• Journal of the Korean Chemical Society
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• v.52 no.5
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• pp.511-514
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• 2008

• Journal of applied mathematics & informatics
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• v.29 no.1_2
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• pp.327-335
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• 2011

Explicit formulas are given for the first and second Zagreb index, degree-distance and Wiener-type invariants of splice and link of graphs. As a consequence, the first and second Zagreb coindex of these classes of composite graphs are also computed.

• Parasites, Hosts and Diseases
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• v.54 no.1
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• pp.9-14
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• 2016

Tamoxifen is an antagonist of the estrogen receptor and currently used for the treatment of breast cancer. The current treatment of cutaneous leishmaniasis with pentavalent antimony compounds is not satisfactory. Therefore, in this study, due to its antileishmanial activity, effects of tamoxifen on the growth of promastigotes and amastigotes of Leishmania major Iranian strain were evaluated in vitro. Promastigotes and amastigotes were treated with different concentrations (1, 5, 10, 20, and $50{\mu}g/ml$) and time periods (24, 48, and 72 hr) of tamoxifen. After tamoxifen treatment, MTT assay (3-[4,5-dimethylthiazol-2-yl]-2,5 biphenyl tetrazolium bromide assay) was used to determine the percentage of live parasites and Graph Pad Prism software to calculate $IC_{50}$. Flow cytometry was applied to investigate the induction of tamoxifen-induced apoptosis in promastigotes. The half maximal inhibitory concentration ($IC_{50}$) of tamoxifen on promastigotes was $2.6{\mu}g/ml$ after 24 hr treatment. Flow cytometry analysis showed that tamoxifen induced early and late apoptosis in Leishmania promastigotes. While after 48 hr in control group the apoptosis was 2.0%, the $50{\mu}g/L$ concentration of tamoxifen increased it to 59.7%. Based on the in vitro antileishmanial effect, tamoxifen might be used for leishmaniasis treatment; however, further researches on in vivo effects of tamoxifen in animal models are needed.

• Steel and Composite Structures
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• v.26 no.4
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• pp.513-531
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• 2018

In this article, static, buckling and free vibration analyses of a sinusoidal micro composite beam reinforced by single-walled carbon nanotubes (SWCNTs) with considering temperature-dependent material properties embedded in an elastic medium in the presence of magnetic field under transverse uniform load are presented. This system is used at micro or sub micro scales to enhance the stiffness of micro composite structures such as bar, beam, plate and shell. In the present work, the size dependent effects based on surface stress effect and modified strain gradient theory (MSGT) are considered. The generalized rule of mixture is employed to predict temperature-dependent mechanical and thermal properties of micro composite beam. Then, the governing equations of motions are derived using Hamilton's principle and energy method. Numerical results are presented to investigate the influences of material length scale parameters, elastic foundation, composite fiber angle, magnetic intensity, temperature changes and carbon nanotubes volume fraction on the bending, buckling and free vibration behaviors of micro composite beam. There is a good agreement between the obtained results by this research and the literature results. The obtained results of this study demonstrate that the magnetic intensity, temperature changes, and two parameters elastic foundations have important effects on micro composite stiffness, while the magnetic field has greater effects on the bending, buckling and free vibration responses of micro composite beams. Moreover, it is shown that the effects of surface layers are important, and observed that the changes of carbon nanotubes volume fraction, beam length-to-thickness ratio and material length scale parameter have noticeable effects on the maximum deflection, critical buckling load and natural frequencies of micro composite beams.

• Structural Engineering and Mechanics
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• v.64 no.3
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• pp.361-379
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• 2017

In this article, the vibration behavior of double-bonded sandwich microplates with homogeneous core and nanocomposite facesheets reinforced by carbon nanotube and boron nitride nanotube under multi physical fields such as 2D magnetic and electric fields is investigated. Symmetric and un-symmetric distributions of nanotubes are considered for facesheets of sandwich microplates such as uniform distribution and various functionally graded distributions. The double-bonded sandwich microplates rest on visco-Pasternak foundation. Material properties of sandwich microplates are obtained by the extended rule of mixture. The sinusoidal shear deformation theory (SSDT) is employed to describe displacement fields of sandwich microplates. Also, the dimensionless natural frequency is obtained by classical plate theory (CPT) and compared with the obtained results by SSDT. It can be seen that the obtained dimensionless natural frequencies by CPT are higher than SSDT. In order to study the material length scale parameters, modified strain gradient theory at micro scale is utilized and then, the equations of motion are derived using Hamilton's principle. The effects of different parameters such as foundation parameters including Winkler, shear layer and damping coefficients, various distributions and volume fraction of nanotubes, core to facesheet thickness ratio, aspect and side ratios on the dimensionless natural frequencies are discussed in details. The results of present work can be used to optimum design and control of similar systems such as micro-electro-mechanical and nano-electro-mechanical devices.

• Steel and Composite Structures
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• v.36 no.6
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• pp.671-687
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• 2020

The aim of this research is to analyze buckling and bending behavior of a sandwich Reddy beam with porous core and composite face sheets reinforced by boron nitride nanotubes (BNNTs) and shape memory alloy (SMA) wires resting on Vlasov's foundation. To this end, first, displacement field's equations are written based on the higher-order shear deformation theory (HSDT). And also, to model the SMA wire properties, constitutive equation of Brinson is used. Then, by utilizing the principle of minimum potential energy, the governing equations are derived and also, Navier's analytical solution is applied to solve the governing equations of the sandwich beam. The effect of some important parameters such as SMA temperature, the volume fraction of SMA, the coefficient of porosity, different patterns of BNNTs and porous distributions on the behavior of buckling and bending of the sandwich beam are investigated. The obtained results show that when SMA wires are in martensite phase, the maximum deflection of the sandwich beam decreases and the critical buckling load increases significantly. Furthermore, the porosity coefficient plays an important role in the maximum deflection and the critical buckling load. It is concluded that increasing porosity coefficient, regardless of porous distribution, leads to an increase in the critical buckling load and a decrease in the maximum deflection of the sandwich beam.

• Steel and Composite Structures
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• v.23 no.5
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• pp.529-541
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• 2017

In the present study, vibration analysis of functionally graded carbon nanotube reinforced composite (FGCNTRC) plate moving in two directions is investigated. Various types of shear deformation theories are utilized to obtain more accurate and simplest theory. Single-walled carbon nanotubes (SWCNTs) are selected as a reinforcement of composite face sheets inside Poly methyl methacrylate (PMMA) matrix. Moreover, different kinds of distributions of CNTs are considered. Based on extended rule of mixture, the structural properties of composite face sheets are considered. Motion equations are obtained by Hamilton's principle and solved analytically. Influences of various parameters such as moving speed in x and y directions, volume fraction and distribution of CNTs, orthotropic viscoelastic surrounding medium, thickness and aspect ratio of composite plate on the vibration characteristics of moving system are discussed in details. The results indicated that thenatural frequency or stability of FGCNTRC plate is strongly dependent on axially moving speed. Moreover, a better configuration of the nanotube embedded in plate can be used to increase the critical speed, as a result, the stability is improved. The results of this investigation can be used in design and manufacturing of marine vessels and aircrafts.

• Structural Engineering and Mechanics
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• v.60 no.3
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• pp.489-505
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• 2016

Sinusoidal shear deformation theory (SSDT) is developed here for dynamic buckling of functionally graded (FG) nano-plates. The material properties of plate are assumed to vary according to power law distribution of the volume fraction of the constituents. In order to present a realistic model, the structural damping of nano-structure is considered using Kelvin-Voigt model. The surrounding elastic medium is modeled with a novel foundation namely as orthotropic visco-Pasternak medium. Size effects are incorporated based on Eringen'n nonlocal theory. Equations of motion are derived from the Hamilton's principle. The differential quadrature method (DQM) in conjunction with Bolotin method is applied for obtaining the dynamic instability region (DIR). The detailed parametric study is conducted, focusing on the combined effects of the nonlocal parameter, orthotropic visco-Pasternak foundation, power index of FG plate, structural damping and boundary conditions on the dynamic instability of system. The results are compared with those of first order shear deformation theory and higher-order shear deformation theory. It can be concluded that the proposed theory is accurate and efficient in predicting the dynamic buckling responses of system.

• Structural Engineering and Mechanics
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• v.63 no.1
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• pp.65-76
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• 2017

This research investigated the vibration frequency of sandwich plate made of piezoelectric fiber reinforced composite core (PFRC) and face sheets of piezomagnetic materials. The effective electroelastic constants for PFRC materials are obtained by the micromechanical approach. The resting medium of sandwich plate is modeled by Pasternak foundation including normal and shear modulus. Besides, sandwich plate is subjected to linearly varying normal stresses that change by load factor. The coupled equations of motion are derived using first order shear deformation theory (FSDT) and energy method. These equations are solved by differential quadrature method (DQM) for simply supported boundary condition. A detailed numerical study is carried out based on piezoelectricity theory to indicate the significant effect of load factor, volume fraction of fibers, modulus of elastic foundation, core-to-face sheet thickness ratio and composite materials on dimensionless frequency of sandwich plate. These findings can be used to aerospace, building and automotive industries.

• Smart Structures and Systems
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• v.22 no.1
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• pp.105-120
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• 2018

In this paper, the nonlinear free and forced vibration responses of sandwich nano-beams with three various functionally graded (FG) patterns of reinforced carbon nanotubes (CNTs) face-sheets are investigated. The sandwich nano-beam is resting on nonlinear Visco-elastic foundation and is subjected to thermal and electrical loads. The nonlinear governing equations of motion are derived for an Euler-Bernoulli beam based on Hamilton principle and von Karman nonlinear relation. To analyze nonlinear vibration, Galerkin's decomposition technique is employed to convert the governing partial differential equation (PDE) to a nonlinear ordinary differential equation (ODE). Furthermore, the Multiple Times Scale (MTS) method is employed to find approximate solution for the nonlinear time, frequency and forced responses of the sandwich nano-beam. Comparison between results of this paper and previous published paper shows that our numerical results are in good agreement with literature. In addition, the nonlinear frequency, force response and nonlinear damping time response is carefully studied. The influences of important parameters such as nonlocal parameter, volume fraction of the CNTs, different patterns of CNTs, length scale parameter, Visco-Pasternak foundation parameter, applied voltage, longitudinal magnetic field and temperature change are investigated on the various responses. One can conclude that frequency of FG-AV pattern is greater than other used patterns.