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Metabolic Abnormalities in Patients with Mitochondrial Myopathy Evaluated by In Vivo $^{31}$P Magnetic Resonance Spectroscopy (인($^{31}$P) 자기공명분광법을 사용하여 사립체 근질병환자와 정상인과의 대사물질 비교조사)

  • Bo-Young Choe
    • Investigative Magnetic Resonance Imaging
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    • v.2 no.1
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    • pp.89-95
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    • 1998
  • Purpose : To investigate the phosphorus metabolic abnormalities in skeletal muscle of patients with mitochondrial myopathy using in vivo $^{31}P$ magnetic resonance spectroscopy(MRS). Materials and Methods : Patients with mitochondrial myopathy(N=10) and normal control subjects (N=10) participated. All in vivo $^{31}P$ MRS examinations were performed on 1.5T whole-body MRI/MRS system by using an image selected in vivo spectroscopy (ISIS) pulse sequence that provided a $4{\times}4{\times}4{\;}cm^{3}$ volume of interest (VOI) in the right thigh muscle tissue. Peak areas for each phophorus methabolite were measured using a Marquart algorithm. Results : The specific features in patients with mitochondrial myopathy were a significant increase of Pi/PCr ratio (p=0.003) and a significant decrease of ATP/PCr ratio (p=0.004) as compared with normal controls. In particular, the ${\beta}-ATP/PCr$ ratio between controls and patients with mitochondrial myopathy was predominantly altered. Conclusions : In vivo $^{31}P$ MRS may be a useful modality in the clinical evaluation of patients with mitochondrial myopathy based on ATP/PCr and Pi/PCr ratios in skeletal muscle tissue and provides a valuable information in further understanding disorders of muscle metabolism.

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The Study of Magnetic Structure of Ni1-xMgxFe2O4 Ferrite System by Mössbauer Spectroscopy (Mössbauer 분광법에 의한 Ni1-xMgxFe2O4 Ferrite의 자기구조 연구)

  • Yoon, In-Seop;Baek, Seung-Do
    • Journal of the Korean Magnetics Society
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    • v.19 no.3
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    • pp.106-112
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    • 2009
  • $Ni_{1-x}Mg_xFe_2O_4$ ferrite system was studied by using X-ray diffraction and $M{\ddot{o}}ssbauer$ spectroscopy. The samples were prepared by ceramic sintering method with Mg content x. The X-ray diffraction patterns of samples show phase of cubic spinel structure. There are no remarkable changes of lattice constants in $Ni_{1-x}Mg_xFe_2O_4$ ferrite system. The $M{\ddot{o}}ssbauer$ spectra were consisted of two sets of six lines, respectively, corresponding to $Fe^{3+}$ at tetrahedral and octahedral sites. The magnetic hyperfine field of samples was decreased as increasing Mg contents x in both sites and it was shown Yafet-Kittel magnetic structure. $NiFe_2O_4$ was shown complete inverse spinel, but $NiFe_2O_4$ was shown partial inverse spinel which absorption area ratio (oct/tet) was 1.449 in $M{\ddot{o}}ssbauer$ spectrum.

A Study of the Health Status of Elderly Residing in Large city, Medium and Small city, Rural areas in Korea (대도시, 중소도시, 농촌 노인의 건강상태에 관한 연구)

  • 최영희;신윤희
    • Journal of Korean Academy of Nursing
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    • v.21 no.3
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    • pp.365-382
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    • 1991
  • This study was designed to measure the physical, mental-emotional and social health status of elderlies according to rural areas, medium - small cities, and large city environment. Data collection was done from July 18 to August 17 1990. The subjects were a convenience sample after their place of residence was stratified into large, medium- small cities and rural areas. Those who attended elderly centers in Seodaemun, Mapo, and Kangnam districts in Seoul were considered to be residents of a large city and interviewed by trained research assistants and student nurses. Elderlies living in Chungju, Jinju, Chuncheon, and Jeonju cities were coded as residents of medium-small cities and were interviewed by professors of nursing colleges. Rural residents were interviewed by the community health practioners working in community health clinics in North and South Kyongsang, North and South Jeolla, and Kyonggi provinces. The tool used in this study was the health assessment tool developed by Choi, Young Hee in 1990. This tool was organized into 20 physical health status, 17 mental - emotional health status, and 37 social health ststus items. Physical health status items consisted of six factors - personal hygiene activity ability, external activity utilizing traffic, mass media, and spare time ability, sexual ability, digestive system related ability, sexual ability, sensory ability, and elimination ability. Mental - emotional health status items consisted of two factors - mental health factor and emotional health factor. Social health status items consisted of seven factors -grandparental role ability, parental role ability, spoused role ability, friendship role ability, kinship role ability, group member role ability, and religious believer role ability. Data Analysis included frequencies, percentage, mean, standard deviation, ANOVA, and chi - square test. The results of the analysis are as follows : 1. The mean physical health status score for large city residents was 4.1132, for rural residents 4.0787, and for medium and small city residents 3.9565. There were significant differences according to residential area for personal hygiene activity ability, external activity ability, sexual ability, and digestive system related ability items 2. The mean mental -emotional health status score for rural residents was 3.8291, for medium and small city residents 3.7967, and for large city residents 3.7807. There was a significant difference according to residential area in the mental health ability item. 3. The mean social health status score for medium and small city residents was 3.0000, for rural residents 2.9362, and for large city residents 2.8960. There were significant differences according to residential area for kinship role ability and religious believer role ability items. The following conclusion was derived from the above results 1. The physical health status of elderlies residing in medium - small cities and in rural areas was lower than that of those residing in Seoul, a large urban area. Therefore, more medical facilities are needed in rural area so as to monitor their health, prevent disease, and promote their health. 2. The mental -emotional ststus and social health status of elderlies residing in the large city were lower than that of those residing in medium - small cities and rural areas. This may reflect weakening of the strong traditional family bond that may happen with urbanization. Continued support for elderly parents is essential and education should emphasize the traditional cultural norm and value of filial piety. 3. Facilities and programs for elderly are needed so that they may spend their time more valuably in their urban environment.

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The Relationship between ${\beta}$-cell Function and Nutrient Intakes in Korean Adult - Using $4^{th}$ Korea National Health and Nutrition Examination Survey 2009 - (한국 성인의 베타세포 기능과 영양소 섭취와의 관련성 - 2009년 국민건강영양조사 자료를 이용하여-)

  • Lee, You-Mi;Chung, Hye-Kyung;Kimm, Hee-Jin;Jee, Sun-Ha
    • Korean Journal of Community Nutrition
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    • v.17 no.2
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    • pp.243-257
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    • 2012
  • The purpose of this study was to evaluate pancreatic ${\beta}$-cell function of Korean adult and to examine the associations between ${\beta}$-cell function and nutrient intakes. Data were analyzed for 1,917 male and 2,885 female subjects older than 30 years using 'The Forth Korean National Health and Nutrition Survey in 2009'. We calculated HOMA ${\beta}$-cell (The homeostasis model assessment of ${\beta}$-cell function) using fasting glucose and fasting insulin for assessing ${\beta}$-cell function. Subjects were divided into HHG (High HOMA ${\beta}$-cell Group) or LHG (Low HOMA ${\beta}$-cell Group) according to median of HOMA ${\beta}$-cell, and then nutrient intakes were compared between two groups. In the entire study population, HHG showed lower percent of carbohydrate intakes (p < 0.05), and higher fat (p < 0.01), percent of fat (p < 0.05), vitamin A (p < 0.05), carotene (p < 0.05) and riboflavin (p < 0.05) intakes than LHG. In addition, levels of HOMA ${\beta}$-cell were negatively correlated with percent of carbohydrate (${\beta}$ = -0.040, p < 0.05), and positively correlated with percent of fat (${\beta}$ = 0.046, p < 0.01). The subjects were then divided into two subgroups according to body mass index values, either $23kg/m^2$ (under- and normal-weight) or ${\geq}23kg/m^2$ (over-weight and obese). Significant differences of some nutrients intakes and correlations with HOMA ${\beta}$-cell were observed only in under- and normal weight subjects, but not in over-weight and obese subjects. In conclusion, high carbohydrate, lower fat and lower vitamin intakes may be related with pancreatic ${\beta}$-cell dysfunction in under- and normal-weight Korean.

Biographical Experience of Persons with Disabilities after an Accident : A Qualitative Study (중도장애인의 사고 이후 생애경험에 관한 질적 연구)

  • Lee, Hyo-Seon
    • Korean Journal of Social Welfare
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    • v.59 no.4
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    • pp.217-244
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    • 2007
  • The purpose of the research is to understand the life of persons with disabilities caused by an accident by reconstructing their post-accident experiences. As a research tool, Fritz $Sch{\ddot{u}}tze's$ narrative interview was used, and three cases were analyzed in terms of a 'process structure of life'. After the researcher reconstructed each case, she sorted the cases comprehensively both according to the common features as well as to the differences among them. In doing so, the researcher came up with three characteristics of persons with disabilities caused by an accident. First, rather than identifying with their present life, the interviewees identified themselves with their life before the accident happened. Such identification problem is connected with their problem of accepting their handicap. And the interviewees identified themselves with disability groups. It showed that they feel more comfortable and secure among other people with disabilities than with families or friends. This makes them stay in the group of the disabled, in which they can understand and respect each other, rather than staying in a group in which people discriminate the disabled from able bodied and do not accept the disabled as equal members. Second, in their narration the interviewees told stories emphasizing their life after the accident happened. This feature can be compared with the experiences of those persons who underwent a trauma. Finally, it was found that our country's welfare policy for persons with disabilities caused by an accident is designed without differentiating people according to gender or educational background. Through these findings, the researcher intends to reflect on our country's current social welfare services and to look for new methods in order to implement proper social welfare practices.

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Acute Respiratory Failure Treated with Veno-venous Extracorporeal Membrane Oxygenation (정-정맥 체외막형산소화요법을 이용한 급성호흡부전의 치료)

  • Kim, Hyoung-Soo;Han, Sang-Jin;Hong, Kyung-Soon;Yoon, Duck-Hyoung;Lee, Chang-Youl;Lee, Myung-Goo;Hong, Won-Ki;Lee, Sun-Hee;Kim, Kun-Il;Lee, Hee-Sung;Cho, Sung-Woo
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.2
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    • pp.62-66
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    • 2010
  • Background: Extracorporeal membrane oxygenation (ECMO) during severe acute respiratory failure helps to recover the pulmonary function. This study evaluated our experience with veno-venous ECMO in adult patients with acute respiratory failure. Methods: From January 2007 to July 2009, ECMO was used on 54 patients. Of these 54 patients, 7 were placed on veno-venous ECMO for acute respiratory failure. The indications of ECMO were based on the lung dysfunction measured as a $PaO_2/FiO_2$ ratio <100 mm Hg on $FiO_2$ of 1.0, or an arterial blood gas pH <7.25 due to hypercapnia despite the optimal treatment. $EBS^{(R)}$, $Bio-pump^{(R)}$, and Centrifugal Rotaflow $pump^{(R)}$ were used and all cannulations were performed percutaneously via both femoral veins. When the lung function was improved, an attempt was made to wean on ECMO at moderate ventilator settings followed by decannulation. Results: Five of the 7 patients were male and the mean age was $46.3{\pm}18.3$. The causes of acute respiratory failure were 3 cases of pneumonia, 2 near-drownings, 1 pulmonary hemorrhage due to acute hepatic failure and 1 mercury vapor poisoning. The mean support time of ECMO was $17.3{\pm}13.7$ days. Of the 7 patients implanted with ECMO, 5 patients (71%) were weaned off ECMO and 3 patients (43%) survived to hospital discharge after a mean 89.6 hospital days. Conclusion: The early use of ECMO for acute respiratory failure in adults due to any cause is a good therapeutic option for those unresponsive to the optimal conventional treatments.

Detailed Representation of Liquid-Solid Mixed Surfaces with Adaptive Framework Based Hybrid SDF and Surface Reconstruction (적응형 프레임워크 기반의 하이브리드 부호거리장과 표면복원을 이용한 액체와 고체 혼합 표면의 세밀한 표현)

  • Kim, Jong-Hyun
    • Journal of the Korea Computer Graphics Society
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    • v.23 no.4
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    • pp.11-19
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    • 2017
  • We propose a new pipeline of fluid surface reconstruction that incorporates hybrid SDF(signed distance fields) and adaptive fluid surface techniques to finely reconstruct liquid-solid mixed surfaces. Previous particle-based fluid simulation suffer from a noisy surface problem when the particles are distributed irregularly. If a smoothing scheme is applied to reduce the problem, sharp and detailed features can be lost by over-smoothing artifacts. Our method constructs a hybrid SDF by combining signed distance values from the solid and liquid parts of the object. We also proposed a method of adaptively reconstructing the surface of the fluid to further improve the overall efficiency. This not only shows the detailed surface of the solid and liquid parts, but also the detail of the solid surface and the smooth fluid surface when both materials are mixed. We introduce the concept of guiding shape and propose a method to get signed distance value quickly. In addition, the hybrid SDF and mesh reconstruction techniques are integrated in the adaptive framework. As a result, our method improves the overall efficiency of the pipeline to restore fluid surfaces.

Python-based Software Education Model for Non-Computer Majors (컴퓨터 비전공자를 위한 파이썬 기반 소프트웨어 교육 모델)

  • Lee, Youngseok
    • Journal of the Korea Convergence Society
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    • v.9 no.3
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    • pp.73-78
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    • 2018
  • Modern society has evolved to such an extent that computing technology has become an integral part of various fields, creating new and superior value to society. Education on computer literacy, including the ability to design and build software, is now becoming a universal education that must be acquired by everyone, regardless of the field of study. Many universities are imparting software education to students to improve their problem-solving ability, including to students who are not majoring in computers. However, software education contains courses that are meant for computer majors and many students encounter difficulty in learning the grammar of programming language. To solve this problem, this paper analyzes the research outcomes of the existing software education model and proposes a Python-based software education model for students who are not majoring in computer science. Along with a Python-based software education model, this paper proposed a curriculum that can be applied during one semester, including learning procedures, and teaching strategies. This curriculum was applied to a liberal arts class and a meaningful result was derived. If the proposed software education model is applied, the students will be interested in the computer literacy class and improve their computational thinking and problem-solving ability.

The Locational Characteristics of Cultural Industries : The Case of the Record Industry in Korea (문화산업의 입지적 특성 분석: 음반산업을 중심으로)

  • 김유미;이금숙
    • Journal of the Economic Geographical Society of Korea
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    • v.4 no.1
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    • pp.37-60
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    • 2001
  • The record industry, which consists of the cultural industries, has been deeply interrelated with the innovations of the science and the technologies. In Korea, the record industry has been developed dramatically since the late 1980s, and thus it has formed a huge business, and has also brought a lot of accompanying economical effects. The record industry is constituted with four circulation steps such as producing, manufacturing, wholesaling and retailing, which follow the different locational orients, respectively. The purpose oi this study is to investigate the locational characteristics of each step. Because of the shortage of the data, this study based on the direct data from field studies, interviews, and surveys, as well as the existing document data. The results of this research are summarized as following: the record industry shows strong concentrations in Seoul and the surrounding areas. It also shows the spatial linkage with other industries that are necessary for the production, advertisement, and sales of records. The locations of the record producers are affected by the location of broadcasting stations. Therefore, they are concentrate in Kangnam and Yeouido, where many broadcasting stations are located.

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Patients' perception about opioids and addiction in South Korea

  • Kim, Cho Long;Hong, Sung Jun;Lim, Yun Hee;Jeong, Jae Hun;Moon, Ho Sik;Choi, Hey Ran;Park, Sun Kyung;Kim, Jung Eun;You, Hakjong;Kim, Jae Hun
    • The Korean Journal of Pain
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    • v.33 no.3
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    • pp.234-244
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    • 2020
  • Background: Chronic pain affects approximately 22% of the world's population. Opioids can be useful in chronic pain management. However, some patients have negative perception of opioids. The purpose of this research was to evaluate patients' perception about opioids and investigate problems associated with prescribing and taking opioids in South Korea. Methods: Patients who visited a pain clinic in 14 university hospitals of South Korea from September through October 2018 were asked to complete anonymous questionnaires about taking opioids. Results: Of the 368 patients that were surveyed (female 53.3%, male 46.7%), 56.8% were prescribed opioids. In the opioid group, 92.8% patients had heard of opioids from their doctor and 72.6% of them had a positive perception about opioids. The side effects associated with opioid use were constipation (35.4%), dizziness (24.6%), nausea and vomiting (17.4%), dysuria (6.2%), and addiction (2.0%). In the no opioid group, the primary sources of information about opioids were doctors (49.2%), mass media (30.8%), and the internet (16.2%). The main reasons why 39.0% patients did not take opioids were fear of addiction (57.7%) and side effects (38.5%). There were 71.5% and 60.9% patients in the opioid and no opioid group, respectively, who wished to take opioids when their numeric rating scale pain score was ≥ 7. Conclusions: Perception of opioids among patients who take them was either neutral or positive. However, 39.0% patients who have not been prescribed opioids did not want an opioid prescription, citing fear of addiction and side effects as the primary reasons.