• 제목/요약/키워드: Kangwon National University

검색결과 16,144건 처리시간 0.053초

Flavonoid Glycosides as Acetylcholinesterase Inhibitors from the Whole Plants of Persicaria thunbergii

  • Kim, Se Young;Park, Jun Young;Park, Pil Sung;Bang, Sang Ho;Lee, Kyung Min;Lee, Yu Ra;Jang, Yong Hyun;Kim, Myong Jo;Chun, Wanjoo;Heo, Moon Young;Kwon, Yongsoo
    • Natural Product Sciences
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    • 제20권3호
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    • pp.191-195
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    • 2014
  • The n-BuOH soluble fraction of the whole plant of Persicaria thungergii showed acetylcholinesterase inhibitory activity. Four flavonoid glycosides and a flavonoid were isolated from this fraction, and identified as quercitrin (1), luteolin-4'-O-${\beta}$-D-glucopyranoside (2), quercetin (3), quercetin-3-O-glucuronide (4), and isorahmnetin-3-O-glucuronid (5), by chromatographed and spectral data, respectively. All isolated compounds were showed acetylcholinesterase inhibitory activity, with $IC_{50}$ values of 243.1, 10.5, 39.1, 8.2 and $23.2{\mu}M$, respectively.

정신지체환자에서 발생한 Streptococcus constellatus와 혐기성 균에 의한 거대 농흉 1예 (A Case of Massive Empyema Caused by Streptococcus constellatus and Anaerobic Bacteria for Mental Retardation)

  • 김경현;김세현;허정원;이상훈;한선숙;이승준;김우진
    • Tuberculosis and Respiratory Diseases
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    • 제71권6호
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    • pp.476-479
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    • 2011
  • The Streptococcus milleri group, which also includes S. anginosus, S. intermedius and S. constellatus, is found in the oropharynx, upper respiratory tract, gastrointestinal tract, and urogenital tract mucosa. Bacteria in the Streptococcus milleri group are associated with bacteremia and abscess formation. Most of the reports of of Streptococcus milleri group (SMG) infection occur in patients with underlying medical conditions. Predisposing factors that have been associated with S. milleri group empyema include mucosal disturbances (sinusitis, periodontal disease, enteric disease), preceding to pneumonia, thoracic surgery, malignancy, neurological disease, alcohol abuse, and also diabetes mellitus. We report on a 42-year-old man with mental retardation. He who suffered from dyspnea and a fever that he had developed for over 14 days. S. constellatus and anaerobic bacterias (Prevotella buccae and Micromonas micros) were cultured. The patient was treated with the drainage of pleural effusion and clindamycin and levofloxacin.

Regioselective Addition Reactions of the Organoindium Reagents onto α,β-Unsaturated Ketones

  • Lee, Phil-Ho;Kim, Hyun;Lee, Koo-Yeon;Seomoon, Dong;Kim, Sun-Dae;Kim, Hee-Chul;Kim, Hyun-Seok;Lee, Mi-Ae;Shim, Eun-Kyong;Lee, Seok-Ju;Kim, Mi-Sook;Han, Mi-Jeong;Noh, Kwang-Hyun;Sridhar, Madabhushi
    • Bulletin of the Korean Chemical Society
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    • 제25권11호
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    • pp.1687-1691
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    • 2004
  • Regioselectivity on the reactions of ${\alpha},{\beta}$--enones with organoindium such as in situ generated allylindium and allenylindium was systematically studied in the presence of TMSCl as an additive. Treatment of 2-cyclohexen-1-one, carvone, 2-cyclohepten-1-one, and chalcone with allylindium reagent produced 1,4-addition products in good yields, while 2-cyclopenten-1-one, 2-methyl-2-cyclopenten-1-one, 4,4-dimethylcyclohexen-1-one, 3-nonen-2-one, 4-hexen-3-one, and 4-phenyl-3-buten-2-one afforded 1,2-addition products. Indium reagent derived from indium and propargyl bromide in Grignard type gave addition products in good yields, under which the successive addition of ${\alpha},{\beta}$-enone and TMSCl were necessary. Although organoindium reagent derived from propargyl bromide produced propargylated compound in Grignard type except 2-cyclohepten-1-one, indium reagent obtained from 1-bromo-2-butyne having ${\gamma}$-methyl group gave allenylated product inBarbier type.

강원의료융합 인재양성을 위한 산학협동 모델 (An Industry-Academia Cooperations Model for Kangwon Medical Convergence)

  • 권호열;최세훈;김용석;조동하;이정형;김헌영
    • 한국정보처리학회:학술대회논문집
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    • 한국정보처리학회 2010년도 춘계학술발표대회
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    • pp.284-286
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    • 2010
  • 본 논문에서는 강원의료융합인재양성센터의 맞춤형 산학협동 교육강좌와 의료융합분야 전략기술포럼 등의 사업을 주관하는 조직으로서 강원의료융합아카데미의 설립과 구성에 대하여 소개하고, 강원의료융합인재양성센터 참여 학과와 가족 회사를 대상으로 산업체의 전문가와 교수들이 실제 의료융합 제품설계과정에 대한 이론 및 기술, 개발과정을 소개하는 의료융합 산학협동 특강의 구현사례를 소개한다.