좋았다. 결 론 : 신기능을 상실한 신장중 대부분은 선천적인 질환에 의한 경우였으며 양측성으로 침범된 경우 만성신부전으로 이행한 경우도 있었으나 편측으로 침범된 경우 예후가 좋은 편이였으며 양측성인 경우도 조기진단 후 수술 받은 경우 신기능이 잘 유지되었다. 본 연구를 통하여 주산기 신장 병변에 대한 평가는 중요하며, 출생후 민감도가 높은 검사방법으로 조기에 진단하고 처치하면 비교적 예후가 좋다는 것을 알 수 있었다.

• Journal of Preventive Medicine and Public Health
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• 제48권3호
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• pp.170-177
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• 2015

Objectives: The goal of this study was to examine the association of various demographic and socioeconomic factors with risk factors for chronic kidney disease (CKD). Methods: We used nationally representative pooled data from the Korea National Health and Nutrition Examination Survey (KNHANES), 2007-2013. We estimated the glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease equation. We defined CKD as a GFR <60 mL/min/$1.73m^2$, and 1304 of the 45 208 individuals included in the KNHANES were found to have CKD by this definition. The outcome variable was whether individual subjects adhered to the CKD prevention and management guidelines recommended by the Korea Centers for Disease Control and Prevention. The guidelines suggest that individuals maintain a normal weight, abstain from alcohol consumption and smoking, manage diabetes and hypertension, and engage in regular exercise in order to prevent and manage CKD. Results: This study found that individuals with CKD were more likely to be obese and have hypertension or diabetes than individuals without CKD. In particular, male and less-educated CKD patients were less likely to adhere to the guidelines. Conclusions: Although the prevalence of CKD, as indicated by the KNHANES data, decreased from 2007 to 2013, the prevalence of most risk factors associated with CKD fluctuated over the same time period. Since a variety of demographic and socioeconomic factors are related to the successful implementation of guidelines for preventing and managing CKD, individually tailored prevention activities should be developed.

• 동의생리병리학회지
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• 제20권4호
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• pp.1057-1062
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• 2006

In order to research the interrelationship of symptoms of 5 visceral diseases through Pearson's correlative coefficient and to understand the diagnostic importances of each symptom and sexual differences in the main symptoms of each visceral diseases using Cronbach alpha. For this 500 female and 120 male cases of questionnaire were collected and analyzed. In the main symptoms of 5 visceral diseases, there were a little differences between this results and existing symptom-complex system. And in the comparison of most frequently manifesting symptoms to male and female subject, Heart and Pancreas and Kidney disease were almost same, but Liver disease was different and Lung disease was slightly different. Conclusively, the diagnostic reliability of the abstracted symptom-complex of 5 viscera was graded from Kidney(Cronbach alpha 0.8771555), Pancreas(0.865978), Liver(0.815013), Heart(0.78653) to Lung disease(0.6294695) sequentially. And the each Cronbach alpha was valuable to be permitted as diagnostic criteria of 5 visceral diseases.

• 대한수의학회지
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• 제38권4호
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• pp.918-928
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• 1998

The present study was done with two aims. First, to evaluate the radiographic measurements of liver volumes in normal and hepatomegaly dogs induced by carbon tetrachloride. Second, to investigate quantitative tissue echo pattern by ultrasonography. Gray level histogram of the normal liver and the kidney were estimated with carbon tetra-chloride intoxication. In normal, r-square for liver volume to body weight was 0.93372, and this showed direct linear regression. Gray level histograms of the normal liver and the kidney were $19.150{\pm}2.490$(mean${\pm}$SD) and $13.175{\pm}2.686$(mean${\pm}$SD) respectively(p < 0.01). Liver parenchymal echogenicity was more hyperechogenic than kidney cortex echogenicity. Liver/Kidney ratio was $1.504{\pm}0.313$ and it can be used relative comparison of liver and kidney parenchymal echogenicity. In carbon-tetrachloride($CCl_4$) intoxication, changes of liver volume appeared to increase up to 24 hours after administration (p < 0.05), and decreased gradually to normal level after 2~5 days. Gray level histogram of liver parenchyma decreased up to 24hours (p < 0.01) after intoxication and then gradually increased to normal level. But that of kidney cortex had no significant change. Liver/Kidney ratio also decreased by 2 days(p < 0.01) and then gradually increased to normal level. On histopathologic features of hepatic tissues in carbon tetrachloride intoxication, both coagulative necrosis of hepatic cell and hemorrhage of centrilobular & midzonal area were identified. Conclusively, plain radiography is a useful diagnostic method for evaluating liver volume in mild hepatomegaly. Especially, it is considered that an adequate numerical processing of the liver length, depth and thoracic width and depth measurement would be helpful. Using gray level histogram, ultrasonographic evaluation was useful objective methods in early diagnosis of diffuse hepatic disease.

• Childhood Kidney Diseases
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• 제16권1호
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• pp.32-37
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• 2012

목적: 본 연구는 방광요관역류를 보이는 소아에서 신초음파 이상소견에 대해 알아보고자 하였다. 방법: 2000년 1월부터 2010년 12월까지 일산병원 소아청소년과에 내원하여 요로감염증으로 입원한 후 배뇨성 방광요도조영술을 시행하여 방광요관역류를 진단받은 83명의 소아를 대상으로 총 166 신단위를 후향적으로 분석하였다. 결과: 대상 소아 중 1세 미만의 평균 나이는 $3.1{\pm}2.56$개월이었고, 1세 이상의 평균 나이는 $58.9{\pm}43.01$개월이었다. 신초음파 이상소견을 보이는 신단위에서 방광요관역류가 있는 경우는 73.9%였고, 신초음파 정상소견을 보이는 신단위에서 방광요관역류가 있는 경우는 58.7%였으며 이는 통계적으로 유의한 차이를 보였다($P$=0.049). 로지스틱 회귀분석에서 신초음파 이상소견이 있을 경우 방광요관역류가 있을 확률은 약 2배 증가하였다. 방광요관역류가 있는 신단위에서 신초음파 정상소견을 보이는 경우는 52.8%, 피질음영증가 16.7%, 수신증 17.6%, 요관확장 8.3%, 수신증을 동반한 요관확장 1.9% 등이었다. 이 중 수신증(82.6%), 요관확장(100%), 중복요관(66.6%), 손상된 위축신(100 %)이 있는 경우 방광요관역류의 빈도가 상대적으로 높았다. 결론: 방광요관역류가 있는 신단위에서 신초음파 이상소견으로 방광요관역류의 중증도를 예측하는 것은 가능하지 않으나 방광요관역류의 존재를 예측하는 것은 가능하다. 그러므로 수신증, 요관확장 같은 신초음파 이상소견이 있을 시, 배뇨성 방광요도조영술의 시행이 필요할 것이다.