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Flavonoid Glycosides as Acetylcholinesterase Inhibitors from the Whole Plants of Persicaria thunbergii  

Kim, Se Young (College of Pharmacy, Kangwon National University)
Park, Jun Young (College of Pharmacy, Kangwon National University)
Park, Pil Sung (College of Pharmacy, Kangwon National University)
Bang, Sang Ho (College of Pharmacy, Kangwon National University)
Lee, Kyung Min (College of Pharmacy, Kangwon National University)
Lee, Yu Ra (College of Pharmacy, Kangwon National University)
Jang, Yong Hyun (College of Pharmacy, Kangwon National University)
Kim, Myong Jo (Oriental Bio-Herb Research Institute, Kangwon National University)
Chun, Wanjoo (College of Medicine, Kangwon National University)
Heo, Moon Young (College of Pharmacy, Kangwon National University)
Kwon, Yongsoo (College of Pharmacy, Kangwon National University)
Publication Information
Natural Product Sciences / v.20, no.3, 2014 , pp. 191-195 More about this Journal
Abstract
The n-BuOH soluble fraction of the whole plant of Persicaria thungergii showed acetylcholinesterase inhibitory activity. Four flavonoid glycosides and a flavonoid were isolated from this fraction, and identified as quercitrin (1), luteolin-4'-O-${\beta}$-D-glucopyranoside (2), quercetin (3), quercetin-3-O-glucuronide (4), and isorahmnetin-3-O-glucuronid (5), by chromatographed and spectral data, respectively. All isolated compounds were showed acetylcholinesterase inhibitory activity, with $IC_{50}$ values of 243.1, 10.5, 39.1, 8.2 and $23.2{\mu}M$, respectively.
Keywords
Persicaria thunbergii; Flavonoids; Acetylcholinesterase inhibitory activity;
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1 Prince, M.; Bryce, R.; Albanese, E.; Wimo, A.; Ribeiro W.; Ferri, C. P. Alzheimer Dementia, 2013, 9, 63-75.   DOI   ScienceOn
2 Roberson, R. M.; Harrell, E. L. Brain Res. Rev., 1997, 25, 50-69.   DOI   ScienceOn
3 Mattson, P. M. J. Neurovirol. 2002, 8, 539-550.   DOI
4 Akiyama, H.; Barger, S.; Barnum, S.; Bradt, B.; Bauer, J.; Cole, M. G; Cooter, R. N.; Eikelenboom, P.; Emmerling, M.; Fiebich, L. B.; Finch, E. C.; Frautschy, S.; Griffin, W. S. T.; Hampel, H.; Hull, M.; Landreth, G.; Lue, L. F.; Mrak, R.; Mackenzie, R. E.; McGeer, L. P.; O'Manion, M. K.; Pachter, J.; Painetti, G.; Plata-Salman, C.; Rogers, J.; Rydel, R.; Shen, Y.; Streit, W.; Strohmeyer, R.; Tooyoma, I.; Muiswinkel, V. L. F.; Veerhuis, R.; Walker, D.; Webster, S.; Wegrzyniak, B.; Wenk, G.; Wyss-Coray, T. Neurobiol. Aging, 2000, 21, 383-421.   DOI   ScienceOn
5 Bartus, R. T.; Dean III, R. L.; Beer, B.; Lippa, A. S. Science, 1982, 217, 408-416.   DOI
6 Coyle, J. T.; Price, D. L.; DeLong, M. R. Science, 1983, 219, 1184-1190.   DOI
7 Mukherjee, P. K.; Kumar, V.; Mal, M.; Houhton, P. J. Phytomedicine, 2007, 14, 289-300.   DOI   ScienceOn
8 Mohle, B.; Heller, W.; Wellmann, E. Phytochemistry, 1985, 24, 465-467.   DOI   ScienceOn
9 Granica, S.; Czerwinska, M. E.; Zyzynska-Granica, B.; Kiss, A. K. Fitotherapia, 2013, 91, 180-188.   DOI   ScienceOn
10 Kim, D. K. Arch. Pharm. Res. 2002, 25, 817-819.   DOI   ScienceOn
11 Lopez, S.; Bastida, J.; Viladomat, F.; Codina, C. Life Sci. 2002, 71, 2521-2529.   DOI   ScienceOn
12 Tang, X. C.; Kindel, G. H.; Kozikowski, A. P.; Hanin, I. J. Ethnopharamcol. 1994, 44, 147-155.   DOI   ScienceOn
13 Kim, D. K.; Lim, J. P.; Yang, J. H.; Yang, J. H..; Eom, D. O.; Eun, J. S.; Leem, K. H. Arch. Pharm. Res. 2002, 25, 856-859.   DOI   ScienceOn
14 Kang, S. Y.; Lee, K. Y.; Sung, S. H.; Park, M. J.; Kim, Y. C. J. Nat. Prod. 2001, 64, 683-685.   DOI   ScienceOn
15 Tareq, M.; Khan H.; Orhan, I.; Senol, F. S.; Kartal, M.; Sener, B.; Dvorska, M.; Smejkal, K.; Slapetova, T. Chemic-Biological Interactions, 2009, 181, 383-389.   DOI   ScienceOn
16 Dohi, S.; Terasaki, M.; Makino, M. J. Agric. Food Chem. 2009, 57, 4313-4318.   DOI   ScienceOn
17 Sim, J. Y.; Kim, M. A.; Kim, M. J.; Chun, W.; Kwon, Y. Nat. Prod. Sci. 2013, 20, 13-16.
18 Uriarte-Pueyo, I.; Calvo, M. I. Curr. Med. Chem., 2011, 18, 5289-5302.   DOI   ScienceOn
19 Fan, P.; Hay, A. E.; Marston, A.; Hostettmann, K. Pharm. Biol. 2008, 46, 596-601.   DOI   ScienceOn
20 Kim, J. Y.; Lee, W. S.; Kim, Y. S.; Curtis-Long, M. J.; Lee, B. W.; Ryu, Y. B.; Park, K. H. J. Agric. Food Chem. 2011, 59, 4589-4596.   DOI   ScienceOn
21 Hernadez, M. F.; Fale, P. L. V.; Araujo, M. E. M.; Serralheiro, M. L. M. Food Chem. 2010, 120, 1076-1082.   DOI   ScienceOn
22 Editorial Committee of Zhong Hua Ben Cao of State Administration of Traditional Chinese Medicine of People's Republic of China, Zhong Hua Ben Cao, Shanghai Science and Technology Press, Shanghai, 1999, Vol. 2, p 696.
23 Houghton, P. J.; Ren, Y.; Howes, M. J. Nat. Prod. Rep. 2006, 23, 181-199.   DOI   ScienceOn
24 Anad, P.; Singh, B. Arch. Pharm. Res., 2013, 36, 375-399.   DOI   ScienceOn
25 Lee, W. T. Colored standard illustrations of Korean plants, Academy press: Seoul, 1996; p 79.
26 Lee, K. T.; Ku, C. H.; Eun, J. S.; Shin, T. Y.; Lim, J. P.; Eom, D. O.; Zee, O. P.; Kim, D. K. Yakhak Hoeji, 2001, 45, 611-616.
27 Lee, K. S.; Kwon, B. M.; Baek, N. I.; Kim, S. H.; Lee, J. H.; Park, H. W.; Kim, J. S.; Moon, M. K.; Kim, D. K. Nat. Prod. Sci. 2006, 12, 214-216.
28 Oh, M. H.; Kwon, B. M.; Baek, N. I.; Kim, S. H.; Chung, I. S.; Park, M. H.; Park. H. W.; Lee, J. H.; Park, H. W.; Kim, E. J.; Kim, D. K. Arch. Pharm. Res. 2005, 28, 169-171.   DOI   ScienceOn
29 Ellman, L. G.; Courtney, K. D.; Andres Jr., V.; Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88-95.   DOI   ScienceOn
30 Dall'Acqua, S.; Maggi, F.; Minesso, P.; Salvagno, M.; Papa, F.; Vittor, S.; Innocenti, G. Fitoterapia, 2010, 81, 1208-1212.   DOI   ScienceOn
31 Kim, G. B.; Shin, K. S.; Kim, C. M.; Kwon, Y. Kor. J. Pharmacogn. 2006, 37, 177-183.
32 Lee, M. H.; Son, Y. K.; Han, Y. N. Arch. Pharm. Res. 2002, 25, 842-850.   DOI   ScienceOn
33 Jin, W.; Na, M. K.; An, R. B.; Lee, H. Y.; Bae, K.; Kang, S. S. Nat. Prod. Sci. 2002, 8, 129-132.
34 Mabry, T. J.; Thomas, M. B. The systematic identification of Flavonoids, Springer-Verlag: New York, 1970; p 268.
35 Agrawal P. K. Carbone-13 NMR of Flavonoids. Elsevier, Amsterdam, 1989, pp. 292-293.
36 Oinonen, P. P.; Jokela, K. J.; Hatakka, I. A.; Vuorela, M. P. Fitoterapia, 2006, 77, 429-434.   DOI   ScienceOn
37 Katalinic, M.; Rusak, G.; Barovic, D. J.; Sinko, G.; Jelic, D.; Antolovic, R.; Kovarik, Z. Eur. J. Med. Chem. 2010, 45, 186-192.   DOI   ScienceOn
38 Pohanka, M. Expert Opin. Ther. Patents, 2012, 22, 871-886.   DOI   ScienceOn