• Proceedings of the Korean Society of Tobacco Science Conference
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• 2005.05a
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• pp.22-22
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• 2005

• Journal of Veterinary Science
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• v.24 no.5
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• pp.69.1-69.11
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• 2023

Background: Kalkitoxin (KT) is an active lipopeptide isolated from the cyanobacterium Lyngbya majuscula found in the bed of the coral reef. Although KT suppresses cell division and inflammation, KT's mechanism of action in vascular smooth muscle cells (VSMCs) is unidentified. Therefore, our main aim was to investigate the impact of KT on vascular calcification for the treatment of cardiovascular disease. Objectives: Using diverse calcification media, we studied the effect of KT on VSMC calcification and the underlying mechanism of this effect. Methods: VSMC was isolated from the 6 weeks ICR mice. Then VSMCs were treated with different concentrations of KT to check the cell viability. Alizarin red and von Kossa staining were carried out to examine the calcium deposition on VSMC. Thoracic aorta of 6 weeks mice were taken and treated with different concentrations of KT, and H and E staining was performed. Real-time polymerase chain reaction and western blot were performed to examine KT's effect on VSMC mineralization. Calcium deposition on VSMC was examined with a calcium deposition quantification kit. Results: Calcium deposition, Alizarin red, and von Kossa staining revealed that KT reduced inorganic phosphate-induced calcification phenotypes. KT also reduced Ca⁺⁺-induced calcification by inhibiting genes that regulate osteoblast differentiation, such as runtrelated transcription factor 2 (RUNX-2), SMAD family member 4, osterix, collagen 1α, and osteopontin. Also, KT repressed Ca²⁺-induced bone morphogenetic protein 2, RUNX-2, collagen 1α, osteoprotegerin, and smooth muscle actin protein expression. Likewise, Alizarin red and von Kossa staining showed that KT markedly decreased the calcification of ex vivo ring formation in the mouse thoracic aorta. Conclusions: This experiment demonstrated that KT decreases vascular calcification and may be developed as a new therapeutic treatment for vascular calcification and arteriosclerosis.

• Biomolecules & Therapeutics
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• v.8 no.3
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• pp.241-247
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• 2000

The present study was designed to assess the protective effect of a selective thromboxane $A_2$ receptor antagonist, KT2-962 (KT2) and possible mechanisms of adriamycin(AD)-induced nephrotoxicity in rats. The male Wistar rats were given either of AD (7.5 mg/kg, i.v.) alone in the AD-group (n=5) or in KT2+AD- group (n=5) which is a combination of AD and KT2 (30 mg/kg/day, i.p.) for 10 days from 3 days before and 7 days after AD injection. The body weight, 24-hours urine volume, urine protein and urinary N-acetyl-$\beta$-D-glu-cosaminidase (NAG) activity were measured with an interval of 2 days during 1 week. BUN, serum creatinine and creatinine clearance were measured on the 7th day. KT2 has significantly suppressed AD-induced change of body weight, 24-hours urine volume, urine protein and urinary NAG activity in the KT2+AD-group. The change of BUN, serum creatinine and creatinine clearance were significantly inhibited in the B7T2+AD-group. Based on these results, it is concluded that KT2 prevents AD-induced nephrotoxicity and suggests that endogenous thromboxane A2 may play an important role in AD-induced nephrotoxicity in rats.

• Proceedings of the Korea Information Processing Society Conference
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• 2009.04a
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• pp.456-458
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• 2009

소프트웨어의 크기가 커지고 복잡도가 증가함에 따라 소프트웨어 품질의 중요성은 점점 증대되고 있다. 소프트웨어의 품질 향상을 위해 소프트웨어 개발 조직은 테스트와 동료검토와 같이 제품 품질 향상을 위한 노력과 CMMI(Capability Maturity Model Integration), 소프트웨어프로세스 품질인증 기준과 같은 프로세스 품질 향상 노력을 하고 있다. 그러나 이러한 소프트웨어 분야의 품질 관리의 노력과 효과에 소요되는 품질비용에 대한 연구는 제조업이나 건설업 등 타 분야에 비해 부족한 실정이다. 본 연구에서는 소프트웨어 프로세스 개선을 위한 모델인 CMMI의 성숙도 레벨에 기반하여, K사의 품질비용관리 방안 적용 결과를 바탕으로 CMMI 성숙도 각 레벨마다 소프트웨어 개발 조직이 품질비용을 관리를 위한 목적과 활동으로 정의된 품질비용 관리 모델의 개발을 연구하였다.

• Journal of Service Research and Studies
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• v.5 no.1
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• pp.91-103
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• 2015

We examine the information transmission between the KT Spot and the KT Futures Index, the SK Telecom Spot and the SK Telecom Futures Index, based on the returns data offered by the Korea Exchange. The data includes daily return data from 1 January 2012 to 31 December 2014. Utilizing a dynamic analytical tool-the VAR model, Granger Causality test, Impulse Response Function and Variance Decomposition have been implemented. The results of the analysis are as follows. Firstly, results of Granger Causality test suggests the existence of mutual causality the KT Futures Index and the SK Telecom Futures Index precede and have explanatory power the KT Spot and the SK Telecom Spot However the results also identified a greater causality and explanatory power of the KT Spot and the SK Telecom Spot over the KT Futures Index and the SK Telecom Futures Index. Secondly, the results of impulse response function suggest that the KT Futures Index show immediate response to the KT Spot and are influenced by till time 4. From time 2, the impact gradually disappears. Also the SKT Futures Index show immediate response to the SKT Spot and are influenced by till time 4. From time 2, the impact gradually disappears. Lastly, the variance decomposition analysis shows that the changes of return of the KT Spot and SKT Spot are dependent on those of the KT Futures Index and the SK Telecom Futures Index. This implies that returns on the KT Spot and SKT Spot have a significant influence over returns on the KT Futures Index and the SK Telecom Futures Index. It contributes to the understanding of market price formation function through analysis of detached the KT Spot and the KT Futures Index, the SK Telecom Spot and the SK Telecom Futures Index.

• Information and Communications Magazine
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• v.27 no.4
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• pp.38-42
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• 2010

최근 지식경제부는 스마트그리드 구축을 통한 저탄소 녹색성장 기반 조성이라는 비전을 가지고, 국가단위 스마트그리드 구축을 위한 지능형 전력망, 소비자, 수송, 신재생, 서비스 등 5대 분야에 대한 로드맵을 포함하는 스마트그리드 국가로드맵을 확정했다. 이러한 스마트그리드의 국가적 비전을 공유하고 스마트그리드의 성공적 구축 및 정착을 위해 통신 사업자로서 KT에서는 기 보유된 통신인프라와 핵심 ICT 기술 역량을 활용하여 KT 스마트그리드 사업을 준비하고 있다. 본 고에서는 스마트그리드와 홈네트워크 동향을 살펴보고 KT의 스마트그리드 홈 서비스에 대해 소개하고자 한다.

• Proceedings of the Korean Institute of Communication Sciences Conference
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• 2006.07a
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• pp.745-745
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• 2006

• Information and Communications Magazine
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• v.23 no.3
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• pp.23-34
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• 2006

정부 BcN의 1차년도 시범사업에 참여한 KT 옥타브 컨소시움에서는 고객이 요구할 것으로 판단되는 서비스를 선별하여 영상 단말기반으로 다양한 통합서비스를 제공하였다. KT의 BcN은 NGN의 핵심표준인 IMS구조를 기반으로 구축하였으나, 보다 광범위한 BcN서비스 지원구조로써는 부족하고 상이한 면이 있다. 본 논문에서는 KT BcN 서비스의 종류. 구조를 IMS 표준에 비교하여 기술하고, 대표적인 시나리오, 시범사업결과 및 향후방향에 대해서 정리하였다.

• Proceedings of the Korean Society of Tobacco Science Conference
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• 2006.05a
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• pp.36-36
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• 2006

• Proceedings of the Ginseng society Conference
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• 2003.12a
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• pp.19-19
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• 2003