• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2009년도 춘계학술대회 논문집
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• pp.354-359
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• 2009

Land cover types of Hustai National Park (HNP) in Mongolia, a hotspot area with rare species, were classified and their temporal changes were evaluated using Landsat MSS TM/ETM data between 1994 and 2000. Maximum likelihood classification analysis showed an overall accuracy of 88.0% and 85.0% for the 1994 and 2000 images, respectively. Kappa coefficients associated with the classification were resulted to 0.85 for 1994 and 0.82 for 2000 image. Land cover types revealed significant temporal changes in the classification maps between 1994 and 2000. The area has increased considerably by $166.5km^2$ for mountain steppe. By contrast, agricultural areas and degraded areas affected by human being activity were decreased by $46.1km^2$ and $194.8km^2$ over the six year span, respectively. These areas were replaced by mountain steppe area. Specifically, forest area was noticeably fragmented, accompanied by the decrease of $\sim400$ ha. The forest area revealed a pattern with systematic gain and loss associated with the specific phenomenon called as forest free-south slope. We discussed the potential environmental conditions responsible for the systematic pattern and addressed other biological impacts by outbreaks of forest pests and ungulates.

• Journal of Mechanical Science and Technology
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• 제20권8호
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• pp.1256-1265
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• 2006

The supersonic flows around tandem cavities were investigated by two-dimensional and three-dimensional numerical simulations using the Reynolds-Averaged Navier-Stokes (RANS) equation with the k- ω turbulence model. The flow around a cavity is characterized as unsteady flow because of the formation and dissipation of vortices due to the interaction between the freestream shear layer and cavity internal flow, the generation of shock and expansion waves, and the acoustic effect transmitted from wake flow to upstream. The upwind TVD scheme based on the flux vector split with van Leer's limiter was used as the numerical method. Numerical calculations were performed by the parallel processing with time discretizations carried out by the 4th-order Runge- Kutta method. The aspect ratios of cavities are 3 for the first cavity and 1 for the second cavity. The ratio of cavity interval to depth is 1. The ratio of cavity width to depth is 1 in the case of three dimensional flow. The Mach number and the Reynolds number were 1.5 and $4.5{\times}10^5$, respectively. The characteristics of the dominant frequency between two- dimensional and three-dimensional flows were compared, and the characteristics of the second cavity flow due to the first cavity flow was analyzed. Both two dimensional and three dimensional flow oscillations were in the 'shear layer mode', which is based on the feedback mechanism of Rossiter's formula. However, three dimensional flow was much less turbulent than two dimensional flow, depending on whether it could inflow and outflow laterally. The dominant frequencies of the two dimensional flow and three dimensional flows coincided with Rossiter's 2nd mode frequency. The another dominant frequency of the three dimensional flow corresponded to Rossiter's 1st mode frequency.

• 대한수의학회지
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• 제36권4호
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• pp.941-948
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• 1996

The accuracy of rectal palpation and ultrasonography for predicting the presence of a functional corpus luteum in subestrous dairy cows was investigated, using the result of a radioimmunoassay for progesterone in plasma. Luteal status (high or low progesterone concentrations) was diagnosed in 820 cows, using rectal palpation and B-mode transrectal ultrasonography, and the results of rectal palpation and ultrasonography were compared in $2{\times}2$ contingency table with plasma progesterone concentrations. A $2{\times}2$ contingency table analysis allowed the calculation of sensitivity, specificity and predictive values for rectal palpation and ultrasonography. The sensitivity, specificity, predictive value of a positive test and predictive value of a negative test were 81.9%, 67.5%, 79.0% and 71.4% for rectal palpation, and 96.3%, 88.8%, 94.5% and 92.4% for ultrasonography, respectively. The percentages of observed agreement and expected agreement between rectal palpation and ultrasonography were 71.8% and 57.1%, respectively. An evaluation of agreement between rectal palpation and ultrasonography, the value of Kappa was 0.34. It was concluded that a ultrasonography was more sensitive and specific than rectal palpation in predicting the presence of a functional corpus luteum. Therefore, ultrasonographic examination is a reliable method for assessing the functional status of ovarian structures in subestrous dairy cows.

• Journal of Preventive Medicine and Public Health
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• 제45권4호
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• pp.251-258
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• 2012

Objectives: The purpose of this paper was to elucidate the potential methylation levels of adjacent normal and cancer tissues by comparing them with normal colorectal tissues, and to describe the correlations between the methylation and clinical parameters in Korean colorectal cancer (CRC) patients. Methods: Hypermethylation profiles of nine genes (RASSF1, APC, $p16^{INK4a}$, Twist1, E-cadherin, TIMP3, Smad4, COX2, and ABCB1) were examined with 100 sets of cancer tissues and 14 normal colorectal tissues. We determined the hypermethylation at a given level by a percent of methylation ratio value of 10 using quantitative methylation real-time polymerase chain reaction. Results: Nine genes' hypermethylation levels in Korean CRC patient tissues were increased more higher than normal colorectal tissues. However, the amounts of $p16^{INK4a}$ and E-cadherin gene hypermethylation in normal and CRC tissues were not significantly different nor did TIMP3 gene hypermethylation in adjacent normal and cancer tissues differ significantly. The hypermethylation of TIMP3, Ecadherin, ABCB1, and COX2 genes among other genes were abundantly found in normal colorectal tissues. The hypermethylation of nine genes' methylation in cancer tissues was not significantly associated with any clinical parameters. In Cohen's kappa test, it was moderately observed that RASSF1 was related with E-cadherin, and Smad4 with ABCB1 and COX2. Conclusions: This study provides evidence for different hypermethylation patterns of cancer-associated genes in normal and CRC tissues, which may serve as useful information on CRC cancer progression.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2018년도 학술발표회
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• pp.316-316
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• 2018

전 세계적으로 다양한 기후변화로 인해 홍수나 가뭄이 자주 발생하고 있다. 이러한 변화에 대응하기 위해 하천관리가 필요하며 효율적인 하천관리를 위해서는 직접유출뿐만 아니라 기저유출에 대한 관리가 필요하다. 건기 및 청천시의 하천유량의 대부분을 구성하는 기저유출은 하천의 건천화와 가뭄 등을 해결하는데 중요한 역할을 한다. 그러나 땅 속을 이동하는 기저유출의 특성상 정확한 측정이 어려워 직접유출에 비해 제한적으로 연구가 수행되어왔다. 특히 유역의 토지이용변화와 기후변화에 따른 기저유출 변화 특성에 대한 연구는 더욱 미비하다. 따라서 본 연구에서는 토지이용변화를 평가한 후 기후변화 시나리오를 이용하여 기후변화와 토지이용 변화에 따른 기저유출 특성을 분석하고자 한다. 우선적으로 갑천 유역에서의 유출량 모의를 위해 장기간 유역단위 유출 및 수질 모의가 가능한 SWAT모델을 사용하였다. 모의된 유출량은 자동보정모듈인 SWAT-CUP을 통해 검 보정을 수행하였다. 그리고 토지이용과 토지이용변화 요소간의 관계를 정량화하여 토지이용변화를 모의할 수 있는 CLUE-S모델을 통해 미래 토지이용변화 자료를 구축하여 SWAT모델의 입력자료로 사용하였다. 또한 기후변화 시나리오인 RCP 시나리오를 SWAT모델 내 기상 입력자료로 사용하였다. 최종적으로 모의 된 미래 유출량은 직접유출과 기저유출 분리가 가능한 WHAT 시스템의 입력자료로 사용하여 미래 토지이용변화와 기후변화를 고려한 기저유출량을 분석하였다. CLUE-S모델을 이용하여 미래 토지이용변화를 예측한 결과 Kappa 값이 0.5 이상으로 미래의 토지이용을 잘 예측하는 것으로 나타났다. 또한 SWAT모델을 통해 모의된 유출량 검 보정 결과 $R^2$와 NSE가 0.7 이상이므로 모델이 자연현상을 잘 모의하는 것으로 판단된다. 미래 토지이용변화와 기후변화가 적용된 SWAT모델을 통해 모의된 유출량을 WHAT 시스템에 적용하여 미래 기저유출을 분석한 결과 도시의 증가, 농지의 감소 그리고 미래 극한사상에 따른 첨두유출량의 증가로 인해 전반적으로 직접유출은 증가하고 기저유출은 감소하는 경향을 보였다. 본 연구의 결과는 향후 다양한 토지이용변화와 기후변화를 고려한 갑천 유역에서의 기저유출 특성을 파악하는 연구의 기초자료로 활용될 수 있을 것이며 향후 도시화 및 가뭄이나 건기 시 효율적인 하천관리 방안을 수립하는데 방향을 제시 할 수 있을 것이라 판단된다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2018년도 학술발표회
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• pp.251-251
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• 2018

도로설계기준(2012)에 따르면 노면 배수시설은 측구, 집수정, 배수관, 배수구(빗물받이, 맨홀) 등으로 구성되며 중앙분리대 배수에서 구조가 방호벽일 경우 원칙적으로 집수정과 종배수관, 횡배수관을 설치하여 노면수를 배수한다. 최근 기후변화에 따른 국지성 집중호우로 교량 배수시설의 배수능력 부족으로 교량의 노후화, 노면의 체수와 수막현상을 야기한다. 교량 설계 시, 교량의 외관은 점배수에 의한 배수불량으로 막힘부에서의 식물생육, 부식, 배수구의 오염 등으로 심미성에 악영향을 미치고 있다. 따라서 국토교통부 도로 배수시설 설계 및 관리지침에서는 기존의 집수정으로 유도하여 배수하는 점배수 형태에서 우수의 지체시간을 저감하기 위해 배수구로 즉시 배수되어 배수 효율을 증가시켜주는 선배수시설을 권장하고 있다. 그러나 선배수 구조의 일반적인 내용만을 기술하고 있으므로 보다 상세한 설계기준이 필요하다. 또한 국내에서는 교면 배수를 위한 횡배수구의 배수능력에 관한 설계 개념은 미국의 빗물받이 설계 개념을 그대로 적용하고 있어서 교량 배수시설의 배수능력 증대를 위한 수치 및 수리실험에 관한 기술적인 자료가 부족한 실정이다. 따라서 도로의 흐름해석 및 선배수를 위한 측구 횡배수관의 흐름개선에 관한 구체적인 연구가 필요한 실정이다. 본 연구에서는 배수로 전반의 유향 분석 및 횡유입관 유입부에서의 상세한 흐름해석과 통수능력을 분석하기 위해서는 수리실험을 통한 연구가 필요한 실정이다. 그러나 최적 횡배수관의 형상 및 간격 설정에 대한 수리실험의 물리적 및 시간적 한계를 극복하기 위해 Fluent 모형(Ansys Workbench 13.0)을 활용한 수치모의를 수행하여 모형의 적용성을 검토하였다. 다상유동 해석을 위해 VOF(Volume of Fluid)방법을 적용하였고, 수치해석 방법으로는 비정상류, 난류 모형으로는 standard ${\kappa}-{\varepsilon}$모형을 적용했다. 도로 형상에 따른 우수유출량을 비교 분석하기 위하여 횡경사는 2%로 고정하고 종경사를 2%로 선정하여 수치모의를 통한 배수능력을 분석하고 설계에 직접적인 적용성을 검토하였다. 횡배수관의 간격변화 및 배수공의 위치 변화 등에 따른 차집량을 분석하였으며, 개략적인 수리실험 결과와 수치모의의 차집율을 비교 및 분석하여 Fluent 모형의 적용성을 확인하였다. 또한, 횡배수관의 유입부에서의 유속 변화 및 유출부에서의 유속이 모의가 가능하므로 배수시설에서 보다 정확한 흐름 해석이 가능하여 보다 적정한 배수능력 분석이 가능할 것으로 판단된다.

• 대한조선학회논문집
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• 제47권5호
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• pp.647-655
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• 2010

In this paper, a numerical study is carried out for super-pipe, flat plate and axisymmetric body flows to investigate a validity of using wall function and high $y_1^+$ in calculation of high Reynolds number flow. The velocity profiles in boundary layer agree well with the law of the wall. And it is found that the range of $y^+$��which validated the logarithmic law of the wall grows with increasing Reynolds number. From the result, an equation is suggested that can be used to estimate a maximum $y^+$ value of validity of the log law. And the slope(1/$\kappa$) of the log region of the numerical result is larger than that of experimental data. On the other hand, as $y_1^+$ is increasing, both the friction and the pressure resistances tend to increase finely. When using $y_1^+$ value beyond the range of log law, the surface shear stress shows a significant error and the pressure resistance increases rapidly. However, when using $y_1^+$ value in the range, the computational result is reasonable. From this study, the use of the wall function with high value of $y_1^+$ can be justified for a full scale Reynolds number ship flow.

• 생약학회지
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• 제52권4호
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• pp.242-250
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• 2021

Artemisia frigida Willd (AW, Fringed sagewort), which is widespread in Mongolia, is a well-known medicinal plant as a member of the Compositae family. This study aims to explore the gastroprotective effect of water extract of AW on 150 mM HCl/60% ethanol-induced acute gastritis in 5 week old male ICR mice. Total polyphenols, total flavonoid contents, and anti-oxidant activity in vitro in AW were evaluated. First, the gross area of gastric mucosal damage was measured. Then western blot analysis was conducted to determine the possible mechanisms of action underlying the effects of AW. AW administration decreased gastric mucosal damage. Moreover, the group with AW treatment effectively inhibited nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression associated with oxidative stress. AW treatment enhanced an anti-oxidant effect through the increase of anti-oxidant proteins. Besides, the increased expressions of inflammatory cytokines induced by nuclear factor-kappa B (NF-κB) activation are alleviated through AW treatment. Taken together, AW exerted a gastroprotective effect against gastric mucosal damage. These results indicate that AW could have the potential used as a natural therapeutic drug for the treatment of acute gastritis.

• 대한한의학방제학회지
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• 제29권4호
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• pp.205-227
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• 2021

Objectives : Jigal-san (JGS, 止渴散) has been used in East Asia including Korea, Japan and China for the treatment of breast inflammatory disorders and severe thirst. JGS originated from Euimunpalbeob (醫門八法; Yimenbafa) composed of Lonicerae Flos and Taraxaci Herba. According to previous studies Lonicerae Flos and Taraxaci Herba have an anti-inflammatory effect, respectively. But, there is no studies regarding on the effects of JGS in the immunological activities. The present study evaluated the anti-inflammatory effects of JGS in vitro and in vivo. Methods : Cell viability was evaluated by MTT assay, and NO was evaluated by content of the nitrite content in culture medium. TNF-α, IL-1β and IL-6 were quantified by ELISA. The protein expression of NF-κB, MAPKs, and iNOS were assessed by western blot analysis. Furthermore, the effects of JGS on acute inflammation were observed in rat paw edema model. Results : The JGS ameliorates the LPS-activated changes in the protein expression of NF-κB, p-JNK, and iNOS, as well as the production of NO and pro-inflammatory cytokines. In rat paw edema study, administration of 0.3 and 1.0 g/kg of JGS for 4 consecutive days inhibited the carrageenan (CA)-induced increases of edema and iNOS expression. Conclusions : These results demonstrate that JGS has anti-inflammatory effect in LPS-stimulated RAW 264.7 cells through decreasing the production of inflammatory mediators, via suppression of the NF-κB and MAPK pathways (JNK, not p-38 and ERK). In addition, the results of the CA-induced paw edema indicate that JGS ameliorates an inflammatory edema. Therefore, the present study could provide scientific evidence for the anti-inflammatory effect of JGS as well as the underlying mechanisms.

• Restorative Dentistry and Endodontics
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• 제44권2호
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• pp.17.1-17.10
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• 2019

Objectives: Root resorption is an unexpected complication after replantation procedures. Combining anti-osteoclastic medicaments with retrograde root filling materials may avert this resorptive activity. The purpose of this study was to assess effects of a cathepsin K inhibitor with calcium silicate-based cements on osteoclastic activity. Methods: MC3T3-E1 cells were cultured for biocompatibility analyses. RAW 264.7 cells were cultured in the presence of the receptor activator of nuclear factor-kappa B and lipopolysaccharide, followed by treatment with Biodentine (BIOD) or ProRoot MTA with or without medicaments (Odanacatib [ODN], a cathepsin inhibitor and alendronate, a bisphosphonate). After drug treatment, the cell counting kit-8 assay and Alizarin red staining were performed to evaluate biocompatibility in MC3T3-E1 cells. Reverse-transcription polymerase chain reaction, tartrate-resistant acid phosphatase (TRAP) staining and enzyme-linked immunosorbent assays were performed in RAW 264.7 cells to determine the expression levels of inflammatory cytokines, interleukin $(IL)-1{\beta}$, IL-6, tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and prostaglandin E2 (PGE2). Data were analyzed by one-way analysis of variance and Tukey's post hoc test (p < 0.05). Results: Biocompatibility results showed that there were no significant differences among any of the groups. RAW 264.7 cells treated with BIOD and ODN showed the lowest levels of $TNF-{\alpha}$ and PGE2. Treatments with BIOD + ODN were more potent suppressors of inflammatory cytokine expression (p < 0.05). Conclusion: The cathepsin K inhibitor with calcium silicate-based cement inhibits osteoclastic activity. This may have clinical application in preventing inflammatory root resorption in replanted teeth.