• 대한한방부인과학회지
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• 제35권2호
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• pp.87-105
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• 2022

Objectives: The purpose of this study is to analysis the Clinical Study Trends on Korean Medicine Treatment for Polycystic Ovary Syndrome. Methods: The key words such as 'polycystic ovary syndrome', 'polycystic ovarian syndrome', 'korean medicine', 'herbal medicine', 'acupuncture' are used for the research through 'OASIS', 'KCI', 'KISS', 'RISS'. Results: Ten clinical studies with 73 patients were selected. All studies were the noncomparative studies, and 8 case reports, 1 case series, 1 retrospective chart review. Symptoms accompanied by PCOS were oligomenorrhea, amenorrhea, irregular menstruation, hirsutism, acne, obesity etc. The most used treatment was herbal medicine in all studies with 72 patients (98.6%). The most frequently used acupuncture and moxibustion point was respectively 合谷 (LI4) and 關元 (CV4). The duration of treatment was between 3 months and 10 months, the average 159 days. Outcome measurements were Recovery of menstrual cycle (97.6%), Hormone test (23.8%), Sonogram (61.9%), Indexes of obesity (23.8%). In terms of menstrual recovery, 35 patients (85.4%) have recovered from menstruation in 8 studies with 41 patients. In hormone tests, all 10 patients have decrease of LH/FSH ratio and LH in 3 studies with 10 patients. Through sonogram, Ovulation menstruation was confirmed in all 6 patients. In all 10 patients of 3 studies evaluating weight before and after treatment, weight was reduced. Conclusions: The effect on Korean Medicine treatment for Polycystic Ovary Syndrome had mostly positive results. However, Further large, well-designed clinical trials are needed to establish the foundation of Korean Medicine treatment for Polycystic Ovary Syndrome.

• 대한감각통합치료학회지
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• 제20권3호
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• pp.60-71
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• 2022

목적 : 본 연구는 국내 장애 및 비장애 아동에게 적용된 그룹 감각통합치료 중재에 대해 정리하고 효과를 제시하고자 하였다. 연구방법 : 검색 기간은 2010년 1월부터 2021년 12월까지로 하였으며, 자료 검색을 위하여 '대한감각통합치료학회', '대한작업치료학회', '한국학술정보(KISS)', '학술연구정보서비스(RISS)', '디비피아(DBpia)'의 데이터베이스를 이용하였다. 총 11편이 선정되었으며, PICO(Patient, Intervention, Comparison, Outcome) 방법을 적용하여 체계적으로 정리하였다. 결과 : 연구 결과 단일 집단 비무작위 연구가 11편 중 8편(72.73%)으로 가장 많았다. 대상자는 99명으로 연령은 3세에서 11세까지였으며, 평균 7.39세였다. 그 중 장애아동이 더 많았으며, 진단은 발달장애가 99명 중 40명(40.41%)으로 가장 많았다. 치료 중재 회기는 총 5회에서 45회까지였으며, 주 1회 또는 2회, 시간은 60분 제공이 가장 많았다. 평가도구는 캐나다 작업 수행 측정(Canadian Occupational Performance Measure; COPM)과 또래 놀이 상호작용 평점 척도(Penn Interactive Peer Play Scale; PIPPS)가 각 4회(12.90%)로 가장 많이 사용되었다. 치료 중재 목표로는 사회 상호작용 기술이 8편(36.36%)으로 가장 많았다. 치료 중재 결과 8편의 연구에서 유의한 결과를 보였다. 결론 : 본 연구를 바탕으로 향후에는 높은 질적 수준을 근거로 한 다양한 그룹 감각통합치료의 중재 방법을 체계적으로 제시하여 임상에서 유용한 정보로 활용될 수 있기를 기대한다.

• 한국응용과학기술학회지
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• 제40권1호
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• pp.59-70
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• 2023

본 연구는 국내 간호대학생에게 적용한 플립러닝 교수법의 효과에 관한 연구를 체계적 고찰을 통해 통합적으로 규명하기 위한 메타분석연구이다. 자료수집은 2022년 11월 20일에서 12월 20일까지 코크란 연합의 체계적 고찰 보고지침을 준수하여 진행하였다. 국내 데이터베이스를 통해 검색된 논문은 RISS 72건, KISS 11건, Dbpia 46건 총 129편이었으며, 중복논문 제거 및 선정기준에 따라 최종 9편의 연구를 선정하였다. 국내 간호대학생을 대상으로 플립러닝 수업을 적용한 결과 플립러닝이 간호대학생의 비판적 사고성향 0.91(Z=8.36, p<.001), 학업적 자기효능감 0.35(Z=2.62, p=.009), 자기주도적 학습능력 0.81(Z=6.53, p<.001), 학업성취도 0.60(Z=5.18, p<.001), 자기효능감 0.66(Z=4.79, p<.001) 향상에 효과적인 것으로 나타났다. 본 연구결과를 토대로 플립러닝은 국내 간호교육 현장에 적용 가능한 효과적인 교수법임을 확인하였고, 플립러닝 수업설계 방향성에 객관적인 근거를 제시하였으며, 향후 플립러닝에 긍정적인 효과를 주는 다양한 결과 변인들의 효과를 통합적으로 분석하는 반복연구를 제언한다.

• Korean Journal of Acupuncture
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• 제40권3호
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• pp.62-78
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• 2023

Objectives : This study aims to assess the impact of acupotomy on migraine through an examination of clinical studies conducted since 2015. Methods : We conducted a comprehensive search for randomized controlled trials (RCTs) and non-randomized controlled trials (nRCTs) related to acupotomy treatment for migraine, utilizing five Korean online databases (OASIS, Science ON, DBPIA, KISS, RISS), as well as four foreign online databases (CNKI, PubMed, EMBASE, Cochrane Library). We identified a total of 10 relevant studies for analysis. Participants characteristics, treatment points, combination treatments, treatment cycles or frequencies, evaluation indices, efficacy, and adverse events were analyzed. The risk of bias in the 10 RCTs was assessed using the Revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0). Results : A total of 931 participants were included in 10 studies. In the intervention group, the average duration of migraine morbidity ranged from 15.5±4.5 months to 15.9±4.2 years. Six studies based their diagnoses on the International Classification of Headache Disorders (ICHD), while five studies relied on Chinese diagnostic criteria. All studies specified the treatment area as the region exhibiting tenderness or induration on the head and neck. Treatment cycles ranged from a minimum of 2 days to a maximum of 1 week, with the number of days per treatment course varied from 5 days to 4 weeks. The diameter of acupuncture needles used varied between 0.3 mm and 1 mm. Of the eight studies specifying needle length, the shortest was 20 mm, and the longest was 40 mm. A total of eight evaluation indices were employed, with total efficacy rate (TER) and visual analogue scale (VAS) being the most frequently used. Statistically, all intervention groups showed more significant results compared to the control groups. Adverse events were reported in only two studies within the intervention group. Overall, the risk of bias assessment for the selected RCTs ranged from 'some concerns' to 'high risk of bias.' Conclusions : This study showed that acupotomy treatments for migraine were effective.

• 동의신경정신과학회지
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• 제34권2호
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• pp.95-113
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• 2023

Objectives: To review studies evaluating effects of acupuncture on pain and depressive symptoms in fibromyalgia. Methods: Quantitative evidences (RCTs) were systematically reviewed. Literature were searched for a combination of fibromyalgia and depression (The Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, medline (via PubMed), Kmbase, KISS, ScienceON, OASIS, CiNii, CNKI). Quantitative research findings were critically appraised by Cochrane risk of bias (RoB) tool and pooled. Meta-analysis was then conducted using Review Manager (RevMan) 5.4. Results: Eighteen studies were selected. American College of Rheumatology (ACR) classification criteria for Fibromyalgia Syndrome was most frequently used as diagnostic criteria for fibromyalgia. As for outcome measurement, Hamilton Rating Scale for Depression (HAMD), Visual Analog Scale (VAS), and Total Effective Rate (TER) were used most commonly. Meta-analysis of ten studies revealed that both Depression and VAS scores of the Acupuncture+Western Medicine group were significantly lower than those of Western Medicine group (Depression: SMD, -0.94, 95% CI, -1.17 to -0.70; VAS: MD, -1.51, 95% CI, -1.83 to -1.19). Also, TERs of both Acupuncture group and Acupuncture+Western Acupuncture+Western Medicine group were significantly higher than those of the Western Medicine group (OR: 2.38, 95% CI: 1.29 to 4.41; and OR: 7.40, 95% CI: 3.41 to 16.07). There was no significant difference in Depression or VAS score between the Acupuncture Group and the Western Medicine Group. Conclusions: Acupuncture might be an effective option for pain and depressive symptoms of fibromyalgia when it is combined with Western Medicine treatment. For more accurate results, more types of Korean medicine treatment should be conducted.

• 한국융합학회논문지
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• 제13권1호
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• pp.425-436
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• 2022

본 연구는 현재까지 국내에서 출판된 간호학생 대상의 MBTI 관련 연구를 분석하고 고찰하여, 최근 연구경향 파악 및 간호교육에의 활용방안에 대한 방향을 제시하기 위해 시도되었다. 문헌검색은 국회전자도서관(National Assembly Library, NAL), 한국학술정보(Korean Studies Information Service System, KISS), 국내학술지(DBPIA), 한국의학논문데이터베이스(Korean Medical database, KMbase), 국가과학기술정보센터(National Discovery for Science Library, NDSL)에서 검색어 '(간호 또는 간호학생 또는 학생간호사) and (성격 또는 MBTI)'로 검색하여 중복논문 및 연구대상자나 연구주제가 맞지 않는 논문을 제외한 총 22편의 논문을 분석대상으로 하였다. 22개의 분석대상 논문 모두 양적연구 였으며 63.6%가 비설험연구였다. MBTI와 함께 가장 많이 연구된 변수는 자기효능, 자존감, 학업적 자기효능 등의 인지-지각적 변수가 가장 많이 연구되었고 그 다음으로 학업스타일, 학업성취, 임상수행능력과 같은 학습관련 변수가 가장 많이 연구되었다. 분석대상 논문에서의 대상자들의 MBTI 성격유형을 2차분석한 결과 총 16가지 MBTI 성격유형 중 가장 많은 분포를 보인 유형은 ISTJ(12.3)%, ESTJ(11.5%) 등이었다. 추후 MBTI 성격유형과 근무부서 선택과 같은 종단연구도 필요할 것으로 생각되며, MBTI 성격유형별 효율적 교수 학습방법을 개발하고 적용하는 후속연구가 필요할 것으로 생각된다.

• 대한한방내과학회지
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• 제44권3호
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• pp.485-505
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• 2023

Objective: The purpose of this study is to assess the effectiveness and safety of using Taeksa-tang for dyslipidemia through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: The search was conducted using keywords such as "dyslipidemia", "hyperlipidemia", "taeksa tang", "zexie tang", and "takusha to" in 12 databases (Pubmed, Cochrane, Embase, ScienceDirect, CNKI, Wanfang, CiNii, RISS, KISS, ScienceON, OASIS, and DBpia) on April 13, 2023. There were no limits on the publication period and language. Cochrane's risk of bias (RoB) was used to evaluate the quality of the studies. A meta-analysis was conducted according to the outcome measurements such as total effective rate (TER), total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and adverse effects, using the Review Manager web. Results: A total of 9 RCTs were selected. In evaluating the RoB, 2 studies mentioning the random sequence generation, 1 study conducting double blindness, and 8 studies without missing values were evaluated as low risk, while 1 study without mentioning the random sequence generation was evaluated as high risk. All other parts were evaluated as unclear risk. The treatment group (Taeksa-tang or Taeksa-tang-gagam) showed more statistically significant effects compared to the control group (Western medicine or Chinese patent medicine) in TER (RR : 1.24, 95% CI 1.15 to 1.34, P<0.00001), TC (MD : -1.12, 95% CI -1.68 to -0.56, P<0.0001), TG (MD : -1.08, 95% CI -1.65 to -0.51, P=0.0002), HDL-C (MD : 0.63, 95% CI 0.34 to 0.93, P<0.0001), LDL-C (MD : -0.81, 95% CI -1.10 to -0.53, P<0.00001). In addition, the treatment group showed lower adverse effects compared to the control group (RR : 0.30, 95% CI 0.12 to 0.74, P=0.008). Conclusion: This study suggests that Taeksa-tang is effective and safe to use for treating dyslipidemia. However, due to the low quality of the included studies, more clinical studies need to be conducted in the future to increase the possibility of clinical use.

• 대한한방내과학회지
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• 제44권3호
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• pp.387-401
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• 2023

Objective: This study was conducted to investigate the preventive effect of herbal medicines on restenosis after percutaneous coronary intervention (PCI) by reviewing randomized controlled trials (RCTs). Methods: RCTs were searched for herbal medicine treatment after PCI using eight online databases (PubMed, CNKI, Wanfang, J-STAGE, OASIS, ScienceON, KTKP, and KISS). Studies that confirmed restenosis through coronary angiography at follow-up were selected according to the inclusion and exclusion criteria. The primary outcome was the restenosis rate, and the secondary outcome was the angina recurrence rate. Data were extracted from the final selected studies according to the research methodology and then analyzed with Review Manager 5.4.1. Study quality was assessed using Cochrane's risk-of-bias (RoB) tool. Results: Of the 252 papers obtained through the primary search, nine studies that met the selection criteria were finally selected. In these nine studies, herbal medicine combined with western medicine was used for the experimental group, and western medicine treatment was used alone for the control group. The meta-analysis result revealed that the restenosis rate and angina recurrence rate were significantly lower in the experimental group than in the control group (RR=0.34, 95% CI: 0.22-0.53, p<0.00001, I²=0% and RR=0.47, 95% CI: 0.29-0.78, p=0.004, I²=0%, respectively). Furthermore, the quality of studies assessed by Cochrane's RoB was low. Conclusions: This study showed that the combined treatment of herbal medicine and western medicine was effective in preventing restenosis and angina after PCI. As the number of papers included in this study was small, a large number of high-quality clinical studies should be considered in the future.

• 한국콘텐츠학회논문지
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• 제22권8호
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• pp.660-670
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• 2022

본 연구는 뇌졸중 환자의 재활 중재에 대한 국내 메타분석 논문의 질을 평가하기 위하여 방법론적 질 평가도구인 AMSTAR-2의 적용하여 분석하였다. 분석된 연구의 질적 수준을 검증하고 근거 중심 실무의 질적 향상과 메타분석 연구를 위한 지침을 제공하고자 한다. 문헌검색은 학술연구정보서비스(Research Information Sharing Service, RISS), 한국 의학 논문 데이터베이스(Korean Medical database, KM base), 한국학술정보(Korean studies Information Service System, KISS)를 이용하였다. 검색을 위해서 주요 핵심어로 '뇌졸중' AND '메타분석'을 주제어로 하여 검색하였다. 최종 18편의 연구 중 AMSTAR-2 질 평가 결과 'Moderate'에 해당하는 연구는 3편(16.67%), 'Low'에 해당하는 연구는 8편(44.44%), 'Critically Low'에 해당하는 연구는 7편(38.89%)으로 나타났다. 향후 연구에서는 과학적이고 객관적인 데이터 선택 및 추출 과정을 수행하고, 문헌의 질적 향상을 위한 방안으로 본 연구에서 분석한 내용을 참고하여 메타분석 연구의 질적 향상을 위한 관심과 노력이 지속되기를 기대한다.

• 동의생리병리학회지
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• 제38권1호
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• pp.1-9
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• 2024

Cognitive reserve (CR) is a concept that can explain the discrepancies between the pathologic burden of the disease and clinical manifestations. It refers to the individual susceptibility to age-related brain changes and pathologies related to Alzheimer's disease, thus recognized as a factor affecting the trajectories of the disease. The purpose of this study was to explore the current states of clinical studies on neural substrates of CR in Alzheimer's disease using functional magnetic resonance imaging. We searched for clinical studies on CR using fMRI in the Pubmed, Cochrane library, RISS, KISS and ScienceON on August 14, 2023. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of CR. Total thirty-four studies were included in this study. As surrogate markers of CR, not only education and occupational complexity, but also composite score and questionnaire-based method, which cover various areas of life, were mainly used. The most utilized methods in resting-state fMRI were independent component analysis, seed-based analysis, and graph theory analysis. Through the analysis, we demonstrated that neuroimaging techniques could capture the neural substrates associated with cognitive reserve. Moreover, functional connectivity of brain regions centered on prefrontal and parietal cortex and network areas such as default mode network showed a significant correlation with CR, which indicated a significant association with cognitive performance. CR may induce differential effects according to the disease status. We hope that this perspective on cognitive reserve would be helpful when conducting clinical researches on the mechanisms of traditional Korean medicine for Alzheimer's disease in the future.