• Title/Summary/Keyword: KD

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Immunostimulating Lectins from Marine Natural Products: Characteristics of the MLA-I, MLA-II and MLA-III (해양 천연물로부터 면역기능 조정제 렉틴 개발 : MLA-I, MLA-II, MLA-III의 특성)

  • 정시련;김장환;전경희
    • YAKHAK HOEJI
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    • v.39 no.3
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    • pp.243-251
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    • 1995
  • Three new lectins, MLA-I, MLA-II and MLA-III, have been isolatedand purified from the hemolymph of Meretrix lusoria and reported previously. Biophysicochemical characteristics were investigated with these three MLA lectins. The MLA lectins agglutinated human erythrocytes non specifically and proved as D-galactose group carbohydrate specific. Molecular weight of ML.A-I. II and III were estimated to be 330, 500 and 310KD, respectively, by gel filtration on Sepharose CL-6B column. On SDS-polyacrylamide gel electrophoresis, ML.A-I was dissociated into a single subunit of 42KD, MLA-II was into the twelve subunits of 46, 32, 30, 28, 25, 23. 22, 20. 19, 16, 15, and 14KD, and MLA-III was into the two subunits of 72 and 44KD. The pl of MLA-I, II, III were 4.0. 4.9 and 5.0. Amino acid analysis revealed a high contents of acidic and hydroxy amino acids, and a paucity of sulfur containing amino acids. Proline was not contained in MLA-II.

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MPEG Video Retrieval using KD-Trees and PCA (KD-Trees 와 PCA를 이용한 MPEG 비디오 검색)

  • 김대일;장혜경;홍종선;김영호;강대성
    • Proceedings of the Korea Institute of Convergence Signal Processing
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    • 2003.06a
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    • pp.118-121
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    • 2003
  • 본 논문은 동영상 압축 부호화에 대한 표준안인 MPEG기반의 압축 비디오 stream에서[1, 2], 질의 영상에 대한 효율적인 검색 기법을 제안한다. 비디오 검색은 높은 차원의 색인 정보를 이용하는데, 높은 차원의 data set을 색인 정보로 하여 효율적인 검색 능력을 보여주는 KD-Trees(K Dimensional-Trees)알고리즘[3]을 비디오 검색기법에 적용하고자 한다. 먼저, key frame에 PCA (Principal Component Analysis) 알고리즘[4]을 이용하여 색인 정보를 추출한 다음, 추출된 색인 정보를 KD-Trees에 적용하여 효율적인 검색을 가능하게 한다. 실험 결과, 기존의 검색 기법보다 상당한 양의 처리 시간과 메모리 공간을 줄일 수 있음을 보였다.

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Applicability of Resistivity Image Profiling to Geologic Survey in the Keoje-do Area (전기비저항 영상법에 의한 거제도의 지반조사)

  • Park, Sam Gyu;Kim, Hee Joon
    • Economic and Environmental Geology
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    • v.27 no.6
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    • pp.563-569
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    • 1994
  • Resistivity Image Profiling has been applied to a geological survey in the Keoje-do area. Survey lines are located near the KD-02 and KD-06 wells in the area, where we have already sampled all rock cores and carried out several kinds of geophysical logs. In each site a resistivity cross-section is obtained by inverting pole-pole apparent resistivities. Comparing the reconstructed resistivity section with the rock cores and logging data obtained in the well provides a detailed picture of subsurface geology. The geology of KD-02 site is composed of conglomerate, sandstone and shale with fractures. The reconstructed resistivity image is useful for assessing the grade of weathering of these rocks. The KD-06 site is mainly underlain by granitic rocks, and its fresh basement can be delineated by resistivities over $1000{\Omega}{\cdot}m$.

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Current concepts of Kimura disease: pathophysiology and evolution of treatment

  • Woo Ju, Kim;Han Koo, Kim
    • Archives of Craniofacial Surgery
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    • v.23 no.6
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    • pp.249-255
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    • 2022
  • Kimura disease (KD) is a chronic inflammatory disorder that frequently involves the subcutaneous tissue of the head and neck regions. It often manifests as regional lymphadenopathy or salivary gland enlargement in the affected area. The histologic architecture of the lymph nodes in KD patients is preserved, while the affected tissues show follicular hyperplasia and eosinophilic infiltration. No single modality has been adopted as an optimal treatment for KD. This article concentrates on the fundamental features of KD and reviews current approaches to its treatment.

Electrophoretic Analysis of Total Proteins in Bacillus sphaericus ts-Dl290 (Bacillus sphaericus ts-D1200 단백질의 전기영동적 분석)

  • 서정희;이형환;김영희
    • Microbiology and Biotechnology Letters
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    • v.18 no.5
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    • pp.541-546
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    • 1990
  • Bacillus sphaericus ts-Dl290 was characterized by SDS-PAGE produced by the mutant at $30^{\circ}C$ and $42^{\circ}C$. The total amount of proteins produced by the mutant at $42^{\circ}C$ decreased to one-fifth of those at $30^{\circ}C$; however, when the culture was shifted down from $42^{\circ}C$ after 4 to $30^{\circ}C$, the total amount of protein decreased to one-third and the 221 kd protein did not appear, but the 155 kd appeared remarkably. When the mutant and the wild type strain were cultured in the media containing 80$\mu g$ per ml of chloramphenicol at $42^{\circ}C$, the wild type strain synthesized half amounts of the total proteins than those at $30^{\circ}C$, and the mutant produced one-tenth of the total protein amounts. When the both strains were cultured in the media containing chloramphenicol, the 155 kd protein was produced was produced in lesser amounts than those without chloramphenicol. The 150 kd protein showed lethal activity to Culex pipiens 3rd instar larvae.

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Hyponatremia May Reflect Severe Inflammation in Children with Kawasaki Disease

  • Lee, I Re;Park, Se Jin;Oh, Ji Young;Jang, Gwang Cheon;Kim, Uria;Shin, Jae Il;Kim, Kee Hyuck
    • Childhood Kidney Diseases
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    • v.19 no.2
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    • pp.159-166
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    • 2015
  • Purpose: The aim of the present study was to investigate the risk factors for the development of coronary artery lesions (CALs) and to determine whether hyponatremia is associated with CALs in children with Kawasaki disease (KD). Methods: We retrospectively analyzed the data of 105 children with KD who were admitted to Ilsan Hospital between January 2000 and July 2011. Results: Erythrocyte sedimentation rate (P = 0.013), total bilirubin levels (P = 0.017) were higher and serum sodium levels (P = 0.027) were lower in KD children with CALs than those without. White blood cell (WBC) counts (P = 0.006), neutrophil counts (P = 0.003) were higher and albumin levels (P = 0.009) were lower in KD children with hyponatremia than those without. On multiple logistic regression analysis, hyponatremia (P = 0.024) and intravenous immunoglobulin-resistance (P = 0.024) were independent risk factors for CALs in KD. Furthermore, serum sodium levels were correlated negatively with WBC counts (P = 0.004), neutrophil counts (P < 0.001), total bilirubin levels (P = 0.005) and positively with albumin levels (P = 0.009). Conclusion: Our study indicates that hyponatremia may reflect severe inflammation in children with KD.

Gram-negative Septicemia after Infliximab Treatment in an Infant with Refractory Kawasaki Disease (불응성 가와사키병 환아에서 infliximab 사용 후 발생한 패혈증)

  • Lee, Jin Hwan;Yoon, Jung Min;Lim, Jae Woo;Ko, Kyong Og;Cheon, Eun Jung
    • Pediatric Infection and Vaccine
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    • v.21 no.3
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    • pp.225-230
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    • 2014
  • Kawasaki disease (KD) is an immune-mediated disease which is a leading cause of acquired cardiovascular disease in developed country. Recently, tumor necrosis factor-alpha (TNF-alpha) blocker, infliximab has been considered a promising option for patients with refractory KD. Although chronic use of a TNF-alpha blocker could increase risk of opportunistic infections, a few studies have documented that use of infliximab was safe without serious adverse effects in patients with KD. We observed serious bacterial infection after infliximab treatment in an infant with refractory KD. Our patient was a 5-month-old male infant diagnosed with KD who did not respond to repeated doses of intravenous immunoglobulin. We effectively treated him with a single infusion of infliximab (5 mg/kg), but gram-negative (Acinetobacter lwoffii) septicemia developed after infliximab infusion. Therefore, we report a case of serious septicemia after treatment with infliximab, and suggest considering the risk of severe infection when deciding whether to prescribe infliximab to an infant with refractory KD.

An efficient acceleration algorithm of GPU ray tracing using CUDA (CUDA를 이용한 효과적인 GPU 광선추적 가속 알고리즘)

  • Ji, Joong-Hyun;Yun, Dong-Ho;Ko, Kwang-Hee
    • 한국HCI학회:학술대회논문집
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    • 2009.02a
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    • pp.469-474
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    • 2009
  • This paper proposes an real time ray tracing system using optimized kd-tree traversal environment and ray/triangle intersection algorithm. The previous kd-tree traversal algorithms search for the upper nodes in a bottom-up manner. In a such way we need to revisit the already visited parent node or use redundant memory after failing to find the intersected primitives in the leaf node. Thus ray tracing for relatively complex scenes become more difficult. The new algorithm contains stacks implemented on GPU's local memory on CUDA framework, thus elegantly eliminate the problems of previous algorithms. After traversing the node we perform the latest CPU-based ray/triangle intersection algorithm 'Plucker coordinate test', which is further accelerated in massively parallel thanks to CUDA. Plucker test can drastically reduce the computational costs since it does not use barycentric coordinates but only simple test using the relations between a ray and the triangle edges. The entire system is consist of a single ray kernel simply and implemented without introduction of complicated synchronization or ray packets. Consequently our experiment shows the new algorithm can is roughly twice as faster as the previous.

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The outcome of short-term low-dose aspirin treatment in Kawasaki disease based on inflammatory markers

  • Yoo, Jae Won;Kim, Ji Mok;Kil, Hong Ryang
    • Clinical and Experimental Pediatrics
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    • v.60 no.1
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    • pp.24-29
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    • 2017
  • Purpose: Previously, Kawasaki disease (KD) treatment with low-dose aspirin was administered for 6-8 weeks after the acute phase. However, inflammatory marker levels normalize before 6-8 weeks. In this study, we aimed to investigate the clinical outcome of short-term low-dose aspirin treatment based on inflammatory and thrombotic marker levels. Methods: We performed a retrospective review of the medical records of patients with KD who were hospitalized at Chungnam National University Hospital between September 2012 and May 2014. When fever subsided, low-dose aspirin treatment was started. Inflammatory (white blood cell count, erythrocyte sedimentation rate, and C-reactive protein) and thrombotic markers (D-dimer) were monitored at follow-ups conducted in 1- to 2-week intervals. The low-dose aspirin administration was terminated when both markers were normalized and no cardiovascular complications were observed. Results: Eighty-four patients with KD (complete KD, n=49; incomplete KD, n=35) were enrolled. The inflammatory and thrombotic marker levels were normalized within 3-4 weeks on average. At the beginning the low-dose aspirin treatment, 9 patients had coronary artery lesions but 75 did not. When the low-dose aspirin administration was terminated at the time the inflammatory marker levels were normalized, no new CALs developed during the follow-up at 6-8 weeks. Conclusion: Most of the inflammatory marker levels were normalized within 3-4 weeks after the acute phase of KD. New cardiovascular complications did not develop during the course of the short-term aspirin treatment based on the inflammatory marker levels, clinical findings, and echocardiography.