• Archives of Pharmacal Research
• /
• v.16 no.2
• /
• pp.114-117
• /
• 1993

Ginsenosides present in the roots of panax ginseng C.A. Meyer were shown to induce a stimulatory effect on the overexpressed cellular chicken c-src protein tyrossine kinase in NH3T3 cells. Among 4 ginsenosides studied $(G-Rb_2,\;G-Rc,\;G-Re\;and\;G-Rg_1),\;G-Rg_1$ showed the most stimulatory effect at $16.7\mu{g/ml}$ ginsenoside concentration increasing the activity by 2-4 times. Inhibitors of either protein synthesis or RNA synthesis blocked the activation of c-src proein tyrosine kinase. These results suggest that the csrc kinase activation apprars to involve an increase in the amount of protein of the kinase by transcriptional control mechanism rather than an increase in the kinase activity.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.404.2-404.2
• /
• 2002

The present study was undertaken to develop the in vitro sun protection factor(SPF) test method having good correlation with in vivo method using human. 8% homomentyl salicylate. P3 reference standard and commercially available sunscreen products were measured by the in vitro method using SPF 290S analyzer. and the SPFs were compared with the SPFs measured by in vivo test method. In vitro SPFs of 8% HMS and P3 reference standard were 4.59$\pm$0.12 and 14.94$\pm$0.83. (omitted)

• Journal of Positioning, Navigation, and Timing
• /
• v.12 no.3
• /
• pp.307-314
• /
• 2023

Wide-Area Differential Global Positioning System (WADGPS) is a system that operates a number of reference stations to provide correction information to improve the accuracy of GPS users, and it is available to service users within the area where the wide-area reference stations are installed. Recently, as positioning information has been used in various applications, the need for WADGPS for precise navigation in long-distance spaced areas where the wide-area reference stations cannot be installed has been raised. This paper tested the user navigation performance outside the wide-area reference stations of the WADGPS system, which serves both GPS Precise Positioning Service (PPS) and Standard Positioning Service (SPS) users. Static and dynamic tests were conducted using vehicles, and as a result, position accuracy improvement through WADGPS was confirmed even at points hundreds of kilometers outside the network area of the wide-area reference stations. Through this, the performance of the PPS/SPS correction system and the possibility of expanding the service area were confirmed.

• Journal of Korea Multimedia Society
• /
• v.19 no.8
• /
• pp.1619-1625
• /
• 2016

Recently, as the public interests about the 3D printing technology are increased, various kinds of 3D printers are being released. But, they are limited to use because they cannot fabricate an object which is larger than the printer's printing volume. To relieve this problem, we propose an interactive 3D mesh editing system for 3D printing the object that is larger than the printing volume. The proposed 3D editing system divides the input 3D mesh using the user's line drawings defining cutting planes and it attaches various connectors. The output meshes are guaranteed to fabricate without post-processing. The printed parts can be assembled using the connectors. Our proposed system has an advantage that it can be used easily by non-professional 3D printer users.

• Preventive Nutrition and Food Science
• /
• v.3 no.2
• /
• pp.163-168
• /
• 1998

Inhibitory effect of indole oligomers induced from indole-3-carbinol(I3C) on the growth of breast cancer cells was studied. We gernerated the reaction mixtures (RXM) at ambient temperature by treating a stirred aqueous solution of I3C (typeically 0.25ml) at a concentration of 12 $\mu$mol/ml) with hydrochloric acid (typically 28$\mu$l of a 1 mmol/ml solution). RXM was fractionated by the column chromatography. The fractions with similar UV-pattern were further fractionated by HPLC and 3.3'-diindoylmethane (DIM) and other indole oligomers were identified. I3C, RXM, and it derived indole compounds were added to MCF-7 cells and cultured in the presence of 10-7M estradiol for 7 days. the growth-inhibitory effect of I3C and DIM on the growth of MCF-7 cell was very strong. The synthetic DIM also revealed antiproliferative effect on MCF-7 cel. The fractions containing high DIM content (77%), were most effective in inhibiting MCF-7 cell growth induced by estradiol. With these results, we suggest that I3C and DIM might have anticarcinogenic effect on the breast cancer.

• Journal of the Korean Ceramic Society
• /
• v.36 no.10
• /
• pp.1102-1107
• /
• 1999

SiC-Si3N4 composites were prepared by mixing $\alpha$-Si3N4 powder to $\alpha$-SiC powder in the range of 10 to 30 vol% with 10vol% interval. 6wg% Al2O3 and 6wt% Y2O3 were respectively added as sintering aids. Hot pressing was performed at 1,80$0^{\circ}C$ for 1 hour with 25 MPa pressure. In the case of adding 20vol% of $\alpha$-Si3N4 powder the relative density to theoretical value and the flexural strength were 99.1% and 34,420 MPa respectively and the worn amount was 2.09$\times$10-3 mm2 which were the highest values in the all range of he composition. Although the composite containig 10 vol% of $\alpha$-Si3N4 powder showed the highest fracture toughness(KIC) of 4.65MN/m3/2 the reduction of the wear resistance in this composite is likely to be affected by the homogeneity and the uniformity of the grain coalescence and growth during the sintering process.

• Journal of Science Education
• /
• v.43 no.3
• /
• pp.400-416
• /
• 2019

The purpose of this study is to find ways to improve education about safe medication use by investigating the current status of medication use by middle and high school students, and by evaluating their knowledge, attitudes, practices and education needs toward safe medication use. For this purpose, a survey was administered to 200 middle and high school students in Seoul and Gyeonggi Province. Over the past year, 92.0% and 57.5% of respondents used over-the counter drugs and prescription drugs at least one time, respectively. Regarding the experience of education on safe medication use, 34.0% of respondents have been educated more than once since their admission to middle school. The overall mean score of knowledge·attitude·practice (KAP) toward safe medication use was 3.79, but the mean score of practice scope was relatively lower than the others. Moreover, there were no significant differences in KAP scores for safe medication use by school grade or educational experience. Based on these findings, we suggest further studies regarding 1) expansion and differentiation of education content on safe medication use, 2) transition of education method to outcome-based education approach, and 3) inclusion of education on safe medication use in the regular curriculum of middle and high schools.

• Journal of radiological science and technology
• /
• v.20 no.2
• /
• pp.79-82
• /
• 1997

Image-based three dimensional radiation treatment planning(3D RTP) has a potential of generating superior treatment plans. Advances in computer technology and software developments quickly make 3D RTP a feasible choice for routine clinical use. However, it has become clear that an evaluation of a 3D plan is more difficult than a 2D plan. A number of tools have been developed to facilitate the evaluation of 3D RTP both qualitatively and quantitatively. For example, beam's eye view(BEV) is one of the most powerful and time-saving method as a qualitative tools. Dose-volume histogram(DVH) has been proven to be one of the most valuable methods for a quantitative tools. But it has a limitation to evaluate several different plans for biological effects of the tissue and critical organ. Therefore, there is a strong interest in developing quantitative models which would predict the likely biological response of irradiated organs and tissues, such as tumor control probability(TCP) and normal tissue complication probability(NTCP). DVH and NTCP of hepatoma were evaluated for three dimensional conformal radiotherapy(3D CRT). Also, 3D RTP was analysed as a dose optimization based on beam arrangement and beam modulation.

• KOREAN JOURNAL OF CROP SCIENCE
• /
• v.32 no.1
• /
• pp.34-39
• /
• 1987

This study was conducted to find out the adequate cutting method for propagation and the optimum treat-ing time of GA$_3$ to enhance the fruit setting of Pepino (Solanum muricatum AIT). Mixture of peat moss (50%) and vermiculite (50%) shows the best rooting for the Pepino stem cuttings. An active rooting was observed 15 days after the cuttings were treated with 1,000 ppm of NAA. Application of GA$_3$ at flowering stage was effective for fruit setting of Pepino and fruit setting was the most satisfactory when GA$_3$ was sprayed over the flowers.