• Journal of Life Science
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• v.33 no.10
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• pp.776-782
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• 2023

Silymarin, which is derived from dried Silybum marianum (milk thistle) seeds and fruits, possesses various beneficial properties, such as hepatoprotective, antioxidative, anti-inflammatory, and anticancer activity. This research aimed to explore the antioxidative activity of silymarin against oxidative stress and understand its molecular mechanism in RAW 264.7 cells. The study employed cell viability and reactive oxygen species (ROS) formation assays and western blot analysis. The results demonstrated that silymarin effectively reduced intracellular ROS levels induced by lipopolysaccharide (LPS) in a dose-dependent manner without causing any cytotoxic effects. Moreover, silymarin treatment significantly upregulated the expression of heme oxygenase (HO)-1, a phase II enzyme known for its potent antioxidative activity. Additionally, silymarin treatment significantly induced the expression of nuclear factor-erythroid 2 p45-related factor (Nrf) 2, a transcription factor responsible for regulating antioxidative enzymes, which was consistent with the upregulated HO-1 expression. To investigate the involvement of key signaling pathways in maintaining cellular redox homeostasis against oxidative stress, the phosphorylation status of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) was estimated by western blot analysis. The results showed that silymarin potently induced HO-1 expression, which was mediated by the phosphorylation of p38 MAPK. To further validate the antioxidative potential of silymarin-induced HO-1 expression, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was employed and attenuated by silymarin treatment, as identified by a selective inhibitor for each signaling molecule. In conclusion, silymarin robustly enhanced antioxidative activity by inducing HO-1 via the Nrf2/p38 MAPK signaling pathway in RAW 264.7 cells.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.68 no.3
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• pp.147-166
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• 2023

Seed color is controlled by several genes and is a key trait in determining the metabolite content and biological activities of legume genotypes. In this study, 296 adzuki bean accessions, including 159 grey, 99 red, and 38 white adzuki beans, were grown in Korea. Variations in total phenolic content (TPC), total saponin content (TSC), DPPH^• scavenging activity, ABTS^•+ scavenging activity, and ferric reducing antioxidant power (FRAP) were assessed and were reported to be in the ranges of 1.52-8.24 mg GAE/g, 14.36-114.22 mg DE/g, 0.23-12.84 mg AAE/g, 1.05-17.66 mg TE/g, and 0.59-13.14 mg AAE/g, respectively, with a wide variation across adzuki beans. Except for DPPH^• scavenging activity, the average values declined in the order gray > red > white adzuki beans, each demonstrating a significant variation (p < 0.05). White adzuki beans, which showed low metabolite content and antioxidant activity, were clearly separated from the gray and red genotypes using principal component and hierarchical cluster analyses. Moreover, TPC, TSC, and antioxidant activities were strongly correlated, regardless of seed color. Overall, the diversity of the TPC, TSC, and antioxidant activity in a broad population of adzuki bean genotypes was determined. Furthermore, this study found that seed color variation in adzuki beans had a significant effect on the metabolite content and antioxidant activity. Superior accessions with high levels of TPC, TSC, and antioxidant activity were also discovered and could be used for functional plant breeding and human consumption. The findings of this study may be useful for understanding the relationship between seed coat color and metabolite concentration in adzuki beans, paving the way for molecular-level analyses.

• Journal of the Korea Society of Computer and Information
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• v.28 no.12
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• pp.41-48
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• 2023

In this paper, we propose an analysis of recent trends in the NFT (Non-Fungible Token) industry using topic modeling techniques, focusing on their universal application across various industrial fields. For this study, patent data was utilized to understand industry trends. We collected data on 371 domestic and 454 international NFT-related patents registered in the patent information search service KIPRIS from 2017, when the first NFT standard was introduced, to October 2023. In the preprocessing stage, stopwords and lemmas were removed, and only noun words were extracted. For the analysis, the top 50 words by frequency were listed, and their corresponding TF-IDF values were examined to derive key keywords of the industry trends. Next, Using the LDA algorithm, we identified four major latent topics within the patent data, both domestically and internationally. We analyzed these topics and presented our findings on NFT industry trends, underpinned by real-world industry cases. While previous review presented trends from an academic perspective using paper data, this study is significant as it provides practical trend information based on data rooted in field practice. It is expected to be a useful reference for professionals in the NFT industry for understanding market conditions and generating new items.

• Journal of Ginseng Research
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• v.47 no.6
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• pp.726-734
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• 2023

Background: Skeletal muscles play a key role in physical activity and energy metabolism. The loss of skeletal muscle mass can cause problems related to metabolism and physical activity. Studies are being conducted to prevent such diseases by increasing the mass and regeneration capacity of muscles. Ginsenoside Rg5 has been reported to exhibit a broad range of pharmacological activities. However, studies on the effects of Rg5 on muscle differentiation and growth are scarce. Methods: To investigate the effects of Rg5 on myogenesis, C2C12 myoblasts were induced to differentiate with Rg5, followed by immunoblotting, immunostaining, and qRT-PCR for myogenic markers and promyogenic signaling (p38MAPK). Immunoprecipitation confirmed that Rg5 increased the interaction between MyoD and E2A via p38MAPK. To investigate the effects of Rg5 on prevention of muscle mass loss, C2C12 myotubes were treated with dexamethasone to induce muscle atrophy. Immunoblotting, immunostaining, and qRT-PCR were performed for myogenic markers, Akt/mTOR signaling for protein synthesis, and atrophy-related genes (Atrogin-1 and MuRF1). Results: Rg5 promoted C2C12 myoblast differentiation through phosphorylation of p38MAPK and MyoD/E2A heterodimerization. Furthermore, Rg5 stimulated C2C12 myotube hypertrophy via phosphorylation of Akt/mTOR. Phosphorylation of Akt induces FoxO3a phosphorylation, which reduces the expression of Atrogin-1 and MuRF1. Conclusion: This study provides an understanding of how Rg5 promotes myogenesis and hypertrophy and prevents dexamethasone-induced muscle atrophy. The study is the first, to the best of our knowledge, to show that Rg5 promotes muscle regeneration and to suggest that Rg5 can be used for therapeutic intervention of muscle weakness and atrophy, including cancer cachexia.

• KIPS Transactions on Computer and Communication Systems
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• v.11 no.6
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• pp.167-174
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• 2022

PIPO lightweight block ciphers were announced in ICISC'20. In this paper, a single-block optimization implementation and parallel optimization implementation of PIPO lightweight block cipher ECB, CBC, and CTR operation modes are performed on a 32-bit RISC-V processor. A single block implementation proposes an efficient 8-bit unit of Rlayer function implementation on a 32-bit register. In a parallel implementation, internal alignment of registers for parallel implementation is performed, and a method for four different blocks to perform Rlayer function operations on one register is described. In addition, since it is difficult to apply the parallel implementation technique to the encryption process in the parallel implementation of the CBC operation mode, it is proposed to apply the parallel implementation technique in the decryption process. In parallel implementation of the CTR operation mode, an extended initialization vector is used to propose a register internal alignment omission technique. This paper shows that the parallel implementation technique is applicable to several block cipher operation modes. As a result, it is confirmed that the performance improvement is 1.7 times in a single-block implementation and 1.89 times in a parallel implementation compared to the performance of the existing research implementation that includes the key schedule process in the ECB operation mode.

• Journal of the Korean GEO-environmental Society
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• v.24 no.12
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• pp.47-52
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• 2023

In order to efficiently maintain heat pipes operated by district heating operators, the facility history and damage history data built by the operator are used to identify key independent variables that are related to the occurrence of damage. Afterwards, the correlation with the frequency of damage was analyzed, and a basic model for estimating the frequency of damage was derived. Considering the correlation with the estimation model based on the use time currently being used by domestic and foreign district heating operators, a simple regression analysis basic model was presented as the independent variable with the highest correlation between continuous variables such as the use time, pipe diameter, burial depth, and insulation level of monitoring system, and the frequency of damage. The remaining independent variables were reflected as factors that modify and supplement the basic model. As a result of the analysis, as in previous research cases, it was confirmed that the analysis model between use time and frequency of damage had the highest correlation between the two variables and could be used as a basic model. Pipe diameter, burial depth, and insulation level of monitoring system information have also been confirmed to have a correlation with the frequency of damage, so they can be used as factors to supplement the basic model.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.85-96
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• 2023

In a reality where negative perceptions and social prejudices towards individuals with mental illnesses persist, the absence and lack of social support systems acquired through personal intimate social networks can be considered a significant hindrance to the quality of life for those with mental disorders. Therefore, this study examined the impact of the characteristics of social networks and social support on the life satisfaction of individuals with mental illnesses. A survey was conducted with 180 patients from seven mental health treatment facilities in the Daegu area. The data were analyzed using MANOVA, hierarchical multiple regression analysis, and Sobel test for mediation analysis with SPSS 25 software. The key findings of the study revealed that the intimacy aspect of social networks had a positive and significant effect on social support and life satisfaction. On the other hand, the size of the social network showed a negative influence on social support. Furthermore, social support partially mediated the relationship between the intimacy of social networks and life satisfaction, and it fully mediated the relationship between the size of social networks and life satisfaction. Based on these research outcomes, practical and policy-related recommendations are provided to enhance life satisfaction through increased social support for this population.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.525-530
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• 2023

Digital drawing subjects require the subdivision of evaluation elements and the graduality of evaluation according to the recent movement of the innovative curriculum. The purpose of this paper is to present the criteria for evaluating the drawing and to propose it as a rubric evaluation. In the text, criteria for beginner evaluation were technical skills such as the accuracy and consistency of the line, the ratio and balance of the picture, and the ability to effectively utilize various brushes and tools at the intermediate levels. In the advanced evaluation section, it is a part of a new perspective or originality centered on creativity and originality, and a unique perspective or interpretation of a given subject. In addition, as an understanding of design principles, the evaluation of completeness was derived focusing on the ability to actively utilize various functions of digital drawing software through design principles such as placement, color, and shape. The importance of introducing rubric evaluation is to allow instructors to make objective and consistent evaluations, and the key to research in rubric evaluation in these art subjects is to help learners clearly grasp their strengths and weaknesses, and learners can identify what needs to be improved and develop better drawing skills accordingly through feedback on each item.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.389-399
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• 2023

Recently, there has been a growing focus on the Entrepreneurial Intention of Chinese College Students as a key driver of motivational behavior. However, previous research has provided limited analysis on the actual impact of Social Support on the Entrepreneurial Intention of Chinese College Students. The purpose of this study is to enhance the Entrepreneurial Intention of Chinese College Students and to ascertain the mediating effect of Career Adaptability in the relationship between Social Support and Entrepreneurial Intention. Zhejiang Province, the top-ranked province in private economy in China, possesses a strong economic development momentum and an innovative entrepreneurial atmosphere. Therefore, this study selected 194 third and fourth-year undergraduate students from universities in Zhejiang Province as participants and collected data through a survey utilizing measures of Social Support, Career Adaptability, and Entrepreneurial Intention. The collected data was analyzed for correlations between the measured variables using SPSS 26 and Stata 17 SEM Builder for quantification and validation. The results of the study revealed that, firstly, while Social Support did not have a direct impact on Entrepreneurial Intention, it was found to have an indirect influence on Entrepreneurial Intention through Career Adaptability and its various sub-variables. Secondly, Social Support among College Students was found to have a positive impact on Career Adaptability. Thirdly, Career Adaptability among College Students was found to have a positive impact on Entrepreneurial Intention. Based on these analytical findings, this study provides theoretical and practical implications as well as fundamental information for entrepreneurship education and Career Adaptability at the university level.

• The Journal of the Convergence on Culture Technology
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• v.9 no.6
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• pp.589-594
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• 2023

K-POP plays a key role in the Korean Wave and is becoming more popular over time. In K-POP, K-POP dance plays an important role in increasing public interest and support and reflects the taste of the audience according to the rapidly changing times. In addition, it has a variety of unique choreography forms, such as point choreography and dance that is perfectly in sync associated with the lyrics of the song, so it has sufficient possibility to raise its status independently. In order to examine the fact that K-POP dance is not an element included in K-POP, this researcher tried to investigate the case of interest in -K-POP dance in various ways and to clarify the meaning of the existence of K-POP dance once again. K-POP dance is gaining international interest and support through the mass media through various examples, raising the awareness of choreographers. In addition, created the integration of various races and ages. It also continues to help the country's economic growth while expanding to education. It also serves as a cultural notification in that it promotes Korean culture and manners along with -K-POP dance. However, this researcher emphasizes that for the continuous growth and independence of K-POP dance in the future, a program to cultivate systematic educators are needed, and the efforts of K-POP dance educators and choreographers are needed accordingly.