• Nutrition Research and Practice
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• v.10 no.1
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• pp.11-18
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• 2016

BACKGROUND/OBJECTIVES: Type 2 diabetes (T2D) is more frequently diagnosed and is characterized by hyperglycemia and insulin resistance. $\small{D}$-xylose, a sucrase inhibitor, may be useful as a functional sugar complement to inhibit increases in blood glucose levels. The objective of this study was to investigate the anti-diabetic effects of $\small{D}$-xylose both in vitro and stretpozotocin (STZ)-nicotinamide (NA)-induced models in vivo. MATERIALS/METHODS: Wistar rats were divided into the following groups: (i) normal control; (ii) diabetic control; (iii) diabetic rats supplemented with a diet where 5% of the total sucrose content in the diet was replaced with $\small{D}$-xylose; and (iv) diabetic rats supplemented with a diet where 10% of the total sucrose content in the diet was replaced with $\small{D}$-xylose. These groups were maintained for two weeks. The effects of $\small{D}$-xylose on blood glucose levels were examined using oral glucose tolerance test, insulin secretion assays, histology of liver and pancreas tissues, and analysis of phosphoenolpyruvate carboxylase (PEPCK) expression in liver tissues of a STZ-NA-induced experimental rat model. Levels of glucose uptake and insulin secretion by differentiated C2C12 muscle cells and INS-1 pancreatic ${\beta}$-cells were analyzed. RESULTS: In vivo, $\small{D}$-xylose supplementation significantly reduced fasting serum glucose levels (P < 0.05), it slightly reduced the area under the glucose curve, and increased insulin levels compared to the diabetic controls. $\small{D}$-xylose supplementation enhanced the regeneration of pancreas tissue and improved the arrangement of hepatocytes compared to the diabetic controls. Lower levels of PEPCK were detected in the liver tissues of $\small{D}$-xylose-supplemented rats (P < 0.05). In vitro, both 2-NBDG uptake by C2C12 cells and insulin secretion by INS-1 cells were increased with $\small{D}$-xylose supplementation in a dose-dependent manner compared to treatment with glucose alone. CONCLUSIONS: In this study, $\small{D}$-xylose exerted anti-diabetic effects in vivo by regulating blood glucose levels via regeneration of damaged pancreas and liver tissues and regulation of PEPCK, a key rate-limiting enzyme in the process of gluconeogenesis. In vitro, $\small{D}$-xylose induced the uptake of glucose by muscle cells and the secretion of insulin cells by ${\beta}$-cells. These mechanistic insights will facilitate the development of highly effective strategy for T2D.

• The KIPS Transactions:PartD
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• v.10D no.2
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• pp.247-260
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• 2003

To share and standardize information, especially in the database environments, MDR (Metadata Registry) can be used to integrate various heterogeneous databases within a particular domain. But due to the discrepancies of data element representation between organizations, global information integration is not so easy. And users who are searching integrated information on the Web have limitation to obtain schema information for the underlying source databases. To solve those problems, in this paper, we present a 3-layered Information Integration System (LI2S) based on MDRs and Ontology. The purpose of proposed architecture is to define information integration model, which combine both of the nature of MDRs standard specification and functionality of ontology for the concept and relation. Adopting agent technology to the proposed model plays a key role to support the hierarchical and independent information integration architecture. Ontology is used as for a role of semantic network from which it extracts concept from the user query and the establishment of relationship between MDRs for the data element. (MDR and Knowledge Base are used as for the solution of discrepancies of data element representation between MDRs. Based on this architectural concept, LI2S was designed and implemented.

• Korean Journal of Construction Engineering and Management
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• v.21 no.4
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• pp.38-49
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• 2020

As the quality of life has been improving, people are getting higher interest and higher expectation for safety. However, the accident rate at the construction site is still high. Therefore, it is urgent to secure the safety at the construction work. Due to the nature of the construction industry, construction sites are directly exposed to the external environment. The possibility of accident occurrence is increased due to various factors such as the always variable processes, the diversity of manpower input, the increase in vulnerable class, and the danger of construction equipment..Particularly, the disasters occurring at the small- or medium-sized construction sites (budget ≤ 12 billion KRW) account for 88.9% of the total disasters at construction sites (73.4% for casualty). It was due to the lack of management caused by the absence of supervisors and insufficient safety measures. Moreover, it is difficult for the small- or medium-sized construction sites to apply basic safety measures such as safety education and safety facility installation by themselves in order to prevent disasters because they don't have sufficient safety organizations. It is because they have relatively less safety personnel and poorer technology system than large-sized construction sites. Therefore, in order to reduce accidents in construction, it is necessary to prevent accidents at the small- and medium-sized construction sites. From this point of view, the objectives of this study were to identify the key risk items causing accidents frequently by analyzing the accidents at construction sites and identifying problems associated with safety management, and to secure the safety at the small- and medium-sized construction sites.

• Korean Journal of Construction Engineering and Management
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• v.21 no.4
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• pp.62-71
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• 2020

Various studies on program management have been attempted due to recent changes in the environment of the construction market, and the importance of closure phase in each phase of the construction program is increasing. However, the reality is that the related research is insufficient and the field has been managed in a rule of thumb according to individual capabilities. Therefore, in order to successfully close the construction program and enhance satisfaction of stakeholders in the closure phase of the construction program, the key stakeholders were identified using the Power and Interest Matrix. The relative importance of the closure phase process was analyzed using AHP analysis method. It was also verified through on-site surveys and interviews about the proposed importance of the closure stakeholder and the relative importance of the process. It is expected that this study will increase the satisfaction of stakeholders and contribute to a successful closure if the user puts a lot of resources into the process that has a high priority in the closure phase of the construction program proposed in this study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.7-17
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• 2019

With increasing demand for large offshore infrastructures, suction cofferdams have been large, and the lid stiffener arrangement for a suction cofferdam has become a key element in cofferdam design to constrain the flexural deformation effectively. This study analyzed the changes in the structural behavior of a lid for a suction cofferdam due to lid stiffeners to provide insights into effective stiffener arrangements. By investigating conventional suction anchors, several stiffener patterns of a lid for a polygonal suction cofferdam were determined and analyzed. The structural performance of the stiffened lids was estimated by comparing the stress and deformation, and the reaction distributions on the edge of lid were investigated to analyze the effects of the stiffener arrangement on the lid-wall interface. Finite element analysis showed that radial stiffeners contribute dominantly to decreasing the stress and vertical deflection of the lids, but the stiffeners cause an increase in shear forces between the lid and wall; the forces are concentrated on the lid near the areas reinforced with radial stiffeners, which is negative to lid-wall connection design. On the other hand, inner and outer circumferential stiffeners show little reinforcement effects in themselves, while they can help reduce the stress and deformation when arranged with partial radial stiffeners simultaneously.

• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.289-296
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• 2019

In the era of M-ICT (mobile information communication technology), it is becoming more and more important to establish a city brand image that is "user-centered" and creates a new experience of "interaction between people, people and things, and people and space". The experience of city users on the brand image of a city is the key factor to determine the competitiveness of the city, among which the user's research on the touch point of the city brand is particularly important. The purpose of this study is to enhance the user's brand experience and enhance the city's brand competitiveness. The research methods of this paper are literature review and investigation. Firstly, the background and purpose of the study are expounded, then the characteristics and ways of user experience touch points are defined through the document review, and the multi-latitude composition model of city brand touch points is proposed. By means of user investigation, the structural characteristics of high frequency touch points between digital touch points and physical touch points are obtained. According to the problems found in the investigation, the optimal design strategy of touch point is put forward in combination with the case. The innovation of this study is to study the relationship between the city brand and the touch point of user experience from the perspective of user experience, and propose a multi-latitude model of the touch point of city brand.

• Journal of the Korea Society for Simulation
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• v.25 no.3
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• pp.107-116
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• 2016

The recent diversification in terms of the scope and techniques used for simulations has highlighted the importance of analyzing state of the art trends and applying these for educational and study purposes. While qualitative methods such as literature research or experts' assessments have previously been used, such methods are in fact likely to reflect the subjective viewpoint of experts, and to involve too much time and money for the results obtained. For the purpose of an objective analysis, a quantitative analysis that included the examination of topics found in domestic academic journal articles was conducted in the present study. In this regard, simulation was found to be most actively used domestically in the electrical and electronic fields. In addition, simulation was also found to be employed for the purpose of education and entertainment in the social sciences. The results of this study are expected to help to facilitate the prediction of the direction of the development of not only the Korea Society for Simulation, but also domestic simulation studies. This study also raises the possibility of applying text mining to trend analysis, and proves that it can be a useful method for deriving future key topics and helping experts' decisions regarding quantitative data.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.153-160
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• 2018

This article examines actions of the department of a university according to Higher Education Evaluation Policy as a case on the department of Christian education of A University. This article consists of background and policy Higher Education Evaluation and actions of the department of Christian education. Specialization, curriculum, management of instructional quality, educational achievement, student support and cooperation of local community as category of trends of the department of Christian education are discussed. Aim of education, model of human resource, educational objects, and key-competency as the specialization of department of Christian education are discussed. Curriculum of department suggests students career track which is related to their career. Positive guidance counseling are implemented for rate of recruit related to educational achievement. Non-subject matter program of University and Department are introduced for students's support. 60 hours of educational service and other educational activities are carried out for local community. Principal, chaplain of school and teachers are invited for educational practical affairs of education. The result of this article can be used as a basic reference for the direction of the higher education.

• Elastomers and Composites
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• v.40 no.2
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• pp.93-103
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• 2005

In this study, surface treatment of the elastomeric matrix was investigated to develop a substituting material for steel dynamic damper of automobile. The key technology is to get ultra high density elastomeric compound in order to substitute steel dynamic damper. The optimum matrix material(chloroprene rubber) and filler(metal powder) were selected for this. The several properties of elastomeric compound were examined. According to the results, the $t_{s2}$ of filled elastomeric compound was decreased with increasing the filler loading whereas the $t_{90}$ was increased. Also, tensile strength and rebound resilience were decreased with filler loading. To solve the problem of high filler loading, the photo grafting technique was employed on elastomeric matrix. The degree of grafting was determined by FTIR-ATR. Also, the filler surface was modified by chemical etching and the surface morphology was examine by SEM. After chemical treatment of filler, the particle size analyzer was used to examined the particle size, size distribution, and morphology of the modified filler.

• Nuclear Engineering and Technology
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• v.16 no.3
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• pp.141-154
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• 1984

An analysis is presented of key phenomena and scenario which imply some general trends for beyond design-basis-accident in Kori-1 PWR dry containment. The study covers a wide range of severe accident sequences initiated by small break LOCA. The MARCH computer code, with KAERI modifications was used in this analysis. The major emphasis of the paper are two folds, 1) the phenomenologic understanding of severe accident and 2) a study of H2 combustion and debris/ water interactions in a specific small break LOCA for Kori-1 plant. The sensitivity studies for the specific plant data and thermal interaction modelings used in the SASA were performed. The results show that if hydrogen burning does occur at low concentration, the resulting peak pressure does not exceed the design value, while the lower concentration assumption results in repeated burning due to the continuing H$_2$ generation. For debris/water interaction, the particle size has no effect on the magnitude of peak pressure for the amount of water assumed to be in the reactor cavity. But, the occurrence of peak pressure is considerably delayed in case of using the dryout correlation. The peak containment pressure predicted from the hydrogen combustion and steam pressure spite during full core meltdown scenario does not present a severe threat to the containment integrity.