• BMB Reports
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• v.43 no.4
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• pp.297-303
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• 2010

In order to demonstrate the potential therapeutic effect of two flavonoids, Baicalein and Wogonin, on suppression of pathological myocardial fibrosis in hypertension, we investigated their in vitro effects on collagen expression in primary cultured cardiac fibroblasts isolated from neonatal normotensive (WKY) and hypertensive (SHR) rats. Our results showed that over-expression of collagen mRNA and protein induced in cardiac fibroblasts by angiotensin (AngII) could be attenuated significantly by both flavonoids at an optimal dosage ($30\;{\mu}M$; P < 0.01). Results of immunoblots showed that expression of 12-LO level, p-ERK/ ERK ratio and MMP-9 in AngII-stimulated SHR cardiac fibroblasts were significantly down-regulated by both flavonoids. Our results show that both Baicalein and Wogonin can suppress collagen deposition in AngII-stimulated SHR and WKY cardiac fibroblasts.

• Journal of Biosystems Engineering
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• v.37 no.1
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• pp.1-10
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• 2012

Purpose: The most important element of an agricultural helicopter is the rotor blade realizing lift force. In order to improve the performance of the rotor blades, two types (KA152313 and KB203611) of airfoils were designed and compared. Methods: The nose shape of the KB203611 airfoil was 'drooped' and 'sharp' compared to the leading edge of the KA152313 airfoil. The performance of the experimental airfoils was simulated using CFD-ACE program, and lifts were measured in situ using the 'AgroHeli-4G', a prototype helicopter. Results: Simulated lifts of the blade with the KA152313 airfoil showed proper values for a wide range of angles of attack between $14^{\circ}{\sim}18^{\circ}$, while the simulated lift of the KB203611 blade exhibited maximum values near $13^{\circ}{\sim}14^{\circ}$. In the lift measurements, the range of operable angles of attack was a collective pitch angle at the grip (GP) of $12^{\circ}{\sim}18^{\circ}$ for the KA152313 blade. On the other hand, the range of angles of attack for the KB203611 blade was a GP of $12^{\circ}{\sim}14^{\circ}$. Conclusions: The blade of KA152313 performed well over a wide range of AoAs and the blade of KB203611 performed better at low AoAs. In this study, a variative airfoil blade, gradually emerging from grip to tip using the two different airfoils, was suggested.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2009.11a
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• pp.101-104
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• 2009

이 연구는 Ka대역 위성 HDTV 방송 서비스를 제공하기 위해 강우강도에 따른 전송방안을 제안하였다. Ka대역은 Ku대역에 비하여 강우에 취약하기 때문에 이를 안정적으로 활용하기 위해서는 강우감쇠를 효과적으로 경감시키는 기술개발이 필수적이다. 유럽위성방송 표준인 DVB-S2에서는 강우감쇠에 대한 대처방안으로 채널상황에 따라 여러 변조방식과 채널 부호 율을 이용하는 적응형 변복조 방식을 지원하고 있으며, 이 논문에서는 DVB-S2기반의 전송방식과 Ka대역 중계기의 규격을 적용하여 강우강도에 따른 전송방안을 제안하였다. 이를 위하여 ITU-R P.618-9 강우감쇠 추정 모델과 기상청에서 측정한 1998년부터 2007년까지의 최근 10년간 국내 주요지역의 30분 누적강우량을 이용하여 지역별 강우 감쇠값을 도출하였고 강우강도와 시간 율 관계분석을 통하여 강우강도에 따른 강우감쇠 값을 획득하였다. 획득한 강우감쇠 값을 무궁화 위성 3호의 링크 설계에 적용하여 강우강도에 따른 적용 가능한 전송방안을 도출하였다. 이 연구를 바탕으로 강우의 지역적 편이가 높은 우리나라의 강우 특성을 유연하게 반영하여 각 지역에 맞는 적응적인 전송 방식을 고려할 수 있다.

• The Journal of Korean Medicine
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• v.36 no.4
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• pp.74-79
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• 2015

Objectives: Here we investigated the anti-lipogenic potential of kaurenoic acid (KA), a diterpene derived from Aralia continentalis, in a cellular model of non-alcoholic fatty liver disease. Methods: HepG2 cells were treated with palmitate for 24h to induce intracellular lipid accumulation. To assess the influence of KA on steatotic HepG2 cells, various concentration of KA was co-administered. After palmitate treatment, Intracellular triglyceride content was measured. Expression level of several lipogenic genes, sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD-1) were measured using Western-blot analyses or RT-PCR. Results: Palmitate markedly increased intracellular triglyceride level and expression of related lipogenic genes in HepG2 cells, and which was relieved by co-administered KA. Conclusions: It is conceivable that that KA may have a pharmacological potential to reduce lipid accumulation in non-alcoholic fatty liver disease.

• Archives of Pharmacal Research
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• v.20 no.4
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• pp.375-378
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• 1997

The Chongmyungtang (CMT; the combination of Acorus gramineus, polygala tenuifolia and Poria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary acidic protein (GFAP) expression. KA induced vigorous convulsions lasting 4-6 hr. Pretreatments with CMT before KA injection significantly reduced the seizure intensity as well as the mortality. CMT pretreatments also attenuated the KA-induced increase in FRA/GFAP expression in the hippocampus. These results suggest that CMT has a neuroprotective effect against KA-induced neurotoxicities.

• Korean Journal of Medicinal Crop Science
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• v.12 no.5
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• pp.415-423
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• 2004

Myristica fragrans seed from Myristica fragrans Houtt (Myristicaceae) has various pharmacological activities peripherally and centrally. The present study aims to investigate the effect of the methanol extract of Myristica fragrans seed (MF) on kainic acid (KA)-induced neurotoxicity in primary cultured rat cerebellar granule neuron. MF, over a concentration range of 0.05 to $5\;{\mu}g/ml$ inhibited KA $(500\;{\mu}M)-induced$ neuronal cell death, which was measured by trypan blue exclusion test and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay. MF $(0.5\;{mu}g/ml)$ inhibited glutamate release into medium induced by KA $(500\;{\mu}M)$, which was measured by HPLC. Pretreatment of MF $(0.5\;{mu}g/ml)$ inhibited KA $(500\;{\mu}M)-induced$ elevation of cytosolic calcium concentration $([Ca^{2+}]_c)$, which was measured by a fluorescent dye, Fura 2-AM, and generation of reactive oxygen species (ROS). These results suggest that MF prevents KA-induced neuronal cell damage in vitro.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2005.03a
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• pp.11-17
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• 2005

Along the Ulsan Fault System, many Quaternary faults have been reported and investigated with outcrop observation and trench excavation to clarify the neotectonic movements and fault parameters such as length, displacement, slip rate and recurrence interval. In the northern part of the Ulsan fault system, we have interpreted small scale(1:10,000) aerial photographs and extracted lineaments by geomophological features to select trench site. After precise field survey and tracing for lineaments, two trench sites at Galgokri, Gyeongju were selected on the lineament to elucidate the fault movement history. One is successful in finding faults but the other is not. In the Galgok-Chisil trench(3m(w) x 1.5m(d) x 10m(l)), very closed two Quaternary faults cut the alluvial deposits of which age shows about 10-3ka. More than three times of fault movements can be inferred by geologic structures and C-14 dating. Repeatedly fault movements had been occurred before 10 ka, between 10ka-4.9 ka, between 4.9-1.4 ka at Galgok-Chisil trench section.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.23 no.7
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• pp.1770-1776
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• 1998

This paper presents a waveguide-to-mircostrip transition at Ka-band using antipodal finlines. Critical design parameters were identified with the help of theoretical analysis. Experimental optimization was performed together with 3-D FEM analysis in an effort to find optimum dimensions of the transition. In addition to the conventional antipodal finline transition, a new dielectric impedance transformer was introduced to further reduce the insertion loss. Optimized waveguide-to-microstrip transition showed an insertion loss of 0.3~0.4dB/transition at Ka-band. This transition provides superior reproducibility and better performance than conventional coaxcable-to-microstrip transition.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.4
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• pp.449-456
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• 2012

Herein, we design a wideband $8{\times}8$ waveguide Butler matrix in order to use in a multi-port amplifiers(MPAs) at Ka-band. To achieve the broadband characteristic, we design a binomial 6-slot 3 dB directional coupler which is used to configure the $8{\times}8$ Butler matrix. The measured results of the fabricated $8{\times}8$ Butler matrix have low insertion loss of less than 0.3 dB, good return loss of over 26 dB and high isolation of over 35 dB within the design bandwidth of 3 GHz.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.4
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• pp.600-610
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• 2001

The effects of group delay and non-linear characteristics on high data rate(HDR) satellite channel are presented in this paper Based on the modeling of group delay and non-linear characteristics the system performances which provide various data rate services were analyzed in Ka-band satellite channel. As the transmission data rate is increased, the degradation due to these channel characteristics is severely increased. The linear component of group delay and the AM-AM component of non-linear characteristics severely affect the system performance. To efficiently provide the various service via the same transmission system it is necessary to equalize the primary impairment factors. The optimum operating points of HDR satellite transmission system are implemented by considering the analyzed results on channel characteristics.