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Standard Performance Measurements of GE $Advance^{TM}$ Positron Emission Tomography (GE $Advance^{TM}$ 양전자방출단층촬영기의 표준 성능평가)

  • Jeong, Ha-Kyu;Kim, Hee-Joung;Son, Hye-Kyung;Bong, Jung-Kyun;Jung, Hai-Jo;Jeon, Tae-Joo;Kim, Jae-Sam;Lee, Jong-Doo;Yoo, Hyung-Sik
    • The Korean Journal of Nuclear Medicine
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    • v.35 no.2
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    • pp.100-112
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    • 2001
  • Purpose: The purpose of this study was to establish optimal imaging acquisition conditions for the GE $Advance^{TM}$ PET imaging system by performing the acceptance tests designed by National Electrical Manufacturers Association (NEMA) protocol and General Electric Medical Systems (GEMS) test procedures. Materials and Methods: Performance tests were carried out with $^{18}FDG$ radioactivity source and phantoms by using a standard acquisition mode. Transaxial resolution and scatter traction tests were performed with a line source and axial resolution with a point source, respectively. A cylindrical phantom made of polymethylmethacrylate (PMMA) was used to measure sensitivity, count rate losses and randoms, uniformity correction, and attenuation inserts were added to measure remaining tests. The test results were acquired in a diagnostic acquisition mode and analyzed mainly on high sensitivity mode. Results: Transaxial resolution and axial resolution were measured as average of 4.65 mm and 3.98 mm at 0 cm, and 6.02 mm and 6.71 mm at 20 cm on high sensitivity mode, respectively. Average scatter fraction was 9.87%, and sensitivity was $225.8kcps/{\mu}Ci/cc$ of trues. Activity at 50% deadtime was $4.6{\mu}Ci/cc$, and the error of count rate correction at that activity was from 1.49% to 3.83%. Average nonuniformity for total slice w3s 8.37%. The accuracy of scatter correction was -0.95%. The accuracies of attenuation correction were 5.68% for air, 0.04% for water and -6.51% for polytetrafluoroethylene (PTFE). Conclusion: The results satisfied most acceptance criteria, indicating that the GE $Advance^{TM}$ PET system can be optimally used for clinical applications.

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Development and Validation of an Analytical Method for Ametoctradin Residue Determination in Domestic Agricultural Commodities by HPLC-PDA (HPLC-PDA를 이용한 국내 유통 농산물 중 ametoctradin 잔류량 분석법 개발 및 검증)

  • Do, Jung-Ah;Kwon, Ji-Eun;Lee, Eun-Mi;Kim, Mi-Ra;Kuk, Ju-Hee;Cho, Yoon-Jae;Kang, Il-Hyun;Kim, Hyung-Su;Kwon, Kisung;Oh, Jae-Ho
    • Korean Journal of Food Science and Technology
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    • v.45 no.3
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    • pp.285-292
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    • 2013
  • This study was carried out to validate the safety of ametoctradin residues in agricultural commodities by developing an official analysis method. An analytical method was developed and validated using HPLC-PDA detectors. The samples were extracted with methanol, subsequently partitioned with dichloromethane and purified with florisil column chromatograph using acetone/hexane (30/70, v/v) as solvent. The method was validated by using grape, hulled rice, mandarin, and potato spiked with ametoctradin at 0.05 and 5.0 mg/kg, and pepper at 0.05 and 2.0 mg/kg. Average recoveries were 76-114.8% with relative standard deviation less than 10%, and the limit of detection and limit of quantification were 0.0125 and 0.05 mg/kg, respectively. The result of recoveries and overall coefficient of variation of the laboratory results from Gwangju regional Food and Drug Administration (FDA) and Daejeon regional FDA was accorded with Codex Alimentarius Commission Guideline (CAC/GL 40). Based on these results, this method was found to be appropriate for ametoctradin residue determination and can be used as the official method of analysis.

Adsorption Removal of Sr by Barium Impregnated 4A Zeolite (BaA) From High Radioactive Seawater Waste (Barium이 함침된 4A 제올라이트 (BaA)에 의한 고방사성해수폐액에서 Sr의 흡착 제거)

  • Lee, Eil-Hee;Lee, Keun-Young;Kim, Kwang-Wook;Kim, Ik-Soo;Chung, Dong-Yong;Moon, Jei-Kwon;Choi, Jong-Won
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.14 no.2
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    • pp.101-112
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    • 2016
  • This study investigated the removal of Sr, which was one of the high radioactive nuclides, by adsorption with Barium (Ba) impregnated 4A zeolite (BaA) from high-radioactive seawater waste (HSW). Adsorption of Sr by BaA (BaA-Sr), in the impregnated Ba concentration of above 20.2wt%, was decreased by increasing the impregnated Ba concentration, and the impregnated Ba concentration was suitable at 20.2wt%. The BaA-Sr adsorption was added to the co-precipitation of Sr with $BaSO_4$ precipitation in the adsorption of Sr by 4A (4A-Sr) within BaA. Thus, it was possible to remove Sr more than 99% at m/V (adsorbent weight/solution volume)=5 g/L for BaA and m/V >20 g/L for 4A, respectively, in the Sr concentration of less than 0.2 mg/L (actual concentration level of Sr in HSW). It shows that BaA-Sr adsorption is better than 4A-Sr adsorption in for the removal capacity of Sr per unit gram of adsorbent, and the reduction of the secondary solid waste generation (spent adsorbent etc.). Also, BaA-Sr adsorption was more excellent removal capacity of Sr in the seawater waste than distilled water. Therefore, it seems to be effective for the direct removal of Sr from HSW. On the other hand, the adsorption of Cs by BaA (BaA-Cs) was mainly performed by 4A within BaA. Accordingly, it seems to be little effect of impregnated Ba into BaA. Meanwhile, BaA-Sr adsorption kinetics could be expressed the pseudo-second order rate equation. By increasing the initial Sr concentrations and the ratios of V/m, the adsorption rate constants ($k_2$) were decreased, but the equilibrium adsorption capacities ($q_e$) were increasing. However, with increasing the temperature of solution, $k_2$ was conversely increased, and $q_e$ was decreased. The activation energy of BaA-Sr adsorption was 38 kJ/mol. Thus, the chemical adsorption seems to be dominant rather than physical adsorption, although it is not a chemisorption with strong bonding form.

Discrimination Analysis of Production Year of Rice and Brown Rice based on Phospholipids (인지질을 이용한 쌀과 현미의 생산연도 판별 분석)

  • Hong, Jee-Hwa;Ahn, Jongsung;Kim, Yong-Kyoung;Choi, Kyung-Hu;Lee, Min-Hui;Park, Young-Jun;Kim, Hyun-Tae;Lee, Jae-Hwon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.62 no.2
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    • pp.105-112
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    • 2017
  • The mixing of rice and brown rice produced in different years is banned in Korea by the grain management act. However, there has been no reported method for discriminating the production year of rice. The objective of this study was to develop a method for discriminating the production year of rice and brown rice based on their phospholipids content. One hundred rice samples and 130 brown rice samples produced between 2012 and 2015 were collected. Twelve phosphatidylcholine components were analyzed by liquid chromatography-tandem mass spectrometry. Phosphatidylcholine was used as an internal standard to calculate the peak intensity of the samples. A statistical analysis of the results showed that the centroid distance between the stale and new rice was 4.16 and the classification ratio was 97%. To verify the calculated discriminant, 61 and 40 rice samples were collected. The accuracy of discrimination was 82% by primary verification and 80% by secondary verification. The statistical analysis of brown rice showed that the centroid distance between the stale and new brown rice was 3.14 and the classification ratio was 96%. To verify the calculated discriminant, 10 samples of new rice and 30 samples of stale rice were collected and the accuracy of discrimination was 93%. The accuracy of discrimination for rice stored at room temperature was 57.9-92.1% and that for rice stored at a low temperature was 86.8-94.7%, depending on the storage period. For brown rice, the detection accuracy was 94.7-100% at room temperature and 92.1-100% at a low temperature, depending on the storage period. The accuracy of discrimination for rice was affected by the storage temperature and time, while that for brown rice was more than 92% regardless of the storage conditions. These results suggest that the developed discriminant analysis method could be utilized to determine the production year of rice and brown rice.

Intake of Antioxidant Nutrients and Risk of Metabolic Syndrome according to Degree of Stress in Rural Korean Women (한국 농촌 여성의 스트레스 정도에 따른 항산화 영양소 섭취와 대사증후군 위험도)

  • Yoon, Jungwon;Shin, Yoonjin;Kang, Bori;Byeon, Suji;Kim, Soo A;Kim, Yangha
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.46 no.7
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    • pp.868-875
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    • 2017
  • The aim of the present study was to investigate antioxidant nutrient intake and risk of metabolic syndrome based on stress level in rural Korean women. Subject were participants from the Multi-Rural Communities Cohort Study, which was a part of the Korean Genome and Epidemiology Study. According to scores of the Psychosocial Well-Being Index Short-Form, a total of 10,111 subjects were classified into 'low stress group (n=8,015)' from 0 to 26 points and 'high stress group (n=2,096)' above 27 points. Data were collected using self-administered questionnaires, anthropometric measurements, and blood chemical analysis. Dietary nutrient consumption was assessed by a semi-quantitative food frequency questionnaire. High stress group showed lower intake of antioxidant nutrients, such as vitamin A, vitamin C, vitamin E, folate, zinc, and carotene compared to the low stress group. Intake of fruits and vegetable was lower in the high stress group compared to the low stress group. Subjects with high stress showed higher risk of hypertension [odd ratio (OR), 95% confidence interval (CI)=1.226 (1.112~1.351)] and hypertriglyceridemia [OR, 95% CI=1.227 (1.110~1.356)] than subjects with low stress. High stress group had a significantly greater odds ratio for metabolic syndrome compared with the low stress group [OR, 95% CI=1.216 (1.101~1.342]). Thus, the present study suggests that high stress might be associated with low intake of antioxidant nutrients and high risk of metabolic syndrome in rural Korean women.

Quality Characteristics of Mul-Kimchi with Chitosan-Ascorbate and Dietary Effect on Serum Lipids of Rats Fed with High Cholesterol Diet (키토산-아스코베이트를 첨가한 물김치의 품질특성과 고콜레스테롤 식이 흰쥐의 혈청지질에 미치는 영향)

  • Shin, Kyung-Ok;Kim, Mee-Jung;Beik, Kyung-Yeun;Kim, Soon-Dong
    • Food Science and Preservation
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    • v.13 no.6
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    • pp.754-761
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    • 2006
  • This study was to investigate the effect of chitosan-ascorbate (CA) prepared with different molecular weight (223, 746, 1110 and 2025 kDa) on the fermentation and quality of mul-kimchi, and also, the effect of the mul-kimchi juice fermented with 0.1% chitosan-ascorbate prepared with 2025 kDa chitosan (CA2025) on the serum lipids of rae fed with high cholesterol diet (HC). The mul-kimchi fermented in 0.1% CA2025 has lower turbidity, longer shelf-life, higher glucosamine content and SOD activity than those of control and the other treatments. In the animal experiment the HC-CA2025 and HC-2CA2025 groups which were administered 0.5 mL per 100 g body weight of mul-kimchi juice fermented with 0.1% CA2025 and administered the same volume of the juice concentrated 112 per nay fed for 5 week, respectively. The average body weight of the HC-CA2025 and HC-2CA2025 group was lower 6.9% and 8.4% than that of HC control group respectively. Total serum cholesterol contents of these groups were 88.33 and 85.00 mg/uL, which were 17.45% and 20.56% lower than HC control group respectively. While, HDL-cholesterol content of these groups were 7% and 23%, higher the LDL-cholesterol content were 13% and 26% lower than those of HC control group respectively. And also, though the atherogenic index, AST and ALT activities were not reached to normal control group, the values were remarkably lower than those of HC control group. This study indicates the possibility of utility for kimchi industry by adding chitosan-ascorbate, especially CA2025 showing not only quality enhancing and shelf-life prolongation but also improving serum lipids and atherogenic index in rats fed with high cholesterol diet.

The Effect of Acupuncture Treatment on the Heart Rate Variability of Chronic Headache Patients (만성두통환자에 대한 침치료가 심박변이도에 미치는 영향)

  • Jung, In-tae;Lee, Sang-hoon;Kim, Su-young;Cha, Nam-hyun;Kim, Keon-sik;Lee, Doo-ik;Lee, Jae-Dong;Lim, Sabina;Lee, Yun-ho;Choi, Do-young
    • Journal of Acupuncture Research
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    • v.22 no.3
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    • pp.105-112
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    • 2005
  • Obiective : The purpose of this study was to assess the effect of acupuncture treatment for chronic headache patients using power spectrum analysis of the heart rate variability(HRV). Methods : 15 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than IS days per month were qualified as Chronic Headache patients. Treatment was afplied 2 times a weeks for 8 weeks. The acupoints, GV2O, HN23, ST8, HN46, TEl7, GB2O, LI2O, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of acupuncture treatment were analyzed using power spectrum analysis of the HRV. HRV was recorded before and after acupuncture treatment. Results : HRV before and after treatment was compared after 8 weeks of acupuncture treatment. Increase in mean values of SDNN and RMSSD were observed but the increases were not statistically significant. Increase in mean values of TP, LF and HF were observed but, the increase was significant(p<0.05) only in TP. Conclusions : The results suggest that acupuncture treatment on chronic headache patients can increase the activity of autonomic nervous system. Further use of HRV for quantitative analysis of acupuncture treatment on autonomic nervous system related symptoms is suggested.

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Fundamental Study for Extension of Application of Recycled Concrete Aggregate: Spun High Strength Concrete (순환골재의 사용성 확대를 위한 연구: 원심력콘크리트로의 적용)

  • Sim, Jong-Sung;Park, Cheol-Woo;Park, Sung-Jae;Kim, Hyun-Jung;Kim, Taeg-Wang;Lee, Man-Suk
    • Journal of the Korean Recycled Construction Resources Institute
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    • v.2 no.1
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    • pp.103-112
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    • 2006
  • Along with recent improvement of recycling technique, the quality of the recycled concrete aggregate have become very competitive to the natural concrete aggregate. Therefore, a practical use of the recycled concrete aggregate may be possible for structural members. Majority studies about the recycled concrete aggregate was emphasized a limitation of fundamental study concerned with a strength characteristics and durability of the recycled aggregate concrete, there is use for the structural members. Therefore, for the extension of application of recycled concrete aggregate, this investigation verifies the strength characteristics recycled concrete aggregate of the spun-concrete products with various coarse and fine recycled aggregate replacement ratio(coarse recycled aggregate: 0%, 20%, 40%, 60%, 100%; fine recycled aggregate: 0%, 30%, 60%, 100%) and with addition of cellulose fibers(0%, 0.01%, 0.03%, 0.05%, 0.08%). From the test results, The strength of spun concrete used with recycled aggregate [NR specimen], was measured as 72MPa, was found to be very approximately to the strength of spun concrete used with the natural aggregate(NN specimen), was measured as 74MPa, when only fine aggregate was replaced with the recycled. Therefore, the fine recycled concrete aggregate can be successfully used in the spun high strength concrete product. The compressive strength of all specimens used the specialty cellulose fiber were measured as about 70M Pa, however, the increasement of the specialty cellulose fiber content is showed to decrease compressive strength of spun concrete. Therefore, it is anticipated that the specialty cellulose fiber can be applied to the various spun concrete products.

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Optimal Selection of Classifier Ensemble Using Genetic Algorithms (유전자 알고리즘을 이용한 분류자 앙상블의 최적 선택)

  • Kim, Myung-Jong
    • Journal of Intelligence and Information Systems
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    • v.16 no.4
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    • pp.99-112
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    • 2010
  • Ensemble learning is a method for improving the performance of classification and prediction algorithms. It is a method for finding a highly accurateclassifier on the training set by constructing and combining an ensemble of weak classifiers, each of which needs only to be moderately accurate on the training set. Ensemble learning has received considerable attention from machine learning and artificial intelligence fields because of its remarkable performance improvement and flexible integration with the traditional learning algorithms such as decision tree (DT), neural networks (NN), and SVM, etc. In those researches, all of DT ensemble studies have demonstrated impressive improvements in the generalization behavior of DT, while NN and SVM ensemble studies have not shown remarkable performance as shown in DT ensembles. Recently, several works have reported that the performance of ensemble can be degraded where multiple classifiers of an ensemble are highly correlated with, and thereby result in multicollinearity problem, which leads to performance degradation of the ensemble. They have also proposed the differentiated learning strategies to cope with performance degradation problem. Hansen and Salamon (1990) insisted that it is necessary and sufficient for the performance enhancement of an ensemble that the ensemble should contain diverse classifiers. Breiman (1996) explored that ensemble learning can increase the performance of unstable learning algorithms, but does not show remarkable performance improvement on stable learning algorithms. Unstable learning algorithms such as decision tree learners are sensitive to the change of the training data, and thus small changes in the training data can yield large changes in the generated classifiers. Therefore, ensemble with unstable learning algorithms can guarantee some diversity among the classifiers. To the contrary, stable learning algorithms such as NN and SVM generate similar classifiers in spite of small changes of the training data, and thus the correlation among the resulting classifiers is very high. This high correlation results in multicollinearity problem, which leads to performance degradation of the ensemble. Kim,s work (2009) showedthe performance comparison in bankruptcy prediction on Korea firms using tradition prediction algorithms such as NN, DT, and SVM. It reports that stable learning algorithms such as NN and SVM have higher predictability than the unstable DT. Meanwhile, with respect to their ensemble learning, DT ensemble shows the more improved performance than NN and SVM ensemble. Further analysis with variance inflation factor (VIF) analysis empirically proves that performance degradation of ensemble is due to multicollinearity problem. It also proposes that optimization of ensemble is needed to cope with such a problem. This paper proposes a hybrid system for coverage optimization of NN ensemble (CO-NN) in order to improve the performance of NN ensemble. Coverage optimization is a technique of choosing a sub-ensemble from an original ensemble to guarantee the diversity of classifiers in coverage optimization process. CO-NN uses GA which has been widely used for various optimization problems to deal with the coverage optimization problem. The GA chromosomes for the coverage optimization are encoded into binary strings, each bit of which indicates individual classifier. The fitness function is defined as maximization of error reduction and a constraint of variance inflation factor (VIF), which is one of the generally used methods to measure multicollinearity, is added to insure the diversity of classifiers by removing high correlation among the classifiers. We use Microsoft Excel and the GAs software package called Evolver. Experiments on company failure prediction have shown that CO-NN is effectively applied in the stable performance enhancement of NNensembles through the choice of classifiers by considering the correlations of the ensemble. The classifiers which have the potential multicollinearity problem are removed by the coverage optimization process of CO-NN and thereby CO-NN has shown higher performance than a single NN classifier and NN ensemble at 1% significance level, and DT ensemble at 5% significance level. However, there remain further research issues. First, decision optimization process to find optimal combination function should be considered in further research. Secondly, various learning strategies to deal with data noise should be introduced in more advanced further researches in the future.

Growth Characteristics of Bay Scallop (Argopecten irradians) reared in the Southern East Sea (동해 남부해역에서 양식된 해만가리비 (Argopecten irradians) 의 성장 특성)

  • Kim, Young Dae;Lee, Chu;Shim, Jeong Min;Kim, Gi Seung;Choi, Jae-Suk;Nam, Myung-Mo
    • The Korean Journal of Malacology
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    • v.31 no.2
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    • pp.103-112
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    • 2015
  • Bay scallop (Argopecten irradians) has been farmed only in the South Sea of Korea. East Sea Fisheries Research Institute (ESFRI) has developed bay scallop aquaculture technologies to extend its aquaculture area to the Southeast Sea of Korea. For the artificial spawning, the water temperature was maintained at $23^{\circ}C$. Over 100,000,000 eggs were spawned through artificial spawning inductions, such as air exposure and thermal shock by rising the water temperature. The fertilization rate was over 91% with nearly 94,000,000 fertilized eggs. The shape of fertilized eggs was spherical with an average diameter of $61.7{\pm}0.05{\mu}m(54.1-67.4{\mu}m)$. Five days after fertilization, the eggs developed into prodissoconch shell, and continuously grew into umbo stage and then umbones stage. After 8 days of fertilization, the size of larva became $179.7{\pm}8.4{\mu}m$ on average ($150.4-204.8{\mu}m$), and the larva formed a foot and an eye spot. The larvae grew to $235.4{\pm}9.7{\mu}m$ in 10 days and attached to adherence material, becoming juvenile bay scallop. The shells grew from 22.71 mm to 72.40 mm in 6 month (June-December). The total weight increased from 2.0 g to 32.7 g at the same period. The daily growth rates of young scallop were $0.35mm\;d^{-1}$ (Apr. to Jun.) and $0.41mm\;d^{-1}$ (Jun. to Aug.), which were comparable to those found in the South Sea. These findings suggest that the bay scallop aquaculture may be suitable in the Southeast Sea of Korea and may provide an additional crop to aquaculturists.