Browse > Article
http://dx.doi.org/10.5720/kjcn.2012.17.2.243

The Relationship between ${\beta}$-cell Function and Nutrient Intakes in Korean Adult - Using $4^{th}$ Korea National Health and Nutrition Examination Survey 2009 -  

Lee, You-Mi (Institute for Health Promotion, Graduate School of Public Health, Yonsei University)
Chung, Hye-Kyung (Department of Nutrition Services, Kangnam Severance Hospital, Yonsei University)
Kimm, Hee-Jin (Institute for Health Promotion, Graduate School of Public Health, Yonsei University)
Jee, Sun-Ha (Institute for Health Promotion, Graduate School of Public Health, Yonsei University)
Publication Information
Korean Journal of Community Nutrition / v.17, no.2, 2012 , pp. 243-257 More about this Journal
Abstract
The purpose of this study was to evaluate pancreatic ${\beta}$-cell function of Korean adult and to examine the associations between ${\beta}$-cell function and nutrient intakes. Data were analyzed for 1,917 male and 2,885 female subjects older than 30 years using 'The Forth Korean National Health and Nutrition Survey in 2009'. We calculated HOMA ${\beta}$-cell (The homeostasis model assessment of ${\beta}$-cell function) using fasting glucose and fasting insulin for assessing ${\beta}$-cell function. Subjects were divided into HHG (High HOMA ${\beta}$-cell Group) or LHG (Low HOMA ${\beta}$-cell Group) according to median of HOMA ${\beta}$-cell, and then nutrient intakes were compared between two groups. In the entire study population, HHG showed lower percent of carbohydrate intakes (p < 0.05), and higher fat (p < 0.01), percent of fat (p < 0.05), vitamin A (p < 0.05), carotene (p < 0.05) and riboflavin (p < 0.05) intakes than LHG. In addition, levels of HOMA ${\beta}$-cell were negatively correlated with percent of carbohydrate (${\beta}$ = -0.040, p < 0.05), and positively correlated with percent of fat (${\beta}$ = 0.046, p < 0.01). The subjects were then divided into two subgroups according to body mass index values, either $23kg/m^2$ (under- and normal-weight) or ${\geq}23kg/m^2$ (over-weight and obese). Significant differences of some nutrients intakes and correlations with HOMA ${\beta}$-cell were observed only in under- and normal weight subjects, but not in over-weight and obese subjects. In conclusion, high carbohydrate, lower fat and lower vitamin intakes may be related with pancreatic ${\beta}$-cell dysfunction in under- and normal-weight Korean.
Keywords
${\beta}$-cell function; HOMA ${\beta}$-cell; carbohydrate; fat; vitamins;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Haffner SM, Miettinen H, Stern MP (1997): The homeostasis model in the San Antonio Heart Study. Diabetes Care 20(7): 1087-1092   DOI
2 Hamer M, Chida Y (2007): Intake of fruit, vegetables, and antioxidants and risk of type 2 diabetes: systematic review and meta-analysis. J Hypertens 25(12): 2361-2369   DOI
3 Huh KB, Lee HC, Chung YS, Park SW, Park YK, Park EJ, Lee JH (1994): Effects of insulin secretion on glucose and lipid metabolism in Korean. Korean J Med 47(3): 295-304
4 Kaneto H, Kajimoto Y, Miyagawa J, Matsuoka T, Fujitani Y, Umayahara Y, Hanafusa T, Matsuzawa Y, Yamasaki Y, Hori M (1999): Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 48(12): 2398-2406   DOI
5 Kautzky-Willer A, Brazzale AR, Moro E, Vrbíkova J, Bendlova B, Sbrignadello S, Tura A, Pacini G (2012): Influence of increasing BMI on insulin sensitivity and secretion in normotolerant men and women of a wide age span. Obesity Silver Spring
6 Kim S, Moon S, Popkin BM (2000): The nutrition transition in South Korea. Am J Clin Nutr 71(1): 44-53   DOI
7 Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU (1985): Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4(2): 110-125
8 Krinsky NI (1993): Actions of carotenoids in biological systems. Annu Rev Nutr 13: 561-587   DOI
9 Kuroe A, Fukushima M, Usami M, Ikeda M, Nakai Y, Taniguchi A, Matsuura T, Suzuki H, Kurose T, Yasuda K, Yamada Y, Seino Y (2003): Impaired $\beta$-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance. Diabetes Res Clin Pract 59(1): 71-77   DOI
10 Leahy JL (1990): Natural history of beta-cell dysfunction in NIDDM. Diabetes Care 13(9): 992-1010   DOI
11 Leahy JL, Bonner-Weir S, Weir GC (1992): Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care 15(3): 442-455   DOI
12 Lee MJ, Popkin BM, Kim S (2002): The unique aspects of the nutrition transition in South Korea: the retention of healthful elements in their traditional diet. Public Health Nutr 5(1A): 197-203
13 Lee SK, Chae BN, Hong EG, Noh HL, Cho HK, Kim YJ, Lee MD, Chung YS, Lee KW, Cho NH, Kim HM (2000): Microvascular complications and its relationship with obesity in outpatient type 2 diabetics. Korean Diabetes J 24(1): 60-70
14 Lee YH, Yoon JH, Lim SK, Yoon KS, Kim WJ, Kim HM, Lee HC, Huh KB (1985): Prevalence of diabetic complications on the basis of the types. Korean Diabetes J 9(2): 197-203
15 Liu JH, Tung TH, Tsai ST, Chou P, Chuang SY, Chen SJ, Lee FL, Shih HC, Li WL (2006): A community-based epidemiologic study of gender differences in the relationship between insulin resistance/beta-cell dysfunction and diabetic retinopathy among type 2 diabetic patients in Kinmen, Taiwan. Ophthalmologica 220(4): 252-258   DOI
16 Lopez S, Bermudez B, Pacheco YM, Villar J, Abia R, Muriana FJ (2008): Distinctive postprandial modulation of beta cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids. Am J Clin Nutr 88(3): 638-644   DOI
17 MacDonald PE, Joseph JW, Rorsman P (2005): Glucose-sensing mechanisms in pancreatic beta-cells. Philos Trans R Soc Lond B Biol Sci 360(1464): 2211-2225   DOI
18 Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985): Homeostasis model assessment: Insulin resistance and $\beta$-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28(7): 412-419   DOI
19 Mckaly KA, Hopkins CM, Smith KJ, McLay RT, Wiliam SM, Taylor RW, Mann JI (2005): Comparison of high-fat and high-protein diets with a high carbohydrate diet in insulin-resistant obese woman. Diabetologia 48(1): 8-16   DOI
20 Mettlin C (1984): Epidemiologic studies on vitamin A and cancer. Adv Nutr Res 6: 47-65
21 Min HK (1992): Clinical characteristics of diabetes in Korea. Korean Diabetes J 16(3): 163-174
22 Mohan V, Vijayaprabha R, Rema M, Premalatha G, Poongothai S, Deepa R, Bhatia E, Mackay IR, Zimmet P (1997): Clinical profile of lean NIDDM in South India. Diabetes Res Clin Pract 38(2): 101-108   DOI
23 Molero-Conejo E, Morales LM, Fernandez V, Raleigh X, Gomez ME, Semprún-Fereira M, Campos G, Ryder E (2003): Lean adolescents with increased risk for metabolic syndrome. Arch Latinoam Nutr 53(1): 39-46
24 Moon HK, Kong JE (2010): Assessment of nutrient intake for middle aged with and without metabolic syndrome using 2005 and 2007Korean National Health and Nutrition Survey. Korean J Nutr 43(1): 69-78   DOI
25 Nishimura C, Kuriyama K (1985): Alteration of lipid peroxide and endogenous antioxidant contents in retina of streptozotocininduced diabetic rats: effect of vitamin A administration. Jpn J Pharmacol 37(4): 365-372
26 Ostgren CJ, Lindblad U, Ranstam J, Melander A, Råstam L (2000): Associations between smoking and beta-cell function in a nonhypertensive and non-diabetic population. Skaraborg Hypertension and Diabetes Project. Diabet Med 17(6): 445-450   DOI
27 Ozkaya D, Naziro lu M, Arma an A, Demirel A, Koroglu BK, Colako lu N, Kukner A, Sonmez TT (2011): Dietary vitamin C and E modulates oxidative stress induced-kidney and lens injury in diabetic aged male rats through modulating glucose homeostasis and antioxidant systems. Cell Biochem Funct 29(4): 287-293   DOI
28 Park SY, Park MS, Ko JA (2008): The association between carbohydrate intake and waist circumference. Korean J Obesity 17(4): 175-181
29 Panagiotakos DB, Tzima N, Pitsavos C, Chrysohoou C, Papakonstantinou E, Zampelas A, Stefanadis C (2005): The relationship between dietary habits, blood glucose and insulin levels among people without cardiovascular disease and type 2 diabetes; the ATTICA study. Rev Diabet Stud 2(4): 208-215   DOI
30 Park SM, Choi MK, Ahn SH, Kim YH, Park CH, Chol SB (2001): The effects of dietary caloric distribution on insulin secretion and insulin resistance in sprague dawley rats. Korean J Nutr 34(5): 485-492
31 Rhee EJ, Choi JH, Yoo SH, Bae JC, Kim WJ, Choi ES, Park SE, Park CY, Park SW, Oh KW, Park SW, Kim SW, Lee WY (2011): The association of unintentional changes in weight, body composition, and homeostasis model assessment index with glycemic progression in non-diabetic healthy subjects. Diabetes Metab J 35(2): 138-148   DOI
32 Rhee SY, Chon S, Oh SW, Kim JW, Kim YS, Woo JT (2006): Insulin secretion and insulin resistance in newly diagnosed, drug nae prediabetes and type 2' diabetes patients with/without metabolic syndrome. Korean Diabetes J 30(3): 193-206
33 Robertson RP, Harmon J, Tran PO, Poitout V (2004): Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2diabetes. Diabetes 53(1): 119-124   DOI
34 Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H (2003): Glucose toxicity in beta cell: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52(3): 581-587   DOI
35 Robertson RP, Zhang HJ, Pyzdrowski KL, Walseth TF (1992): Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentration. J Cin Inves 90(2): 320-325   DOI
36 Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, Zimmet P, Son HY (2006): Epidemic obesity and type 2 diabetes in Asia. Lancet 368: 1681-1688   DOI
37 Sardas S, Yilmaz M, Oztok U, Cakir N, Karakaya AE (2001): Assessment of DNA strand breakage by comet assay in diabetic patients and the role of antioxidant supplementation. Mutat Res 490(2): 123-129   DOI
38 Ylönen K, Alfthan G, Groop L, Saloranta C, Aro A, Virtanen SM (2003): Dietary intakes and plasma concentrations of carotenoids and tocopherolsin relation to glucose metabolism in subjects at high risk of type 2 diabetes: the Botnia Dietary Study. Am J Clin Nutr 77(6): 1434-1441   DOI
39 Yoon KH (1998): The feature of diabetes in Korean adults: insulin secretion function of Korean. Proceeding of 1998 diabetes educator seminar of Korean Diabetes Association, pp.39-52
40 Zhu S, St-Onge MP, Heshka S, Heymsfield SB (2004): Lifestyle behaviors associated with lower risk of having the metabolic syndrome. Metabolism 53(11): 1503-1511   DOI
41 Zobali F, Avci A, Canbolat O, Karasu C (2002): Effects of vitamin A and insulin on the antioxidative state of diabetic rat heart: a comparison study with combination treatment. Cell Biochem Funct 20(2): 75-80   DOI
42 Tajiri Y, Grill VE (1999): Interactions between vitamin E and glucose on $\beta$-cell functions in the rat: an in vivo and in vitro study. Pancreas 18(3): 274-281   DOI
43 Sartorelli DS, Franco LJ, Damiãao R, Gimeno S, Cardoso MA, Ferreira SR (2009): Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced beta-cell function in prediabetic Japanese migrants. Arq Bras Endocrinol Metabol 53(4): 429-434   DOI
44 Schuit FC, Huypens P, Heimberg H, Pipeleers DG (2001): Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 50(1): 1-11   DOI
45 Shim WS, Kim SK, Kim HJ, Park SE, Kang ES, Rhee YM, Ahn CW, Lim SK, Kim KR, Lee HC, Cha BS (2005): Clinical meaning of postprandial insulin secretory function in Korean type 2 diabetes mellitus. Korean Diabetes J 29(4): 367-377
46 Solomon TP, Haus JM, Kelly KR, Cook MD, Filion J, Rocco M, Kashyap SR, Watanabe RM, Barkoukis H, Kirwan JP (2010): A lowglycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucosedependent insulinotropic polypeptide responses in obese, prediabetic humans. Am J Clin Nutr 92(6): 1359-1368   DOI
47 Song Y, Manson JE, Tinker L, Howard BV, Kuller LH, Nathan L, Rifai N, Liu S (2007): Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study. Diabetes Care 30(7): 1747-1752   DOI
48 The Korean Dietetic Association (2008): Manual of medical nutrition therapy. The 3rd ed. Medrang, Seoul, p.220
49 Utzschneider KM, Carr DB, Hull RL, Kodama K, Shofer JB, Retzlaff BM, Knopp RH, Kahn SE (2004): Impact of intraabdominal fat and age on insulin sensitivity and beta-cell function. Diabetes 53(11): 2867-2872   DOI
50 Wallace TM, Levy JC, Matthews DR (2004): Use and abuse of HOMA modeling. Diabetes Care 27(6): 1487-1495   DOI
51 Yamada Y, Noborisaka Y, Ishizaki M, Tsuritani I, Honda R, Yamada S (2004): Alcohol consumption, homeostasis model assessment indices and blood pressure in middle-aged healthy men. J Hum Hypertens 18(5): 343-550   DOI
52 Weyer C, Bogardus C, Mott DM, Pratley RE (1999): The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104(6): 787-794   DOI
53 Wolever TMS, Mehling C (2002): High-carbohydrate-low-glycemic index dietary advice improves glucose disposition index in subjects with impaired glucose tolerance. Br J Nutr 87(5): 477-487   DOI
54 Won KJ (2004): Oxidative stress in pancreatic islet beta-cells exposed to high glucose concentration. Korean Diabetes J 28(4): 250-254
55 Yates AP, Laing I (2002): Age-related increase in haemoglobin A1c and fasting plasma glucose is accompanied by a decrease in $\beta$-cell function without change in insulin sensitivity: evidence from a cross-sectional study of hospital personnel. Diabet Med 19(3): 254-258   DOI
56 Alenzi FQ (2009): Effect of nicotinamide on experimental induced diabetes. Iran J Allergy Asthma Immunol 8(1): 11-18
57 Bi Y, Zeng L, Zhu D, Yan J, Zhang Y, Tong G, Mu P, Shen S, HuY, Yu Q, Liang H, Weng J (2012): Association of $\beta$-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population. Diabetes Obes Metab 14(2): 174-180   DOI
58 Bonnefont-Rousselot D (2004): The role of antioxidant micronutrients in the prevention of diabetic complications. Treat Endocrinol 3(1): 41-52   DOI
59 Chiu KC, Lee NP, Cohan P, Chuang LM (2000): Beta cell function declines with age in glucose tolerant Caucasians. Clin Endocrinol (Oxf) 53(5): 569-575
60 Chiu KC, Martinez DS, Chu A (2005): Comparison of the relationship of age and beta cell function in three ethnic groups. Clin Endocrinol (Oxf) 62(3): 296-302   DOI
61 Cho JH, Lee IK, Yoon KH, Ko SH, Suh SH, Lee JM, Kim SR, Ahn YB, Lee JM, Son HS, Kang MI, Cha BY, Lee KW, Son HY, Kang SG (2001): Selective $beta$-cell loss and a-cell expansion in islets of type 2 diabetic patients. Korean Diabetes J 25(2): 164-177
62 Choi ES, Rhee EJ, Kim JH, Won JC, Park YC, Lee WY, Oh KW, Park SW, Kim SW (2008): Insulin sensitivity and insulin secretion determined by homeostasis model assessment and future risk of diabetes mellitus in Korean men. Korean Diabetes J 32(6): 498-505   DOI
63 Chung HK, Kang JH, Shin MJ (2010): Assessment for nutrient intakes in Korean women according to obesity and metabolic syndrome. Korean J Community Nutr 15(5): 694-703
64 DeFronzo RA (2004): Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 88(4): 787-835   DOI
65 Frei B, Stocker R, Ames BN (1988): Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 85(24): 9748-9752   DOI
66 Funakoshi S, Fujimoto S, Hamasaki A, Fujiwara H, Fujita Y, Ikeda K, Hamamoto Y, Hosokawa M, Seino Y, Inagaki N (2008): Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure. Diabetes Res Clin Pract 82(3): 353-358   DOI
67 Garg MK, Dutta MK, Mahalle N (2011): Study of beta-cell function (by HOMA model) in metabolic syndrome. Indian J Endocrinol Metab 15(1): 44-49   DOI
68 Haffner SM, Kennedy E, Gonzalez C, Stern MP, Miettinen H (1996): A prospective analysis of the HOMA model. The Mexico City Diabetes Study. Diabetes Care 19(10): 1138-1141   DOI