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Association between Single Nucleotide Polymorphisms in the Dgat2 Gene and Beef Carcass and Quality Traits in Commercial Feedlot Steers

  • Li, J.;Xu, X.;Zhang, Q.;Wang, X.;Deng, G.;Fang, X.;Gao, X.;Ren, H.;Xu, S.
    • Asian-Australasian Journal of Animal Sciences
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    • v.22 no.7
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    • pp.943-954
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    • 2009
  • Diacylglycerol acyltransferase (DGAT) is a key enzyme that catalyzes the final and rate-limiting step of triglyceride synthesis. Both DGAT1 and DGAT2 genes code proteins with DGAT activity. Studies have shown DGAT1 polymorphisms associate with intramuscular fat deposition in beef cattle, but fewer associations between DGAT2 and beef cattle economic traits have been reported. The objective of this study was to investigate single nucleotide polymorphism (SNP) in intron3 of bovine DGAT2 and evaluate the associations of that with carcass, meat quality, and fat yield traits. Test animals were 157 commercial feedlot steers belonging to 3 Chinese native breeds (22 for Luxi, 24 for Jinnan, and 23 for Qinchuan), 3 cross populations (20 for Charolais${\times}$Fuzhou, 18 for Limousin ${\times}$Luxi, and 17 for Simmental${\times}$Jinan) and 1 Taurus pure breed population (16 Angus steers). In the current study, 15 SNP were discovered in intron3 and exon4 of DGAT2 at positions 65, 128, 178, 210, 241, 255, 270, 312, 328, 334, 365, 366, 371, 415, and 437 (named as their positions in PCR amplified fragments). Only 7 of them (128, 178, 241, 270, 312, 328, and 371) were analyzed, because SNP in three groups (65-128-255, 178-210-365 and 241-334-366) were in complete linkage disequilibrium within the group, and SNP 415 was a deletion and 437 was a null mutation. Frequencies for rare alleles in the 3 native breed populations were higher than in the 3 cross populations for 178 (p = 0.04), 270 (p = 0.001), 312 (p = 0.03) and 371 (p = 0.002). A general linear model was used to evaluate the associations between either SNP genotypes or allele substitutions and the measured traits. Results showed that SNP 270 had a significant association with the fat yield associated with kidney, pelvic cavity, heart, intestine, and stomach (KPHISY). Animals with genotype CC and CT for 270 had less (CC: -7.71${\pm}$3.3 kg and CT: -5.34${\pm}$2.5 kg) KPHISY than animals with genotype TT (p = 0.02). Allele C for 270 was associated with an increase of -4.26${\pm}$1.52 kg KPHISY (p = 0.006) and $-0.92{\pm}0.45%$ of retail cuts weight percentage (NMP, Retail cuts weight/slaughter body weight) (p = 0.045); allele G for 312 was associated with an increase of -5.45${\pm}$2.41 kg KPHISY (p = 0.026). An initial conclusion was that associations do exist between DGAT2 gene and carcass fat traits. Because of the small sample size of this study, it is proposed that further effort is required to validate these findings in larger populations.

Tmr-Tree : An Efficient Spatial Index Technique in Main Memory Databases (Tmr-트리 : 주기억 데이터베이스에서 효율적인 공간 색인 기법)

  • Yun Suk-Woo;Kim Kyung-Chang
    • The KIPS Transactions:PartD
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    • v.12D no.4 s.100
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    • pp.543-552
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    • 2005
  • As random access memory chip gets cheaper, it becomes affordable to realize main memory-based database systems. The disk-based spatial indexing techniques, however, cannot direct apply to main memory databases, because the main purpose of disk-based techniques is to reduce the number of disk accesses. In main memory-based indexing techniques, the node access time is much faster than that in disk-based indexing techniques, because all index nodes reside in a main memory. Unlike disk-based index techniques, main memory-based spatial indexing techniques must reduce key comparing time as well as node access time. In this paper, we propose an efficient spatial index structure for main memory-based databases, called Tmr-tree. Tmr-tree integrates the characteristics of R-tree and T-tree. Therefore, Nodes of Tmr-tree consist of several entries for data objects, main memory pointers to left and right child, and three additional fields. First is a MBR of a self node, which tightly encloses all data MBRs (Minimum Bounding Rectangles) in a current node, and second and third are MBRs of left and right sub-tree, respectively. Because Tmr-tree needs not to visit all leaf nodes, in terms of search time, proposed Tmr-tree outperforms R-tree in our experiments. As node size is increased, search time is drastically decreased followed by a gradual increase. However, in terms of insertion time, the performance of Tmr-tree was slightly lower than R-tree.

A Scalable Hardware Implementation of Modular Inverse (모듈러 역원 연산의 확장 가능형 하드웨어 구현)

  • Choi, Jun-Baek;Shin, Kyung-Wook
    • Journal of IKEEE
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    • v.24 no.3
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    • pp.901-908
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    • 2020
  • This paper describes a method for scalable hardware implementation of modular inversion. The proposed scalable architecture has a one-dimensional array of processing elements (PEs) that perform arithmetic operations in 32-bit word, and its performance and hardware size can be adjusted depending on the number of PEs used. The hardware operation of the scalable processor for modular inversion was verified by implementing it on Spartan-6 FPGA device. As a result of logic synthesis with a 180-nm CMOS standard cells, the operating frequency was estimated to be in the range of 167 to 131 MHz and the gate counts were in the range of 60,000 to 91,000 gate equivalents when the number of PEs was in the range of 1 to 10. When calculating 256-bit modular inverse, the average performance was 18.7 to 118.2 Mbps, depending on the number of PEs in the range of 1 to 10. Since our scalable architecture for computing modular inversion in GF(p) has the trade-off relationship between performance and hardware complexity depending on the number of PEs used, it can be used to efficiently implement modular inversion processor optimized for performance and hardware complexity required by applications.

Determinants of Credit Default Swap Spreads: The Case of Korean Firms (한국 기업들의 신용부도스왑 스프레드에 대한 결정요인 분석)

  • Park, Yoon-S.;Kim, Han-Joon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.12 no.10
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    • pp.4359-4368
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    • 2011
  • Among several macroeconomic missteps blamed for the recent global financial crisis including the social problems of income distribution and the lack of proper financial remedies, two of them have received particular attention: the global BOP(Balance of Payment) imbalance and the misguided monetary policy. Such BOP imbalance was blamed for massive foreign exchange investment flows from Asia into the U.S., triggering the financial and real estate bubble in America. The latter refers to the excessively loose monetary policy of the U.S. Federal Reserve, which pushed financial institutions and households into reckless investment behavior in search of higher returns. Given the abuse of certain innovative financial techniques and new investment instruments that have been created in recent decades, both collateralized debt obligations (CDOs) and credit default swaps (CDS) enjoyed a symbiotic and toxic relationship prior to the financial crisis This paper is organized as follows: The first section analyzes the real causes of the recent financial crisis. The second details the role of CDOs and CDS. Then, to identify key determinants of the CDS spreads in an emerging capital market, the sample data of major Korean firms' CDS spreads are used to estimate the risk premium by utilizing the multiple regression analysis. The empirical test result indicates that Korean 3-year treasury bond rate(TYIELD), market to book value ratio(MV/BV), and assets size(INASSETS) are shown to demonstrate statistically significant influences on the changes of the CDS premium for sample firms.

A Study on the Reduction of Waiting Time and Moving Distance through Optimal Allocation of Service Space in a Health Examination Center (건강검진센터의 공간서비스 적정할당을 통한 대기시간 및 이동거리 단축에 관한 연구)

  • Kim, Suk-Tae;Oh, Sung-Jin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.12
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    • pp.167-175
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    • 2019
  • Recently, health examination centers have been changing from auxiliary medical facilities to key and independent medical facilities. However, it is not easy to improve medical facilities, including health examination centers, due to the variable characteristics of the relationship between humans and space. Therefore, this study was done to develop a pedestrian-based discrete event simulation analysis program to examine the problems and develop methods for improvement. The program was developed to analyze five evaluation indices and the density of examinees. The problems were derived by analyzing the required time, capacity, and queue size for each examination through simulations. We reduced the examination time and moving distance, increased the capacity, and distributed the queues by adjusting the medical services and relocating the examination rooms. The results were then quantitatively verified by simulations.

Assessment of Cutting Performance of a TBM Disc Cutter for Anisotropic Rock by Linear Cutting Test (선형절삭시험에 의한 이방성 암석에 대한 TBM 디스크커터 절삭 성능 평가 연구)

  • Jeong, Ho-Young;Jeon, Seok-Won;Cho, Jung-Woo;Chang, Soo-Ho;Bae, Gyu-Jin
    • Tunnel and Underground Space
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    • v.21 no.6
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    • pp.508-517
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    • 2011
  • The linear cutting test is the most reliable and accurate approach to measuring cutting forces and cutting efficiency using full-size disc cutter in various rock types. The result of linear cutting tests can be used to obtain the key parameters of cutter-head design (i.e. optimum cutter spacing, cutter forces). In Korea, LCM (Linear Cutting Machine) tests have been performed for typical Korean rock types, but these studies focused on the isotropic rocktypes. For prediction of TBM (Tunnel Boring Machine) performances in complex geological conditions including a bedded and schistose rockmass, it is important to consider the effects of anisotropy of rockmass on cutting performances and cutting efficiency. This study discusses a series of LCM tests that were performed for Asan Gneiss having two types of anisotropy angles to assess the effect of the anisotropy angle on rock-cutting performances of TBM. The result shows that the rock-cutting performances and optimum cutting conditions are affected by anisotropy angle and the effect of anisotropy on rock strength should be considered in a prediction of the cutting performances and efficiency of TBM.

Identifying Key Factors to Affect Bus Headway Deviation using Hierarchical Linear Model (Seoul Case Study) (HLM을 이용한 버스차두간격 편차에 미치는 요인분석 (서울시사례를 중심으로))

  • Lee, Ho-Sang;Kim, Do-Gyeong;Kim, Yeong-Chan;Hwang, Gyeong-Su
    • Journal of Korean Society of Transportation
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    • v.27 no.6
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    • pp.119-127
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    • 2009
  • It has been known that bus route and company related characteristics have influences on punctuality, but fewer research have been conducted. Independent variables used in this study were selected using correlation analysis, and OLS(Ordinary Least Square) and HLM(Hierarchical Linear Model) were employed to identify factors affecting bus punctuality(headway deviation). The results showed that ICC(intraclass Correlation Coefficient) is 0.10, indicating that hierarchical linear models are more adequate for these data because there is effective variation in the subjects between companies. Punctuality was found to be negatively associated with the number of vehicles, the number of persons per vehicle, and total travel time. On the other hand, average headway and company size have a positive relationship with punctuality. Therefore, the number of vehicles per route, average headway, and the number of vehicles managed by a company should be considered for more accurately evaluating the management of piunctuality.

Comparison of Diagnostic Accuracy for Detecting Coronary Artery Disease of Dipyridamole $^{99m}Tc$-MIBI Myocardial SPECT and It's Defect Map between Men and Women (디피리다몰 부하 $^{99m}Tc$-MIBI 심근 SPECT 극성결손지도를 이용한 관동맥질환 진단의 남녀 비교)

  • Bae, Sang-Kyun;Lee, Dong-Soo;Oh, Byung-Hee;Chung, June-Key;Lee, Myoung-Mook;Park, Young-Bae;Lee, Myung-Chul;Seo, Jung-Don;Lee, Young-Woo;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.27 no.1
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    • pp.59-64
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    • 1993
  • To evaluate the usefulness and differences in diagnosing coronary artery disease (CAD) between men and women of intravenous dipyridamole $^{99m}Tc$-MIBI myocardial SPECT, we obtained $^{99m}Tc$-MIBI myocardial SPECT and compared with the findings of coronary angiographies. Ninety eight male and 37 female patients who underwent dipyridamole $^{99m}Tc$-MIBI myocardial imaging within one month of cardiac catheterization were studied. Scans were considered abnormal if perfusion defect was detected and the defect size was more than 12% for left anterior descending artery (LAD) and circumflex (LCX) and 8% for right coronary artery (RCA) territories. Lesions${\geqq}$50% luminal diameter narrowing were considered significant CAD. Overall sensitivity for detection of CAD was 94.3% in men and 96.4% in women; specificity was 70% in men and 52.6% in women (P=not significant, ns). Vessel-matched sensitivity was 75.3% in men and 72.7% in women (P=ns): specificity was 84.6% in men and 67.9% in women (P < 0.025). For individual coronary artery, the sensitivity in men and women was 87.7%, 81.8% for LAD; 78%, 83.3% for RCA and 52.2%, 46.7% for LCX (P=ns): the specificity was 80%, 40% for LAD (P<0.01), 82.5%, 68.4% for RCA, 88.9%, 86.4% for LCX (P=ns). The hemodynamic parameter after intravenous dipyridamole in men and women were significantly changed; the heart rate was increased and systolic, diastolic blood pressure was decreased. Adverse effects were reported in 58.8% of men and 72.7% in women (P=ns). The incidence of chest pain and headache were higher in women. There was no significant difference in the incidences of nausea, abdominal pain, dizziness, facial flushing, dyspnea. In conclusion, dipyridamole $^{99m}Tc$-MIBI myocardial SPECT is a safe, noninvasive test for evaluation of CAD. There was no gender difference to detect CAD, but more false-positive rate in women especially in the territory of LAD.

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Effective Index and Backup Techniques for HLR System in Mobile Networks (이동통신 HLR 시스템에서의 효과적인 색인 및 백업 기법)

  • 김장환;이충세
    • Journal of KIISE:Computing Practices and Letters
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    • v.9 no.1
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    • pp.33-46
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    • 2003
  • A Home Location Register(HLR) database system manages each subscriber's location information, which continuously changes in a cellular network. For this purpose, the HLR database system provides table management, index management, and backup management facilities. In this thesis, we propose using a two-level index method for the mobile directory number(MDN) as a suitable method and a chained bucket hashing method for the electronic serial number(ESN). Both the MDN and the ESN are used as keys in the HLR database system. We also propose an efficient backup method that takes into account the characteristics of HLR database transactions. The retrieval speed and the memory usage of the two-level index method are better than those of the R-tree index method. The insertion and deletion overhead of the chained bucket hashing method is less than that of the modified linear hashing method. In the proposed backup method, we use two kinds of dirty flags in order to solve the performance degradation problem caused by frequent registration-location operations. For a million subscribers, proposed techniques support reduction of memory size(more than 62%), directory operations (2500,000 times), and backup operations(more than 80%) compared with current techniques.

Evaluation of Dynamic Modulus based on Aged Asphalt Binder (아스팔트 바인더의 노화특성을 고려한 동탄성계수 평가)

  • Lee, Kwan-Ho;Cho, Kyung-Rae;Lee, Byung-Sik;Song, Yong-Seon
    • Journal of the Korean Society of Hazard Mitigation
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    • v.8 no.3
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    • pp.51-58
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    • 2008
  • Development of a new design guide which is based on empirical-mechanistic concept for pavement design is in action. It is called AASHTO 2002 Design Guide in USA and the KPRP(Korean Pavement Research Project) in Korea. The material characteristic of hot mix asphalt is a key role in the design guide. Therefore it is urgent to get a proper materials database, especially the dynamic modulus of hot mix asphalt. In this research, dynamic modulus test, which is based on aged asphalt binder, has been carried out and proposed the predicted equation of dynamic modulus. Nine different hot mix asphalt with three different asphalt binder have been used for the dynamic modulus test. Short-term aging, which is covers the time for the production of asphalt plant, transportation, lay-down, and compaction, can be simulated at $135^{\circ}C$ with 2 hour curing. Long-term aging has been carried out for a performance period of asphalt pavement. The dynamic modulus of asphalt pavement increases with aging time. As the nominal aggregate size increases, the change of dynamic modulus is not big.